• Biomolecules & Therapeutics
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• v.6 no.1
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• pp.37-44
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• 1998

This study was performed to examine the effects of DA-9601, a novel antiulcer agent extracted from Artemisiae Herba, on radiation colitis in the rat. Female Wistar rats received a 30 Gy dose of irradiation to the 2 cm of distal colon in length using an intrarectal applicator system. 30 mg/tg or 100 mg/kg of DA- 9601 was administered orally 30 min before and 4 h after radiation on day 1. And the same dose of DA-9601 was given to the animals twice a day from day 2 to 14. As a reference control, sucralfate suspension (100 or 300 mg/head) was given as an enema based on the same treatment schedule of DA-9601. Body weight change and the frequency of diarrhea were recorded during the observation period as markers of radiationinduced injury, All animals were sacrificed on day 15 for evaluation of macro- and microscopic findings and mucosal myeloperoxidase (MPO) activity. Radiated animals showed diarrhea, mucosal redness and histologic changes characterized by edema and eosinophilic infiltration of the periglandular lamina propria with loss of colonic epithelium. Radiation also significantly increased mucosal MfO activity of affected colon f\\\\\\\\`<0.05). However, most of these changes were completely protected by oral administration with DA-9601. DA-9601 reduced radiation-induced histologic alteration significantly in a dose-related manner (P<0.05). In addition, mucosal MPO activity in rats receiving high dose of DA-9601 decreased significantly when compared with that in radiated control. High dose of sucralfate (300 mg/head) alleviated radiation-induced histologic lesion, but failed to reach statistical significance. The results of this study suggest that DA-9601 can be useful for the prevention of acute clinical symptoms of radiation proctocolitis and that decrease of mucosal MPO by DA-9601 plays a role in its protective mechanism(s), at least in part.

• Korean Journal of Soil Science and Fertilizer
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• v.47 no.6
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• pp.525-532
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• 2014

Since mine wastes were merely dumped in the mine waste dump, they have produced acid mine drainage (AMD). Therefore, main objective of this study was to evaluate the effect of coal combustion products (CCPs) on heavy metal stabilization and detoxification for mine wastes. Total six treatments for incubation test were conducted depending on mixing method (completely mixing and layered). Also, lysimeter experiment was conducted to examine efficiency of polyacrylamide (PAM) on reduction of mine wastes erosion. Result of incubation test showed that concentrations of soluble aluminium (Al) and iron (Fe) in leachate decreased compared to control. The lowest soluble Al and Fe in leachate was observed in 50% mixed treatment (14.2 and $1.03mg\;kg^{-1}$ for Al and Fe respectively) compared to control treatment (253.0 for Al and $52.6mg\;kg^{-1}$ for Fe). The pH of mine wastes (MW) and leachate increased compared to control after mixing with CCPs and ordered as control (MW 6.4, leachate 6.3) < 10% (MW 7.7, leachate 7.1) < 20% (MW 9.0, leachate 7.8) < 30% (MW 9.5, leachate 8.3) < 40% (MW 9.9, leachate 8.5) < 50% (MW 10.5, leachate 8.6). Application of PAM, both in liquid and granular type, dramatically decreased the suspended solid (SS) concentration of CCPs treatments. Reduction of SS loss was ordered as MW70CR30L ($24.4mg\;L^{-1}$) > MW70CR30LPL ($6.7mg\;L^{-1}$) > NT ($3.1mg\;L^{-1}$) > MW70CR30M ($1.6mg\;L^{-1}$) > MW70CR30MPL ($1.1mg\;L^{-1}$) > MW70CR30PGM ($0.7mg\;L^{-1}$) > MW70CR30LPG ($0.5mg\;L^{-1}$) > MW70CR30MPG ($0.4mg\;L^{-1}$). Overall, application of CCPs can be environmental friendly and cost-effective way to remediate coal mine wastes contaminated with heavy metals. In addition, use of PAM could help to prevent the erosion coal mine wastes in mine waste disposal area.

