• The Journal of Korean Obstetrics and Gynecology
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• v.22 no.3
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• pp.117-134
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• 2009

Purpose: In the theory of traditional medicine, Scutellariae Radix (SR) can clear away heat and remove dampness, purge the sthenic fire and remove toxic materials, cool blood and stop bleeding to prevent miscarriage. Recently, SR is known to have anti-cancer activity. For this reason, the present author designed to investigate the effect of SR on proliferation rates of cervical cancer cell line, then effects on genetic profile by SR. Methods: The genetic profile for the effect of SR on human derived cervical cancer cell line, SNU-703, was measured using microarray technique, and the functional analysis on these genes was conducted. Results: Total 519 genes were up-regulated and 606 genes down-regulated in cells treated with SR. Genes induced or suppressed by SR were all mainly concerned with metabolic process, regulation of biological process and protein binding. The network of total protein interactions was measured using cytoscape program, and some key molecules, such as TNFRSF1A, AKT1, MAPK3, and STAT3 that can be used for elucidation of therapeutical mechanism of medicine in future were identified. Conclusion: These results suggest possibility of SR as anti-cancer drug and also suggest that related mechanisms are involved in TNFRSF1A, AKT1, MAPK3, and STAT3 related signalling pathways.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.2
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• pp.50.2-50.2
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• 2019

We present the results of high-resolution (R ≥ 30,000) optical and near-infrared spectroscopic monitoring observations of a FU Orionis-type object, 2MASS J06593158-0405277. We have monitored 2MASS J06593158-0405277 with the Bohyunsan Optical Echelle Spectrograph (BOES) and the Immersion GRating INfrared Spectrograph (IGRINS) since December 2014. Various features produced by wind, disk, and outflow/jet were detected. The wind features varied over time and disappeared about a year after the outburst occurred. The double-peaked line profiles were detected in the optical and near-infrared, and the line widths decrease with increasing wavelength. The disk features in the optical spectra are fit well with G2-type or G5-type stellar spectra convolved with a disk rotational profile of about 45 km s^-1, which corresponds to a disk radius of about 71 R_⊙for a central mass of 0.75 M_⊙. Disk features in near-infrared spectra are fit well with a K1-type stellar spectrum convolved with a disk rotational profile of about 35 km s^-1, which corresponds to a disk radius of about 117 R_⊙ for a central mass of 0.75 M_⊙. We also detected [S II] and H2 emission lines, which are rarely found in FUors but are usually found in the earlier stage of young stellar objects. Therefore, we suggest that 2MASS J06593158-0405277 is in the relatively earlier part of Class II stage.

• The Bulletin of The Korean Astronomical Society
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• v.45 no.1
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• pp.61.4-62
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• 2020

We present H I gas kinematics and star formation activities of NGC 6822, a dwarf galaxy located in the Local Volume at a distance of ~490 kpc. We perform profile decomposition of the line-of-sight velocity profiles of the high-resolution (~42.4" × 12") spatial; ~1.6 km/s spectral) H I data cube taken with the Australia Telescope Compact Array (ATCA). For this, we use a new tool, the so-called BAYGAUD (BAYesian GAUssian Decompositor) which is based on Bayesian Markov Chain Monte Carlo (MCMC) techniques, allowing us to decompose a line-of-sight velocity profile into an optimal number of Gaussian components in a quantitative manner. We classify the decomposed H I gas components of NGC 6822 into kinematically cold, warm or hot ones with respect to their velocity dispersion: 1) cold: < 4 km/s, 2) warm: 4 ~ 8 km/s, 3) hot: > 8 km/s. We then derive the Toomre-Q parameters of NGC 6822 using the kinematically decomposed H I gas maps. We also correlate their gas surface densities with the surface star formation rates derived using both GALEX far-ultraviolet and WISE 22 micron data to examine the impact of gas turbulence caused by stellar feedback on the Kennicutt-Schmidt (K-S) law. The kinematically cold component is likely to better follow the linear extension of the Kennicutt-Schmidt (K-S) law for molecular hydrogen (H2) at the low gas surface density regime where H I is not saturated.

• Journal of the Korean earth science society
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• v.38 no.4
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• pp.263-268
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• 2017

The determination algorithm of the location of a line source with strike and dip using the gravity gradient tensor on a single profile is proposed. We already proposed the determination of strike and dip in the previous paper and then, now we improved the algorithm to locate a line source after determining strike and dip. The strike and dip of the line source can be determined by rotating the gravity gradient tensor matrix as reducing 2 independent components. Using the ratio of remaining 2 components, the location can be determined by the least square manner of the pointing vectors on each observation point. A synthetic model is tested for proving the usefulness of the proposed algorithm.

• Wind and Structures
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• v.34 no.2
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• pp.185-197
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• 2022

