• 제목/요약/키워드: Localized Strategy

검색결과 54건 처리시간 0.028초

Preemptive application of QX-314 attenuates trigeminal neuropathic mechanical allodynia in rats

  • Yoon, Jeong-Ho;Son, Jo-Young;Kim, Min-Ji;Kang, Song-Hee;Ju, Jin-Sook;Bae, Yong-Chul;Ahn, Dong-Kuk
    • The Korean Journal of Physiology and Pharmacology
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    • 제22권3호
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    • pp.331-341
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    • 2018
  • The aim of the present study was to examine the effects of preemptive analgesia on the development of trigeminal neuropathic pain. For this purpose, mechanical allodynia was evaluated in male Sprague-Dawley rats using chronic constriction injury of the infraorbital nerve (CCI-ION) and perineural application of 2% QX-314 to the infraorbital nerve. CCI-ION produced severe mechanical allodynia, which was maintained until postoperative day (POD) 30. An immediate single application of 2% QX-314 to the infraorbital nerve following CCI-ION significantly reduced neuropathic mechanical allodynia. Immediate double application of QX-314 produced a greater attenuation of mechanical allodynia than a single application of QX-314. Immediate double application of 2% QX-314 reduced the CCI-ION-induced upregulation of GFAP and p-p38 expression in the trigeminal ganglion. The upregulated p-p38 expression was co-localized with NeuN, a neuronal cell marker. We also investigated the role of voltage-gated sodium channels (Navs) in the antinociception produced by preemptive application of QX-314 through analysis of the changes in Nav expression in the trigeminal ganglion following CCI-ION. Preemptive application of QX-314 significantly reduced the upregulation of Nav1.3, 1.7, and 1.9 produced by CCI-ION. These results suggest that long-lasting blockade of the transmission of pain signaling inhibits the development of neuropathic pain through the regulation of Nav isoform expression in the trigeminal ganglion. Importantly, these results provide a potential preemptive therapeutic strategy for the treatment of neuropathic pain after nerve injury.

정위성 비소세포폐암의 동물 모델의 개발 (Development of Animal Model for Orthotopic Non-Small Cell Lung Cancer in Nude Rat)

  • 김진국;김관만
    • Journal of Chest Surgery
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    • 제30권6호
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    • pp.566-572
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    • 1997
  • 유전자 치료등 폐암에 대한 새로운 치료법의 개발및 그 효능의 검증에 있어 적절한 동물 모델이 없음은 큰 제 한점중의 하나이다. 특히 종양의 생물학적 특성이나 치료에의 효과등이 장기자체의 환경에 크게 영향 을 받는다는 사실은, 인체에서의 폐암의 특성을 가지며 폐에 정 위적으로 발생하는 폐암의 동물모델의 개발 을 시급하게 한다. 저자등은 Nude rat을 대상 동물로 하여, 개흉하에 종양세포 부유액을 원하는 폐말단 부위에 직접 주입함으로 폐에 정 위적으로 폐암의 발달을 유도하였으며 이를 이용하여 발생된 비소세포 폐암의 병태를 연구하였다. 종양은 실험 대상 등물에서 모두 발생하였으며 이용한 두 가지 종류의 세포주(NCI-H46O과 NCI-H1299)에서 모두 효과적으로 발생하였다. 발생된 폐종양은 시간 경과에 따라 주위 조직으로의 침윤과 종격동 전이의 양상를 보였다. 종양 숙주 동물의 평균 수명은 약 5주 정도였다. 저자등이 개발한 비소세포폐암의 동물 모델은 기관지를 통한 종양 세포 주입법에 의한 폐암 모델에 비해 국소적으로 진행된 폐암을 원하는 부위에 정확히 만들 수 있음은 물론 외과적 처치를 비롯한 국소적 치료 방법의 개발이나 ?과의 검증에 두루 이용되기에 적절하다고 사료된다.

