• 대한간호학회지
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• 제24권1호
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• pp.18-32
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• 1994

It is important to understand that patients with hemiplegia are under stress during the rehabilitation process. This study was designed to determine what changes occur in the stress perceived by these patients during the rehabilitation process. and what changes occur in the ways they coped with stress. A decriptive study with a longitudinal design was conducted. A total of 57 patients with hemiplegia who were admitted to one general hospital made up the sample for this study. A questionnaire, observations and interviews were used for the data collection which was done in three phases(within one week after admission : within one week before discharge ; within one month after discharge ). Data were analyzed using t-test, ANOVA repeated measures of ANOVA, and post hoc paired t -test, Bonferroni correction. The results of this study are : 1. Changes in the perception of stress during the rehabilitation process : There was a statistically significant differencs in the perception of stress among these patients during the rehabilitation process. On the post-hoc test. the perception of stress showed a statistically significant decrease from admission to discharge. The perception of psychological stress was high during the rehabilitation process as compared with the perception of physical and social stress. 2. Changes in the way the patients coped during the rehabilitation process : On admission passive coping was used by most of the subjects(91.2％). Passive coping showed an decrease from admission to discharge, but an increase from discharge to follow-up at one month post discharge. There was, however, no statistically significant changes in the way the patients coped during the rehabilitation process. 3. Changes in perception of stress during the rehabilitation process according to variables. Perception of stress among patients classified as So-Um was higher during the rehabilitation process, when compared with patients classified as So- Yang and Tae-Um. There was, however, no statistically significant difference in perception of stress over time. The patients with right sided paralysis perceived higher stress than those with left sided paralysis. There was, however, no statistically significant difference in perception of stress over time. Hence, stress was not influenced by which side was paralyzed th frequency of the relapse of the disease, or the time in the rehabilitation process. 4. Changes in coping during the rehabilitation process according to variables. There was a statistically significant difference in the way the patients coped at follow- up according to the three different kinds of the constitution groups. In other words, coping was not used by patients classified as Tae-Um but was used by those classified as So-Um. On the repeated measures of ANOVA, there was a statstically significant difference in stress over time, and an interaction between constitution and time. But the way of coping during the rehabilitation process was not influenced by which side was paralyzed nor by the frequency of the relapse of the disease. In conclusion, perception of psychological stress was high during the rehabilitation process, as compared to perception of physical and social stress. There was a statistcally significant difference in the perception of stress over time, Perception of stress showed a gradual decrease from over admission to follow-up period. There was. however, no statistically significant difference in the way of coping over time. Passive coping was used by most of patients. In the study, these findings suggest a need for nursing care related to the psychological support for patients with hemiplegia both in the hospital as well as at home, and the need for education and counseling on independent self-care to help the hemiplegic patients adapt to stress using active coping.

• 여성건강간호학회지
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• 제4권1호
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• pp.5-35
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• 1998

