• Title/Summary/Keyword: Limitation Factor

검색결과 553건 처리시간 0.028초

Analysis of Protease and Antiprotease Concentrations in Retired Workers Exposed to Inorganic Dusts

  • Shin, Jae-Hoon;Hwang, Joo-Hwan;Lee, Kyung-Myung;Lee, Jong-Seong;Lee, Jeong-Oh;Choi, Byung-Soon;Kim, In-Sik
    • 대한의생명과학회지
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    • 제15권4호
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    • pp.309-317
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    • 2009
  • Occupational exposure to inorganic dusts such as coal and silica has been identified as a chronic obstructive pulmonary disease (COPD) risk factor. This risk factor causes lung inflammation and protease-antiprotease imbalance. This abnormal inflammatory response of the lung induces parenchymal tissue destruction and leads to progressive airflow limitation that is characteristics of COPD. The aim of this study was to determine the relationship of proteases such as neutrophil elastase (NE) and matrix metalloproteinase (MMP)-9 and antiproteases such as alpha-1 antitrypsin (AAT) and tissue inhibitors of metalloproteinase (TIMP)-1 with lung function. The study population contained 223 retired workers exposed to inorganic dusts. We performed lung function test, including percent of forced expiratory volume in one second ($%FEV_1$) predicted and $%FEV_1$/forced vital capacity (FVC). We analyzed serum MMP-9, AAT, TIMP-1 and plasma NE concentrations by sandwich enzyme immunoassay. NE, AAT, and TIMP-1 concentrations in workers, who had $%FEV_1$<80% predicted, were higher than those of workers who had $%FEV_1{\geq}80%$ (P<0.05). Both AAT and TIMP-1 concentrations in workers with airflow limitation were higher than those of workers with normal airflow (P<0.05). $%FEV_1$ predicted showed significant negative correlation with AAT (r=-0.255, P<0.0l), TIMP-1 (r=-0.232, P<0.01), and NE (r=-0.196, P<0.01). $%FEV_1$/FVC predicted showed significant negative correlation with NE (r=-0.172, P<0.05). From the results of stepwise multiple regression analysis about $%FEV_1$ and $%FEV_1$/FVC, significant independents were NE (r=-0.135, P=0.001) and AAT (r=-0.100, P=0.013) in $%FEV_1$, and NE (r=-0.160, P=0.014) in $%FEV_1$/FVC. In the present study, there were significant correlations between airflow limitation and protease concentration and between airflow limitation and antiprotease concentration. Serum protease and antiprotease concentrations, however, may be affected by the biological and inflammatory responses. It is necessary to evaluate specimens more reflected the effects of proteases and antiproteases in the lung such as lung tissue, bronchoalveolar lavage fluid, and exhaled breath condensate (EBC).

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Revisiting Prediction Tools for Daylight Adequacy and Its Potential Improvement

  • Kim, Dong Hyun
    • KIEAE Journal
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    • 제17권3호
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    • pp.35-44
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    • 2017
  • Purpose: This study questioned the efficiency of daylight factor as a daylight adequacy and investigated a method of how to complement its weakness by considering a direct sunlight component under a clear sky condition. Method: The Snowdon visitor centre cafe was chosen as a case study building and various techniques such as BRE formula, BRE sky protractor, Pilkington dot diagram and mock-upscale model under the artificial sky simulator were used to analyse and compare daylight factor values. An analysis of direct sunlight component under the clear sky condition was carried out by Climate Consultant 5.5, sun path diagram, and the artificial sky simulator. Result: The result of daylight factor analysis differed by the adopted techniques and it was also contradictory to the results on a direct sunlight penetration. The result not only showed the limitation of daylight factor as a metric but also suggested an improvement by combining it with direct sunlight analysis. The techniques used in this study had a merit of being applied in the early design stage and thus be beneficial to many design professions in order for early daylight performance analysis.

On the Use of Adaptive Weights for the F-Norm Support Vector Machine

  • Bang, Sung-Wan;Jhun, Myoung-Shic
    • 응용통계연구
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    • 제25권5호
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    • pp.829-835
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    • 2012
  • When the input features are generated by factors in a classification problem, it is more meaningful to identify important factors, rather than individual features. The $F_{\infty}$-norm support vector machine(SVM) has been developed to perform automatic factor selection in classification. However, the $F_{\infty}$-norm SVM may suffer from estimation inefficiency and model selection inconsistency because it applies the same amount of shrinkage to each factor without assessing its relative importance. To overcome such a limitation, we propose the adaptive $F_{\infty}$-norm ($AF_{\infty}$-norm) SVM, which penalizes the empirical hinge loss by the sum of the adaptively weighted factor-wise $L_{\infty}$-norm penalty. The $AF_{\infty}$-norm SVM computes the weights by the 2-norm SVM estimator and can be formulated as a linear programming(LP) problem which is similar to the one of the $F_{\infty}$-norm SVM. The simulation studies show that the proposed $AF_{\infty}$-norm SVM improves upon the $F_{\infty}$-norm SVM in terms of classification accuracy and factor selection performance.

