• Asian Pacific Journal of Cancer Prevention
• /
• 제15권11호
• /
• pp.4567-4570
• /
• 2014

Background: This systemic analysis was conducted to evaluate the efficacy and safety of pemetrexed based chemotherapy in treating patients with metastatic breast cancer as first or second line chemotherapy. Methods: Clinical studies evaluating the efficacy and safety of pemetrexed based regimens on response and safety for patients with breast cancer were identified using a predefined search strategy. Pooled response rate (RR) of treatment were calculated. Results: In first line pemetrexed based regimens, 10 clinical studies which including 513 patients with advanced breast cancer were considered eligible for inclusion. For second line pemetrexed based chemotherapy, 5 clinical studies which including 281 patients with advanced breast cancer were considered eligible. Systemic analysis suggested that, in all patients, pooled RR was 32.6% (167/513) in pemetrexed based first line regimens, and 13.9 % (39/281) in pemetrexed based second line regimens. Major adverse effects were neutropenia, leukopenia, fatigue, and anemia in pemetrexed based first line treatment; and lymphopenia, neutropenia, leukopenia, as well as anemia in second line chemotherapy. One treatment related death occurred with pemetrexed based second line treatment. Conclusion: This systemic analysis suggests that pemetrexed based first line regimens are associated with a reasonable response rate and acceptable toxicity, however with low response rate for treating patients with metastatic breast cancer when is used in the second line.

• International Journal of Automotive Technology
• /
• 제6권1호
• /
• pp.65-70
• /
• 2005

Pressure ripples, which are inevitably generated by a fluctuation of flow rate caused by a pump mechanism, include noises and vibrations in hydraulic pipeline. These noises and vibration deteriorate the stability and accuracy of hydraulic systems. The accumulator and hydraulic attenuator are normally used to reduce the pressure ripples. In this study, a parallel line is introduced to the hydraulic pipeline for the hydraulic system with a bent-axis piston pump as a method to reduce the pressure ripples. The dynamic characteristics of the hydraulic pipeline with a parallel line are analyzed by a transfer matrix in the frequency domain. The usefulness of the hydraulic pipeline with a parallel line was ascertained by experiment and simulation. The results from the experiment and simulation show that the hydraulic pipeline with a parallel line were effective in reducing the pressure ripples.

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2004년도 춘계학술대회
• /
• pp.1070-1075
• /
• 2004

Many mid-sized companies in Korean automotive industry have attempted to solve the lack of human power, to control the quality of components, to improve the production rate, and to innovate the manufacturing line. The goals of this study are to analyze the production rate of an automotive component manufacturing line using simulation software, to construct a Flexible Automation Subassembly (FAS) system and to suggest an optimized layout design using FAS line. In this research, the simulation model for manufacturing line was developed and used the realistic data (production planning, component type, working order, process time, queue time, line rules, etc) of a medium sized company in Korean automotive industry. To complete this research, a simulation software 'ARENA' was used.

• 제어로봇시스템학회:학술대회논문집
• /
• 제어로봇시스템학회 1993년도 한국자동제어학술회의논문집(국내학술편); Seoul National University, Seoul; 20-22 Oct. 1993
• /
• pp.1123-1128
• /
• 1993

In this paper, utilizing the line balancing algorithm proposed to deal with various situations of automated assembly line, the optimal solution can be derived by the branch and bound method of analysis. By the application of line balancing algorithm to telephone assembly line, thoughput is improved by 3.38%. Therefore, in the proposed line, blicking phenomena were reduced and smooth line-flow was achieved, and uniform distribution of utilization rate of each machine is obtained.

• 수산해양기술연구
• /
• 제32권3호
• /
• pp.241-248
• /
• 1996

The relationship between width of line target and distance at the limit of discrimination was examined by means of the behavioral method, for filefish Stephanolepis cirrhifer from 11 to 15cm body length. Target distance was distance from beginning of partition board to target plate, and was varied from 50cm to 200cm. The target plate was made of white acrylic resin with a vertical black line in the center. The width of line target was varied from 0.2mm to 8.0mm. Fish were trained to respond to a line target and the width of line target reduced until the minimum width required to elicit a response was established. Rate of success was expressed as the percentage of target choices in 90 trials. The line acuity of filefish was found to be 0.58 at a target distance of 50cm. The rate of success decreased slowly as line target width decreased from 8.0mm to 1.5mm, and decreased suddenly for target widths less than about 1.5mm. The width of the line target D(mm) at the limit of discrimination was shown to be an exponential function of the target distance L(cm) as follows : D=exp(9.947$\times$$10^-3$.L+0.146)

