• Title/Summary/Keyword: Linkage

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QTL analysis of agronomic traits in recombinant inbred lines of sunflower under partial irrigation

  • Haddadi, P.;Yazdi-Samadi, B.;Naghavi, M.R.;Kalantari, A.;Maury, P.;Sarrafi, A.
    • Plant Biotechnology Reports
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    • v.5 no.2
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    • pp.135-146
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    • 2011
  • The objective of the present research was to map QTLs associated with agronomic traits such as days from sowing to flowering, plant height, yield and leaf-related traits in a population of recombinant inbred lines (RILs) of sunflower (Helianthus annuus). Two field experiments were conducted with well-irrigated and partially irrigated conditions in randomized complete block design with three replications. A map with 304 AFLP and 191 SSR markers with a mean density of 1 marker per 3.7 cM was used to identify QTLs related to the studied traits. The difference among RILs was significant for all studied traits in both conditions. Three to seven QTLs were found for each studied trait in both conditions. The percentage of phenotypic variance ($R^2$) explained by QTLs ranged from 4 to 49%. Three to six QTLs were found for each yield-related trait in both conditions. The most important QTL for grain yield per plant on linkage group 13 (GYP-P-13-1) under partial-irrigated condition controls 49% of phenotypic variance ($R^2$). The most important QTL for 1,000-grain weight (TGW-P-11-1) was identified on linkage group 11. Favorable alleles for this QTL come from RHA266. The major QTL for days from sowing to flowering (DSF-P-14-1) were observed on linkage group 14 and explained 38% of the phenotypic variance. The positive alleles for this QTL come from RHA266. The major QTL for HD (HD-P-13-1) was also identified on linkage group 13 and explained 37% of the phenotypic variance. Both parents (PAC2 and RHA266) contributed to QTLs controlling leaf-related traits in both conditions. Common QTL for leaf area at flowering (LAF-P-12-1, LAF-W-12-1) was detected in linkage group 12. The results emphasise the importance of the role of linkage groups 2, 10 and 13 for studied traits. Genomic regions on the linkage groups 9 and 12 are specific for QTLs of leaf-related traits in sunflower.

Case Study of 4-Bar Linkage KAFO in Person With Poliomyelitis (소아마비에서 4절 연쇄 장하지보조기 사례연구)

  • Kim, Jang-Hwan;Kwon, Oh-Yun;Yi, Chung-Hwi;Cho, Sang-Hyun;Cynn, Heon-Seock;Choi, Heung-Sik
    • Physical Therapy Korea
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    • v.20 no.1
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    • pp.18-27
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    • 2013
  • The purpose of this study was to compare the ring lock type knee-ankle-foot orthosis (KAFO) with newly developed 4-bar linkage KAFO on the gait characteristics of persons with poliomyelitis clinically. This 4-bar linkage is the stance control type KAFO which provide the stability during stance phase and knee flexion during swing phase. Two subjects participated in this study voluntarily. We provided the customized 4-bar linkage KAFO then asked the subjects to walk in level surface and stairs under the two different KAFO conditions. The characteristics of gait in the persons with poliomyelitis were evaluated using a 3D motion analysis system and force plate. Additionally 6 minute walk test for physiological cost index were conducted using pulse oximeter to measure the energy consumption. In the results of this study, the differences of 4-bar linkage KAFO compared with ring lock type KAFO are as follows: (1) Walking speed, stride length, and step length on level increased in subjects, (2) The gait symmetry was improved by generated knee flexion and decreased pelvic external rotation on level and stairs walking, (3) Decreased vertical excursion of center of mass and pelvic elevation during swing phase was decreased on level, (4) Knee extension moment, hip flexion moment, hip and knee internal rotation moment of non-braced limb were decreased on level walking, (5) Walking speed in 6-minute walk test was increased and physiological cost index was decreased. These findings indicate that 4-bar linkage KAFO compared with ring lock type KAFO is effective in enhancing pattern, endurance, and energy consumption in level surface and stairs walking.

Comparison of Principal Component Regression and Nonparametric Multivariate Trend Test for Multivariate Linkage (다변량 형질의 유전연관성에 대한 주성분을 이용한 회귀방법와 다변량 비모수 추세검정법의 비교)

  • Kim, Su-Young;Song, Hae-Hiang
    • The Korean Journal of Applied Statistics
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    • v.21 no.1
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    • pp.19-33
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    • 2008
  • Linear regression method, proposed by Haseman and Elston(1972), for detecting linkage to a quantitative trait of sib pairs is a linkage testing method for a single locus and a single trait. However, multivariate methods for detecting linkage are needed, when information from each of several traits that are affected by the same major gene are available on each individual. Amos et al. (1990) extended the regression method of Haseman and Elston(1972) to incorporate observations of two or more traits by estimating the principal component linear function that results in the strongest correlation between the squared pair differences in the trait measurements and identity by descent at a marker locus. But, it is impossible to control the probability of type I errors with this method at present, since the exact distribution of the statistic that they use is yet unknown. In this paper, we propose a multivariate nonparametric trend test for detecting linkage to multiple traits. We compared with a simulation study the efficiencies of multivariate nonparametric trend test with those of the method developed by Amos et al. (1990) for quantitative traits data. For multivariate nonparametric trend test, the results of the simulation study reveal that the Type I error rates are close to the predetermined significance levels, and have in general high powers.