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글로벌 한국어 방송사의 경영전략 연구 : 기업자원모델을 중심으로 (Analysis of Business Strategy for Korean Ethnic Media Companies based on Resource Based View)

  • 김종하;정윤경
    • 문화경제연구
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    • 제19권2호
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    • pp.147-170
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    • 2016
  • 본 연구는 세계 한국어방송사의 경영개선을 통해 모국의 지원정책 방향을 수립하고자, 미국과 캐나다, 중국, 호주 뉴질랜드을 중심으로 해외 한국어방송사의 미디어 운영환경과 경영자원, 모국에서 10년간 운영중인 지원사업 등을 분석하였다. 연구결과, 미국과 캐나다는 치열한 경쟁에 노출된 완전경쟁시장으로 한국어방송사간 경쟁, 자국내 미디어와의 경쟁, 뉴미디어도입에 따른 경쟁, 모국 미디어와의 경쟁이 존재했다. 중국은 정부의 규제 및 소수민 미디어에 대한 지원이 시행되어 제한적 현지화가 구현되고 있었으며, 호주 및 뉴질랜드는 동포의 수가 적고 밀집도가 떨어져, 방송시장의 규모 또한 영세하거나 미발달했지만, 잠재적 성장을 기대할 수 있는 시장으로 구분되었다. 각 국가별 해외 한국어 방송사 활성화를 위해 미국의 한국어방송사들은 콘텐츠 차별화를 위한 사업구조와 조직개선을 위한 지원과 협력이 필요하며, 중국은 재무자원 다각화 및 콘텐츠 역량 강화가 시급한 것으로 분석되었다. 호주 및 뉴질랜드의 경우 양질의 콘텐츠확보를 위한 모국의 지원 및 협력강화가 중요한 이슈로 연구되었다.

Reduction of Inflammation and Enhancement of Motility after Pancreatic Islet Derived Stem Cell Transplantation Following Spinal Cord Injury

  • Karaoz, Erdal;Tepekoy, Filiz;Yilmaz, Irem;Subasi, Cansu;Kabatas, Serdar
    • Journal of Korean Neurosurgical Society
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    • 제62권2호
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    • pp.153-165
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    • 2019
  • Objective : Spinal cord injury (SCI) is a very serious health problem, usually caused by a trauma and accompanied by elevated levels of inflammation indicators. Stem cell-based therapy is promising some valuable strategies for its functional recovery. Nestin-positive progenitor and/or stem cells (SC) isolated from pancreatic islets (PI) show mesenchymal stem cell (MSC) characteristics. For this reason, we aimed to analyze the effects of rat pancreatic islet derived stem cell (rPI-SC) delivery on functional recovery, as well as the levels of inflammation factors following SCI. Methods : rPI-SCs were isolated, cultured and their MSC characteristics were determined through flow cytometry and immunofluorescence analysis. The experimental rat population was divided into three groups : 1) laminectomy & trauma, 2) laminectomy & trauma & phosphate-buffered saline (PBS), and 3) laminectomy+trauma+SCs. Green fluorescent protein (GFP) labelled rPI-SCs were transplanted into the injured rat spinal cord. Their motilities were evaluated with Basso, Beattie and Bresnahan (BBB) Score. After 4-weeks, spinal cord sections were analyzed for GFP labeled SCs and stained for vimentin, $S100{\beta}$, brain derived neurotrophic factor (BDNF), 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNPase), vascular endothelial growth factor (VEGF) and proinflammatory (interleukin [IL]-6, transforming growth factor $[TGF]-{\beta}$, macrophage inflammatory protein [MIP]-2, myeloperoxidase [MPO]) and anti-inflammatory (IL-1 receptor antagonis) factors. Results : rPI-SCs were revealed to display MSC characteristics and express neural and glial cell markers including BDNF, glial fibrillary acidic protein (GFAP), fibronectin, microtubule associated protein-2a,b (MAP2a,b), ${\beta}3$-tubulin and nestin as well as anti-inflammatory prostaglandin E2 receptor, EP3. The BBB scores showed significant motor recovery in group 3. GFP-labelled cells were localized on the injury site. In addition, decreased proinflammatory factor levels and increased intensity of anti-inflammatory factors were determined. Conclusion : Transplantation of PI-SCs might be an effective strategy to improve functional recovery following spinal cord trauma.

