• IMMUNE NETWORK
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• v.15 no.3
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• pp.135-141
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• 2015

Dysfunction of gut immune regulation is involved in mucosal damage in inflammatory bowel disease (IBD). However, there is still no efficacious immune-regulator for the treatment of IBD. Alloferon is a novel immune-modulatory peptide that was originally isolated from infected insects. It shows anti-inflammatory effects by the regulation of cytokine production by immune cells and their activities. Therefore, we investigated the effect of alloferon in a mouse model of colitis using dextran sulfate sodium (DSS). Colitis was induced by administration of DSS in drinking water for 7 consecutive days. It was confirmed by the presence of weight loss, diarrhea, hematochezia, and colon contraction. Alloferon was injected 4 days after DSS administration. We found that alloferon improved the pathogenesis of IBD based on the reduced disease activity index (DAI) and colon contraction. Edema, epithelial erosion, and immune cell infiltration were found in mice administered DSS, but the phenomena were reduced following alloferon treatment. The plasma level of IL-6, a classical pro-inflammatory cytokine in colitis, was also decreased by alloferon. Moreover, alloferon inhibited the TNF-${\alpha}$-induced degradation and phosphorylation of $I{\kappa}B$ in Colo205 colon cancer cells. Taken together, these results show that alloferon has anti-inflammatory effects and attenuates DSS-induced colitis.

• Tunnel and Underground Space
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• v.27 no.6
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• pp.387-392
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• 2017

Recently, road cave-ins, also referred to as ground sinking, have become a problem in urban environments. Public utility facilities such as sewage pipelines, communications pipes, gas pipes, power cables, and other types of underground structures are installed below the roads. It was reported that cave-ins are caused by the aging and lack of proper maintenance of underground facilities, as well as by construction problems. A road cave-in is first initiated by the formation of cavities typically induced by the breakage of underground pipelines. The cavities then grow and reach the base of the pavement. The traffic load applied at the surface of the roads causes an abrupt plastic deformation. This type of accident can be considered as a type of disaster. A road cave-in can threaten both human safety and the economy. It may even result in the loss of human life. In the city of Seoul, efforts to prevent damage before cave-ins occur have been prioritized, through a method of discovering and repairing joints through the 3D GPR survey.

• Nuclear Engineering and Technology
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• v.52 no.11
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• pp.2585-2593
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• 2020

Swift heavy ion (SHI) beam irradiation can generate desirable defects in materials by transferring sufficient energy to the lattice that favours huge possibilities in tailoring of materials. The effect of Ag¹⁵⁺ ion irradiation with energy 200 MeV on spray deposited V₂O₅ thin films of thickness 253 nm is studied at various ion doses from 5 × 10¹¹ to 1 × 10¹³ ions/㎠. The XRD results of pristine film confirmed orthorhombic structure of V₂O₅ and its average crystallite size was found to be 20 nm. The peak at 394 cm^-1 in Raman spectra confirmed O-V-O bonding of V₂O₅, whereas 917 cm^-1 arise because of distortion in stoichiometry by a loss of oxygen atoms. Raman peaks vanished completely above the ion fluence of 5 × 10¹² ions/㎠. Optical studies by UV-Vis spectroscopy shows decrement in transmittance with an increase in ion fluence up to 5 × 10¹² ions/㎠. The red shift is observed both in the direct and indirect band gaps until 5 × 10¹² ions/㎠. The surface topography of the pristine film revealed sheath like structure with randomly distributed spherical nano-particles. The roughness of film decreased and the density of spherical nanoparticles increased upon irradiation. Irradiation improved the conductivity significantly for fluence 5 × 10¹¹ ions/㎠ due to band gap reduction and grain growth.

• Journal of the Korean Association of Geographic Information Studies
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• v.16 no.4
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• pp.1-15
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• 2013

Great loss of life and property has been occurred by the severe flood globally. In Korea, a flood inundation map is used as one of the non-structural measures for reducing flood damage, and various inundation models have been studied for flood inundation analysis. This study applies LiDAR data and LISFLOOD model for flood inundation analysis and discusses the the modeling results from levee breaching scenarios for evaluating the applicability of the model to stream inundation modeling. In the results of LISFLOOD modeling, maximum inundation area was similar to the inundation map by HEC-RAS model just less than 4%. The inundation area by each levee breaching scenario showed the difference from 0.2% to 6.5%. Inundation processes were different each other according to the position of levee breach point, and maximum inundation area and depth were changed by the flow direction of stream and flood plain. This study shows that LISFLOOD model can be applied properly to stream inundation analysis using various inundation scenarios.

• Journal of Life Science
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• v.24 no.9
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• pp.1019-1024
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• 2014

Skeletal muscle atrophy can be defined as a decrease in or a disease of the muscle tissue, or as a disorder of the nerves that control the muscle, through injury or lack of use. This condition is associated with reactive oxygen species (ROS), resulting in various muscular disorders. Exposure to ROS induces muscle atrophy through several biological factors, such as SOD1 and HSP70. We found that cymbidium root extract reduced the $H_2O_2$-induced viability loss in C2C12 myoblasts and inhibited apoptosis. In addition, we showed that the cymbidium root extract increased the expression of HSP70 and decreased the expression of SOD1 in the $H_2O_2$-induced C2C12 myoblasts. These results suggest that cymbidium root extract might have therapeutic value in reducing ROS-induced muscle atrophy.