Distribution of DArT Markers in a Genetic Linkage Map of Tomato (토마토 유전자연관지도 상의 DarT 마커 분포)

  • Truong, Hai Thi Hong;Graham, Elaine;Esch, Elisabeth;Wang, Jaw-Fen;Hanson, Peter
    • Horticultural Science & Technology
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    • v.28 no.4
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    • pp.664-671
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    • 2010
  • A genetic linkage map was constructed using 188 $F_9$ RILs derived from a cross between $Solanum$ $lycopersicum$ H7996 (resistant to bacterial wilt) and $S.$ $pimpinellifolium$ WVa700 (highly susceptible to bacterial wilt). The map consisted of 361 markers including 260 DArTs, 74 AFLPs, 4 RFLPs, 1 SNP, and 22 SSRs. The resulting linkage map was comprised of 13 linkage groups covering 2042.7 cM. The genetic linkage map had an average map distance between markers of 5.7 cM, with an average DArT marker density of 1/7.9 cM. Based on the distribution of anchor SSR markers, 11 linkage groups were assigned to 10 chromosomes of tomato except chromosomes 5 and 12. The DArT markers were distributed across the genome in a similar way as other markers and showed the highest frequency of clustering (38.8%) at ${\leq}$ 0.5 cM intervals between adjacent markers, which is 3 times higher than AFLPs (13.5%). The present study is the first utilization of DArT markers in tomato linkage map construction.

Analysis of Characteristics of Linkage between Science and Technology in U.S. Considering R&D Expenditure (연구개발비규모를 고려한 과학지식의 기술연계 특성 분석 : 미국 사례)

  • Shim, Woo-Jung
    • Journal of Korea Technology Innovation Society
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    • v.15 no.1
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    • pp.47-75
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    • 2012
  • Basic research have contributed to technological growth or economic growth in U.S. Specially recent studies say that universities also contribute to economic development through scientific activities like science research, education, technology transfers. But we can not assure whether scientific knowledge was connected to real technology or economic performance, and it is difficult to figure out the effect of scientific output. "What is the exact performance of scientific knowledge?" It is still obscure. In this context, this paper analyzes characteristics of the linkage of science and technology. Data are U.S. R&D expenditure, scientific articles, citation of articles in U.S. patents by fields and sectors. As a result, university sector has the most weight of the linkage of science and technology. But, in relative connection rate analysis, industrial sector's is stronger than any other sectors. In the field analysis, linkage of science and technology is very strong in Chemistry, Physics, Biological sciences fields. And recently the linkage was increased in the fields of Computer science, Agricultural science, Engineering. Finally, this paper supports funding policy or estimation policy of government to product of scientific knowledge. University sector is still important because it has the most weight of the linkage. Scientific knowledge of industrial sector is also important. The connection rate of industrial science is the strongest in all sectors. And this research classify the R&D type by science fields. Considering the differences of science fields is needed to product science knowledge effectively.

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The relationship between organizational climate and resource linkage skills of social workers in community welfare centers: The mediating effect of reflective thinking (지역사회복지관 조직풍토와 사회복지사의 자원연계기술과의 관계: 성찰적 사고의 매개효과)

  • Park, Mijin;Hyun, Anna
    • Korean Journal of Social Welfare Studies
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    • v.48 no.2
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    • pp.203-231
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    • 2017
  • The purpose of this study is to examine the impact of organizational climate on the resource linking skills of social workers working in community welfare centers as well as the mediating effects of reflective thinking in these relationships. To test the mediating effects, we set up a research model based on previous studies on the organizational climate, resource linkage skills, and reflective thinking of social workers. The subjects of this study were social workers in community welfare centers in the Busan metropolitan city. Data were collected using mail surveys, and data from 526 respondents were used for the final analysis. The main results are as follows. First, the organizational climate of community welfare centers has a statistically significant impact on social workers' resource linkage skills. In other words, the more the social workers recognize positively about the organizational climate, the more the utilization of resource linkage skills increases. Second, reflective thinking has a mediating effect in the relationship between the organizational climate and resource linkage skills of social workers in community welfare centers. Based on the study results, practical suggestions for improved resource linkage skills and reflective thinking of social workers in community welfare centers were suggested, and practical implications and future research were discussed.