Examining the Generative Artificial Intelligence Landscape: Current Status and Policy Strategies

  • Hyoung-Goo Kang;Ahram Moon;Seongmin Jeon
    • Asia pacific journal of information systems
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    • 제34권1호
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    • pp.150-190
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    • 2024
  • This article proposes a framework to elucidate the structural dynamics of the generative AI ecosystem. It also outlines the practical application of this proposed framework through illustrative policies, with a specific emphasis on the development of the Korean generative AI ecosystem and its implications of platform strategies at AI platform-squared. We propose a comprehensive classification scheme within generative AI ecosystems, including app builders, technology partners, app stores, foundational AI models operating as operating systems, cloud services, and chip manufacturers. The market competitiveness for both app builders and technology partners will be highly contingent on their ability to effectively navigate the customer decision journey (CDJ) while offering localized services that fill the gaps left by foundational models. The strategically important platform of platforms in the generative AI ecosystem (i.e., AI platform-squared) is constituted by app stores, foundational AIs as operating systems, and cloud services. A few companies, primarily in the U.S. and China, are projected to dominate this AI platform squared, and consequently, they are likely to become the primary targets of non-market strategies by diverse governments and communities. Korea still has chances in AI platform-squared, but the window of opportunities is narrowing. A cautious approach is necessary when considering potential regulations for domestic large AI models and platforms. Hastily importing foreign regulatory frameworks and non-market strategies, such as those from Europe, could overlook the essential hierarchical structure that our framework underscores. Our study suggests a clear strategic pathway for Korea to emerge as a generative AI powerhouse. As one of the few countries boasting significant companies within the foundational AI models (which need to collaborate with each other) and chip manufacturing sectors, it is vital for Korea to leverage its unique position and strategically penetrate the platform-squared segment-app stores, operating systems, and cloud services. Given the potential network effects and winner-takes-all dynamics in AI platform-squared, this endeavor is of immediate urgency. To facilitate this transition, it is recommended that the government implement promotional policies that strategically nurture these AI platform-squared, rather than restrict them through regulations and stakeholder pressures.

기후변화 시나리오를 활용한 공간정보 기반 극단적 기후사상 분석 도구(EEAT) 개발 (Development of Extreme Event Analysis Tool Base on Spatial Information Using Climate Change Scenarios)

  • 한국진;이명진
    • 대한원격탐사학회지
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    • 제36권3호
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    • pp.475-486
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    • 2020
  • 기후변화 시나리오는 기후변화 대응 연구의 기반이 되는 사항으로, 대용량 시공간 데이터로 구성되어 있다. 데이터의 관점에서는 1종의 시나리오가 약 83 기가바이트(Giga bytes) 이상의 대용량이며, 데이터 형식은 반정형으로 검색, 추출, 저장 및 분석 등 활용상 제약이 있다. 본 연구에서는 대용량, 다중시기 기후변화 시나리오의 활용을 편리하게 개선하기 위하여 공간정보 기반의 극단적 기후사상 분석 도구를 개발하였다. 또한, 개발된 도구를 RCP8.5 기후변화 시나리오에 적용하여 과거 발생한 집중호우 임계치가 미래 발생 가능한 시기와 공간에 대한 시범 분석을 수행하였다. 분석결과, 3일 누적 강우량 587.6 mm 이상인 날이 2080년대 약 76회 발생하는 것으로 분석되었으며, 집중호우는 국지적으로 발생하였다. 개발된 분석도구는 초기 설정부터 분석결과를 도출하는 전 과정이 단일 플랫폼에서 구현되도록 하였다. 더불어 상용 소프트웨어가 없어도 분석결과를 다양한 형식(웹 문서형식(HTML), 이미지(PNG), 기후변화 시나리오(ESR), 통계(XLS))으로 구현되도록 하였다. 따라서 본 분석도구 활용을 통해 기후변화에 대한 미래 전망이나 취약성 평가 등의 활용에 도움이 될 것으로 사료되며, 향후 제공될 기후변화 보고서에 따른 기후변화 시나리오 분석 도구 개발에도 사용될 것으로 기대된다.