• Journal of Bio-Environment Control
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• v.2 no.1
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• pp.27-36
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• 1993

Carbon dioxide enrichment for greenhouse crops has generally been a standard commercial practice for many years. Vegetable crops such as tomato, cucumber, and lettuce respond positively to the $CO_2$ enrichment. But improper $CO_2$ enrichment leads to physiological damage and economical loss. This study was carried out to develop a $CO_2$ concentration control algorithm considering growth stage and efficiency. The measurand was $CO_2$ consumption rate and top fresh weight that represents growth stage. The weight of top fresh lettuce as a whole in the tray was measured through a non-destructive method. The demand in $CO_2$ concentration according to growth stage was investigated. The results are summarized as follows. 1. The $CO_2$ consumption rate could be measured within the error of $\pm$ 15.4mg$CO_2$/hr in the range of $CO_2$ concentration of 500-1500ppm. 2. The weight of top fresh lettuce could be measured within the error $\pm$ 4.3g in the range of 0-1400g. 3. The $CO_2$ control model developed could determine an economical $CO_2$ supply rate considering $CO_2$ consumption rate and leakage rate. 4. The $CO_2$ control algorithm based on the control model was composed of feedforward control for maintaining a stable $CO_2$ concentration level, and feedback control with $CO_2$ consumption rate and top fresh weight for adapting to the change in $CO_2$ demand by growth stage. 5. For the performance test with the developed control algorithm on lettuce the decrease in $CO_2$ supply rate was obtained without a significant decrease in top fresh weight.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.13 no.1
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• pp.81-87
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• 2020

Recently, the network configuration is being rapidly changed to enable easy and free network service configuration based on SDN/NFV. Despite the many advantages and applications of SDN, many security issues such as Distributed Denial of Service (DDoS) attacks are being constantly raised as research issues. In particular, the effectiveness of DDoS attacks is much faster, SDN is causing more and more fatal damage. In this paper, we propose an entropy-based technique to detect and mitigate DDoS attacks in SDN, and prove it through experiments. The proposed scheme is designed to mitigate these attacks by detecting DDoS attacks on single and multiple victim systems and using time - specific techniques. We confirmed the effectiveness of the proposed scheme to reduce packet loss rate by 20(19.86)% while generating 3.21% network congestion.

• KEPCO Journal on Electric Power and Energy
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• v.5 no.2
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• pp.93-101
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• 2019

The mechanical properties and microstructure of 1st stage used and casted buckets of $1,100^{\circ}C$ class gas turbine were analyzed to evaluate quality of the components. Gas turbine 1st stage buckets are exposed and operated in the most severe environment except 1st nozzle among the hot path gas components. Additionally, since the 1st stage bucket is a rotating component, so it may cause additional damage to the rear buckets and nozzles which cause a huge financial loss. Therefore, the quality of the casted bucket must be evaluated prior to use at the plant site. In this study, the microstructure analysis and mechanical properties of the casted bucket were evaluated to verify the casting quality and it was confirmed that the quality conditions designed by KEPCO were satisfied. A bucket operated 46% (11,067EOH) of its life time also evaluated for quality comparison.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.11
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• pp.332-337
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• 2018

Aircraft searchlights are used in search or rescue missions when performing night missions, and provide infrared light to keep operations in concealment. During aircraft operation, the infrared ray transmission filter glass for generating infrared rays can break, resulting in problems such as loss of concealment ability and maintenance. In this paper, we describe the procedure for testing the operating conditions of the searchlight when the defect occurs and finding the cause of the defect. We also summarize various methods to improve the cause and process of making the improved filter prototype. In addition, we also describe the results of verifying the performance requirements of the searchlight. As a result of the test and verification, the damage of the filter was improved and the improved filter was applied to the aircraft.

• The Journal of Korean Academy of Prosthodontics
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• v.57 no.3
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• pp.280-287
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• 2019

In the oral cavity, the teeth undergo wear and corrosion throughout their lives. Progressive and constant tooth wear is a natural phenomenon of aging, but wear and corrosion due to specific factors are pathological factors. It can cause pathological damage of the occlusal surface, aesthetic problems, dimensional loss and jaw joint disorders. This case is a 26-year-old female patient with general tooth abrasion and erosion on the entire dentition. Diagnostic wax-up was fabricated based on the information including digital facial analysis, physiological stabilization, and evaluation of anterior crown length. Through the digital analysis, the necessary guides for crown lengthening were prepared and the mastication function and esthetics were evaluated by using temporary crowns. Definitive prosthesis was fabricated with the zirconia restorations. The results were satisfactory when they were observed 3 months of follow-up.