• Bulletin of the Korean Chemical Society
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• v.34 no.1
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• pp.49-53
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• 2013

Second-order rate constants have been measured spectrophotometrically for the reactions of phenyl Y-substituted-phenyl carbonates 7a-g with butane-2,3-dione monoximate ($Ox^-$) in 80 mol % $H_2O$/20 mol % DMSO at $25.0{\pm}0.1^{\circ}C$. The ${\alpha}$-nucleophile $Ox^-$ is 53-95 times more reactive than the corresponding normal-nucleophile 4-$ClPhO^-$ toward 7a-g, indicating that the ${\alpha}$-effect is operative. The magnitude of the ${\alpha}$-effect (e.g., the $k_{Ox^-}/k_{4-ClPhO^-}$ ratio) is independent of the electronic nature of the substituent Y. The cause of the ${\alpha}$-effect for the reactions of 7a-g has been suggested to be ground-state (GS) effect rather than transition-state (TS) stabilization through a six-membered cyclic TS, in which $Ox^-$ behaves a general acid/base catalyst. This idea is further supported by the result that $OH^-$ exhibits negative deviation from the linear Br${\o}$nsted-type plot composed of a series of aryloxides, while $Ox^-$ deviates positively from the linearity. Differential solvation of the GS of $Ox^-$ and 4-$ClPhO^-$ has been suggested to be responsible for the ${\alpha}$-effect exerted by $Ox^-$.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.55 no.1
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• pp.35-41
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• 2006

Although reachers have studied for a long time, they don't make criteria for anesthesia depth. anesthetists can't make a prediction about patient's reaction. Therefor, patients have potential risk such as poisonous side effect late-awake, early-awake and strain reaction. EEG are received from twenty-five patients who agreed to investigate themselves during operation with Enflurane-anesthesis in progress of anesthesia. EEG are divided pre-anesthesia, before incision of skin, operation 1, operation 2, awaking, post-anesthesia by anesthesia progress step. EEG is applied pre-processing, base line correct, linear detrend to get more reliable data. EEG data are handled by electronic processing and the EEG data are calculated by bicoherence. During pre-anesthesia and post anesthesia, appearance rate of bicoherence value is observed strong appearance rate in high frequency range($15\~30Hz$). During the anesthesia of patient, a strong appearance rate is revealed the low frequency area(0~10Hz). After bicoherence is calculated by percentage of a appearance rate, that is, Bicpara$\#$1, Bicpara$\#$2, Bicpara$\#$3 and Bicpara$\#$4 parameter are extracted. In result of bicoherence analysis, Bicpara$\#$2 and Bicpara#4 are considered that the best parameter showed progress of anesthesia effectively. And each separated bicoherence are calculated by average bicoherence's numerical value, divide by 2 area, appear by each BicHz$\#$1, BicHz$\#$2, and observed BicHz$\#$1/BicHz$\#$2's change. In result of bicoherence analysis, BicHz$\#$1, BicHz$\#$2 and BicHz$\#$1/BicHz$\#$2 are considered that the best parameter showed progress of anesthesia effectively. In conclusion, I confirmed the anesthesia progress phase, concluded to usefulness of parameter on bispectrum and bicoherence analysis and evaluated the depth of anesthesia. In the future, it is going to use for doctor's diagnosis and apply to protect an medical accident owing to anesthesia.

• Transactions of the Korean Society of Automotive Engineers
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• v.21 no.2
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• pp.26-36
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• 2013

Purpose of this study is to develop virtual components and environment for developing a controller of an Active Air Suspension System in laboratory that slough off existing development environment using real vehicle test. This paper presents an air spring modeling and analysis of air suspension system for a commercial vehicle. Preferentially, It was performed vehicle test for pneumatic system and an air spring for characteristic analysis of system. Each component of an air spring suspension system was developed through emulations and modeling of system for pressure and height sensors in the basis on test results in SILS environment. Non-linear characteristics of air spring are accounted for using the measured data. Also, pressure and volume relations for vehicle hight control is considered. After performance verification of virtual model was performed, we developed virtual environment based on HILS for an Active Air Suspension System. We studied estimation and verification technology for control algorithm that developed.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.13 no.5
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• pp.313-322
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• 2020