This study attempted to determine the relation between the maternal role strain and their husbands' support in employed and nonemployed first-time mothers, and how it changed over time. A descriptive, longitudinal and comparative study design was conducted to collect and analyzed the data at three times(at 3-4days, at 4-6wks and at 3-month postpartum) regarding the change of maternal role strain and their husbands' support in employed and nonemployed first-time mothers. The subjects were 133 first-time mothers who delivered vaginally at K university hospital in Deagu, Korea from Dec., 1994 to Oct., 1995. Among these 58 were employed and 75 were nonemployed first-time mothers. This instruments used to data collection in this study were by Hobbs(1968 : The Difficulty Index for First-time Parents), Staffensmeier(1982: Transition Difficulty Measure), Tayer(1976: Emotional Support from Husband), Lee, Hae Kyoung(1992 : Physical Support from Husband). The analysis of data was done with SAS/PC program which included percentage, $x^2$-test, Pearson correlation, Repeated Measure ANOVA, Time Contrast Analysis and t-test. The results were as follows : 1. There was a significant negative correlation only at 3-4days(r=-.19, P=.0265) and at 4-6wks postpartum(r=-.18, P=.0392) between maternal role strain and husband's support of the first-time mothers. Thus, the more support from husband, the less maternal role strains the first-time mothers felt. Therefore, the 1st hypothesis that "the more husband's support the first-time mother felt at all the time of testing, the less maternal role strains they got" was partially supported at 3-days and 4-6 weeks postpartum. There was no correlation between maternal role strain and t husband's support of the employed first-time mothers at al testing times(at 3-4days postpartum : r=-.95, P=.9548, at 4-6wks postpartum : r=-.0960, P=.4733 and at 3-month postpartum : r=-.05, P=7306). On the contrary, the unemployed first-time mothers felt less maternal role strain when they received more support from their husband at 3-4 days postpartum(r=-.31, P=.0073) and at 4-6wks postpartum(r=-.23, P=.0490). 2. There was no difference of maternal role strain between two groups with regards to employment status(F=.97, P=.3270). But the maternal role strains of two groups were changed differently each other over time(F=3.89, P=.00234). Therefore, the 2nd hypothesis that "there was the difference in the maternal role strains with regard to employment status and over time" was rejected. 3. There was no difference in husband's support between the employed and the nonemployed first-time mothers(F=3.06, P=.0826). But there was a significant interaction between employment status and over time(F=3.64, P=.0267), so the support from husband of the employed and the unemployed first-time mothers was changed differently each other over time. The support from husband of the employed first-time mothers was lowered significantly and continuously at 4-6wks (F=5.20, P=.0263) and at 3-month postpartum(F=6.47, P=.0137) than at 3-4 days postpartum. On the contrary, there was no difference in change of husband's support of the employed first-time mothers between the 3-4 days and the 4-6wks postpartum(F=1.70, P=.1962) and between the 3-4 days and the 3-month postpartum(F=.21, P=.6513). Mean husband's support of the nonemployed first-time mothers was raised at 4-6wks postpartum than at 3-4 days postpartum but lowed at 3-month postpartum. The support form husband of both groups was tending downwards at 3-month postpartum than at 4-6wks postpartum, but the one between two groups was changed differently each other over time. The husband's support of the employed first-time mothers(M${\pm}$SD=64. 26${\pm}$8.63) was higher than the one of the nonemployed first-time mothers(M${\pm}$SD=59.16${\pm}$11.11) (t=-2.98, P=.0035), so the 3rd hypothesis that "there was the difference in the husband's support with regard to employment status and over time" was supported. On the basis of these conclusions, the following suggestion is proposed. This study examined the change and relationship between maternal role strain and husband's support in the employed and the nonemployed first-time mothers. So the further study regarding the comparison between the employed and the nonemployed multiparas is necessary.

• 한국노년학
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• 제41권4호
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• pp.547-566
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• 2021

본 연구의 목적은 노인의 성별에 따른 사회활동 유형별 참여가 건강수명에 미치는 영향력을 분석하는 것이다. 이를 위해 고령화연구패널조사(KLoSA)의 1차(2006년)에서 7차(2018년)까지의 13년간 데이터 중 65세 이상 노인 4,029명(남성노인=1,710명, 여성노인=2,319명)의 자료를 사용하여 생존분석의 하나인 Cox 비례해저드모형(Cox proportional hazard model)으로 분석을 시도했다. 분석결과 첫째, 여성노인의 건강수명은 75.34세, 남성노인의 건강수명은 76.94세로 나타났다. 여성노인은 남성노인에 비하여 질병 및 장애의 발생 강도와 발생 비율이 더 컸고, 질병 및 장애가 발생한 노인의 비율도 더 높았다. 둘째, 남성노인과 여성노인의 건강수명에 공통적인 영향요인은 연령, 만성질환 수와 주관적 건강상태로 나타났다. 학력은 남성노인의 건강수명에만 유의한 것으로 나타났고, 거주지역, 과거 음주 경험, 삶의 만족도는 여성노인의 건강수명에만 유의한 것으로 나타났다. 셋째, 건강수명에 유의한 영향을 미치는 사회활동 유형은 남성노인의 경우 종교활동과 연고집단활동, 여성노인의 경우 종교활동으로 나타났다. 본 연구는 노인의 건강수명에 대한 사회적 활동 유형의 효과가 성별에 따라 다르다는 점을 보여준다. 또한, 건강수명 단축의 위험은 남성노인보다 여성노인이 상대적으로 높게 나타났다. 연구자들은 건강수명 연장을 위하여 성별 특성을 고려한 사회활동 참여의 기회 확대와 유형별 참여의 행태나 질에 대한 고려, 그리고 남녀 간 건강격차를 감소시키기 위한 정책개발의 필요성을 제안하였다.

