• 동국한의학연구소논문집
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• 제7권2호
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• pp.1-8
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• 1999

한의학은 유기체의 관점에서 생체기능의 통일성을 중요시하고 있다. 생체기능의 유기적 통일성은 기운(氣運)과 이치로 인식되며, 경락(經絡)은 기혈(氣血)의 매개를 통하여 장부(臟腑) 조직 기관의 사이를 밀접하게 연계하여 유기체에 대한 생리(生理) 병리(病理)의 보다 완전한 인식과 변증논치(辨證論治)의 이론적 근거를 제공하고 있다. 이러한 학문적 배경에 근거하여 신장(腎臟)생리의 유기성과 그 병후(病候)를 경기(經氣)의 교통(交通)을 중심으로 고찰하였다. 족소음신경(足少陰腎經)의 경기교통(經氣交通)은 신장(腎臟)과 간(肝) 폐(肺) 심(心) 방광(膀胱) 및 후롱 설본(舌本) 흉부(胸部) 족심(足心) 고내후염(股內後廉) 요(腰)의 형체조직(形體組織)과 밀접한 관계를 구축하여 협조(協助) 통일(統一)의 생리를 발휘하고, 병리적으로 신장(腎臟)의 병변(病變) 병후(病候)에 대한 유기적 인식을 가능케 한다. 따라서 신장(腎臟)과 그 경락(經絡)의 동시적 인식은 한의학의 이론과 임상의 실재에 부합되는 변증논치(辨證論治)의 관건이 된다고 사료(思料)된다.

• 한국어병학회지
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• 제10권1호
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• pp.39-44
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• 1997

Metallothionein은 세균에서 척추동물에 이르기 까지 모든 생명체에 존재하며, 중금속의 세포내농도를 조절하는 중요한 단백질이다. 현재까지 metallothionein의 기능 및 유도기작에 관한 연구는 많이 진척되지는 않았으나, 여러 metallothionein 유전자의 구조가 밝혀져 있는 실정이다. 특히 어류의 metallothionein은 여러종류의 중금속과 환경적인 자극에 의하여 유도되고 정량적인 RT-PCR의 방법으로 metallothionein 유전자의 RNA transcript를 측정함으로써 환경적인 자극의 정도와 중금 속의 상대적인 양을 측정할 수 있기 때문에 중요한 단백질로 인식되고 있다. 본 연구에서는 유전자내부의 특이적 primer와 통상적인 3`말단의 primer를 이용하여 PCR에 의해 450 bp에 해당하는 metallothionein 유전자의 일부의 특성을 조사하였다. 챠넬메기의 cDNA library로부터 PCR에 의해 증폭된 450 bp의 PCR 절편은 다른 어류의 metallothionein 유전자와는 유사성을 보이지 않았다.

• 대한본초학회지
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• 제29권5호
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• pp.1-8
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• 2014

Objectives : To prove the channel-tropism theory of herbal medicines on diabetes mellitus as emaciation-thirst disease in Korean Medicine Theory, we investigated the selective therapeutic effects of Mori Cortex Radidus (MCR), Schisandrae Fructus (SF), Anemarrhenae Rhizoma (AR) for the upper emaciation on different organs in high fat and high sucrose (HF/HS) feeding-induced prediabetic mice. Methods : Diabetes in C57BL/6 mice was induced by the administration of high fat (45 kal%) and high sucrose (32 kal%) for 8 weeks, and them treated with each extract at 250 or 500 mg/kg body weight for 4 weeks (once a day). Oral glucose tolerance test and body weight was measured once a week. Insulin, total cholesterol, triglyceride, ${\gamma}GTP$, GOT and GPT were measured in the sera of all mice. Histopathological changes of different organs, lung, heart, pancreas, stomach, liver, and kidney were observed by H&E staining. Results : The results revealed that MCR extract inhibited the impaired glucose tolerance and lung damage, and increased serum insulin levels in HF/HS-induced prediabetic mice. SF extract inhibited the impaired glucose tolerance and lung damage, increased serum insulin levels, and decreased serum triglycerige levels. Meanwhile, AR extract inhibited the impaired glucose tolerance and lung damage, and decreased serum levels of insulin, total cholesterol and triglycerige levels. Conclusions : These results demonstrated that MCR, SF, and AR extract as the upper emaciation herbal medicines were followed their channel-tropism theory like a lung, and may have a selective therapeutic potential for control of diabetic stage.

