• 대한방사선치료학회지
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• 제10권1호
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• pp.69-77
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• 1998

When a high energy photon beam is used to treat lesions located in the upper respiratory air passages or in maxillary sinus, the beams often must traverse an air cavity before it reaches the lesion. Because of this traversal of air, it is not clear that the surface layers of the lesion forming the air-tumor tissue interface will be in a state of near electronic equilibrium; if they are not, underdosing of these layers could result. Although dose corrections at large distances beyond an air cavity are accountable by attenuation differences, perturbations at air-tissue interfaces are complex to measure or calculate. This problem has been investigated for 4MV and 10MV X-ray beams which are becoming widely available for radiotherapy with linear accelerator. Markus chamber was used for measurement with variouse air cavity geometries in X-ray beams. Underdosing effects occur at both the distal and proximal air cavity interface. The magnitude depended on geometry, energy, field sizes and distance from the air-tissue interfaces. As the cavity thickness increased, the central axis dose at the distal interface decreased. Increasing field size remedied the underdosing, as did the introduction of lateral walls. Fellowing a $20{\times}2{\times}2\;cm^3$\;air\;cavity,\;4{\times}4\;cm\;field\;there\;was\;an\;11.5\%\;and\;13\%\;underdose\;at\;the\;distal\;interface,\;while\;a\;20{\times}20{\times}2\;cm^3\;air\;cavity\;yielded\;a\;24\%\;and\;29\%$ loss for the 4MV and 10MV beams, respectively. The losses were slightly larger for the 10MV beams. The measurements reported here can be used to guide the development of new calculation models under non-equilibrium conditions. This situation is of clinical concern when lesions such as larynx and maxillary carcinoma beyond air cavities are irradiated.

• Nuclear Engineering and Technology
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• 제25권4호
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• pp.552-560
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• 1993

지진 및 냉각재상시사고시 핵연료집합체의 건전성 확인은 원자로심모델의 핵연료집합체 집중질량모델을 이용하여 지지격자에 발생한 충격 해석치와 동적좌굴시험치와의 비교를 통해 사고시의 핵연료집합체 건전성을 평가하여 왔다. 그러나 이 방법은 사고시 핵연료집합체 부품별 설계 요구사항 만족여부를 평가하는데 미흡하여 본 연구에서는 지진 및 냉각재상실사고시 핵연료집합체 구조적건전성 평가를 위한 수평방향 핵연료집합체 응력해석모델을 개발하였다. 이를 위해 첫번째 단계로써 원자로심모델의 해석 결과인 각 절점에서의 변위와 회전각으로부터 응력을 계산하고 가장 큰 응력을 갖는 핵연료를 찾아내는 MAIN이라는 전산프로그램을 개발하였다. 그리고 다음단계로써 이 .프로그램에서 구한 핵연료집합체 변위와 회전각을 이용하여 핵연료집합체의 주요부품에 가해지는 응력을 계산하기 위한 핵연료집합체 응력해석모델을 개발하였다. 이 모델은 집합체주요부품인 안내관과 연료봉을 3차원보요소로, 지지격자스프링을 선형 및 회전스프링으로 각각 모델링 하였으며, MAIN 프로그램의 출력인 집합체의 변위를 구속조건으로 사용하였다. 또한, 개발된 프로그램과 응력해석모델을 이용하여 하나의 적용 예로써 임의의 지진하중하에서 16$\times$16형 핵연료집합체에 대한 응력해석을 수행하였다. 이 모델을 개발하므로써 지진 및 냉각재상실사고시 핵연료집합체 설계용구사항 만족여부를 평가할 수 있는 기틀을 마련하였다.

• The Journal of Korean Physical Therapy
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• 제15권1호
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• pp.38-60
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• 2003

The purpose of this study was to observe the effects of Far-infrared on mice rheumatoid arthritis induced by type II collagen. The author peformed several experimental tests which were the hematoxylin-eosin tissue stain, the hind paw thickness, and ELSIA of cytokines(TNF-$\alpha$, IL-1$\beta$). On day 14 and 21, FIR-Tx. group decreased in synovial membrane thickness more than control II group FIR-Tx group decreased in hind paw thickness more than control II group. In the ELISA test of TNF-$\alpha$ concentration, control II group significantly increased in the concentration more than normal and FIR-Tx. group on day 7, 14, and 21. In the ELISA test of IL-$\beta$ concentration, FIR-Tx. group decreased in the concentration more than control II group on day 14 and 21. With J's Linear Function Data Process Program, researchers can get the estimated the concentration or the hind paw thickness from this experiment. The estimated results would be a good guide to therapists and researchers, planning Far-infrared application on the rheumatoid arthritis. These results indicated that far-infrared irradiating appeared to reduce the concentration of TNF-$\alpha$ and IL-1$\beta$ at mouse model of autoimmune arthritis. It would be considered that Far-infrared has an effect on relieving rheumatoid arthritis.