• 보건행정학회지
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• 제34권3호
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• pp.319-333
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• 2024

연구배경: 65세 이상 독거노인을 대상으로 재난적 의료비 발생의 영향요인을 파악하고, 이를 바탕으로 독거노인의 재난적 의료비 지출(catastrophic health expenditure) 관리방안을 논한다. 방법: 본 연구에서는 한국고령화패널조사 6차(2016년), 7차(2018년), 8차(2020년) 자료를 활용하여, 독거노인의 재난적 의료비 발생률을 파악하고 패널로짓 분석을 실시했다. 종속변수는 재난적 의료비 지출의 발생 여부(역치: 10%, 20%, 30%)이며, 독립변수로는 인구통계학적 요인(성별, 연령 구분, 지역), 사회경제학 요인(교육수준, 경제활동 상태, 소득분위, 자녀의 재정지원율), 건강 관련 요인(주관적 건강상태, 규칙적 운동, 흡연, 음주, 만성질환 개수), 의료보장 요인(의료보장 형태, 민간의료보험 가입)을 선정했다. 결과: 성별을 구분한 기술통계 결과를 보면, 질환 유병, 사회·경제적 측면에서 여성 독거노인이 남성 독거노인보다 취약한 것으로 나타났으며, 모든 역치에서 여성 독거노인의 재난적 의료비 발생률이 남성 독거노인보다 높았다. 패널로짓 분석의 주요 결과를 보면, 교육수준, 소득분위, 자녀의 재정지원율이 높아질수록 재난적 의료비 발생확률이 낮고, 주관적 건강상태가 나쁘고 만성질환 개수가 많을수록 재난적 의료비 발생확률이 높게 나타났다. 의료급여 수급자는 건강보험 가입자보다 재난적 의료비 발생확률이 낮았다. 결론: 본 연구의 결론은 다음과 같다. 첫째, 독거노인 중에서도 건강상태가 나쁘고, 소득·교육수준이 낮은 취약 독거노인의 경우 재난적 의료비 발생확률이 높았다. 둘째, 이처럼 건강 및 사회·경제적 측면에서 취약한 독거노인을 중심으로 재난적 의료비 지원사업, 만성질환 관리사업 등의 제도를 점검할 필요가 있다. 셋째, 재난적 의료비 지원제도를 환자 중심적(patient-centered)으로 운영하여 도움이 필요한 독거노인을 선별해 지원하는 맞춤형 제도를 검토해 볼 필요가 있다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제9권1호
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• pp.54-66
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• 1998

