• Title/Summary/Keyword: Low LET

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Effect on Pancreatic Beta Cells and Nerve Cells by Low LET X-ray (Low LET X-ray가 췌장 ${\beta}$ 세포와 신경세포에 미치는 효과)

  • Park, Kwang-Hun;Kim, Kgu-Hwan
    • Journal of radiological science and technology
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    • v.37 no.1
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    • pp.21-28
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    • 2014
  • Cultured pancreatic beta cells and nerve cells, it is given normal condition of 10% FBS (fetal bovine serum), 11.1 mM glucose and hyperglycemia codition of 1% FBS, 30 mM glucose. For low LET X-ray irradiated with 0.5 Gy/hr dose-rate(total dose: 0.5 to 5 Gy). Survival rates were measured by MTT assay. When non irradiated, differentiated in the pancreatic beta cells experiment is hyperglycemia conditions survival rate compared to normal conditions survival rate seemed a small reduction. However increasing the total dose of X-ray, the survival rate of normal conditions decreased slightly compared to the survival rate of hyperglycemia conditions, the synergistic effect was drastically reduced. When non irradiated, undifferentiated in the nerve cells experiment is hyperglycemia conditions survival rate compared to normal conditions survival rate seemed a large reduction. As the cumulative dose of X-ray normal conditions and hyperglycemia were all relatively rapid cell death. But the rate of decreased survivals by almost parallel to the reduction proceed and it didn't show synergistic effect.

MicroRNA let-7c inhibits Bcl-xl expression and regulates ox-LDL-induced endothelial apoptosis

  • Qin, Bing;Xiao, Bo;Liang, Desheng;Li, Ye;Jiang, Ting;Yang, Huan
    • BMB Reports
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    • v.45 no.8
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    • pp.464-469
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    • 2012
  • Endothelial cells (ECs) apoptosis induced by oxidized low-density lipoprotein (ox-LDL) is thought to play a critical role in atherosclerosis. MicroRNAs (miRNAs) are a class of noncoding RNAs that posttranscriptionally regulate the expression of genes involved in diverse cell functions, including differentiation, growth, proliferation, and apoptosis. MiRNA let-7 family is known to be involved in the regulation of cell apoptosis. However, the function of let-7 in ox-LDL induced ECs apoptosis and atherosclerosis is still unknown. Here, we show that let-7c expression was markedly up-regulated in ox-LDL induced apoptotic human umbilical cord vein endothelial cells (HUVECs). Let-7c over-expression enhanced apoptosis in ECs whereas inhibition of let-7c could partly alleviate apoptotic cell death mediated by ox-LDL. Searching for how let-7c affected apoptosis, we discovered that antiapoptotic protein Bcl-xl was a direct target of let-7c in ECs. Our data suggest that let-7c contributes to endothelial apoptosis through suppression of Bcl-xl.

PREVENTION OF CIGARETTE SMOKE INDUCED LUNG CANCER BY LOW LET IONIZING RADIATION

  • Sanders, Charles L.
    • Nuclear Engineering and Technology
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    • v.40 no.7
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    • pp.539-550
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    • 2008
  • Lung cancer is the most prevalent global cancer, ${\sim}90%$ of which is caused by cigarette smoking. The LNT hypothesis has been inappropriately applied to estimate lung cancer risk due to ionizing radiation. A threshold of ${\sim}1\;Gy$ for lung cancer has been observed in never smokers. Lung cancer risk among nuclear workers, radiologists and diagnostically exposed patients was typically reduced by ${\sim}40%$ following exposure to <100 mSv low LET radiation. The consistency and magnitude of reduced lung cancer in nuclear workers and occurrence of reduced lung cancer in exposed non-worker populations could not be explained by the HWE. Ecologic studies of indoor radon showed highly significant reductions in lung cancer risk. A similar reduction in lung cancer was seen in a recent well designed case-control study of indoor radon, indicating that exposure to radon at the EPA action level is associated with a decrease of ${\sim}60%$ in lung cancer. A cumulative whole-body dose of ${\sim}1\;Gy$ gamma rays is associated with a marked decrease in smoking-induced lung cancer in plutonium workers. Low dose, low LET radiation appears to increase apoptosis mediated removal of $\alpha$-particle and cigarette smoke transformed pulmonary cells before they can develop into lung cancer.

