• Journal of the Korean Society of Hazard Mitigation
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• v.4 no.1 s.12
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• pp.65-75
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• 2004

Roadbed failure due to the natural disaster may bring out social and economic damage such as the loss of life and property, the consumption of time and cost for recovery, and the delay of logistics in railway In this study, the method using geosynthetic soilbag was applied to rehabilitation of the railway roadbed which was failed by disaster. The full scale tests with the simulated train loading were performed in order to evaluate the static and dynamic performance at the railway roadbed using geosynthetic soilbag. The results of these tests were compared with unreinforced and reinforced cases with geosynthetic soilbag, respectively The data gathered by various measurement devices from these full scale tests would be useful to evaluate and understand the roadbed with geosynthetic soilbag. In conclusion, geosynthetic soilbag was evaluated as a permanent restoration method to reinforce the roadbed of railway.

• Korean Journal of Veterinary Research
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• v.48 no.3
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• pp.251-258
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• 2008

The neurotoxicity of C-terminal fragments of amyloid precusor protein (CT) is known to play some roles in Alzheimer's disease progression. In this study, we investigated the effects of the recombinant C-terminal 105 amino acid fragment of amyloid precusor protein (CT105) on cholinergic function using CT105-injected rat. To study the effects of CT105 on septohippocampal pathway, choline acetyltransferase (ChAT) positive neurons were examined in the medial septum and in the diagonal band after an injection of CT105 peptide into the lateral ventricle. Immunohistological analysis revealed that the number of ChAT-immunopositive cells decreased significantly in both medial septum and diagonal band. In addition, CT105 decreased ChAT-immunopositive cells in the hippocampal area, particulary in the dentate gyros. To study the effect of amyloid beta peptide ($A{\beta}$) and CT105 on the cholinergic system, each peptide was injected into the left lateral ventricle, and acetylcholine (ACh) levels were monitored in hippocampus. ACh level in the hippocampal area was reduced to 60% of control level in $A{\beta}$-treated group, and the level was reduced to 15% of control level in CT105-treated group, at one week after the injection. ACh level was further reduced to 35% of control in $A{\beta}$-treated group, whereas the level was slightly increased to 30% of control in CT105-treated group at 4 weeks after the injection. Taken together, the results in the present study suggest that CT105 impairs the septohippocampal pathway by reducing acetylcholine synthesis and release, which results in damage of learning and memory.

• Korean Journal of Construction Engineering and Management
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• v.10 no.1
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• pp.78-90
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• 2009

Recently, operation of highway is the complex digital Infrastructure based on complicated IT. The application of IT is increasing more and more in digital Infrastructure. Though IT is very convenient, if unpredicted operating risk of highway occurs, widespread damage can be large. When operating risk of highway occurs, road users are out of smoothly-run service because of the operating interruption. This risk causes unpredicted operating management cost and additional maintenance cost. It will excess over the planned operating cost, which may leads to users's unsafety and operator's insolvency because of income loss. Until now, related studies to find out the risk are not sufficient. The purpose of this study is to suggest risk cost items and to estimate the reasonable risk cost by using simulation method in case of occurring the huge power failure at the operating digitalized highway. This study indicates the several plans to hedge against risk cost and the management of highway project. From now on, it will be used as basic data to confirm the soundness of operating system in Digital Infrastructure.

• Korean Journal of Construction Engineering and Management
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• v.10 no.1
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• pp.126-135
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• 2009

Recently, operation of highway is the complex digital Infrastructure based on complicated IT. The application of IT is increasing more and more in digital Infrastructure. Though IT is very convenient, if unpredicted operating risk of highway occurs, widespread damage can be large. When operating risk of highway occurs, road users are out of smoothly-run service because of the operating interruption. This risk causes unpredicted operating management cost and additional maintenance cost. It will excess over the planned operating cost, which may leads to users's unsafety and operator's insolvency because of income loss. Until now, related studies to find out the risk are not sufficient. The purpose of this study is to suggest risk cost items and to estimate the reasonable risk cost by using simulation method in case of occurring the huge power failure at the operating digitalized highway. This study indicates the several plans to hedge against risk cost and the management of highway project. From now on, it will be used as basic data to confirm the soundness of operating system in Digital Infrastructure.

• The Journal of Internal Korean Medicine
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• v.41 no.1
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• pp.44-58
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• 2020

Objectives: This study was conducted to identify the protective effects of Chongmyunggongjin-dan (CMGJD) on Hydrogen peroxide (H₂O₂)-induced apoptosis mechanisms in C6 glial cells. Method: We used CMGJD after distilled water extraction, filtration, and lyophilization. The ROS scavenging effect was examined by fluorescence microscopy. Expression levels of proteins related to ROS generation were investigated by western blotting. Functional changes in organelles related to Reactive oxygen species (ROS) generation were investigated by immunoblotting and by verifying expression level of relevant enzymes. Results: The CMGJD extract protected the cells against H₂O₂-induced morphological changes and DNA fragmentation, inhibited the increase of Heme_oxygenase-1(HO^-1) and the decrease in catalase, protected against the loss of mitochondrial membrane potential, inhibited disturbances of lysosomal function, and induced an increase in peroxisomes. Conclusion: CMGJD was confirmed to have a protective effect on H₂O₂-induced C6 glial cell death possibly by blocking the pathways causing damage to subcellular organelles, such as mitochondria, lysosomes, and peroxisomes. We assume that CMGJD will be effective for the prevention and treatment of ischemic stroke in a clinical environment.