본 연구의 목적은 정신과 환자의 자녀가 정상인의 자녀와 비교하여 불안, 우울 등의 정신병리와 자기 개념, 가정환경에 대한 인식에 있어서 차이가 있는지를 알아봄으로써 부모의 정신병리가 자녀에게 어떤 영향을 주는가를 밝히기 위함이다. 아울러 환자집단 내에서 환자의 성별에 따라, 환자의 발병 당시의 자녀의 나이에 따라, 환자 진단에 따라 자녀의 불안, 우울 등의 정신병리와 자기 개념, 가정환경에 대한 인식에서 차이가 있는가를 알아보고자 하였다. 1997년 6월부터 1998년 4월까지 서울, 경기지역의 신경정신과 성인 외래 환자 39명을 대상으로 하여 이들의 자녀 중 초등학교 4학년부터 고등학교 3학년까지의 남녀 학생 52명에게 한국형 소아 상태-특성불안척도, 한국형 소아 우울 척도, 한국형 소아자기개념척도, 한국형 가정환경척도를 작성하도록 하고 이를 동 수의 정상인 자녀와 비교하였다. 그리고 환자의 자녀 내에서는 환자가 남자인지 혹은 여자인지, 환자의 발병 연령이 자녀가 3세 이전이었는지 이후였는지, 환자의 진단이 어떤 것인지에 따라 척도들을 비교하였다. 결과는 다음과 같다. 1) 정신과 환자의 자녀들이 정상인의 자녀들과 비교하여 가정환경척도 중 표현력 척도에서 유의하게 낮은점수를 보였고 상태 불안 척도에서는 유의하게 높은 점수를 보였다(p<0.05). 그러나 소아 자기개념척도의 지적 및 학업 상태 소척도와 인기도 소척도에서는 오히려 환자의 자녀가 정상인의 자녀보다 유의미하게 높은 점수를 보였다(p<0.05). 2) 환자군 내에서 환자의 남녀 성별에 따른 자녀의 척도들의 차이는 없었다. 3) 환자군 내에서 환자가 자녀 나이 3세 이전에 발병한 경우가 3세 이후에 발병한 경우보다 가정환경척도 중 조절성 소척도 점수는 유의하게 낮고 특성불안척도는 유의하게 높았다(p<0.05). 4) 환자군 내에서 환자의 진단(정신분열병 범주 장애-정동장애-신경증)에 따른 자녀의 척도들의 차이는 없었다. 자기 보고식 설문으로 측정한 우울, 불안 등의 정신병리는 환자의 자녀와 정상인의 자녀간 유의미한 차이를 보이지 않았다. 환자의 진단이나 남녀 성별의 차이 역시 자녀에게 영향을 주지 않는 것으로 밝혀졌으나 자녀가 3세 이전에 부모가 정신질환에 이환 될 경우에는 자녀의 특성불안이 높은 경향을 보였다. 향후 고위험군 자녀의 발달학적 측면에서 영향을 주는 요인을 밝히는 연구를 위해서는 자녀의 자기보고 이외에도 부모, 선생님 등의 관찰과의 일치도에 대한 조사, 직접적인 면담 등이 필요할 것으로 보이며 통제된 환경에서의 전향적 연구가 필요할 것이다.

• 수면정신생리
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• 제22권2호
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• pp.57-63
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• 2015

목 적 : 그동안의 인터넷 중독에 대한 연구는 청소년과 초기 성인기만을 대상으로 이루어졌다. 본 연구는 우리나라 성인 연령에서의 인터넷 중독의 위험성을 확인하고, 인터넷 중독이 수면에 미치는 영향에 대해 알아보기 위해 시행되었다. 방 법 : 우리나라 성인인구를 대표할 수 있도록 인구비례 추출을 통해 508명의 대상을 선정하였고, Alcohol Use Disorder Identification Test-Korea (Audit-K), Zung's Self-Rating Depression Scale (SDS), 최근 1년간의 약물 사용, 자살시도를 확인하여 325명을 최종 대상으로 연령, 성별, 거주지 등의 사회인구학적 요인과 함께 Young's Internet Addiction Scale (IAS)와 Morningness-Eveningness Questionnaire (MEQ), 주중과 주말의 입면시각, 기상시각 그리고 카페인 음료 섭취 여부 등을 온라인 설문조사를 통해 조사하였다. 결 과 : 인터넷 중독 고위험 군은 총 325명 중 136명(41.8%), 정상사용 군은 189명(58.2%)이었다. 인터넷 중독 고위험 군은 정상사용 군에 비해 통계적으로 유의하게 남성이 많고, 나이가 어릴수록 인터넷 중독 고위험 군에 속하는 비율이 높은 것으로 나타났지만 차이가 통계적으로 유의하지는 않았다. 인터넷 중독 고위험 군은 정상사용 군에 비해 저녁형의 비율이 높았으며, 인터넷을 사용하기 위해 카페인 음료를 섭취하는 비율이 높았다. 결 론 : 본 연구 결과는 성인에서도 인터넷 중독의 고위험 군이 많고, 청소년과 초기 성인기와 유사하게 성인에서도 인터넷 중독과 수면 사이에 의미 있는 연관이 있음을 보여주었다. 향후 인터넷 중독과 아침형-저녁형 간의 인과 관계를 밝히기 위한 종단 연구가 필요하다.