• Journal of Environmental Policy
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• v.5 no.4
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• pp.1-18
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• 2006

Recently, the damage by fresh flood increases in Gangwon-do and Gyeongsangbuk-do of the north-eastern area of Korea. Even though the recent pattern of rain fall keeps changing, there is no strategy to mitigate damage by disaster. For the appropriate measure and policy for decreasing damage, an index for vulnerability is necessary to provide evidence of local climate change. The present work analyzes the flooding damage cost during the past 20 years. During 80's, the southern area of Korea was seriously damaged by over-floods on the agricultural ground. After that time, the loss and damage has decreased in the southern area but the middle part has shown slight but distinct increases of damage. The absolute coast of damage in the northern part has kept constant. However, the relative regional damage to the total country damage has kept increasing over 20 years in the same area. The surface area of floods is strongly correlated with the regional damage cost in the southern part but the north-eastern part has weak correlation between flooded area and cost. It implies that the recent damage in the north-eastern mountain area was not caused by flood itself but the other factors such as avalanches. The present work expects that the damage cost can be a good proxy value for index for climate change impact assessment.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.5
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• pp.1000-1008
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• 2009

It also increases the competitive power of the nation. With all these merits of electronic documents, there exist threats to the security such as illegal outflow, destroying, loss, distortion, etc. Currently, the techniques to protect the electronic documents against illegal forgery, alteration or removal are not enough. Until now, various security technologies have been developed for electronic documents. However, most of them are limited to prevention of forgery or repudiation. Cryptography for electronic documents is quite heavy that direct cryptography is not in progress. Additionally, key management for encryption/decryption has many difficulties that security has many weak points. Security has inversely proportional to efficiency. It is strongly requested to adopt various cryptography technologies into the electronic document system to offer more efficient and safer services. Therefore, this paper presents some problems in cryptography technologies currently used in the existing electronic document systems, and offer efficient methods to adopt cryptography algorithms to improve and secure the electronic document systems. To validate performance of proposed method compare with the existing cryptographies, critical elements have been compared, and it has been proved that the proposed method gives better results both in security and efficiency.

• Korean Security Journal
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• no.49
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• pp.187-214
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• 2016

In the mordern society, the reliance on the cyber domain and the cyber connectivity has been increasingly strengthened. Due to this phenomenon, the cyberterror against critical infrastructures and state organs might lead to fatal consequences. Lately, North Korea's cyberattacks against South Korea's national organizations and financial computer networks are becoming more and more intelligent and sophisticated. The cyberattacks against such critical infrastructures have caused enormous economic loss and social disorder. This paper is designed to examine comparatively the cyberterror related laws and organizations of the advanced countries such as U.S. and U.K. and to draw implications. Although those countries are under different institutional and cultural backgrounds with varying security envrionments, they are identically pursuing measures by establishing government-wide counterterror system for coordination and cooperation. They are also commonly focusing upon creating new organizations equipped with new system and upon enhancing intelligence performance and devising punishment regulations. Korea is lack of framework laws regulating cyber security, having only scattered individual laws. Since such legal base is far from efficient counterterror activities, it is necessary that the legal and policy response of the advanced countries should be closely studied for selective introduction. That will eventually lead to legislation of cyber security law. With such legislation on hand, it is subsequently required to strengthen crisis management for prevention of cyberterror and to create joint response team, cooperating with private organizations.

• Journal of the Korean Geographical Society
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• v.50 no.3
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• pp.355-373
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• 2015

In this study the factors of fire damage are analyzed through previous research reviews. Local environmental factors as well as those factors attributed to fire damage (number of fire events, number of injured, number of death, economic loss) were selected to compose mutual relationship model. In order to verify this relationship model, official statistics concerning fire damage were collected from 228 local governments and compared with results from previous research. As a result of this comparison four dependent variables and 22 independent variables that affect fire damage were analyzed. Independent variables are divided into human vulnerability factors, physical vulnerability factors, economic vulnerability factors, mitigating factors and local characteristics. To analyze a relationship between selected dependent variables and independent variables, we applied a semi-logarithm model and performed regression analysis. Among the 22 independent variables, the number of the weak to disaster, social welfare service workers, workers in manufacturing industry, and the number of workers in restaurants and bars per 10,000 people show the significant correlation with the number of fire incidence. The number of death from fire is significantly related to two variables which are the number of social welfare service workers per 10,000 and the ratio of commercial area. Damage cost is significantly dependent on the property taxes per 10,000 people. These factors were included in the research model as vulnerability factors (human, physical, economic) and mitigating factors and local characteristics, and the validity of research model was verified. The result could contribute to fire-fighting resource allocation in Korea or they can be utilized in establishing fire prevention policy, which will enhance the national level of fire safety.

