• Journal of Microbiology and Biotechnology
• /
• v.20 no.2
• /
• pp.346-349
• /
• 2010

Coenzyme $Q_{10}$ ($CoQ_{10}$) production from Rhizobium radiobacter T6102 was monitored under various oxygen supply conditions by controlling the agitation speeds, aeration rates, and dissolved oxygen levels. As the results, the $CoQ_{10}$ production was enhanced by limited oxygen supply. To investigate whether the $CoQ_{10}$ production is associated with its physiological functions of electron carrier and antioxidant, the effects of sodium azide and hydrogen peroxide on the $CoQ_{10}$ production were studied, showing that the $CoQ_{10}$ contents were slightly enhanced with increasing sodium azide (up to 0.4 mM) and hydrogen peroxide (up to $10\;{\mu}M$) concentrations. These results suggest the plausible mechanism where the limited electron transfer stimulating the environments of limited oxygen supply and oxidative stress could accumulate the $CoQ_{10}$, providing the relationship between the $CoQ_{10}$ physiological functions and its regulation system.

• Archives of design research
• /
• v.18 no.1 s.59
• /
• pp.205-214
• /
• 2005

A development proposal that maximizes the trend of travel souvenir and articles toward tourism and natural resources through utilization of the Limited Production method was the focus of the present research. First, the flaws of travel souvenir and articles, currently produced in Inje, Kangwon-Do, were identified, as were the regional uniqueness of the area. The comparative advantages of developmental conditions of the above-specified region to various other Si/Kun regions were demonstrated to ascertain the optimal production method of travel souvenir and articles. The results are as follows. Superior supply of,7aw materials necessary for production of wood-worked travel souvenir and articles are abundantly available and the dose proximity of 17 existing workshops self-contain the production capacity to sustain the Limited Production method. Furthermore, the regional governing council conveyed positive attitudes towards the prospect of creating a regional production complex of wood-worked travel souvenir and articles. The results demonstrate that the optimal method of maximizing the trend of travel souvenir and articles toward tourism and natural resources is achieved through systematic collaboration of industry, education, and tourism that promote development, production, and merchandising of Inje's regional travel souvenir and articles.

• 한국생물공학회:학술대회논문집
• /
• 2001.11a
• /
• pp.426-429
• /
• 2001

The continuous production of L -proline was studied using L-histidine auxotrophic mutant of Corynebacterium acetoacidophilum under various substrate limited conditions. Among the $NH_4\;^+$ $PO_4\;^3$ and L -histidine limited conditions, the highest production of L -proline was observed under the L-histidine limited condition. Under $NH_4\;^+$ and $PO_4\;^3$ limited conditions, no or poor L-proline production was observed, respectively. For the kinetic parameters under L -histidine limitation the specific rate of L -proline production was increased with dilution rate upto $0.1hr^{-1}$ but decreased above $0.1hr^{-1}$. The volumetric rate of L -proline production was showed similar pattern with specific rate. The dried cell weight was gradually increased according to decrease the dilution rate. Specific rate of glucose consumption was proportionally increased with dilution rate. The results of continuous culture (higher production of L-proline at dilution rate $0.1hr^{-1}$) will be used in fed-batch culture for the control of cell growth rate and mass production of L-proline.

• Journal of Korean Institute of Industrial Engineers
• /
• v.15 no.2
• /
• pp.109-116
• /
• 1989

In many cases, production-inventory systems involves significant demand variations. Actual demand is probabilistic and the production capacity is also limited. Finding the proper production lot sizes to this problem usually requires heavy computational procedures. Therefore a heuristic approach were under various assumptions is highly recommended. In this paper, an approach with consideration of probabilistic demand and limited production capacity is proposed.

