• Journal of mucopolysaccharidosis and rare diseases
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• v.3 no.1
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• pp.14-19
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• 2017

Lysosomal storage diseases (LSDs) are a group of rare inherited metabolic disorders caused by the deficiency of specific lysosomal enzymes and subsequent accumulation of substrates. Enzyme deficiency leads to progressive intra-lysosomal accumulation of the incompletely degraded substances, which cause dysfunction and destruction of the cell and eventually multiple organ damage. Patients have a broad spectrum of clinical phenotypes which are generally not specific for some LSDs, leading to missed or delayed diagnosis. Due to the availability of treatment including enzyme replacement therapy (ERT) and hematopoietic stem cell transplantation for some LSDs, early diagnosis is important. ERT products have been approved with optimal outcomes for some LSDs in the recent decades, including Gaucher, Fabry, mucopolysaccharidosis (MPS) I, Pompe, MPS VI, MPS II, and MPS IVA diseases. ERT can stabilize the clinical condition, prevent disease progression, and improve the long-term outcome of these diseases, especially if started prior to irreversible organ damage. Based on the availability of therapy and suitable screening methods in the recent years, some LSDs, including Pompe, Fabry, Gaucher, MPS I, MPS II, and MPS VI diseases have been incorporated into nationwide newborn screening panels in Taiwan.

• Journal of The Korean Society of Agricultural Engineers
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• v.51 no.5
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• pp.107-113
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• 2009

The purpose of this study is to estimate the design flood runoff for ungaged forest watershed to reduce the flood damage in national park. Daewonsa watershed in Jirisan National Park was selected as study watershed, of which characteristic factors were obtained from GIS data. Flood runoff was simulated using SCS unit hydrograph module in HEC-HMS model. SCS Curve Number (CN) was calculated from forest type area weighted average method. Huff's time distribution of second-quartile storm of the Sancheong weather station, which is nearest from study watershed, was used for design flood runoff estimation. Critical storm duration for the study watershed was 3 hrs. Based on the critical duration, the peak runoff for each sub-watershed were simulated. It is recommended to monitor the long-term flow data for major stream stations in National Park for a better reliable peak runoff simulation results.

• Journal of Korea Multimedia Society
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• v.17 no.7
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• pp.886-894
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• 2014

Recently, domestic animal disease caused tremendous damage to farmhouses and the damage stretched in nationwide with the spread of epidemic disease. To prevent animal diseases from happening again, the system development to easily measure the temperature of sick animals and identify of them is needed, thereby quickly treat them, reducing losses of farmhouses. However, a lack of related equipment and human resource hampered its effort to minimize its losses. This study tries to develop diagnosis system as part of measures to curb these domestic animal diseases. This paper present the 센서 node based on IEEE 802.15.4 which can be attached to the animal body for real-time temperature measurement. We design and implement tiny chip-type that can be attached to the body of animals. Then, we use available power only when measuring temperatures in a long term-basis. In this paper, the 센서 node was applied to horse's neck. We measure the horse's body temperature between $32.2^{\circ}C{\sim}33.7^{\circ}C$ and analyze phenomenon data for 4 months.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.24 no.4
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• pp.149-155
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• 2010

This paper was carried out to estimate pollution levels of various insulators in tunnel and establish cleaning period in each tunnel section. We estimate pollution level that is attached to insulators in environmental pollution area, industrial area, salt damage area. These results that the pollution quantity and conductivity were increased by pollution accumulation period. However, the conductivity showed each other big difference in each tunnel. In particular, the conductivity showed big in environmental pollution(tunnel A) and salt damage(tunnel C) area, It is considered to prevent accident that manage establishing periodic state of cleaning plan. Also, the Grease that spread on the insulator surface in existing is considered that it can prevent accident for long-term by restrain use.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.1
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• pp.1-8
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• 2016

Damage in the periphery or spinal cord induces maladaptive plastic changes along the somatosensory nervous system from the periphery to the cortex, often leading to chronic pain. Although the role of neural circuit remodeling and structural synaptic plasticity in the 'pain matrix' cortices in chronic pain has been thought as a secondary epiphenomenon to altered nociceptive signaling in the spinal cord, progress in whole brain imaging studies on human patients and animal models has suggested a possibility that plastic changes in cortical neural circuits may actively contribute to chronic pain symptoms. Furthermore, recent development in two-photon microscopy and fluorescence labeling techniques have enabled us to longitudinally trace the structural and functional changes in local circuits, single neurons and even individual synapses in the brain of living animals. These technical advances has started to reveal that cortical structural remodeling following tissue or nerve damage could rapidly occur within days, which are temporally correlated with functional plasticity of cortical circuits as well as the development and maintenance of chronic pain behavior, thereby modifying the previous concept that it takes much longer periods (e.g. months or years). In this review, we discuss the relation of neural circuit plasticity in the 'pain matrix' cortices, such as the anterior cingulate cortex, prefrontal cortex and primary somatosensory cortex, with chronic pain. We also introduce how to apply long-term in vivo two-photon imaging approaches for the study of pathophysiological mechanisms of chronic pain.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.22 no.2
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• pp.179-186
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• 2012