A study on the Regulatory Environment of the French Distribution Industry and the Intermarche's Management strategies

  • Choi, In-Sik;Lee, Sang-Youn
    • 산경연구논집
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    • 제3권1호
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    • pp.7-16
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    • 2012
  • Despite the enforcement of SSM control laws such as 'the Law of Developing the Distribution Industry (LDDI)' and 'the Law of Promoting Mutual Cooperation between Large and Small/medium Enterprises (LPMC)' stipulating the business adjustment system, the number of super-supermarkets (SSMs) has ever been expanding in Korea. In France, however, Super Centers are being regulated most strongly and directly in the whole Europe viewing that there is not a single SSM in Paris, which is emphasized to be the outcome from French government's regulation exerted on the opening of large scale retail stores. In France, the authority to approve store opening is deeply centralized and the store opening regulation is a socio-economic regulation driven by economic laws whereas EU strongly regulates the distribution industry. To control the French distribution industry, such seven laws and regulations as Commission départementale d'urbanisme commercial guidelines (CDLIC) (1969), the Royer Law (1973), the Doubin Law (1990), the Sapin Law (1993), the Raffarin Law (1996), solidarite et renouvellement urbains (SRU) (2000), and Loi de modernisation de l'économie (LME) (2009) have been promulgated one by one since the amendment of the Fontanet guidelines, through which commercial adjustment laws and regulations have been complemented and reinforced while regulatory measures have been taken. Even in the course of forming such strong regulatory laws, InterMarche, the largest supermarket chain in France, has been in existence as a global enterprise specialized in retail distribution with over 4,000 stores in Europe. InterMarche's business can be divided largely into two segments of food and non-food. As a supermarket chain, InterMarche's food segment has 2,300 stores in Europe and as a hard-discounter store chain in France, Netto has 420 stores. Restaumarch is a chain of traditional family restaurants and the steak house restaurant chain of Poivre Rouge has 4 restaurants currently. In addition, there are others like Ecomarche which is a supermarket chain for small and medium cities. In the non-food segment, the DIY and gardening chain of Bricomarche has a total of 620 stores in Europe. And the car-related chain of Roady has a total of 158 stores in Europe. There is the clothing chain of Veti as well. In view of InterMarche's management strategies, since its distribution strategy is to sell goods at cheap prices, buying goods cheap only is not enough. In other words, in order to sell goods cheap, it is all important to buy goods cheap, manage them cheap, systemize them cheap, and transport them cheap. In quality assurance, InterMarche has guaranteed the purchase safety for consumers by providing its own private brand products. InterMarche has 90 private brands of its own, thus being the retailer with the largest number of distributor brands in France. In view of its IT service strategy, InterMarche is utilizing a high performance IT system so as to obtainas much of the market information as possible and also to find out the best locations for opening stores. In its global expansion strategy of international alliance, InterMarche has established the ALDIS group together with the distribution enterprises of both Spain and Germany in order to expand its food purchase, whereas in the non-food segment, it has established the ARENA group in alliance with 11 international distribution enterprises. Such strategies of InterMarche have been intended to find out the consumer needs for both price and quality of goods and to secure the purchase and supply networks which are closely localized. It is necessary to cope promptly with the constantly changing circumstances through being unified with relevant regions and by providing diversified customer services as well. In view of the InterMarche's positive policy for promoting local partnerships as well as the assistance for enhancing the local economic structure, implications are existing for those retail distributors of our country.