• Journal of Korean Academy of Nursing
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• v.18 no.1
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• pp.80-93
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• 1988

This study was planned and carried out to investigate the correlation between premenstrual syndrome and personality in order to provide informations basic to the prevention, alleviation, and care for the premenstrual syndrome. Data on premenstrual syndrome were gatherd from October 20 to 25, 1986 by questionnaire modified by the researcher based on Endicott's Premenstrual Assessment Form. Reliability of the instrument was tested by Cronbach's $\alpha$. Data on personality were gathered in March, 1986, by the high school autorities by standardized Personality Inventory Scale developed by Eung Yun Hwang were used. Subjects numbered 457, 95.2% of the first grade students of H. Girls High School located in Seoul. The correlation and difference between personality traits and premenstrual syndrome analysed by Pearson's Correlation Coefficient, and difference between groups were analysed by the t-test. Personality traits influencing premenstrual syndromal categories were analysed by the multiple regression. The results are as follows : I. The five highist categories of premenstrual syndrome among 18 categories revealed to be Social withdrawal, General discomfort, Lability, Fatigue and Hostility / Anger in rank order. II. Personality traits and Premenstrual syndrome ; 1. Tendency of Psychoneuroses(r＝0.43, p＜.001), psychoses(r＝.39, p＜.001) and anti-social behaviors (r＝0.43, p＜.001) revealed to be significantly correlated to premenstrual syndrome. Hypothesis 1 is accepted. 2. Emotional stability(r＝ -0.38, p＜.001), reflectiveness (r＝ -0.14, p＜.01), masculinity (r＝ -0.10, p＜05) and antonomy (r＝ -0.12, p＜.05) revealed significant correlation, While activity, dominance, sociability and achivement revealed no significant correlation. Hypothesis 2 is partially accepted. III. Significant models of personality traits influencing the premenstrual syndromal categories are ; 1. 5 personality traits : tendency of psychoneuroses, emotional stability, dominance, activity and autonomy revealed to influence Low mood / loss of pleasure significantly. ($R^2$＝.19) 2. 3 personality traits ; tendency of psychoneuroses, emotional stability and sociability revealed to influence Lability significantly. ($R^2$＝.15) 3. 5 personality traits ; tendency of psychoneuroses, activity, emotional stability, sociability and achievement revealed to influence Anxiety significantly.($R^2$＝.18) 4. 3 personality traits : tendency of psychoneuroses, emotional stability and sociability revealed to influence Miscellaneous mood / behavior changes significantly.($R^2$＝.18) 5. 3 personality traits : tendency of psychoneuroses, psychoses and reflectiveness revealed to influence Hysteroid features significantly.($R^2$＝.16) IV. No significant correlation between irregularity of menstruation and premenstrual syndrome was revealed. No significant difference between group of dysmenorrhea and group of non-dysmenorrhea in premenstrual syndrome was revealed.

• Journal of Applied Tourism Food and Beverage Management and Research
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• v.8
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• pp.21-33
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• 1997

This study reviews the scientific management theories and discusses those theories within the food service industry. By providing the principles and the practical implications of the theories on the food service industry, this study tries to identify their philosophies and usefulness to the industry so that the managers in the industry use them in their dylmanic operations. In the fastly changing modern globalized world, we now face a situation where it's becoming more and more difficult to mange a restaurant business. In order to build a food industry business that can maintain a continuous development in today's business environment, one will have to apply the professional management theory in a cost-reduce strategy. It is more important though to have managers, organization members, in short, any person who can work to be motivated in accomplishing these two major issues-income increase and cost reduction. In this erawhere it's getting so difficult for researches on possible strategies for these business managers to overcome their difficulties. It is for certain that in the upcoming second millenium the travel and tourism industry will be one of the world's biggest industry worldwide. Korea's hotel industry has developed since the 1988 Seoul Olympic Games and has shown great amount of competition within the same business. Thus managers have become acquainted with the "know-how" strategy and the practical and scientific managemnet theories were introduced. This helped not only to increase income but also to maximize profit. However, rather than concentration on the "Hard-ware" aspect "Soft-ware" related professional management strategies were developed along with professionalism and human service were emphazied. As such, the actual cost of food and beverages are for the hotel industry business managers the biggest shortterm expense item. Due to the natural state of food items, there is a great chance of "Loss" in preservance, and this is the reason it is complicated to effectively maintain food. As a consequence, very often, the failure to managea hotel or restaurant depends on the capability of the food and beverage preservance mangement: on how they are able to manage effectively the original price of food and beverage. Finally, the main problem of the original price management of food and beverage in Korean hotels are: a) No fixation of set price b) The difficulty to calculate the price difference between a set price and an original price. c) Lack of professinalism in managing the food and beverage original price. d) Lack of perception of the highest ranking management personnels. So as to reform these matters it is necessary to : a) Reform on the management accounting system b) Emphasize to the people in charge on the idea of original price management c) Reinforce original price mangement prevention and assurance of indepedent inspection rights d) Reat manpower

