• Proceedings of the Microbiological Society of Korea Conference
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• 2007.05a
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• pp.120-122
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• 2007

All living organisms use numerous signal-transduction pathways to sense and respond to their environments and thereby survive and proliferate in a range of biological niches. Molecular dissection of these signalling networks has increased our understanding of these communication processes and provides a platform for therapeutic intervention when these pathways malfunction in disease states, including infection. Owing to the expanding availability of sequenced genomes, a wealth of genetic and molecular tools and the conservation of signalling networks, members of the fungal kingdom serve as excellent model systems for more complex, multicellular organisms. Here, we employed Cryptococcus neoformans as a model system to understand how fungal-signalling circuits operate at the molecular level to sense and respond to a plethora of environmental stresses, including osmoticshock, UV, high temperature, oxidative stress and toxic drugs/metabolites. The stress-activated p38/Hog1 MAPK pathway is structurally conserved in many organisms as diverse as yeast and mammals, but its regulation is uniquely specialized in a majority of clinical Cryptococcus neoformans serotype A and D strains to control differentiation and virulence factor regulation. C. neoformans Hog1 MAPK is controlled by Pbs2 MAPK kinase (MAPKK). The Pbs2-Hog1 MAPK cascade is controlled by the fungal "two-component" system that is composed of a response regulator, Ssk1, and multiple sensor kinases, including two-component.like (Tco) 1 and Tco2. Tco1 and Tco2 play shared and distinct roles in stress responses and drug sensitivity through the Hog1 MAPK system. Furthermore, each sensor kinase mediates unique cellular functions for virulence and morphological differentiation. We also identified and characterized the Ssk2 MAPKKK upstream of the MAPKK Pbs2 and the MAPK Hog1 in C. neoformans. The SSK2 gene was identified as a potential component responsible for differential Hog1 regulation between the serotype D sibling f1 strains B3501 and B3502 through comparative analysis of their meiotic map with the meiotic segregation of Hog1-dependent sensitivity to the fungicide fludioxonil. Ssk2 is the only polymorphic component in the Hog1 MAPK module, including two coding sequence changes between the SSK2 alleles in B3501 and B3502 strains. To further support this finding, the SSK2 allele exchange completely swapped Hog1-related phenotypes between B3501 and B3502 strains. In the serotype A strain H99, disruption of the SSK2 gene dramatically enhanced capsule biosynthesis and mating efficiency, similar to pbs2 and hog1 mutations. Furthermore, ssk2, pbs2, and hog1 mutants are all hypersensitive to a variety of stresses and completely resistant to fludioxonil. Taken together, these findings indicate that Ssk2 is the critical interface protein connecting the two-component system and the Pbs2-Hog1 pathway in C. neoformans.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.31 no.2
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• pp.58-69
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• 2013

This research try to review about individuals' living culture place by record to before process of transition and modify of Bugundang village's forest in Itaewon. A result is as follows. First, Itaewon Bugundang is located in highest site of center building of twon forest, it has been preserve by double fence and taboo subject. Physical element of village forest is a factor which give sanctity of Buhundang. Second, it is connecting Namsan and Yongsan Family Park as green space. Also Itaewon Bugundang isolated from the current residential area. but in the past, the main beliefs and rituals of its area are responsible for a diverse community where public service was strong. Itaewon Bugundang have played a role presenting a local taboos and social norms. Therefore, these elements of the local community have the traditional cultural values. Third, Zelkova and Kalopanax pictus need to be preserved the value by the Seoul Metropolitan Government. Fourth, components of Bugundang are built by Hwajucheong, Dangjigi house, seonangdan, monument, fence, masonry and various trees. And the function and role of each of these elements remains as traditional culture. And the structural features of historic architectural properties has the value as a registered cultural properties. Fifth, due to these features, the traditional landscape of Itaewon bugundang play a role succeeding disappearing traditional culture and is worth as a potentially valuable landscape elements. This study has significance to the excavation community tradition disappearing landscape and excavation of candidate new tradition.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.12
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• pp.822-827
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• 2019

There is a high demand for off-base dwellings around Camp Humphreys in Pyeongtaek in accordance with the USFK base relocation project, but their residential planning needs to reflect their requirements. On the other hand, no studies that examined their requirements directly have been found. This study examined the requirements of USFK stationed in Camp Humphreys to identify their requirements. In general, residential planning requires a determination of the demand-based location and size, identification of the facility elements required for the site plan, and analysis of detailed architectural planning elements required for the building plan. Among these, preference analysis of the off-base dwelling demand, location, and site planning elements were performed in this study, and the architectural planning elements were left as following studies. The analysis showed that the demand for off-base dwellings is high, rental houses are preferred, and the commuting time is the most important factor in the location. In addition, while enjoying urban convenience, the location of the foothills near nature is preferred, the importance of the orientation is low and living with Koreans is not a problem. In addition, the demands for exercise facilities in the complex are relatively high.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.12
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• pp.189-199
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• 2017