The potential hazards resulting from a low-velocity impact(bird-strike, tool drop, runway debris, etc.) on aircraft structures, such as engine nacelle or leading edges has been a long-term concern to the aircraft industry. Certification authorities require that exposed aircraft components must be tested to prove their capability to withstand low-velocity impact without suffering critical damage. In most of the past research studies unloaded specimens have been used for impact tests, however, in reality it is much more likely that a composite structure is exposed to a certain stress state when it is being impacted, which can have a significant effect on the impact performance. And the radiated impact sound induced by impact is analyzed for the damage detection evaluation. In this study, an investigation was undertaken to evaluate the effect in-plane loading on the impact force and sound of composite laminates numerically.

• Journal of the Korea institute for structural maintenance and inspection
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• v.1 no.2
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• pp.87-94
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• 1997

This research aims to develop an algorithm of optimal transducer placement using Kinetic Energy of the structural system. The structural vibration response-based health monitoring is considered one of the best for the system which requires a long-term, continuous monitoring. In its experimental modal testing, however, it is difficult to decide on the measurement locations and their number, especially for complex structures, which have a major influence on the quality of the results. In order to minimize the number of sensing operations and optimize the transducer location while maximizing the accuracy of results, this paper discusses about an optimum transducer placement criterion suitable for the identification of structural damage. As a criterion algorithm, it proposes the Kinetic Energy Optimization Technique (EOT), and then addresses the numerical issues which are subsequently applicable to actual experiment where a bridge model is used. By using the experimental data, it compares the EOT with the EIM (Effective Independence Method) which is generally used to optimize the transducer placement for the damage identification and control purposes. The comparison conclusively shows that the EOT algorithm proposed in this paper is preferable when a structure is to be instrumented with fewer sensors.

• Proceedings of the KIEE Conference
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• 2007.07a
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• pp.696-698
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• 2007

As overhead transmission lines are exposed to the outdoor weather, lightning induced fault accounts for about 66% of faults in transmission lines. The lightning may cause the damage of power system apparatus or the shut down of electricity. Not only in order to decrease the damage of the power system itself but also to ensure the reliable power supply, an appropriate insulation design based on the long-term lightning statistics is required. Meanwhile, real time information of lightning might be more useful to quickly locate the point of lightning induced fault in the line, leading to minimization of the adverse effects derived from the fault. Korea Electric Power Corporation has been providing an on-line lightning information service, named as KLDNet, since 2006 in order to meet the need inside our company. This paper describes the development and application of the information system.

• Nuclear Engineering and Technology
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• v.46 no.1
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• pp.101-108
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• 2014

About 40% of reactors in the world are being operated beyond design life or are approaching the end of their life cycle. During long-term operation, various degradation mechanisms occur. Fatigue caused by alternating operational stresses in terms of temperature or pressure change is an important damage mechanism in continued operation of nuclear power plants. To monitor the fatigue damage of components, Fatigue Monitoring System (FMS) has been installed. Most FMSs have used Green's Function Approach (GFA) to calculate the thermal stresses rapidly. However, if temperature-dependent material properties are used in a detailed FEM, there is a maximum peak stress discrepancy between a conventional GFA and a detailed FEM because constant material properties are used in a conventional method. Therefore, if a conventional method is used in the fatigue evaluation, thermal stresses for various operating cycles may be calculated incorrectly and it may lead to an unreliable estimation. So, in this paper, the modified GFA which can consider temperature-dependent material properties is proposed by using an artificial neural network and weight factor. To verify the proposed method, thermal stresses by the new method are compared with those by FEM. Finally, pros and cons of the new method as well as technical findings from the assessment are discussed.

• Fire Science and Engineering
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• v.33 no.6
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• pp.95-104
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• 2019

Smoke generated in a fire consists of gaseous substances and particulate matter, such as unburned carbon that adsorbed the gases. Human injury caused by inhalation of gaseous substances present in smoke is mostly short-term, whereas damage caused by inhalation of particulate matter is relatively a long-term phenomenon depending on the state of the gas-phase adsorption. The amount and location of the deposited smoke particles are important factors in estimating the damage caused to humans, which are affected by the breathing conditions as well as particle conditions, such as the size and concentration affected by the combustion conditions. In this study, in order to understand the characteristics of the deposition of smoke particles in the respiratory tract related to the study of human smoke inhalation injury, the number and mass concentration of smoke particles deposited in different areas of the respiratory tract for different fuel types, combustion conditions and breathing conditions were calculated. In addition, the amount of mass deposition of smoke in the respiratory tract for a certain period of inhalation was compared with the atmospheric standard of fine dust.