A large volume of data will improve the robustness of deep learning models and avoid overfitting problems. In automatic tongue segmentation, the availability of annotated tongue images is often limited because of the difficulty of collecting and labeling the tongue image datasets in reality. Data augmentation can expand the training dataset and increase the diversity of training data by using label-preserving transformations without collecting new data. In this paper, augmented tongue image datasets were developed using seven augmentation techniques such as image cropping, rotation, flipping, color transformations. Performance of the data augmentation techniques were studied using state-of-the-art transfer learning models, for instance, InceptionV3, EfficientNet, ResNet, DenseNet and etc. Our results show that geometric transformations can lead to more performance gains than color transformations and the segmentation accuracy can be increased by 5% to 20% compared with no augmentation. Furthermore, a random linear combination of geometric and color transformations augmentation dataset gives the superior segmentation performance than all other datasets and results in a better accuracy of 94.98% with InceptionV3 models.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.4
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• pp.1509-1514
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• 2011

The core of IT products, electronic components, especially the MLCC, chip inductors, chip Varistors and so on. In order to test the electrical characteristics of the chip using the Reno-pin contact test method has been used. In current chips, mass production of semiconductor manufacturing processes, high-speed production test for the chip speed up, precision is required. But Vibration displacement is a very short, so in order to overcome these shortcomings, the displacement amplification to design the structure has been actively studied. In this paper, a building structure with a flexible hinge was designed amplification instrument, semiconductor chip industry in the performance test and inspection equipment to measure the electrical characteristics of high speed linear actuators Reno-Pin using system was developed.

• Korean Journal of Clinical Pharmacy
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• v.31 no.3
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• pp.237-246
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• 2021

Background: Pembrolizumab, an anti-cancer drug, is known to increase the activity of the immune system, leading to side effects called immune-related adverse events (irAE), including type 1 diabetes. This study analyzed the correlation between blood glucose level and pembrolizumab administration and investigated the covariates that affect those changes in cancer treatment. Methods: The information of 133 adult cancer patients was obtained from the electronic medical record (EMR) to identify the changes in random blood glucose (RBG) levels during the pembrolizumab treatment. Subjects were classified into subgroups according to their baseline RBG level, history of diabetes, and the use of steroids, and linear regression analysis was conducted. In addition, a secondary analysis was performed within the group of subjects having a strong correlation to glycemic change, which was based on the Pearson correlation coefficient being less than -0.7 or greater than +0.7. Univariate and multivariate logistic regressions were conducted to identify the risk factors to glycemic increase. Results: The RBG level tended to descend without significant differences in total patients during the administration period of pembrolizumab. Despite the insignificance, the logistic regression analysis presents that the odds ratios of baseline RBG less than 130 mg/dL, prophylactic steroid use, and higher dose of pembrolizumab per cycle (mg/kg/cycle) were greater than 1. Conclusions: Prophylactic administration of steroids and a higher dose of pembrolizumab per cycle may increase the blood glucose level as irAE in cancer patients with a strong tendency to glycemic change.

• Journal of Convergence for Information Technology
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• v.11 no.7
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• pp.104-110
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• 2021

A novel selective oxidation process has been developed for low source/drain (S/D) series resistance of the fin channel metal oxide semiconductor field effect transistor (MOSFET). Using this technique, the selective oxidation fin-channel MOSFET (SoxFET) has the gate-all-around structure and gradually enhanced S/D extension regions. The SoxFET demonstrated over 70% reduction in S/D series resistance compared to the control device. Moreover, it was found that the SoxFET behaved better in performance, not only a higher drive current but also higher transconductances with suppressing subthreshold swing and drain induced barrier lowering (DIBL) characteristics, than the control device. The saturation current, threshold voltage, peak linear transconductance, peak saturation transconductance, subthreshold swing, and DIBL for the fabricated SoxFET are 305 ㎂/㎛, 0.33 V, 13.5 𝜇S, 76.4 𝜇S, 78 mV/dec, and 62 mV/V, respectively.