This study investigated the effects of life stress, cultural adaptation stress, and academic satisfaction amongst a total of 283 20's Chinese students majoring in cosmetology at colleges in Seoul. For this, data was collected from February to March 2017. The frequency analysis was conducted to verity the general characteristic of Chinese student studying in Korea who are study objects while utilizing SPSS Statistics V22.0 for data processing and analysis while the factor analysis and reliability analysis were conducted to investigate the validity of measurement tool and evaluate the reliability. Moreover, the regression analysis between variables and regression analysis were utilized. The results found the following: First, in terms of life stress, as peer relationship, appearance stress, economic stress, family relationship stress and academic stresses decreased, their academic satisfaction increased. Second, regarding cultural adaptation stress, as interpersonal and living culture stresses were lowered, academic satisfaction increased. Therefore, this study targets to derive implications on an efficient plan to improve the academic satisfaction of Chinese students studying in the Republic of Korea by developing and providing a proper academic program with a decent support system in terms of culture, life, and education after investigating their life and cultural adaptation stresses.

• Journal of the Korean Regional Science Association
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• v.34 no.1
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• pp.31-47
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• 2018

This study examines the locational characteristics and change of business type in the residental areas that have commercial gentrification issues in Seoul, Korea, using the logistic regression model. The analysis results indicate that the gentrification occurrence areas are strongly associated with low-density and old residential areas. In addition, those areas are more likely to have great accessibilities to highway ramp, subway station, colleges, and other facilities that attract people. Regarding the characteristics of the road, gentrification occurrence areas are associated with longer road length, lower rate of road areas, higher local integration of road network, and higher rate of three-way intersections. This finding indicates that low-density and old residential areas with organic road networks have strong links with commercial gentrification. This study also finds that the business type has been substantially changed from 2006 to 2014 in the commercially gentrified residential areas. While the coffee shops and drinking places have been increased, but neighborhood-living facilities have been decreased. This study also shows that the business life-cycles of drinking places or Korean restaurant are getting short. Finally, this study discusses the commercial gentrification issues and policy implications in the residential districts in Seoul, Korea.

• The Journal of the Korea Contents Association
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• v.19 no.11
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• pp.314-324
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• 2019

This study inspected 203 employees with disabilities who are working in social enterprises based in Seoul and Gyeonggi-do from March to June 2019 in order to find out the factors of self-efficacy, social support, wages and welfare, relationship with upper management and co-worker relationships which influence job Performance and job satisfaction of disabled workers. The implications of this research are as follows. First, the factors that positively affect work performance are self-efficacy and co-worker relationships. It was shown that trust and respect that disabled workers working in domestic social corporations perceive while diligently performing the work without any bias and getting from coworkers led to good work performance. Second, when the current wage was determined by the employee's perceived ability, skill and current workloads that fit to their ability, the workers expressed job satisfaction. Moreover, job satisfaction by the employees was followed by the perception of the possibility of living a more stable life with the current monthly income. Third, upper managements' care on personal issues, acknowledgment of autonomy and support through communication have led to job satisfaction among the employees. Lastly, considering the research result in which the social support that the disabled workers perceive does not show any positive effect on work performance or work satisfaction, it can be concluded that there is a need for a change in the social perception of disabled workers.

• Korean Journal of Environmental Biology
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• v.17 no.1
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• pp.1-9
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• 1999

Numerous observations revealed strong evidence of increased middle ultraviolet radiation or UV-B (280 ~ 320 nm) at the earth's surface resulting from stratospheric ozone depletion. UV is the waveband of electromagnetic radiation which is strongly absorbed by nucleic acids and proteins, thus causing damage to living systems. It has been recorded in the East Sea, Korea that solar UV-B impinging on the ocean surface penetrates seawater to significant depths. Recent researches showed that exposure to UV-B for as short as 2h at the ambient level (2.0 Wm$^{-2}$) decreased macroalgal growth and photosynthesis and destroyed photosynthetic pigments. These may suggest that UV-B could be an important environmental factor to determine algal survival and distribution. Some adaptive mechanisms to protect macroalgae from UV-damage have been found, which include photoreactivation and formation of UV-absorbing pigments. Post-illumination of visible light mitigated UV-induced damage in laminarian young sporophytes with blue the most effective waveband. The existence of UV-B absorbing pigments has been recognized in the green alga, Ulva pertusa and the red alga, Pachymeniopsis sp., which is likely to exert protective function for photosynthetic pigments inside the thalli from UV-damage. Further studies are however needed to confirm that these mechanisms are of general occurrence in seaweeds. Macroalgae together with phytoplankton are the primary producers to incorporate about 100 Gt of carbons per year, and provide half of the total biomass on the earth. UV-driven reduction in macroalgal biomass, if any, would therefore cause deleterious effects on marine ecosystem. The ultimate impacts of increasing UV-B flux due to ozone destruction are still unknown, but the impression from UV studies made so far seems to highlight the importance of setting up long-term monitoring system for us to be able to predict and detect the onset of large -scale deterioration in aquatic ecosystem.