• Journal of the korean academy of Pediatric Dentistry
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• v.30 no.1
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• pp.80-91
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• 2003

Mutans streptococci, especially S. mutans and S. sobrinus strongly implicated in pathogenesis of dental caries, the major cause of tooth loss in children. Use of an antibacterial agent controlling dental caries has been rationalized. The present study was performed to observe the antibacterial effect of inorganic polyphosphates (polyP) on S. mutans and S. sobrinus. S. mutans GS5 and S. sobrinus 6715 were grown in brain-heart infusion broth with or without polyP. Minimal inhibitory concentration (MIC) of polyP for S. mutans GS5 was determined to be 0.08% and that for S. sobrius 6715 was 0.17%. PolyP 15 added to the growing culture of S. mutans GS5 and S. sobrinus 6715 at their exponential phase was as effective in inhibiting the growth of S. mutans GS5 and S. sobrinus 6715 as polyP added at the very beginning of the culture. More than 85% of the cells lost their viability determined by viable cell count when polyP 15 was added to the culture of growing S. mutans GS5 at MIC, suggesting that polyP 15 has bacterial effect on the bacterium. And more than 99.9% of the cells lost their viability determined by viable cell count when polyP 15 was added to the culture of growing S. sobrinus 6715 at MIC, suggesting that polyP 15 has bacterial effect on the bacterium. Intracellular nucleotide release from S. mutans CS5 and S. sobrinus 6715 was increased in the presence of polyP 15 for 5h but was not really reversed by the addition of divalent cations like $Ca^{++}\;and\;Mg^{++}$. The majority of the cells appeared to be atypical in their shape, demonstrating accumulation of highly electron-dense granules and ghost cells. The overall results suggest that polyP have a strong bactericidal activity against S. mutans and S. sobrinus in which lysis in relation to chelation may not play the major role but unknown mechanism that possibly affects the viability of the bacterium may be involved. PolyP may be used as an agent for prevention of dental caries.

• Molecules and Cells
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• v.37 no.12
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• pp.873-880
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• 2014

In our previous study, miRNA-183, a miRNA in the miR-96-182-183 cluster, was significantly over-expressed in esophageal squamous cell carcinoma (ESCC). In the present study, we explored the oncogenic roles of miR-183 in ESCC by gain and loss of function analysis in an esophageal cancer cell line (EC9706). Genome-wide mRNA micro-array was applied to determine the genes that were regulated directly or indirectly by miR-183. 3'UTR luciferase reporter assay, RT-PCR, and Western blot were conducted to verify the target gene of miR-183. Cell culture results showed that miR-183 inhibited apoptosis (p < 0.05), enhanced cell proliferation (p < 0.05), and accelerated G1/S transition (p < 0.05). Moreover, the inhibitory effect of miR-183 on apoptosis was rescued when miR-183 was suppressed via miR-183 inhibitor (p < 0.05). Western blot analysis showed that the expression of programmed cell death 4 (PDCD4), which was predicted as the target gene of miR-183 by microarray profiling and bioinformatics predictions, decreased when miR-183 was over-expressed. The 3'UTR luciferase reporter assay confirmed that miR-183 directly regulated PDCD4 by binding to sequences in the 3'UTR of PDCD4. Pearson correlation analysis further confirmed the significant negative correlation between miR-183 and PDCD4 in both cell lines and in ESCC patients. Our data suggest that miR-183 might play an oncogenic role in ESCC by regulating PDCD4 expression.