• 여성건강간호학회지
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• 제4권2호
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• pp.217-230
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• 1998

The purpose of this descriptive correlational study was to define the relationship between the experience of Sanhuujori, Korean traditional non-professional postpartal care after delivery and abortion and present health status of chronic arthritis female patient who visited to outpatient clinic of rheumatic internal medicine at a hospital located in Seoul, Korea. A convenience sample of 64 women who orally agreed to be a participant and data were collected form October 1996 to May, 1997 for sis months by way of interview with semistructured questionnaire. The data were analyzed by the SPSS pc program using t-test, ANOVA and Scheffe test as a post hoc and Pearson Correlation Coefficient. The results of the study were as follows ; Mean age of participants was 53.2 years and mean number of children was 3.1. Mean frequency of abortion was 2.1 times per woman. Seventy four percentage of respondents did not have Sanhujori after abortion. The mean period of Sanhujori after delivery was 17.7, 15.2, 13.8 days from the first child to third child and shorter than that of general woman such as 20.0, 19.0, 17.3 days in the previous study. On the subjective evaluation of whether the women did Sanhujori well or not, the rate of 'did Sanhujori wrongly' was the highest rank in each child where as general woman 'did Sanhujori well' at the first child, 'moderate' at the second and third child and 'did Sanhujori wrongly' at the 4th and fifth child. The health status implies both subjective health status women perceived and the rate of complaints of physical symptom distress women are experiencing presently. The respondents of 82.5% perceived them as unhealthy or sick and 68.9% of women complained more than two symptoms. Mean number of physical symptom distress women complained was 2.33. The main sites of physical symptom distress were upper & lower extremities 69.1% including knee and hand, whole body 19.1%, neck 3.7%, waist & shoulders 2.7% respectively. The characteristics of the symptoms were mostly pain 60%, swelling 19.8%, rigidity & deformity 7.9% respectively, sensation of heat 6.8% and weakness 1.7%. Women perceived the etiology of the chronic arthritis as stress 25.8%, 'did Sanhujori wrongly' & overwork 23.4% respectively, genetic 12.9%, malnutrition, 4.8%, and aging process 3.2%. There were significant positive correlation between subjective health status and the period of Sanhujori after delivery of the second child(r=-0.22) and negative correlation with the number of child at the level of 5% of significance statistically(r=0.27). There were significant negative correlation between the rate of complaints of physical symptom distress and the subjective evaluation whether she did Sanhujori well or not at the level of 5% of significance statistically(r=-0.23). And the rate of complaints of physical symptom distress in the group of women who experienced abortion was significantly higher than that of women who did not experience it at the level of 5% significance statistically(t=2.00) In conclusion, this finding reconfirmed the possible relationship between health status of chronic arthritis female patient and the experience of Sanhujori after delivery & abortion. It provides a challenge to the professional care givers to research further on the effects of Sanhujori on the health status, health recovery after abortion or delivery from the various aspects through the crosssectional and longitudinal research for the refinement of the reality of not only as cultural phenomenon but as conceptual model for the appropriateness of intervention and quality of care for desirable health outcomes.

• 여성건강간호학회지
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• 제5권1호
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• pp.111-132
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• 1999