• Journal of radiological science and technology
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• v.39 no.3
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• pp.353-359
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• 2016

This study were to evaluate risk factors of GB polpy in Busan and Gyeongnam area. This study was performed with patients by abdominal ultrasonography among the patients who came to the P hospital from January to May 2016. Among them, risk factors were analyzed on 399 people at the same time when abdominal ultrasonography and hematological test. The statistical analysis of risk factors related to the GB ployp was performed by independent t-test and chi-square test. In consider of difference verification result for calculations odds ratio about independent variables, multiple logistic regression analysis to conduct verify adequacy by calculating forecasting model from variable. As a result, GB polyp risk factors have relevance to male, HBsAg positive, triglyceride. GB polyp risk factors confirmed to male, HBsAg positive, triglyceride were calculated forecasting model and forecasting probability value. Forecasting probability sensitivity 61.0%, specificity 76.8%, ROC area under curve 0.735 showed, it confirmed validity of forecasting model. When analyzing the GB polyps morphologically, among the GB polyp types observed from abdominal ultrasonography, the hyperechoic and homogeneous pattern with neck was the largest as shown from 27.5% and two GB polyps were shown most from 38%, sizes were shown most by maximum diameter, 5 to 10mm from 53%. As a disease accompany with GB polyp showed mild fatty liver(23%), diffuse hepatopathy(21%).

• Journal of Wetlands Research
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• v.20 no.2
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• pp.173-180
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• 2018

The utilization of TOC(Total organic carbon), a new environmental standard, was evaluated for 30 lakes in the Nakdong River Basin, which is used for drinking and agricultural usage. The active use of water resources begins with securing satisfactory water quality. Since this allows people and nature to maintain stability of quality, water quality standards are being tightened to ensure good water quality. In order to improve the pollution level of organic matter in lakes in the living environment, it is important to use the appropriate organic substance index. The relationship between the newly introduced TOC and the existing COD(Chemical oxygen demand) in the targeted lake was positively correlated with the possibility of replacing the TOC with COD. However, the environmental grade standard using TOC is better than the environmental grade standard using COD, so it has the same effect as that of the grade of water quality using TOC as an organic substance factor. This indicates the limitation of TOC to directly replace existing COD when trying to determine or improve the quality level using organic indicators of lakes. Therefore, in order to secure the qualitative safety of the lake, it is required to strengthen environmental standards of TOC in terms of water quality grade. In addition, the correlation between TOC and COD shows a great difference depending on the utilization characteristics of the lake. This requires clear scientific identification, and it requires continuous monitoring of COD that has been used to accumulate indicators of lake organic matter.

• Economic and Environmental Geology
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• v.35 no.5
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• pp.407-420
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• 2002

The Buddhist Triad Cave in Gunwi (National treasure No. 109) consists of porphyritic biotite granite, and it has been deteriorated into microorganic smears, white films, brown rusts, granular decay, color changes, and joints by the same weathering factors as rain, moisture, temperature variation and microorganic living. Main origin is probably the rain that leaks into the cave along joints in Palgongsan granite, and then its moisture grows many microorganism and is frozen over during winter. The granites around the cave regularly develop two NEE and NWW joint sets that are conjugate to be a joint system. The NEE set extends far away with narrow joint spacings and affects the leakage of the rains, and is divided into 4 joint zones, among which J$_{m}$ and J$_{3}$ immediately affect the leaking water into the cave. An extensional Joint, in northern wall of the cave, was formed by toppling of the block between J$_{m}$and J$_{3}$joint zones from widening the Jm aperture by roots of a big pine tree, and passes through the J$_{m}$joint zone. This bypass allows no circulation of small rain, but a good circulation of heavy rain from influx to the cave for a long pathway. Many Joints and cracks, in the ceiling near the cave entrance, immediately get through the J$_3$ joint zone, and have a good circulation of small rain 10 mm. Both J$_{m}$and J$_{3}$ joint zones are, therefore, chief influxes that cause leakage of the rains.