• 대한한의학원전학회지
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• 제17권4호
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• pp.37-56
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• 2004

In the Circular flow of Meridians(經脈), the circulation of Nutrient Gi(營氣) is that the essence Gi(精氣) of food starts from Middle Cho(中焦), via heart and lung into the ring-type round of 12 Meridians(十二經脈) in turn of hand Meridians(水經) and foot Meridians(足經), Yang Meridians(陽經) and Eum Meridians(陰經). The circulation of Defensive Gi(衛氣) is that if going out from Eum part(陰分) into Yang part(陽分), is rounding on the Yang Meridians, if going out from Yang part into Eum part, is rounding on the five Jang(五臟) in order of Kidney(腎)-Heart(心)-Lung(肺)-Liver(肝)-Spleen(脾). Because the process of accumulating the essence Gi has a property of One-way flow, it flows from terminal to the direction of body trunk, has no distinct channel with its immaterial nature. and is concentrated on the lower part to that the five Jang belong.

• 혜화의학회지
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• 제10권1호
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• pp.47-53
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• 2001

In the result of investigating traditional chinese medical literatures to understand drug-processing about Pyritum, we could reach conclusions as follows: 1. Pyritum are divided into fresh Pyritum, calcining Pyritum, tempered Pyritum with vinegar by methods of drug-processing. 2. The methods of drug-procession about Pyritum like calcination, quenching, refining drugs with water or medicinal broth of Glycyrrhizae Radix(licorice), boiling with medicinal broth of Glycyrrhizae Radix(licorice) were used complicately. 3. Calcining Pyritum are grinded easily, convenient to apply a pill and powder and As, S are easily removed. Quenching Pyritum act on liver channel and then are reinforced the effects of relieving blood stasis, Pain and gushed out effecive ingredients. Refining Pyritum with water are reinforced the effect of tranquilizing the mind and clearing heat. above results indicates that using calcination, quenching and refining drugs with water together is the best method of drug-processing about Pyritum.

• Nutrition Research and Practice
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• 제6권2호
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• pp.106-112
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• 2012

This study was conducted to investigate the effects of $Sasa$ $quelpaertensis$ bamboo and green tea on plasma and liver lipids, platelet aggregation, and erythrocyte membrane Na channels in ovariectomized (OVX) rats. Thirty female rats were OVX, and ten female rats were sham-operated at the age of 6 weeks. The rats were divided into four groups at the age of 10 weeks and fed the experiment diets: sham-control, OVX-control, OVX-bamboo leaves (10%), or OVX-green tea leaves (10%) for four weeks. Final body weight increased significantly in the OVX groups compared with that in the sham-control, whereas body weight in the OVX-green tea group decreased significantly compared with that in the OVX-control ($P$ < 0.01). High density lipoprotein (HDL)-cholesterol level decreased in all OVX groups compared with that in the sham-control rats ($P$ < 0.05) but without a difference in plasma total cholesterol. Plasma triglycerides in the OVX-green tea group were significantly lower than those in the sham-control or OVX-control group ($P$ < 0.05). Liver triglycerides increased significantly in the OVX-control compared with those in the sham-control ($P$ < 0.01) but decreased significantly in the OVX-green tea group compared with those in the OVX-control or OVX-bamboo group ($P$ < 0.01). Platelet aggregation in both maximum and initial slope tended to be lower in all OVX rats compared with that in the sham-control rats but was not significantly different. Na-K ATPase tended to increase and Na-K cotransport tended to decrease following ovariectomy. Na-K ATPase decreased significantly in the OVX-green tea group compared with that in the OVX-control group ($P$ < 0.01), and Na-K cotransport increased significantly in the OVX-bamboo and OVX-green tea groups compared with that in the OVX-control ($P$ < 0.05). Femoral bone mineral density tended to be lower in OVX rats than that in the sham-control, whereas the green tea and bamboo leaves groups recovered bone density to some extent. The results show that ovariectomy caused an increase in body weight and liver triglycerides, and that green tea was effective for lowering body weight and triglycerides in OVX rats. Ovariectomy induced an increase in Na efflux via Na-K ATPase and a decrease in Na efflux via Na-K cotransport. Furthermore, consumption of green tea and bamboo leaves affected Na efflux channels, controlling electrolyte and body water balance.