This correlational descriptive study sought to define the relationship between the experience of Sanhujori, Korean tradition non-professional postpartal care after delivery and abortion and present physical symptom distress of arthritis female who visited to outpatient clinic of rheumatic internal medicine at three hospital located in Seoul, Pusan, Chongju, Korea. Data from a convenience sample of 98 women who orally agreed to be respondent were collected from September 1, 1998 to October 31, 1998 for two months by way of interview with semi-structured questionnaire. Data analysis consisted of frequency, percentage, mean, S. D., Pearson Correlation Coefficient, t-test, ANOVA and Scheffe test as a post hoc by SPSS. The results of the study were as follows ; Mean age of participants as 52.8 years and mean number of children 3.3. Mean frequency of child birth was 3.1 times per woman, 67.4% of respondents had menopause, 57.0% did not have Sunhujori after abortion. The health status implies the subjective health status women perceived, which came from the three points of view of the present, comparative with other of same age and changed after delivery. The respondents of 76.1% perceived them as unhealthy and the main sites of physical symptom distress were upper & lower extremities including knee and hand 34.8%, shoulder 26.5%, waist 22.4%. Women perceived the etiology of the arthritis as 'did Sanhujori wrongly' 36.7%, 'aging process' 24.5%, 'stress' 16.3%, 'overwork' 15.3%, 'Immunocompromize' & 'physical constitution' 7.1% respectively, 'character' 3.1%, 'genetic' 2.0%, 'malnutrition' 1.0%. The mean period of Sanhujori after delivery was 20.4 at the first child and 18.1 at the second child. The higher frequency of child birth, the shorter period of Sanhujori. For the subjective evaluation of whether the women did Sanhujori well or not, the rate of 'did Sanhujori well' was the highest rank in the first child and the rate of 'did not particularly Sanhujori well' was the highest rank in the last child. There was a significant positive correlation between physical function disability and rheumatoid arthritis symptom at the level of 1% of significance statistically(r=.406). And a positive correlation between physical function disability and Sanhubyung symptom at the level of 5% of significance statistically(r=.224). There was a significant positive correlation among rheumatoid arthritis symptom, Sanhubyung symptom and menopause symptom at the level of 1%-5% of significance statistically. Most of all, the correlation between Sanhubyung symptom and menopause symptom was the higher than others. There was a negative correlation between the present physical symptom distress and experience of Sanhujori(r=.-130), however it was not significant statistically. However, there was a positive correlation between subjective health status and experience of Sanhujori at the level of 1% of significance statistically(r=.328). In conclusion, this finding reconfirmed the positive relationship between the perceived health status and experience of Sanhujori after delivery among women of arthritis. It provides a challenge to the professional care givers to study further on the effects of Sanhuiori after abortion or delivery on the physical symptom distress from the variouis aspects through the cross-sectional and longitudinal research. The strategy for the development of the appropriate intervention for primary prevention of sequele after childbirth and quality of care for desirable health outcomes for postpartal women with considering deeply on the relationship between women's health and postapartal care.

• 한국응급구조학회지
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• 제5권1호
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• pp.37-51
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• 2001

This study is aimed at examining the ethical values of EMT students. The results below are based on the revised questionnaires, which can be applicable to EMT from the original questionnaires developed by Lee(1990), with a sample of 124 students consisting of 63 first and 61 second year students, conducted November 2-8, 2001. Data were analyzed using SPSS in terms of means, standard deviations, t-test, ANOVA, Pearson's correlation coefficient. The results are as follows: 1. In the area of Human life, all subjects showed utilitarian disposition. All respondents perceived the item "When patients recognizing there is no hope for survival ask for euthanasia, it is ethically right to accommodate their opinions." as the most utilitarian item, whereas they perceived the item "When an hopeless patient is on cardiac arrest, it is ethically right to do CPR as the most deontoogical item. 2. In the area of patient relationship, all students of two groups took on deontoogical characteristics, but there were no statistically significant differences between two groups. All students perceived an item "EMT have to keep it secret if patients disclose their suicide intentions and ask for absolute secrecy" the most utilitarian item, whereas they perceived an item "Even though patients act and speak in a very rude manner, EMT people should do their best to provide care for patients." as the most deontoogical item. 3. In the area of task relationship, first year students perceived an item "Given time limitations, it is ethically right to give priority to the patients who can be rehabilitated over the patients who can't be fully recovered." as the most utilitarian item, whereas second year students perceived an item "Under no circumstances should any placebo be administered to patients." as the most utilitarian item. All students perceived an item "When EMT students see an unconscious person lying in the street, they have to give him/her emergency treatment." as the most deontoogical item. 4. In the area of coworker relationship, all students of two groups took on deontoogical disposition, but there were no significant differences between two groups. All students of two groups perceived an item "Suppose you are regarded as the person who would be promoted. However, you think that your coworker is more competent than you. In that case you should tell your supervisor about your coworker." as the most utilitarian item. First year students perceived an item, whereas second year students perceived an item "When you observe coworkers' misconduct at work, it is ethically right to ignore their misdeeds." as the most deontoogical item. 5. This study demonstrated that for the first year students, there is a correlational relationship between areas of human life and task relationship, and between areas of task relationship and coworker relationship, whereas for the second year students, there is a correlational relationship between areas of human life and task relationship. 6. In areas of human life and task relationship, there are significant differences according to attitudes toward EMT and attendance at ethics training sessions. In the area of coworker relationship, there are significant differences according to religion, attendance at ethics training sessions, and a code of ethics. Recommendations for future research, 1. Sample items to measure ethical values and the instrument tailored to the needs of EMT should be developed. 2. A longitudinal study to track ethical value changes according to the amount of work experience is needed. 3. A code of ethics and/or ethics training, which could apply in actual situations, should be implemented.