• Journal of Korean society of Dental Hygiene
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• v.19 no.5
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• pp.743-752
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• 2019

Objectives: Grip strength is a measure for assessing overall muscle strength, muscle mass, and nutritional status, and is a useful tool for early examination of a person's general health. Thus, this study analyzed the association between oral health-related factors and grip strength, using the 6th Korea National Health and Nutrition Examination Survey (KNHANES) data. Methods: Data were analyzed using the IBM SPSS version 25.0 (IBM Co., Armonk, NY, USA) software with a complex sampling analysis of stratified and clustered variables, all with weighted values, applied for every analysis conducted. From the 6th KNHANES data, a total of 26,101 people were selected as the study population. A complex sample generalized linear model analysis was performed for participants' sociodemographic characteristics, health status, use of oral care products, and factors such as adult mastication and speaking habits. Results: Grip strength was found to be higher among men compared to women. Grip strength was the highest in the 20-39 year old group. Furthermore, grip strength was statistically significantly higher among married and employed individuals, and in the right hand (p<0.001). Grip strength was statistically significantly higher among people who perceived themselves to have good health and among those who did not have health-related problems in the past two weeks (p<0.001). It was also higher among those who used interdental brushes and electronic toothbrushes (p<0.001), but decreased with greater discomfort in mastication and speaking among adults (p<0.05). Conclusions: Grip strength was found to be associated with oral health-related factors and therefore, these could be helpful tools in evaluating both general and subjective health statuses. In general, oral care products are small in size with oral care involving the use of hands and certain precise motions and actions to remove foreign substances in the oral cavity. As shown in the findings, grip strength declines with increased age and as a result, the use of oral care products should be strongly recommended in order to promote better general health.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.13 no.6
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• pp.483-488
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• 2020

In recent years, the demand for wireless devices incorporating several wireless communication systems into one has been increasing in order to provide services that meet the diverse needs of consumers. Wireless devices consisting of various wireless communication systems require many frequency fixed filters. A frequency tunable filter can replace a number of frequency fixed filters in the wireless devices. If a frequency tunable filter is used in wireless systems, the system can be configured more efficiently. In this paper, a 3-pole frequency tunable BPF(bandpass filter) operating in the frequency band of 800 ~ 2400MHz is designed. In order to widen the operating frequency band, a tuning screw is designed to have a step and a linear motor is used to facilitate the adjustment of the tuning screw. The implemented frequency tunable BPF operates in the designed frequency range and has the maximum insertion loss of 2.82dB in the channel band and the minimum attenuation of 18.7dB at ± 50MHz frequency offset from the center frequency of the band.

• Clinical and Experimental Reproductive Medicine
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• v.48 no.2
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• pp.163-173
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• 2021

Objective: This study aimed to characterize a validated model for predicting oocyte retrieval in controlled ovarian stimulation (COS) and to construct model-based nomograms for assistance in clinical decision-making regarding the gonadotropin protocol and dose. Methods: This observational, retrospective, cohort study included 636 women with primary unexplained infertility and a normal menstrual cycle who were attempting assisted reproductive therapy for the first time. The enrolled women were split into an index group (n=497) for model building and a validation group (n=139). The primary outcome was absolute oocyte count. The dose-response relationship was tested using modified Poisson, negative binomial, hybrid Poisson-E_max, and linear models. The validation group was similarly analyzed, and its results were compared to that of the index group. Results: The Poisson model with the log-link function demonstrated superior predictive performance and precision (Akaike information criterion, 2,704; λ=8.27; relative standard error (λ)=2.02%). The covariate analysis included women's age (p<0.001), antral follicle count (p<0.001), basal follicle-stimulating hormone level (p<0.001), gonadotropin dose (p=0.042), and protocol type (p=0.002 and p<0.001 for short and antagonist protocols, respectively). The estimates from 500 bootstrap samples were close to those of the original model. The validation group showed model assessment metrics comparable to the index model. Based on the fitted model, a static nomogram was built to improve visualization. In addition, a dynamic electronic tool was created for convenience of use. Conclusion: Based on our validated model, nomograms were constructed to help clinicians individualize the stimulation protocol and gonadotropin doses in COS cycles.