• Journal of the Korean GEO-environmental Society
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• v.11 no.8
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• pp.15-23
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• 2010

Debris flows are a natural hazard which looks like a combination of flood, land and rock slide. Large rainfall in July 2006 produced several large scale debris flows and many small debris flows that resulted in loss of life and considerable property and railway damage, as was widely reported in the national media. The hazard "debris flow" is still insufficiently researched. Furthermore debris flows are very hard to predict. Flexible Ring net barriers are multi-functional mitigation devices commonly applied to rock fall or floating wood protection in floods, snow avalanches and also mud flows or granular debris flows, if properly dimensioned for the process or processes for which they are intended. Overtopping of the barriers by debris flows and sediment transport is possible, supporting the design concept that a series of barriers may be used to stop volumes of debris larger than are possible using only one barrier. The future for these barrier concepts looks promising because these barriers represent the state of art for such applications and are superior to many other available options.

• Journal of the Korea Society of Computer and Information
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• v.17 no.3
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• pp.41-50
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• 2012

In the monitoring system based on web service application, it is faced with the problems like code reproduction, difficult scalability and error recovery derived from the frequent change of data structure. So we propose a technique of monitoring system by DTD(Document Type Definition) automatic generation. This technique is to use dynamic server-side script to cope with the change of sensor data structure, generate the DTD dynamically. An it also adapt the AJAX(Asynchronous JavaScript and XML) for XML data parsing, it can support mass data transmission and exception processing for data loss and damage. This technique shows the result of recovery time is decreased about 44.8ms in case of temporary data failure by comparing to the conventional XML method.

• Journal of the Korean Society of Safety
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• v.26 no.6
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• pp.130-136
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• 2011

Since out of a lot of traffic problems traffic accidents cause damage to life and properties of people, it stands out as one of traffic problems which needs improvement, and the loss due to traffic accident negatively affects not only the parties to the accident but also the national economy. Thus, continual concern of the government toward traffic safety is getting bigger and lately each local government is preparing a basic plan for traffic safety and vitalizing traffic safety policies. As expanding the responsibility and role of local governments for traffic safety, traffic safety measures which are based on the characteristics of each local government should be studied. Most of analytical methods in the existing traffic accidents prediction models with macroscopic vision focus on socioeconomic variables such as local population and the number of registered vehicles, and present a great deal of prediction error when they are applied in practice. In this context, this study proposed a traffic accident prediction model in respect of macroscopic level for autonomous districts (administrative districts) of Seoul City. The model development was not based on the entire city but on the type of local land usage (development density) whose relationship with traffic accident frequency was analyzed.

• The Journal of Fisheries Business Administration
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• v.42 no.2
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• pp.31-45
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• 2011

Costal fisheries use small boat. The boats are frequently substituted with newly made boat or proper boat. When the boat which is substituted with another one after the fixed date for compensation is estimated for fisheries loss by public project, it is matter that which boat is the object for estimating average catch of fish. There are three ways in practical business. They are based on the date of spot probe, the date of conference for compensation and fixed date for compensation. In case of applying the first and the second ways, as the object of compensation is not fixed, there is problem that estimated result can be changed depending on changing boat tons even after the date of spot probe and the fixed date for compensation. Most of all, these ways are against Attached Form No.4 of the Enforcement Ordinance of Fisheries Law which regulate to calculate average catch of fish applying result of fishery for retroactively counted 3 years from the year before the year in which administrative measure day is. The other side, in applying boat tons based on the fixed date for compensation, estimated result of compensation will not change even boat substituted after the fixed date for compensation. Even though applying tons based on the fixed date for compensation, a problem still remains. If the boat get bigger after the fixed date for compensation, the then boat size must be applied for calculating average catch. But the boat get smaller, the changed boat size must be applied. Because changed small boat would be damaged less than the previous boat. And decrease in catch by changing boat into small one is not due to the project but due to the personal responsibility. This will help to increase objectivity and reliance on the compensation result. As the other objects are fixed based on the fixed date for compensation in the Act on Acquisition and Compensation of Land and Others for Public Project, it can be balanced with other object.

• Journal of the Korea institute for structural maintenance and inspection
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• v.16 no.1
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• pp.131-139
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• 2012

The lateral reinforcements of concrete such as hoops and spiral bars are known to confine concrete to compensate the strength loss due to fire by reducing explosive spalling and improving the capacity of ductility. In this context, a study was conducted to investigate the residual mechanical properties of confined and unconfined concrete($f_{ck}$=60MPa) after a single thermal cycle at 300, 600, $800^{\circ}C$. The main parameters required to establish the stress-strain relationship are the peak stress, the elastic modulus, and the strain at peak stress. The knowledge of the residual mechanical properties of concrete is necessary whenever the thermally damaged structure is required to bear a significant share of the loads, even after a severe thermal accident. Based on the results obtained in this study, the residual stress of confined concrete under thermal damage is higher according to the level of confinement and the larger strain made it to have better ductility. The decreasing ratio of elastic modulus from the relationship of stress and strain was also smaller than that of unconfined concrete.