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전략적(戰略的) 기술경쟁(技術競爭)과 산업(産業)·무역정책(貿易政策) (Effects of Trade and Industrial Policies in the Presence of Strategic Technology Competition)

  • 이홍구
    • KDI Journal of Economic Policy
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    • 제14권3호
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    • pp.3-21
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    • 1992
  • 기술경쟁과 생산경쟁에 범위(範圍)의 경제(經濟)가 존재하고, 두 기업이 생산경쟁에서 전략적(戰略的) 대체관계(代替關係)에 있는 경우 경쟁기업간의 기술경쟁(技術競爭)은 적극적인 양상을 띠게 된다. 생산단계의 경쟁자를 견제하기 위환 전략적 대응으로 기술경쟁단계(技術競爭段階)에서 과잉된 기술투자(技術投資)와 기술이전(技術移轉)이 유발되는 것이다. 또한 과잉된 기술경쟁은 제품가격(製品價格)의 급속한 하락(下落)으로 연결된다. 이와 같은 맥락에서 최근 보도 된 바 있는 국산화 신제품에 대한 외국기업의 저가공세(低價攻勢)는 과점적(寡占的) 시장(市場)에서 나타나는 자연스런 현상으로 이해할 수 있다. 또한 기술경쟁단계에서 기술개발투자(技術開發投資)와 기술이전(技術移轉)은 전략적(戰略的) 대체관계(代替關係)뿐만 아니라 전략적(戰略的) 보완관계(補完關係)를 가질 수 있다. 이와 같이 대조적인 전략적 대응관계가 가능하기 때문에 국산화(國産化) 노력(努力)을 견제하고 국내시장(國內市場) 점유율(占有率)을 유지하기 위해 저가공세를 취하는 외국기업에 대한 대응방안(對應方案)으로 검토되고 있는 수입품에 대한 조정관세(調整關稅), 국산화 신제품에 대한 수요창출(需要創出), 기술투자의 채산성 보장을 위한 보조금지급(補助金支給) 등과 같은 정책변수(政策變數) 활용(活用)이 바람직한가를 사전적으로 규정하기는 어렵다. 즉 전략적 무역(산업)정책이론에서 주장하는 것처럼 관세부과(關稅賦課)나 보조금지급(補助金支給)이 국내기업의 시장점유율(市場占有率)과 기술투자규모(技術投資規模)를 향상 증대시키는 것은 아니라는 것이다.

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두정엽 및 후두엽 간질에 대한 수술전략 (Surgical Strategy of Epilepsy Arising from Parietal and Occipital Lobes)

  • 심병수;최하영
    • Journal of Korean Neurosurgical Society
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    • 제29권2호
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    • pp.222-230
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    • 2000
  • Purpose : Resection of the epileptogenic zone in the parietal and occipital lobes may be relevant although only few studies have been reported. Methods : Eight patients with parietal epilepsy and nine patients with occipital epilepsy were included for this study. Preoperatively, all had video-EEG monitoring with extracranial electrodes, MRI, 3D-surface rendering of MRI using Allegro(ISG Technologies Inc., Toronto, Canada), and PET scans. Sixteen patients underwent invasive recording with subdural grid. Eight had parietal resection including the sensory cortex in two. Seven had partial occipital resection. Two underwent total unilateral occipital lobectomy. The extent of the resection was made based mainly on the data of invasive EEG recordings, MRI, and 3D-surface rendering of MRI, not on the intraoperative electrocorticographic findings as usually done. During resection, electrocortical stimulation was performed on the motor cortex and speech area. Results : Out of eight patients with parietal epilepsy, three had sensory aura, two had gustatory aura, and two had visual aura. Six of nine patients with occipital epilepsy had visual auras. All had complex partial seizures with lateralizing signs in 15 patients. Four had quadrantopsia. One had mild right hemiparesis. Abnormality in MRI was noticed in six out of eight parietal epilepsy and in eight out of nine occipital epilepsy. 3D-surface rendering of MRI visualized volumetric abnormality with geometric spatial relationships adjacent to the normal brain, in all of parietal and occipital epilepsy. Surface EEG recording was not reliable in localizing the epileptogenic zone in any patient. The subdural grid electrodes can be implanted on the core of the structural abnormality in 3D-reconstructed brain. Ictal onset zone was localized accurately by subdural grid EEGs in 16 patients. Motor cortex in nine and sensory speech area in two were identified by electrocortical stimulation. Histopathologic findings revealed cortical dysplasia in 10 patients ; tuberous sclerosis was combined in two, hamartoma and ganglioglioma in one each, and subpial gliosis in six. Eleven patients were seizure free at follow-up of 6 months to 37 months(mean 19.7 months) after surgery. Seizures recurred in two and were unchanged in one. Six produced transient sensory loss and one developed hemiparesis and tactile agnosia. One revealed transient apraxia. Two patients with preoperative quadrantopsia developed homonymous hemianopsia. Conclusion : This study suggests that surgical treatment was relevant in parietal and occipital epilepsies with good surgical outcome, without significant neurologic sequelae. Neuroimaging studies including conventional MRI, 3Dsurface rendering of MRI were necessary in identifying the epileptogenic zone. In particular, 3D-surface rendering of MRI was very helpful in presuming the epileptogenic zone in patients with unidentifiable lesion in the conventional MRI, in planning surgical approach to lesions, and also in making a decision of the extent of the epileptogenic zone in patients with identifiable lesion in conventional MRI. Invasive EEG recording with the subdural grid electrodes helped to confirm a core of the epileptogenic zone which was revealed in 3D-surface rendered brain.