• Advances in Energy Research
• /
• v.3 no.1
• /
• pp.59-70
• /
• 2015

In India, continuous production of electricity and sweet/potable water from Solar power and desalination plant plays a major role in the industries. Particularly in Copper industry, Solar power adopts Solar field collector combined with thermal storage system and steam Boiler, Turbine & Generator (BTG) for electricity production and desalination plant adopts Reverse osmosis (RO) for sweet/potable water production which cannot be used for long hours of power generation and consistency of energy supply for industrial processes and power generation cannot be ensured. This paper presents an overview of enhanced technology for Solar power and Desalination plant for Copper industry making it continuous production of electricity and sweet/potable water. The conventional technology can be replaced with this proposed technique in the existing and upcoming industries.

• Journal of Mechanical Science and Technology
• /
• v.14 no.4
• /
• pp.380-392
• /
• 2000

A typical production-distribution system consist of three main echelons representing the retailer, distributors, and a factory each with an on-site warehouse. The system is sufficiently general and realistic to represent many industrial situations. However, decision functions and parameters have been selected to apply particularly to the production and distribution of consumer durables. The flows included in the model are materials, orders, and those information flows needed to support the material and order-rate decisions. In this work, a realistic production-distribution system has been used as a basic model, which consists of three sectors: retailer, distributor, and factory. That system is a nonlinear 25th-order continuous system interconnected between the echelons. Using a modern control algorithm, a typical multi-echelon production-distribution system using a dynamic controller is numerically simulated in the nominal plant and in the perturbed plant when the piecewise constant manufacturing decision is limited by a factory manufacturing upper-limit due to capital equipment, manpower, and factory lotsize.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.41 no.1
• /
• pp.102-109
• /
• 2018

This paper seeks to present a multi-control method that can contribute to effective control of the production line with multiple bottleneck processes. The multi-control method is the production system that complements shortcomings of CONWIP and DBR, and it is designed to determine the raw material input according to the WIP level of two bottleneck processes and WIP level of total process. The effectiveness of the production system developed by applying the multi-control method was verified by the following three procedures. Raw material input conditions of the multi-control method are as follows. First, raw materials are go into the production line when the number of the total process WIP is lower than established number of WIP in total process and first process is idle. Second, raw materials are introduced when the number of WIP of two bottleneck processes is lower than the established number of WIP of each bottleneck process. Third, raw materials are introduced when the first process and in front of bottleneck process are idle even if the number of WIP in the total process is less than established number of WIP of the total process. The production line with two bottleneck processes was selected as the condition for production environment, and the production process modeling of CONWIP, DBR and multi-control production method was defined according to the production condition. And the optimum limited WIP level suitable for each system was obtained by applying a genetic algorithm to determine the total limited number of WIP of CONWIP, the limited number of WIP of DBR bottleneck process, the number of WIP in the total process of multi-control method and the limited number of WIP of bottleneck process. The limited number of WIP of CONWIP, DBR and multi-control method obtained by the genetic algorithm were applied to ARENA modeling, which is simulation software, and a simulation was conducted to derive result values on the basis of three criteria such as production volume, lead time and number of goods in-progress.

• Korean Membrane Journal
• /
• v.2 no.1
• /
• pp.9-18
• /
• 2000

• Proceedings of the Membrane Society of Korea Conference
• /
• 2000.04b
• /
• pp.17-27
• /
• 2000

• Biotechnology and Bioprocess Engineering:BBE
• /
• v.7 no.5
• /
• pp.252-262
• /
• 2002

The growing interest in the application of arachidonic acid (ARA) in various fields of health and dietary requirements has elicited much attention on the industrial production of ARA-containing oil by the cultivation of Mortierella fungi. For the industrial production of ARA, various studies, such as isolation of a high-potential strain and optimization of culture conditions, have been conducted. Studies including the investigation of morphology are important because ARA is accumulated in the mycelia, and thus cultivation with high biomass concentration is essential for obtaining a high ARA yield. Combining the results derived from various studies, a high ARA yield was attained in an industrial fermentor. These ARA production techniques are applicable to the production of other polyunsaturated fatty acids (PUFAs), and will contribute to the improvement of fermentation technology especially in the field of fungal cultivation.