• The Plant Pathology Journal
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• 제36권6호
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• pp.600-607
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• 2020

Phytophthora capsici Leonian is a major pathogen of pepper worldwide and few resistance sources to this pathogen have been identified so far. The goals of this study were to identify new sources of resistance against P. capsici in Capsicum landraces and analyze the relationship between the resistance indicator of plant symptoms and some plant phenotype parameters of plant height, stem width, leaf length and leaf width. Thirty-two landraces of pepper were collected from fourteen states in Mexico. From each population, 36 plants were inoculated with 10,000 zoospores of P. capsici under controlled conditions. This experiment was repeated twice. Out of the 32 landraces, six showed high level of resistance, four showed intermediate resistance and five showed low level of resistance when compared with the susceptible control 'Bravo' and the resistant control 'CM334', indicating that these landraces are promising novel sources of resistance to P. capsici. There was no correlation between the symptoms and plant phenotype parameters. However, these parameters were not affected in the group classified as highly resistant, indicating that P. capsici does not affect the growing of these resistant pepper landraces. The other resistant groups were significantly affected in a differently manner regarding their phenotype, indicating that this pathogen reduce their growth in different ways. This study reports novel resistance sources with great potential that could be used in breeding programs to develop new pepper cultivars with durable resistance to P. capsici.

• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4353-4358
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• 2013

Introduction: Breast cancer aggressiveness can be correlated with proliferation status of tumor cells, which can be ascertained with tumor grade and Ki67 indexing. However due to lack of reproducibility, the ASCO do not recommend routine use of Ki67 in determining prognosis in newly diagnosed breast cancers. We therefore aimed to determine associations of the Ki67 index with other prognostic markers like tumor size, grade, lymph node metastasis, ER, PR and HER2neu status. Methods: A total of 194 cases of newly diagnosed breast cancer were included in the study. Immunohistochemical staining for ER, PR, HER2neu and Ki67 was performed by the DAKO envision method. Associations of the Ki67 index with other prognostic factors were evaluated both as continuous and categorical variables. Results: Mean age of the patients was 51.7 years (24-90). Mean Ki67 index was 26.9% (1-90). ER, PR, HER2neu positivity was noted in 90/194 cases (46.4%), 74/194 cases (38.1%) and 110/194 cases (56.70%) respectively. Significant association was found between Ki67 and tumor grade, PR, HER2neu positivity and lymph node status, but no link was apparent with ER positivity and tumor size. There wasan inverse relation between Ki67 index and PR positivity, whereas a direct correlation was seen with HER2neu positivity. However, high Ki67 (>30%) was associated with decreased HER2neu positivity as compared to intermediate Ki67 (16-30%). The same trend was established with lymph node metastasis. Conclusion: Our study indicates that with high grade tumors, clinical utility of ki67 is greater in combination with other prognostic markers because we found that tumors with Ki67 higher than 30% have better prognostic profile compared to tumors with intermediate Ki67 level, as reflected by slightly lower frequency of lymph node metastasis and HER2neu expression. Therefore we suggest that Ki67 index should be categorized into high, intermediate and low groups when considering adjuvant chemotherapy and prognostic stratification.

• Nuclear Engineering and Technology
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• 제48권3호
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• pp.613-623
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• 2016

Molybdenum-99 ($^{99}Mo$) is the most important isotope because its daughter isotope, technetium-99m ($^{99m}Tc$), has been the most widely used medical radioisotope for more than 50 years, accounting for > 80% of total nuclear diagnostics worldwide. In this review, radiochemical routes for the production of $^{99}Mo$, and the aspects for selecting a suitable process strategy are discussed from the historical viewpoint of $^{99}Mo$ technology developments. Most of the industrial-scale $^{99}Mo$ processes have been based on the fission of $^{235}U$. Recently, important issues have been raised for the conversion of fission $^{99}Mo$ targets from highly enriched uranium to low enriched uranium (LEU). The development of new LEU targets with higher density was requested to compensate for the loss of $^{99}Mo$ yield, caused by a significant reduction of $^{235}U$ enrichment, from the conversion. As the dramatic increment of intermediate level liquid waste is also expected from the conversion, an effective strategy to reduce the waste generation from the fission $^{99}Mo$ production is required. The mitigation of radioxenon emission from medical radioisotope production facilities is discussed in relation with the monitoring of nuclear explosions and comprehensive nuclear test ban. Lastly, the $^{99}Mo$ production process paired with the Korea Atomic Energy Research Institute's own LEU target is proposed as one of the most suitable processes for the LEU target.