• 전자공학회논문지SC
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• 제47권5호
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• pp.52-61
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• 2010

최근 피부의 마찰계수를 이용하여 한의학에서의 체질을 구별하는 연구가 활발히 이루어지고 있다. 피부의 마찰계수는 여러 고문헌에서도 알려져 있듯이 태음인과 소양인의 체질을 구별하는 인자로 활용되고 있다. 본 연구에서는 다축 로드셀과 일정하중식 접촉 프로브를 이용하여 피부의 마찰계수를 정량적으로 측정하는 장비를 개발하였고 이의 측정 불확도를 측정하였다. 개발된 장비의 상대 반복도는 2 %였다. 태음인과 소양인의 체질진단 구분을 위해 왼속 손등을 측정부위로 선택하여 실험한 결과 약지를 따라 측정하는 것이 가장 효과적임을 알 수 있었다. 20명의 피험자를 대상으로 임상측정을 한 결과, 개발된 장비의 경우 3 % 이내의 측정 불확도를 가지고 태음인과 소양인의 체질 구분을 할 수 있었다.

• Horticulture, Environment, and Biotechnology : HEB
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• 제59권6호
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• pp.815-826
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• 2018

The intense drought affecting olive production in Northern Chile underscores the need to research non-traditional irrigation strategies to obtain the best crop performance. Accordingly, this study aimed to obtain preliminary data to guide future research on this topic. Different water replenishment levels on crop evapotranspiration ($ET_c$ ; 13.5, 27.0, 40.5, and 54%) were established in a young orchard, cv. Arbequina, from the end of fruit drop (EFD) to full bloom in the next season. We evaluated the influence of plant water status (${\Psi}_{stem}$ ) and crop load, considered as function of fruit number divided by trunk cross-sectional area, on reproductive and productive variables using multiple linear regressions. Our results show that crop load and ${\Psi}_{stem}$ measured from EFD to harvest affected yield components. Nevertheless, ${\Psi}_{stem}$ had the strongest influence on fruit size, pulp development, oil accumulation, and yield. Oil content and yield were reduced by 54% and 50% for each MPa, respectively, from ${\Psi}_{stem\;EFD-H}$ -1.8 MPa, an effect that intensified as crop load increased. During the period of flower development (September-November), the number of flowers per inflorescence and percentage of perfect flowers were reduced when ${\Psi}_{stem}$ was less than -2.0 MPa. These preliminary results showed that bud differentiation, inflorescence and flower formation are highly sensitive to water deficit.

• Journal of Microbiology and Biotechnology
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• 제31권1호
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• pp.8-15
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• 2021

More and more available fungal genome sequence data reveal a large amount of secondary metabolite (SM) biosynthetic 'dark matter' to be discovered. Heterogeneous expression is one of the most effective approaches to exploit these novel natural products, but it is limited by having to clone entire biosynthetic gene clusters (BGCs) without errors. So far, few effective technologies have been developed to manipulate the specific large DNA fragments in filamentous fungi. Here, we developed a fungal BGC-capturing system based on CRISPR/Cas9 cleavage in vitro. In our system, Cas9 protein was purified and CRISPR guide sequences in combination with in vivo yeast assembly were rationally designed. Using targeted cleavages of plasmid DNAs with linear (8.5 kb) or circular (8.5 kb and 28 kb) states, we were able to cleave the plasmids precisely, demonstrating the high efficiency of this system. Furthermore, we successfully captured the entire Nrc gene cluster from the genomic DNA of Neosartorya fischeri. Our results provide an easy and efficient approach to manipulate fungal genomic DNA based on the in vitro application of Cas9 endonuclease. Our methodology will lay a foundation for capturing entire groups of BGCs in filamentous fungi and accelerate fungal SMs mining.

• Geomechanics and Engineering
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• 제30권3호
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• pp.259-272
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• 2022

Rockburst is a dynamic, multivariate, and non-linear phenomenon that occurs in underground mining and civil engineering structures. Predicting rockburst is challenging since conventional models are not standardized. Hence, machine learning techniques would improve the prediction accuracies. This study describes decision based uncertainty models to predict rockburst in underground engineering structures using gradient boosting algorithms (GBM). The model input variables were uniaxial compressive strength (UCS), uniaxial tensile strength (UTS), maximum tangential stress (MTS), excavation depth (D), stress ratio (SR), and brittleness coefficient (BC). Several models were trained using different combinations of the input variables and a 3-fold cross-validation resampling procedure. The hyperparameters comprising learning rate, number of boosting iterations, tree depth, and number of minimum observations were tuned to attain the optimum models. The performance of the models was tested using classification accuracy, Cohen's kappa coefficient (k), sensitivity and specificity. The best-performing model showed a classification accuracy, k, sensitivity and specificity values of 98%, 93%, 1.00 and 0.957 respectively by optimizing model ROC metrics. The most and least influential input variables were MTS and BC, respectively. The partial dependence plots revealed the relationship between the changes in the input variables and model predictions. The findings reveal that GBM can be used to anticipate rockburst and guide decisions about support requirements before mining development.