This study aimed to analyze the wind-induced mechanical energy (WME) of a proposed super high-rise and long-span transmission tower-line system (SHLTTS), which, in 2021, is the tallest tower-line system with the longest span. Anew index - the WME, accounting for the wind-induced vibration behavior of the whole system rather than the local part, was first proposed. The occurrence of the maximum WME for a transmission tower, with or without conductors, under synoptic winds, was analyzed, and the corresponding formulae were derived based on stochastic vibration theory. Some calculation data, such as the drag coefficient, dynamic parameters, windshielding areas, mass, calculation point coordinates, mode shape and influence function, derived from wind tunnel testing on reducedscale models and finite element software were used in calculating the maximum WME of the transmission tower under three cases. Then, the influence of conductors, wind speed, gradient wind height and wind yaw angle on WME components and the energy transfer relationship between substructures (transmission tower and conductor) were analyzed. The study showed that the presence of conductors increases the WME of transmission towers and changes the proportion of the mean component (MC), background component (BC) and resonant component (RC) for WME; The RC of WME is more susceptible to the wind speed change. Affected by the gradient wind height, the WME components decrease. With the RC decreasing the fastest and the MC decreasing the slowest; The WME reaches the its maximum value at the wind yaw angle of 30°. Due to the influence of three factors, namely: the long span of the conductors, the gradient wind height and the complex geometrical profile, it is important that the tower-line coupling effect, the potential for fatigue damage and the most unfavorable wind yaw angle should be given particular attention in the wind-resistant design of SHLTTSs

• The Journal of Engineering Geology
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• v.12 no.1
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• pp.89-93
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• 2002

Seismic geotomography method was performed to verify rock-filled settlement and its stability in No.38+0 profile and No.40+0 profile. The velocity distributions of geotomography method expressed the quantitative value of the ground conditions. The rock-filled layer and in-situ sediments layer are clearly divided on the basis of seismic velocity 2100 m/sec which is derived from the results of seismic geotomography and boring. Current rock-filled settlement conditions are somewhat different from designed settlement estimation line. Seismic geotomography represents current settlement conditions as a quantitative analysis.

• Journal of Welding and Joining
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• v.14 no.5
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• pp.95-105
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• 1996

Korea Gas Corporation has operated high pressure gas transmission line of about 600 kilometers and, therefore, a series of repair welding processes are required in order to cope with external defects such as dent, gouge, cracking usually due to mechanical attacks. Most of gas pipelines repair processes are performed after completely venting remaining gas. However, in some case, though it is very unusual, repairs require without venting gas. For instance, this case is that damaged pipeline is remedied with split sleeve by welding. In this paper, in an effort to confirm a safe application of the split sleeve welding, residual stress, strain and temperature distributions are evaluated by computer simulation and experiments. The results obtained are as follows : 1) Computer modelling is supposed to be reasonable because microstructure changes due to welding is simulated coincidently as compare to that of real condition. 2) The maximal temperature on inside surface of pipeline is 50$0^{\circ}C$ for the repair welding process. 3) The amount of residual stress is estimated as the stress corresponding to 0.8% strain. 4) The repair process employed is determined to be technically preferable because of its avoiding cracks and fractures in the course of welding.

• Molecular & Cellular Toxicology
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• v.1 no.1
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• pp.52-61
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• 2005

Transcript profiling is a particularly valuable tool in the field of steroid receptor biology, as these receptors are ligand-activated transcription factors and therefore exert their initial effects through altering gene expression in responsive cells. Also, an awareness of endocrine disrupting chemicals (EDCs) and their potential screening methods to identify endocrine activity have been increased. Here we developed an in-house cDNA microarray, named KISTCHIP-400 ver. 1.0, with 416 clones, based on public database and research papers. These clones contained estrogen, androgen, thyroid hormone & receptors, sex hormone signal transduction & regulation, c-fos, c-myc, ps2 gene, metabolism related genes etc. Also, to validate the KISTCHIP-400 ver. 1.0, we investigated gene expression profiles with reference hormones, $10^{8}\;M\;17{\beta}-estradiol,\;10^{-7}\;M\;testosterone\;and\;10^{-7}\;M$ progesterone in MCF-7 cell line. As the results, gene expression profiles of three reference hormones were distinguished from each other with significant and identified 33 $17{\beta}-estradiol$ responsive genes. This study is in first step of validation for KISTCHIP-400 ver. 1.0, as following step transcriptional profile analysis on not only low concentrations of EDCs but suspected EDCs using KISTCHIP-400 ver. 1.0 is processing. Our results indicate that the developed microarray may be a useful laboratory tool for screening EDCs and elucidating endocrine disrupting mechanism.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.4
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• pp.730-738
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• 2007

As well known when the linear machine is operated between two points repeatedly under positioning control, there are various positioning error at the moment of zero speed owing to the non-linear disturbance like as unpredictable friction force. To remove this positioning error, a simple least order disturbance observer is introduced and is actually implemented in this study. Due to this simple algorithm the over-all machine system can be modified to simple arbitrary given one-mass load without any disturbance. So, the total construction process for positioning control system is much easier than old one. Moreover, to generate a proper effective position profile with the limited actual machine force, a very powerful on-line mass identification algorithm using the load force estimator is presented. In the proposed mass identification algorithm, the exact load mass can be calculated during only one moving stage under a normally generated position profile. All presented algorithm is verified with experimental result with commercial linear servo machine system.

• Bulletin of the Korean Chemical Society
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• v.35 no.3
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• pp.908-912
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• 2014

Microgratings whose diffracted field at a fixed angle generate IR spectra of $SF_6$ or $NH_3$ were fabricated by MEMS techniques for the purpose of IR correlation spectroscopy. Each micrograting was composed of 1441 reflecting lines in the area of $19.2{\times}19.2mm^2$. The depth profile of the line elements was determined with a gradient searching method that was described in our previous publication (J. Mod. Opt. 2013, 60, 324-330), and was discretized into 16 levels between 0 and $6.90{\mu}m$. The diffraction field from a given depth profile was calculated with Fraunhofer equation. The fabricated microgratings showed errors in the depth and the width within acceptable ranges. As the result, the diffracted IR spectrum of each micrograting matched well with its target reference spectrum within spectral resolution of our optical setup.