• Geomechanics and Engineering
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• 제18권3호
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• pp.267-275
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• 2019

Tabriz is a large Iranian city and the capital of the East Azerbaijan province. The bed rock of this city is mainly consisted of marl layers. Marl layers have some outcrops in the northern and eastern parts of city that mainly belong to the Baghmisheh formation. Based on their colors, these marls are classified into three types: yellow, green, and gray marls. The city is developing toward its eastern side wherein various civil projects are under construction including tunnels, underground excavation, and high-rise building. In this regard, the swelling behavior assessment of these marls is of critical importance. Also, in lightweight structures with foundation pressure less than swelling pressure, several problems such as walls cracking and jamming of door and windows may occur. In the present study, physical properties and swelling behavior of Baghmisheh marls are investigated. According to the X-ray diffractometer (XRD) results, the marls are mainly composed of Illite, Kaolinite, Montmorillonite, and Chloride minerals. Type and content of clay minerals and initial void ratio have a decisive role in swelling behavior of these marls. The swelling potential of these marls was investigated using one-dimensional odometer apparatus under stress level up to 10 kPa. The results showed that yellow marls have high swelling potential and expansibility compared to the other marls. In addition, green and gray marls showed intermediate and low swelling potential and swelling pressure, respectively.

• Geomechanics and Engineering
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• 제12권4호
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• pp.561-577
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• 2017

Vast parts of the east of Tabriz city have been covered by Baghmisheh formation marls. These marls can be classified into three types based on their color as identified in yellow, green, and gray marls. Many high-rise buildings and other projects were founded and now is constructing on these marls. Baghmisheh formation marls are classified as stiff soil to very weak rock, therefore they undergo considerable consolidation settlement under foundation loads. This study presents the physical properties and consolidation behavior of these marls. According to the XRD tests, major clay minerals of marls are Illite, Kaolinite, Montmorillonite and Chloride. Uniaxial compressive strength are 100-250, 300-480 and 500-560 kPa for yellow, green and gray marls, respectively. Consolidation and creep behavior of Baghmisheh marls investigated by using of one dimensional consolidation apparatus under stress level up to 5 MPa. The results indicate that yellow marls have high compressibility, settlement and deformation modules. Green marls have an intermediate compressibility and settlement and while gray marls have low compressibility and settlement and from the foundation point of view have high stability. According to the creep test results, all types of marls have not been entered to progressive creep phase up to pressure 5 MPa.

• Parasites, Hosts and Diseases
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• 제44권1호
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• pp.43-48
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• 2006

Experimental murine models with high, intermediate and low levels of genetically based susceptibility to Leishmania major infection reproduce almost entire spectrum of clinical manifestations of the human disease. There are increasing non-comparative studies on immune responses against isolated antigens of L. major in different murine strains. The aim of the present study was to find out whether there is an antigen that can induce protective immune response in resistant and susceptible murine strains. To do that, crude antigenic extract of procyclic and metacyclic promastigotes of L. major was prepared and subjected to SDS-PAGE electrophoresis. Western-blotting was used to search for antigen(s) capable of raising high antibody level of IgG2a versus IgG1 in the sera of both infected resistant and susceptible strains. Two novel antigens from metacyclic promastigotes of L. major (140 and 152 kDa) were potentially able to induce specific dominant IgG2a responses in BALB/c and C57BU6 mice. The 2 antigens also reacted with IgG antibody of cutaneous leishmaniasis patients. We confirm that 140 and 152 kDa proteins of L. major promastigotes are inducing IgG production in mice and humans.