Technology Development Strategy for Spatial Information Linkage of Public Data Portal Attribute Data (공공데이터포털 속성데이터의 공간정보 연계를 위한 기술개발 전략)

  • Min, Kyung-Ju;Lee, Sung-Hun;Yu, Seon-Cheol;Ahn, Jong-Wook
    • Journal of Cadastre & Land InformatiX
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    • v.53 no.2
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    • pp.107-122
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    • 2023
  • The demand for spatial information in the era of the 4th Industrial Revolution is expanding Additionally, interest in attribute data related to geography or location is increasing. In the field of spatial information, spatial information policies and services tailored to the public can be provided through linkage and integration with new attribute data, and these data are resources for this purpose. In order to meet this expanding and diverse demand for spatial information utilization, it is necessary to develop technologies for linking and utilizing various attribute information such as public data. In this study, we aim to present a technology development strategy for linking and integrating attribute data and spatial information through a review of theories related to data linkage and integration, the current status of data on public data portals, and existing prior research. As a result, it was suggested that the data identifier of the attribute data to be linked should be used to develop linkage technology between spatial information and attribute data, and an attribute data linkage process that can be used when designing a prototype for technology development was presented.

Detection of QTL on Bovine X Chromosome by Exploiting Linkage Disequilibrium

  • Kim, Jong-Joo
    • Asian-Australasian Journal of Animal Sciences
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    • v.21 no.5
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    • pp.617-623
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    • 2008
  • A fine-mapping method exploiting linkage disequilibrium was used to detect quantitative trait loci (QTL) on the X chromosome affecting milk production, body conformation and productivity traits. The pedigree comprised 22 paternal half-sib families of Black-and-White Holstein bulls in the Netherlands in a grand-daughter design for a total of 955 sons. Twenty-five microsatellite markers were genotyped to construct a linkage map on the chromosome X spanning 170 Haldane cM with an average inter-marker distance of 7.1 cM. A covariance matrix including elements about identical-by-descent probabilities between haplotypes regarding QTL allele effects was incorporated into the animal model, and a restricted maximum-likelihood method was applied for the presence of QTL using the LDVCM program. Significance thresholds were obtained by permuting haplotypes to phenotypes and by using a false discovery rate procedure. Seven QTL responsible for conformation types (teat length, rump width, rear leg set, angularity and fore udder attachment), behavior (temperament) and a mixture of production and health (durable prestation) were detected at the suggestive level. Some QTL affecting teat length, rump width, durable prestation and rear leg set had small numbers of haplotype clusters, which may indicate good classification of alleles for causal genes or markers that are tightly associated with the causal mutation. However, higher maker density is required to better refine the QTL position and to better characterize functionally distinct haplotypes which will provide information to find causal genes for the traits.

A Study on Nursing Diagnoses, Interventions, Outcomes Frequently Used and Linkage to NANDA-NOC-NIC in Major Nursing Departments (간호 대상자별 다빈도 간호진단, 간호중재, 간호결과 및 연계 체계조사)

  • Kim, Jong-Kyung
    • Journal of Korean Academy of Nursing Administration
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    • v.16 no.2
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    • pp.121-142
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    • 2010
  • Purpose: The purpose of this study was to identify NANDA, NIC, and NOC frequently used and their linkages in major nursing departments for development of the nursing process and nursing management system. Methods: This study was a descriptive study. Data were collected from 123 nurses who worked in medical, surgical, pediatric, gynecologic, and psychiatric department. The questionnaire was based on the NANDA, NOC, NIC, and NANDA-NOC-NIC linkage system. This research was analyzed by an EXCEL program and SPSS $Pc^{+}15.0$. Results: Nursing diagnoses frequently used were 'anxiety', 'disturbed sleep pattern', 'activity intolerance', 'social isolation', 'nausea', 'ineffective airway clearance', 'chronic pain', nursing outcomes frequently used were 'thermoregulation', 'bowel elimination', 'pain control', 'vital sign status', 'pain level', and nursing interventions frequently used were 'nausea management', 'airway suctioning', 'bowel elimination management', 'diarrhea management', 'medication management'. NANDA-NOC-NIC linkages in major nursing departments were recognized, and these results were similar to the results of other researches. Conclusion: The results of this study will be provided as a guideline to apply to the nursing process and development of the nursing process system with the NANDA-NOC-NIC linkage in major nursing department.

Torque Ripple Reduction based on Flux Linkage Harmonics Observer for an Interior PM Synchronous Motor including Back EMF Harmonics (왜곡된 역기전력을 갖는 매입형 영구자석 동기전동기의 쇄교자속 고조파 관측기를 이용한 토크리플 저감)

  • Jin, Yong-Sin;Kim, Hag-Wone;Cho, Kwan-Yuhl;Lim, Byung-Kuk
    • The Transactions of the Korean Institute of Power Electronics
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    • v.18 no.4
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    • pp.367-375
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    • 2013
  • The mechanical vibration of a PM synchronous motor at low speeds due to the back emf harmonics may be serious problems in some application such as MDPS(Motor driven power steering), electric vehicles. In this paper, torque ripple reduction for an interior PM synchronous motor including back emf harmonics is proposed. The dq flux linkage harmonics of the permanent magnet are estimated on real time by using the dq currents of the real system and the model of the MRAS observer. Based on the estimated flux linkage harmonics, the dq harmonic currents for reducing the torque ripples are compensated on the dq reference currents. The estimation of the flux linkage harmonics by the MRAS observer and the torque ripple reduction of the proposed algorithm was verified by the simulation and experiment.