A Fuzzy Controller for Warp Tension Control in The Weaving Process (퍼지제어기를 이용한 제작공정에서의 경사장력제어)

  • 류도훈;이연정
    • Proceedings of the Korean Institute of Intelligent Systems Conference
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    • 2000.11a
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    • pp.335-339
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    • 2000
  • In the weaving process, tension control of the warp is important. The variation of the warp tension cause irregularities of the weft density and low quality of the woven fabrics. Due to the fact that the warp tension varies in depending on the difference between take-up velocity and let-off velocity, it is necessary to regulate the velocity of let-off in relation to that of take-up for keeping the warp tension. Futhermore, the diameter of warp beam changes in the weaving process. The changing diameter of warp beam cause changing inertia of warp beam and the velocity of the let-off. It makes the control of such a system more complex. In this paper, we propose a fuzzy controller for the warp tension control. From the computer simulation, it was observed that a developed fuzzy controller has a better performance than that of conventional PI controller.

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Low Complexity LDPC Encoder (저 복잡도 LPDC 부호화기)

  • Jiang, Xueqin;Lee, Moon-Ho
    • Proceedings of the KIEE Conference
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    • 2007.04a
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    • pp.252-254
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    • 2007
  • In this paper, we will introduce an encoding algorithm of LDPC Codes in Direct-Sequence UWB systems. We evaluate the performance of the coded systems in an AWGN channel. This new algorithm is based on the Jacket matrics. Mathematically let A = ($a_{kl}$) be a matnx, if $A^{-1}$ = $(a^{-1}_{kl})^r$,then the matrix A is a Jacket matrix. If the Jacket matrices if Low density, the inverse matrices is also Low density which is very important to the introduced encoding algorithm.

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Flow and Heat Transfer Characteristics due to the Variations of the Angle of Attack at the Vortex Generators located behind a Circular Cylinder (원주 후미에 부착된 와동발생기의 영각 변화에 따른 유동 및 열전달 특성)

  • 하홍영;홍철현;양장식;이기백
    • Journal of Advanced Marine Engineering and Technology
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    • v.26 no.4
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    • pp.439-449
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    • 2002
  • Experimental investigations of the flow structure and heat transfer enhancement in a channel with a built-in circular cylinder and a wing-let type vortex generator are presented. Without any vortex generators, relatively low heat transfer takes place in the downstream of the circular cylinder where is a recirculation region with low velocity fluid is formed. However with a wing-let type longitudinal vortex generator in the wake region behind the cylinder, heat transfer in the region can be enhanced. In order to control the strength of longitudinal vortices, the angle of attack of the vortex generators is varied from $20^{circ} to 45^{\circ}$, but spacings between the vortex generations are fixed to be 5 mm. The 3-dimensional mean velocity field downstream of the vortex generator is measured by a five-hole pressure probe, and the hue-capturing method using thermochromatic liquid crystals has been used to provide the local distribution of the heat transfer coefficient. The vorticity field and streamwise velocity contour are obtained from the velocity field. Streamwise distributions of averaged Stanton number on the measurement planes show very similar trends for all the experimental cases($\beta=20^{circ}, 30^{circ} and 45^{\circ}$). Circulation strength and heat transfer coefficient have the maximum values when the angle of attack($\beta$) is $30^{\circ}$.

Impact of experience on government policy toward acceptance of Hydrogen fuel cell vehicles (정부정책에 대한 경험이 수소 연료전지 자동차의 수용에 미치는 영향)

  • Gang, Min-Jeong;Park, Hui-Jun
    • Proceedings of the Korean Society for Quality Management Conference
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    • 2010.04a
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    • pp.465-470
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    • 2010
  • Korea government declared that "low carbon, green growth" through green technologies and clean energy to be the new national vision for the next 60 years(President's Liberation Day speech on Aug. 15, 2008). And succeeding "Green New Deal" plan involves nine core projects including energy saving, recycling, clean energy development. It is because hydrogen fuel cell vehicles, using electricity from chemical reaction of hydrogen and oxygen, let out water which is a by-product of such chemical reaction instead of emitting harmful particulate and gases such as NOX, SOX and CO2 that hydrogen fuel cell vehicles and its technology are drawing public attention as one of the sensible solutions in accomplishing "low carbon, green growth" agenda. Nevertheless There are many chances that let the people have a practical experience of hydrogen fuel cell vehicles. Sometimes new products, including hydrogen fuel cell vehicles, made by advanced technology can not penetrate through the market when it faces public skepticism that is stimulated from lack of knowledge and experience. That is the reason why not only cost benefit analyses and scientific risk assessments but also public acceptance studies toward hydrogen fuel cell vehicles have to be performed [Schulte, 2004]. This research address a need for comprehensive study on factors influencing public acceptance of hydrogen fuel cell car, specifically focusing on impacts of personal experience related to governmental science and technology policy toward public acceptance.