• Nuclear Engineering and Technology
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• 제55권8호
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• pp.2797-2801
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• 2023

CdZnTeSe (CZTS) has attracted attention for applications in X- and gamma-ray detectors owing to its improved properties compared to those of CdZnTe (CZT). In this study, we grew and processed single crystals of CZT and CZTS using the Bridgeman method to confirm the feasibility of using a dosimeter for high-energy X-rays in radiotherapy. We evaluated their linearity and precision using the coefficient of determination (R²) and relative standard deviation (RSD). CZTS showed sufficient RSD values lower than 1.5% of the standard for X-ray dosimetry, whereas CZT's RSD values increased dramatically under some conditions. CZTS exhibited an R² value of 0.9968 at 500 V/cm, whereas CZT has an R² value of 0.9373 under the same conditions. The X-ray response of CZTS maintains its pulse shape at various dose rates, and its properties are improved by adding selenium to the CdTe matrix to lower the defect density and sub-grain boundaries. Thus, we validated that CZTS shows a better response than CZT to high-energy X-rays used for radiotherapy. Further, the applicability of an onboard imager, a high-energy X-ray (>6 MV) image, is presented. The proposed methodology and results can guide future advances in X-ray dose detection.

• 한국진공학회:학술대회논문집
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• 한국진공학회 1998년도 제14회 학술발표회 논문개요집
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• pp.17-17
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• 1998

Synchrotron radiation is produced when charged particles moving with relativistic velocities a are accelerated - for example, deflected by the bending magnets which guide the electron or p positrons in circular accelerators or storage rings. By using special focusing magnetic lattices i in the particle accelerators it is possible to make the dimensions of the particle beam very small with a hi맹 charge density which results in a light source with high b디lIiance. Synchrotron light h has important properties which make it ideal for a wide range of investigations in surface s science. The fact that the spectrum of electromagnetic radiation emitted in a bending magnet e extends in a continuum from the 얹r infra red region to hard x-rays means that it is id않I for a v variety of spectroscopic studies. Since there are no convenient lasers, or other really bright l light sources, in the vacuum ultraviolet and soft x-ray re.밍ons the development of synchrotron r radiation has enabled enormous advances to be made in this di펌C비t spectr따 re밍on. P Polarization-dependent measurements, for ex없nple ellipsometry or circular dichroism studies a are possible because the radiation has a well-defined polarization - linear in the plane of orbit w with additional right-circular, or left-circular, components for emission an생es above, or below, t the horizontal, respectively. Since the synchrotron light is emitted from a bunch of charge c circulating in a ring the light is emitted with a well-defined time structure with a short flash of l light every time a bunch passes an exit port. The time structure depends on the size of the ring a and the number and sequence of filling of the bunches. A pulsed light source enables time¬r resolved studies to be performed which provide direct information on the lifetimes and decay m modes of excited states and in addition opens up the possibility of using time of flight t techniques for spectroscopic studies. The fact that synchrotron radiation is produced in a clean u ultrahi야 vacuum environment is of gr않t importance for surce science studies. The current t비rd generation synchrotron light sources provide exceptionally high baliance and stability a and open up possibilities for experiments which would have been inconceivable only a short time ago.

• Journal of Animal Science and Technology
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• 제65권6호
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• pp.1270-1289
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• 2023

This study evaluates how different feeding systems impact ruminal fermentation, methane production, and microbiota of Hanwoo steers native to Korea. In a replicated 2 × 2 crossover design over 29 days per period, eight Hanwoo steers (507.1 ± 67.4 kg) were fed twice daily using a separate feeding (SF) system comprising separate concentrate mix and forage or total mixed rations (TMR) in a 15:85 ratio. The TMR-feeding group exhibited a considerable neutral detergent fiber digestibility increase than the SF group. However, ruminal fermentation parameters and methane production did not differ between two feeding strategies. In addition, TMR-fed steers expressed elevated Prevotellaceae family, Christensenellaceae R-7 group, and an unidentified Veillonellaceae family genus abundance in their rumen, whereas SF-fed steers were rich in the Rikenellaceae RC9 gut group, Erysipelotrichaceae UCG-004, and Succinivibrio. Through linear regression modeling, positive correlations were observed between the Shannon Diversity Index and the SF group's dry matter intake and methane production. Although feeding systems do not affect methane production, they can alter ruminal microbes. These results may guide future feeding system investigations or ruminal microbiota manipulations as a methane-mitigation practice examining different feed ingredients.