• 음성과학
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• 제12권4호
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• pp.95-112
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• 2005

We investigate Korean learners' speech-timing of English before and after instruction in comparison with native speech, in an attempt to resolve disagreements in the literature as to whether speech-timing is measurable (Lehiste, 1977; Roach, 1982; Dauer, 1983 vs. Low et al., 2000; Yun 2002; Jian, 2004). We measured the pair-wise variability between the adjacent stressed and unstressed syllables within a foot as well as that among adjacent feet in approximately 555 English sentences, which were read by 29 native speakers and 41 Korean learners in the intermediate proficiency level. The results show that in comparison with native American English, Korean learner speech is before instruction significantly (p<.001) smaller for the pair-wise variability between the adjacent stressed and unstressed syllables within a foot; and significantly (p=.01) bigger for the variability among adjacent feet within the utterance. The learner speech after instruction showed significant (p=.01) improvement in the pair-wise variability of syllable sequence toward native speech values. The variability among adjacent feet was progressively smaller for learner speech before and after instruction and for native speech (p=.03). We thus conclude that the speech timing difference between Korean English and American English is measurable in terms of the duration. of stressed and unstressed syllables and that the latter is stress-timed and the former is syllable-timing interfered.

• 방사성폐기물학회지
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• 제18권4호
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• pp.537-548
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• 2020

Currently, radioactive waste for disposal has been restricted to low and intermediate level radioactive waste generated during operation of nuclear power plants, and these radioactive wastes were managed and disposed of the 200 L and 320 L of steel drums. However, it is expected that it will be difficult to manage a large amount of decommissioning waste of the Kori unit 1 with the existing drums and transportation containers. Accordingly, the KORAD is currently developing various and large-sized containers for packaging, transportation, and disposal of decommissioning waste. In this study, the radiation exposure doses of workers and the public were evaluated using RADTRAN computational analysis code in case of the domestic on-road transportation of new package and transportation containers under development. The results were compared with the domestic annual dose limit. In addition, the sensitivity of the expected exposure dose according to the change in the leakage rate of radionuclides in the waste packaging was evaluated. As a result of the evaluation, it was confirmed that the exposure dose under normal and accident condition was less than the domestic annual exposure dose limit. However, in the case of a number of loading and unloading operations, working systems should be prepared to reduce the exposure of workers.

• 방사성폐기물학회지
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• 제14권1호
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• pp.11-19
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• 2016

This paper focuses on the estimation of durability and service-life of reinforced concrete structures in Wolsong Low- and intermediate-level wastes Disposal Center (WLDC) in Korea. There are six disposal silos located in the saturated environment. The silo concrete is degraded due to reactions with groundwater and chemical attacks, and finally it will lose its properties as a transport barrier. The infiltration of sulfate and magnesium, leaching of potassium hydroxide, and chlorine induced corrosion are the most significant factors for degradation of reinforced concrete structure in underground environment. From the result of evaluation of the degradation time for each factor, the degradation rate of the reinforced concrete due to sulfate and magnesium is $1.308{\times}10^{-3}cm/yr$, and it is estimated to take 48,000 years for full degradation while potassium hydroxide is leached in depth of less than 1.5 cm at 1,000 years after the initiation of degradation. In case of chlorine induced corrosion, it takes 1,648 years to initiate corrosion in the main reinforced bar and 2,288 years to reach the lifetime limit of the structural integrity, and thus it is evaluated as the most significant factor.

• 방사성폐기물학회지
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• 제6권4호
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• pp.369-385
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• 2008

부지감시 및 조사의 목적은 운영 전, 운영중 및 폐쇄 후 단계에서 변화가 예상되는 주요 부지특성을 지속적으로 감시함으로써 방사성폐기물처분장의 성능평가 및 설계에 필요한 기초자료를 제공하는 것이다. 부지감시의 단계별 주요내용은 다음과 같다. 운영전 단계에는 부지의 적합성 평가 및 처분장 건설과 운영에 필요한 주요 부지특성을 감시하며, 운영 중 단계에는 안전하고 효율적인 운영과 환경에 미치는 영향을 판단하기 위하여 주변지역을 포함하여 주요 부지특성을 감시한다. 폐쇄 후 단계에는 처분장의 방사성 물질로 인한 영향을 사전에 예방하고, 처분장의 장기적 안전성을 위하여 필요한 주요 부지특성 항목을 감시한다.