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BETTER UNDERSTANDING OF THE BIOLOGICAL EFFECTS OF RADIATION BY MICROSCOPIC APPROACHES

  • Kim, Eun-Hee
    • Nuclear Engineering and Technology
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    • v.40 no.7
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    • pp.551-560
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    • 2008
  • Radiation has stochastic aspects in its generation, its choice of interaction mode during traveling in media, and its impact on living bodies. In certain circumstances, like in high dose environments resulting from low-LET radiation, the variance in its impact on a target volume is negligible. On the contrary, in low dose environments, especially when they are attributed to high-LET radiation, the impact on the target carries with it a large variance. This variation is more significant for smaller target volumes. Microdosimetric techniques, which have been developed to estimate the distribution of radiation energy deposited to cellular and subcellular-sized targets, contrast with macrodosimetric techniques which count only the average value. Since cells and DNA compounds are the critical targets in human bodies, microdosimetry, or dose estimation by microscopic approach, helps one better analyze the biological effects of radiation on the human body. By utilizing microbeam systems designed for individual cell irradiation, scientists have discovered that human cells exhibit radiosensitive reactions without being hit themselves (bystander effect). During the past 10 or more years, a new therapeutic protocol using discontinuous multiple micro-slit beams has been investigated for its clinical application. It has been suggested that the beneficial bystander effect is the essence of this protocol.

A Study on Increase of Consumption of Seaweeds of Marine Product Distributors: Focused on Increase of Consumption of Seaweeds

  • Kim, Mi-Song;Kim, Sang-Cheol
    • The Journal of Economics, Marketing and Management
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    • v.6 no.4
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    • pp.41-49
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    • 2018
  • Purpose - The purpose of the study was to investigate restaurants increasing seaweed of marine products and to let consumers live healthy and happy lives and to discuss increase of seaweeds consumption. The purpose of the study was to give consumers good food and to live healthy and happy life and to elevate life quality and to produce added value by increase of consumption of seaweeds such as laver, brown seaweed, tangle and gracilaria and others and to give economic advantage. The seaweed could be produced in large quantity without spending of much money in accordance with demand to make use of it at restaurants. Research design, data, and Methodology - The author visited restaurant businessmen at Suwon, Anyang, Hwaseong and Yongin to investigate low sales by in-depth interview. The study investigated Kodari-jorim restaurants that made use of laver ssam for side dish. The subject was HS distributors to let restaurant keepers think of seaweeds and replacement of vegetable by seaweed. Results - Women customers who thought of health and diet usually selected menu at the restaurants not to appeal. Conclusions - Menu with high quality seaweeds (low calory, satiety and health) can satisfy women customers thinking much of health and diet to increase consumption of seaweeds. The study was exploratory to investigate in qualitative and quantitative way in the future.

Low Temperature Dyeing Process by Intercellular diffusion through Cell Membrane Complex Modification of Wool. - Technology based on CSIRO and ICI (양모의 저온 염색 소개 - Sirolan LTD Process from ICI)

  • 윤일남
    • Proceedings of the Korean Society of Dyers and Finishers Conference
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    • 2001.11a
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    • pp.3-11
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    • 2001
  • Fundamental studies at the CSIRO division of Wool technology and ICI on the diffusion of dyes into wool〔1,2〕have let to development of a new approach to wool dyeing. In this method, the cell membrane complex of wool is modified before dyeing by treatment under mildly alkaline conditions with a special chemicals. Wool pretreated with ethoxylated quaternary ammonium salt has an increased rate of dyebath exhaustion and dye penetration early in the dyeing cycle. This enables the treated material to be dyed below the boil for a similar time to the conventional cycle. This technique can be used on untreated and shrinkresist-treated wool and wool/nylon blends. In addition to good macro-levelness and excellent coverage of tippiness, the low temperature dyeing process give higher exhaustion levels of dyestuffs and insect-resist agent and hence cleaner effluent liquors, compared with conventional dyeing process. Low Temperature Dyeing process cause significantly less fiber damage than conventional way. The reduction in damage is reflected in improved processing performance of the dyed wool.

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