• 대한한의학회지
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• 제16권2호
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• pp.453-489
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• 1995

The research of the phrases related with physiology of stomach and spleen in the contents of Huang Di Nei Jing(黃帝內經) known as the Bible of oriental medicine will make a contribution to a deep understanding of disease of stomach and spleen and a proper clinical diagnosis and treatment of them. In this research of the most appropriate glosses recorded nine kinds of representative medical books including Huang Di Nei Jing Somoon(黃帝內經素問) of Wang Bing(王氷) were picked out: The summaries of the selected contents are as follows: 1. The word 'saliva(涎)' in 'the spleen controls saliva(脾爲涎)' can be viewed as a generic term referring to oral cavity secretion gland as well as the secretion fluid of salivary gland. 2. The phases 'a large reservoir(太倉)', barn organs', 'a reserboir of food stuff', 'a stomach as the market(胃爲之市)', etc mean the function of stomach to receive food(胃主受納). 3. The phase 'generation of five tastes(五味出焉)' means both 'the function of stomach to transform food into chyme(胃主腐熟)' and 'the channelling function of spleen.(脾主運化)' 4. The flowing of the food-Qi(食氣) into stomach brings about spreading Jung(精) into liver and then percolating Jung(精) flow into channel. The channel-Qi(脈氣) flows into lung through channel. As a result, all kinds of channels gather together in lung and Jung(精) is sent into skin and hair. The assembly of Jung(精) with skins and channels moves Qi(氣) into fu-organ and so jung(精) and mental activity(神明) in fu-organ(府) come to be in four organs(四臟). Then if Qi(氣) comes back to power balance unit(權衡) being in the state of equilibrium(權衡以平), the hole of Qi(氣口) comes to determine the matter of life and death through achieving Chun-quan-chi(-寸-關-尺). The above mentioned phrases means the digestion, asorption and transmission of food. When food is taken in stomach, Jung-Qi(精氣) comes to be over flowed upward into spleen, back into lung, finally downward into bladders through water-conduit(水道) controlled by lung. When water- Jung(水精) radiates into whole body with channels of five organs(五臟), both of them fit together with and yin-yang(陰-陽). Therefore, the grasping of the rise and decline of yin-yang(陰C-陽) is necessary to consult patients. The above mentioned phrases is properly viewed to designate the asorption, transmission and excretion of food. 5. Spleen controls flesh(脾之合肉也), the state of spleen is known by human lips, and what this means is that liver plays functions of spread and expansion(肝主疏泄). 6. The phrase 'Jung Jung'((中精)) in 'gallbladder dominates Jung jung(膽主中精)', which in one of the specific expression of 'liver plays functions of spread and expansion(肝主疏泄). 7. It is right that the phase 'The eleven organs in all are determined by gallbladder'(凡十,一臟取決於膽也) is correctly paraphrased as 'only one of ten organs, spleen, is determined by gallbladder'.(凡十,一臟取決於膽也), 8. The small intestine is an organ. which receives the materials digested and sends them out. This means that the function of transforming materials(化物) factually refers to that of separating clearity and blur(泌別淸濁). And it is also thought to have the function of ascending clearity and descending blur(升淸降濁), 9. A large intestine is a transmitting organ(傳導之官) from which a change comes out(變化出焉). the phrase 'change'(變化) in this sentence means both the intake of water and nutrition and the formation procedure of stool through excretion of mucocele.

• 한국식품위생안전성학회지
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• 제15권3호
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• pp.226-234
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• 2000

