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http://dx.doi.org/10.5352/JLS.2014.24.9.1019

Effect of Cymbidium Root Extracts on Oxidative Stress-induced Myoblasts Damage  

Kim, Wan Joong (Division of Biological Science and Technology, Yonsei-Fraunhofer Medical Device Lab., College of Science and Technology, Yonsei University)
Kim, Han-Sung (Department of Biomedical Engineering, Yonsei-Fraunhofer Medical Device Lab., College of Health Science, Yonsei University)
Opitz, Joerg (Fraunhofer Institute for Ceramic Technologies and Systems-Material Diagnostics)
Kabayama, Kazuya (Department of Chemistry, Graduate School of Science, Osaka University)
Kim, Tack-Joong (Division of Biological Science and Technology, Yonsei-Fraunhofer Medical Device Lab., College of Science and Technology, Yonsei University)
Publication Information
Journal of Life Science / v.24, no.9, 2014 , pp. 1019-1024 More about this Journal
Abstract
Skeletal muscle atrophy can be defined as a decrease in or a disease of the muscle tissue, or as a disorder of the nerves that control the muscle, through injury or lack of use. This condition is associated with reactive oxygen species (ROS), resulting in various muscular disorders. Exposure to ROS induces muscle atrophy through several biological factors, such as SOD1 and HSP70. We found that cymbidium root extract reduced the $H_2O_2$-induced viability loss in C2C12 myoblasts and inhibited apoptosis. In addition, we showed that the cymbidium root extract increased the expression of HSP70 and decreased the expression of SOD1 in the $H_2O_2$-induced C2C12 myoblasts. These results suggest that cymbidium root extract might have therapeutic value in reducing ROS-induced muscle atrophy.
Keywords
Cymbidium; heat shock protein 70; reactive oxygen species;
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