• 대한미생물학회지
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• 제21권4호
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• pp.503-513
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• 1986

치주질환의 처치에 있어서 tetracycline의 전신적 투여는 치은연하 세균의 제거 및 감소에 매우 효과가 있는 것으로 알려져 있다. 본 연구는 전신적 투여시의 문제점 보완과 국소적 투여시 기할 수 있는 병소부위의 보다 높은 농도의 유지를 위하여 국소도포용 tetracycline gel을 제조하여 예비실험을 시행하였으며, 본 실험에서는 치주낭 깊이 $4{\sim}6mm$의 중등도 치주염 환자 13명에서 double-blind, split-mouth design으로 상악 또는 하악중 한악은 scaling 및 root planing을 시행하였고, 나머지 악은 그대로 두었으며, 좌측 또는 우측중 한측에는 예비실험결과 가장 효과가 있는 것으로 나타난 국소도포용 3% tetracycline gel을 치주낭내 깊숙히 주2회 2주간 투여하여, (1) tetracycline-scaled (2) tetracycline-unscaled (3) placebo-scaled (4) placebo-unscaled의 4군에서 0일, 14일, 49일에 임상적, 미생물학적 검사를 시행하여 각기 그 효과를 비교하였다. 또한 치주질환과 관련이 깊은, 그람 음성혐기성 세균, 특히 black-pigmented Bacteroides의 분포 변화를 관찰하기 위하여, 시험부위에서 치은연하 치태세균을 채취하여 pre-reduced Ringer액에 혐기성조건으로 보관 운반하여 $37^{\circ}C$혐기성 세균 배양기 내에서 혈액배지에 담아 7일간 배양하여 분리한 후, 생화학 검사를 통하여 Bacteroides균주를 검정하였으며, 이로써 tetracycline투여와 관련된 치주질환의 disease activity를 분석 검토하였다. 이상의 임상적, 미생물학적 검사결과 다음과 같은 결론을 얻었다. 1. 예비실험 결과 국소도포시 가장 효과가 있었던 3% tetracycline gel은 본 실험사용시 치주질환치료 및 치은연하 세균분포변화에 매우 효과가 있으며, 임상적으로 scaling, root planing과 병행시에 가장 효과가 있는 것으로 나타났다. 2. Bacterial morphotype의 관찰결과 tetracycline투여군에서 coccal form의 증가와 spirochetes의 현저한 감소를 보였으며, non-motile rods와 motile rods의 비율에는 다소증감이 있었으나 의미있는 변화는 없었다. 3. Streptococcus균주간의 분포 비율은 tetracycline-scaled군에서 S. sanguis I은 14일에 현저히 증가하였고, 49일에는 다소 감소하였으며, S. mitis는 증가하는 경향을 보였다. 4. Tetracycline-scaled군에서는 black-pigmented Bacteroides의 비율이 현저히 감소하였으며, tetracycline 투여만으로도 black-pigmented Bacteroides 비율은 감소되었다. 그러나 scaling만으로는 black-pigmented Bacteroides 비율에는 변화를 주지못했다. 5. Black-pigmented Bacteroides 균주간의 분포를 보면 실험 및 대조군 모두에서 B. loeschii가 가장 많이 나타났으며, 시간의 경과에 따라 거의 변화가 얼었다. 또한 tetracycline 투여군에서는 B. intermedius와 B. gingivalis가 감소하였고, B. melaninogenicus는 증가하였다.