본 연구에서는 현호색의 methanol추출물에 대하여 사염화탄소에 의한 간 손상 보호효과를 확인한 후 이를 hexane, chloroform, butanol 및 물로 계통분획하여 사염화탄소에 의한 간 손상 보호효과를 검색하였다. 이 결과 현호색 물분획물이 유의성 있는 간 보호효과를 보임으로써 간손상 보호효과를 확인하고 그 기전을 밝히고자 하였다. 그 결과 혈액중의 ALT활성 및 cholesterol함량은 사염화탄소 단독투여군에 비하여 감소하였으며 간조직의 TG와 지질과산화물 함량은 사염화탄소 단독투여군에 비하여 감소하여 사염화탄소에 의한 지방의 축적이나 세포막의 손상은 억제된 것으로 보인다. 기전연구를 위하여 측정한 CYP함량과 calcium함량은 사염화탄소 단독투여군에 비하여 감소하였으며 GST활성도는 사염화탄소 단독투여군에 비하여 증가하였다. 항산화 효소의 유도로 인하여 증가할 것으로 기대한 SOD, GPX, GST활성도는 모든 처치군에서 감소하는 경향을 보여 간손상 보호 효과는 free radical scavenging effect보다는 CYP함량의 감소와 CCB로서의 작용 및 GST활성도의 증가에 기인한 것으로 생각된다.

• 혜화의학회지
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• 제14권2호
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• pp.159-169
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• 2005

Objectives and methods: We investigated 17 books to study symptoms, pathology and acupuncture & moxibustion treatment of Hu-Ro(fatigue). Results and Conclusions: 1. The symptoms of Hu-Ro are the deafness, the amblyopia, the mass of sweat, the stiff joint, etc. There are also symptoms such as the fever of palm and legs, avoiding cold temperature in the afternoon, the fever during night time, the stomach fullness and diarrhea, the powerlessness of limbs, red colored urine. 3. The representing pathological mechanisms of Hu-Ro are Yang-deficiency(陽虛), Yin-deficiency(陰虛), Energy(Qi)-deficiency(氣虛), Blood(Hyul)-deficiency(血虛). The other pathological mechanisms are deficiency of Liver, Heart, Spleen, Lung, Kidney and the basic Energy. 4. The fundamental treatment of Hu-Ro is "warming on worned ones(勞者溫之), supplying on damaged ones(損者益之), strengthening the weakened ones(虛卽補之)" as basis and also supplying blood with fostering spleen(養血建脾) and droping fever with clearing the clogged(降火淸鬱). 5. The meridians that could be used in acupuncture and moxibustion treatment application of Hu-Ro are the urinary bladder meridian, the conception vessel meridian(任脈), governor channel meridian(督脈), kidney meridian(腎經), liver meridian, heart meridian, spleen meridian, lung meridian, stomach meridian, small intestine meridian, gall bladder meridian, pericardium meridian and triple-warmer meridian in order of frequently refered. 6. The meridian points that could be used in acupuncture and moxibustion treatment application of Hu-Ro are Joksamni (足三里:25times), Sinsu(腎兪:20回), Bisu(脾兪:19回), Pyesu(肺兪:18回), Qihye(氣海:17回), Gohwang(膏肓:15回), Kwanwon(關元:14回), Sameumgyo(三陰交:13回), Eumgeuk(陰郄:12回), Daechu(大樞:12回), Sinmun(神門:11回), Simsu(心兪:11回), Nyegwan(內關:10回), Jungwan(中脘:10回) in order of frequently refered.

• 대한본초학회지
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• 제35권6호
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• pp.1-9
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• 2020

Objective : For the purpose of developing Boraginaceae plants recorded in Korean Herbology in Korea, the literatures of the successive generations have been thoroughly investigated to prepare this article. Methods : Books and research papers about Herbology which published at Korea and other countries were examined. Results : A list was made about Boraginaceae plant which were cultivated or grew naturally in Korea, after investigated the data on domestic and foreign Boraginaceae plants. Boraginaceae(grew in Korea) were divided into 14 classes with 24 species. Out of those, 6 classes with 9 species were found serviceable which indicates 37.5% of all. Out of all 24 species of Boraginaceae family, Trigonotis genus were found 5 species, which were shown the most. Among 3 genus of Lithospermum species, medicinal plants were all one species each. Out of all serviceable parts in Boraginaceae, Herb·Radix·Fructus parts took first place as 3 species. There are 2 species toxic, the survey said. 3 Classifying medicinal plants among the Borginaceae plants by part, whole herbs, roots, and fruits are found to be 3 separate species each. When it comes to the nature of taste, 5 kinds of taste without action and seven kinds of bitter taste are the most common. For channel tropism, liver channel has the largest number of 5 types. Conclusion : There were totaled to 14 genera and 24 species in Boraginaceae in Korea and among them medicinal plants are 6 genera, 9 species, some 37.5% in total.