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창조융합시장을 위한 유럽 연합 (EU)의 시장과문화적 지역특화방안 (Creative Cultural Localization Ways and IT Market of the EU to Converge the Creative Industries)

  • 서대성
    • 유통과학연구
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    • 제13권1호
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    • pp.27-33
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    • 2015
  • Purpose - The ICT market in the EU is lagging behind that of the US; however, algorithm and software development within the EU have grown steadily, and they involve focusing on the creative cultural convergence conceptualized as part of Horizon 2020 and connecting neighboring markets in the EE and the Mediterranean region. It is essential to study the requirements to market the EU's creative ICT development in emerging industrial countries after examining its applicability in these countries. Research design, data, and methodology - This study deals with data pertaining to the EU's creative industry and competitive edge. The global cultural expansion of the EU facilitates a new concept involving not only low-cost IT products to enhance local cultural artifacts through R&D and the construction of efficient infrastructure services, but also information exchange with a realistic commercialization of the technology that can be applied for creative cultural localization. In the European industry, research on algorithms has been applied for the benefit of consumers. We investigated how the process is conducted in the EU. Results - Europe needs to adjust its economic structure to the local culture as part of IT distribution convergence. The convergence has been converted into a production algorithm with IT in the form of low-cost production. This is because there is an attempt to improve the quality of transport infrastructure, workforce availability, and the distribution of the distance to the local industries and consumers, using IT algorithms. Integrated into the manufacturing industry, based on the ICT infrastructure and solutions, smart localized regional clusters are formed with the help of grafting. Europe has own strategy to increase the number of hub-and-spoke cities. Europe is now becoming integrated, with an EPC system for regional cooperation rather than national competition in ICT technology. Europe has also been recognized in this study as changing the step-by-step paradigm for global competitiveness through new creative culture industries. Conclusions - As a result, there are several ways of converging with others through EU R&D intensity; therefore, the EU can be seen as successfully increasing marginal value, which is useful in developing a special industrial cluster or local cultural cities that create converged development by connecting people and objects with IT. In fact, when compared to the US, Europe has a strong culture and the car industries have a tendency to overshadow the IT industries with integration of services in IT distribution. Considering the rapid environmental changes, the convergence of IT services is likely to take place in Europe, similar to the pharmaceutical industry and the automotive industry. This requires a focus on human resources and automated systems management. The trend is to move away from low-wage industries, switched to key personnel centers of the local university-industry. EU emphasizes the creation of IT market demand in Europe involving local cultural convergence for marketing as the second step to strengthen the economic hub-and-spoke areas.