한국판 자기자비 척도의 요인 타당성 연구 (Study of Factor Validity of Korean Version Self-Compassion)

  • 구도연;정민철
    • 한국콘텐츠학회논문지
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    • 제16권9호
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    • pp.160-169
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    • 2016
  • 자기자비 척도(Self-Compassion Scale: SCS)는 Neff(2003a)에 의해 개발되었고, 국내에서는 김경의, 이금단, 조용래, 채숙희, 이우경(2008)에 의해 번안 및 타당화 되었다. 하지만, 원척도와 한국판 자기자비 척도가 대학생만을 대상으로 타당화 한 제한점이 있고, 자기자비 척도의 요인 구조가 일관되지 않는다는 국외 연구 결과도 보고되고 있다. 따라서 본 연구에서는 18세에서 79세의 성인 435명을 대상으로 설문한 자료를 바탕으로 자기자비 척도의 요인 타당성을 검증하였다. 이를 위해 탐색적 요인분석과 확인적 요인분석을 실시하였고, 확인적 요인분석에서는 2요인, 3요인, 6요인 구조 세 가지 모형으로 구성하여 모델의 적합도를 비교 검증하였다. 분석결과, 탐색적 요인분석에서 6개의 요인이 나타났으며, 확인적 요인분석에서도 6요인 구조가 가장 적합한 것으로 나타났다.

슬라이닥을 이용하는 전압 제어 방식의 역률보상시스템 개발 (Development of Voltage Controlled Power Factor Compensation System using Slidac)

  • 정상현;이현우;박영균;박철우
    • 전자공학회논문지
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    • 제54권8호
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    • pp.115-122
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    • 2017
  • 본 논문에서는 슬라이닥을 이용하는 새로운 역률보상시스템을 제안한다. 제안하는 역률보상시스템은 슬라이닥의 출력전압을 커패시터에 인가하여 역률을 보상하는 구조이다. 기존의 커패시터 뱅크 방법을 이용하는 역률보상시스템은 선택 가능한 커패시터 용량이 한정되어 있어 부하 상황에 따라 역률 보상 오차가 발생하지만, 제안 시스템은 커패시터 인가 전압을 슬라이닥을 이용하여 세밀하게 변화시킬 수 있어 변화하는 부하를 추종하여 오차 없이 역률을 100%까지 보상할 수 있다. 기존 시스템과 제안 시스템을 비교하여 제시하고, 제안 시스템의 역률 보상 성능이 우수함을 모의실험과 실험을 통해 확인한다. 제안 시스템을 수용가에 설치할 경우 역률 개선을 통한 전기료 감소, 선로손실 감소, 부하 용량 증대 효과가 기대된다. 특히 발전 사업가측에서는 역률 보상 성능의 향상으로 송전 여유 용량 확보와 발전량 절감이 가능하다.

일회성 티켓을 필요로 하는 사용자에게 동기화된 시계를 요구하지 않는 방식의 Kerberos

  • 김해영;한상근
    • Journal of the Korean Society for Industrial and Applied Mathematics
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    • 제3권1호
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    • pp.17-29
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    • 1999
  • The reliable authentication of a communicating party and a network component is an essential factor to achieve the security in a computer network. The Kerberos Authentication Services has been the most successful solution which is widely used today but its requirement for synchronized clocks has been a serious limitation to use it. In this paper we presented an extended Kerberos method which avoids the synchronization requirement for a single-time ticket user. We modified the Kerberos protocol minimally by replacing the synchronization requirement with the challenge-response method.

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경영정보의 인과구조 구축을 위한 다변량통계기법 적용에 관한 연구 (A study on applying multivariate statistical method for making casual structure in management information)

  • 조성훈;김태성
    • 한국경영과학회:학술대회논문집
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    • 한국경영과학회 1996년도 추계학술대회발표논문집; 고려대학교, 서울; 26 Oct. 1996
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    • pp.117-120
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    • 1996
  • The objective of this study is to suggest modified Covariance Structure Analysis that combine with existing Multivariate Statistical Method which is used Casual Analysis Method in Management Information. For this purpose, we'll consider special feature and limitation about Correlation Analysis, Regression Analysis, Path Analysis and connect Covariance Structure Analysis with Statistical Factor Analysis so that theoretical casual model compare with variables structure in collecting data. A example is also presented to show the practical applicability of this approach.

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신제품의 품질차원 분류에 관한 연구 (A Study on the Dimensions of Quality of New Products)

  • 강준모;박영택
    • 품질경영학회지
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    • 제27권2호
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    • pp.20-46
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    • 1999
  • Many researches have concluded that product advantage or superiority is the most important factor for the commercial success of new products. However, the specific dimensions of product advantage have not been studied as yet. Based on a survey of newly introduced products in recent years, we suggest the eight dimensions of quality of new product: function, time, limitation, usability, problem prevention, economy, maintainability, nativeness. The dimensions and their constituents are explained with examples.

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DYNAMIC WEDGE의 임상 적용 가능성에 관한 고찰

  • 김영범;정세영;황웅구
    • 대한방사선치료학회지
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    • 제7권1호
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    • pp.103-110
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    • 1995
  • Dynamic wedge system has been introduced to modify the beam profile and to make homogeneous isodose curves in the mass of irregular shape. Before the clinical use of dynamic wedge, several factors such as wedge transmission factor, dose profile, percent depth dose, and wedge angle have to be measured quantitatively. Film dosimetry is used to evaluate these factors in this study. A comparison of the result of the dynamic wedge to physical wedge system is made. A positive result for the application of the dynamic wedge to clinic is derived even though there is a limitation in accuracy of the dosimetry system used. To measure all factors quantitatively, more accurate dosimetry systems are required.

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Solution of periodic notch problems in an infinite plate using BIE in conjunction with remainder estimation technique

  • Chen, Y.Z.
    • Structural Engineering and Mechanics
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    • 제38권5호
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    • pp.619-631
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    • 2011
  • This paper provides a complex variable BIE for solving the periodic notch problems in plane plasticity. There is no limitation for the configuration of notches. For the periodic notch problem, the remainder estimation technique is suggested. In the technique, the influences on the central notch from many neighboring notches are evaluated exactly. The influences on the central notch from many remote notches are approximated by one term with a multiplying factor. This technique provides an effective way to solve the problems of periodic structures. Several numerical examples are presented, and most of them have not been reported previously.