• 설비공학논문집
• /
• 제18권7호
• /
• pp.571-577
• /
• 2006

The characteristics of ice packing factor (IPF) at the ice slurry system using one line type are compared with the system using two lines type. The installation space for one transporting line is saved at the one line system. For the one line type, the ice packing factor is reduced along the downstream, but for the two lines type, the ice packing factor is fixed. For the one line system, mass flow rate in the main line is fixed along the down-stream, but for two lines system, the mass flow rate in the main line is reduced along the downstream. For one line system, along the down stream after IPF=0, the temperature at the main steam is increased, and the extracted mass flow is increased. The initial IPF, at which the IPF is not arrived at zero upto the final node, is proposed for the B area.

• 한국정밀공학회지
• /
• 제15권7호
• /
• pp.91-97
• /
• 1998

The analysis model is the infinite body consisted of power law creep material containing a rigid inclusion with line crack shape subjected to the arbitrarily directional stress on an infinite boundary. The crack analysis is performed using the complex pseudo-stress function. The strain rate intensity factor is determined in the closed form as new fracture mechanics parmeter which represents the magnitudes of stress and strain rate near the tip in power law creep material.

• 산업기술연구
• /
• 제21권A호
• /
• pp.329-336
• /
• 2001

In this study, a series of fatigue tests are carried out in order to estimate quantitatively the characteristics of fatigue crack growth rate for high strength steels of SM570, POSTEN60, and POSTEN80 steel, that is, the influence on fatigue crack growth rate according to the welding line, the characteristics of fatigue crack growth according to the welding method and the kinds of steel, and the characteristics of fatigue crack growth for base metal, heat affected zone and weld metal. From the test results, in case that the notch if parallel to welding line, it knows that the retardations of fatigue crack growth rate in crack tip at early stage increase remarkably than in case that the notch is perpendicular to welding line due to compressive residual stress. And the characteristics of fatigue crack growth rate according to welding method are that the dispersion of fatigue crack growth rate in case of FCAW method is smaller than that of SAW method. Also, it knows that the fatigue crack growth rate converges in high stress intensity factor range.

• 한국지능시스템학회논문지
• /
• 제6권2호
• /
• pp.52-56
• /
• 1996

신경망을 학습하는데 있어서, 망의 학습속도는 학습율에 의해 크게 좌우된다. 그러나 대부분의 정적인 학습율 선택 방법들은 몇몇 결정적인 방법들을 제외하곤 경험적인 방식에 의존해 왔다. 경험적인 방식을 사용하여 좋은 학습율을 찾아내는 것은 배우 지류하고 어려운 일이다. 또한 결정적인 방법들은 학습율의 질을 보장하지는 못한다. 본 논문에서 우리는 새로운 학습율 선택 방법을 제안한다. 우리의 방법은 진화 프로그래밍기법을 사용하여 통계적인 방식으로 접근함으로써 좋은 학습율을 찾을 수 있다. 모의 실험을 통하여 우리의 방식이 경험적인 방식들이나 결정적인 방식보다 우수함을 보였다.

• ETRI Journal
• /
• 제30권2호
• /
• pp.261-267
• /
• 2008

In this paper, we propose and demonstrate a cost-effective technique to upgrade the capacity of dense wavelength division multiplexing (DWDM) networks to a 40 Gb/s line rate using the existing 10 Gb/s-based infrastructure. To accommodate 40 Gb/s over the link optimized for 10 Gb/s, we propose applying a combination of super-FEC, carrier-suppressed return-to-zero, and pre-emphasis to the 40 Gb/s transponder. The transmission of 40 Gb/s DWDM channels over existing 10 Gb/s line-rate long-haul DWDM links, including $40{\times}40$ Gb/s transmission over KT's standard single-mode fiber optimized for 10 Gb/s achieves successful results. The proposed upgrading technique allows the Q-value margin for a 40 Gb/s line rate to be compatible with that of 10 Gb/s.