• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.04a
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• pp.38-40
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• 1995

There have reports suggested that cerebral blood flow (CBF) has decreased in patients with both senile dementia of the Alzheimer's type and multi-infarct dementia, which are characterized by marked cognitive impairments. In addition, recent studies have demonstrated that decrease of CBF precedes the onset of multi-infarct dementia. These findings further suggest that chronic reduction of CBF may play an important role in the formation and progression of cerebral vascular dementia. Although transient cerebral ischemia, based upon vascular “reperfusion”, is apparently not paralleling the clinical condition, the transient cerebral ischemia model is one of the major methods investigated and the other is the cerebral embolism operation. Cognitive impairment and neuronal damages have been fully studied using these transient and/or embolic ischemia models. There are, however, few investigations focused the attention on the influence of chronic decrease of CBF on cognitive processes. In the present study, we have chosen a chronic ischemic model which is produced by permanent occlusion of bilateral common carotid arteries (2VO) in rats to investigate the neuronal damage and cognitive deficits through radial maze performance. We investigated furtherly the effects of tetramethylpyrazine (TMP), a constituent isolated from Ligusticum Chuanxiong on such a model.

• The Korean Journal of Mycology
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• v.47 no.2
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• pp.113-120
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• 2019

We isolated endophytic fungal strains from the roots of three medicinal crops, Ligusticum chuanxiong, Angelica gigas, and Cnidium officinale, cultivated at Yeongju, Korea. The fungal strains were identified based on their morphological characteristics and molecular analyses of their internal transcribed spacer, large subunit rDNA, and beta-tubulin regions. Thereby, we identified three previously unrecorded endophytic fungal species, Dactylonectria pauciseptata, Rhizopycnis vagum, and Sistotrema sernanderi, in Korea. In this report, we describe the morphological characteristics and phylogenetic analyses of these three fungal species.

• The Journal of Pediatrics of Korean Medicine
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• v.32 no.1
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• pp.30-43
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• 2018

Objectives The purpose of this study is to analyze the clinical research literature of TCM (traditional Chinese medicine) which is applicable to pediatric fracture and to broaden the field about clinical application of Korean medicine treatment for pediatric fracture. Methods We searched randomized controlled trials about TCM treatment of pediatric fracture from the CNKI (China National Knowledge Infrastructure) January 2013 to December 2017. We searched the literature and analyzed the treatment methods and the results. Results 31 papers were selected from 63 studies. In most studies, the total effective rate of the treatment group was significantly higher than that of the control group, and the bone healing time of the treatment group was significantly lower than that of the control group. Methods of herb treatment include internal medicine (IM), fumigation (FG) and external application (EA). The most commonly used herb medicine were Angelicae Gigantis Radix (當歸), Carthami Flos (紅花), Drynaria Fortunei (骨碎補), Paeonia Lactiflora Pallas (芍藥), Persicae Semen (桃仁), Lycopodii Herba (伸筋草), Ligusticum Chuanxiong Hort (川芎), Olibanum (乳香), Salviae Miltiorrhizae Radix (丹蔘), and Panax Noto Ginseng (三七). Conclusions The use of herb medicine in pediatric fractures has resulted in faster and more effective restoration of fracture union than the Western medical therapy alone. Based on the results of this study, it is possible to widen the scope of Korean medicine if additional clinical studies on pediatric fracture were conducted.

• Journal of Acupuncture Research
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• v.37 no.1
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• pp.35-41
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• 2020

The aim of this study was to examine pharmacopuncture treatment for lateral epicondylitis, and to contribute to developing a standardized treatment regimen by reviewing trends in clinical trials. Five randomized controlled trials, 1 case-control study, and 8 cohort studies published after 1999, that involved pharmacopuncture for lateral epicondylitis, were selected from Korean and international online databases (n = 8). The type of pharmacopuncture, dose, frequency, efficacy, and adverse events were analyzed. Seven types of pharmacopuncture were used, namely Bee Venom, Illicium henryi Diels, Akebiae Caulis, Angelicae sinensis Diels, Ligusticum chuanxiong Hort, Hominis Placenta, and Salviae Miltiorrhizae Radix. Dose, treatment duration, and treatment frequency varied widely. One study assessed the treatment efficacy according to frequency. Nine studies lacked data on adverse events. The quality of 5 randomized controlled trials was low. Although pharmacopuncture treatment appeared to be effective for lateral epicondylitis, it was difficult to standardize the regimen for lateral epicondylitis.

• The Korea Journal of Herbology
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• v.37 no.6
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• pp.29-36
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• 2022

Objectives : The objective of this study was to investigate the possibility for the treatment of hypertension of herbal medicines belong to Umbelliferae family. Methods : Domestic and international articles about Herbology were investigated. A review was performed via the database (DB) search engines such as Pubmed, Korean studies Information Service System (KISS), KoreaScience, and Google Scholar. Hypertension-related terms including "vasorelaxation", "vasorelaxant", "vasodilation", "vasodilatory", "vasodilative", "hypotension", and "hypotensive" were performed as search terms. Results : A list was made about herbal medicines and origin plants belonging to the Umbelliferae family in Korean Pharmacopoeia 12 and Korean Herbal Pharmacopoeia. 14 herbal medicine and 22 origin plants were searched. Ostericum koreanum root and rhizome, Notopterygium incisum root and rhizome, N. forbesii root and rhizome, Ligusticum tenuissimum root and rhizome, L. jeholense root and rhizome, Angelica gigas root, A. dahurica root, A. dahurica var. formosana root, Bupleurum falcatum root, Peucedanum japonicum root, P. praeruptorum root, A. decursiva root, Cnidium officinale rhizome, L. chuanxiong rhizome, Foeniculum vulgare fruit, and Ferula assa-foetida resin and stem showed significant vasorelaxant or hypotensive effects. Conclusion : These review results showed that Osterici seu Notopterygii Radix et Rhizoma, Ligustici Tenuissimi Rhizoma et Radix, Angelicae Gigantis Radix, Angelicae Dahuricae Radix, Bupleuri Radix, Peucedani Japonici Radix, Peucedani Radix, Cnidii Rhizoma, Foeniculi Fructus, and Ferulae Resina had vasorelaxant or hypotensive effects. The results are expected as basic data in clinical trials and experimental researches for the treatment of hypertension of herbal medicines.

• Korean Journal of Medicinal Crop Science
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• v.2 no.3
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• pp.181-186
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• 1994

Vegetative node and rhizome of Ligusticum chuanxiong Hort. were planted in spring and autumn and harvested after one and two years to determine the appropriate harvesting time which produced a high yield. Plant height, leaf number and branch number per plant were increased in order of rhizome planted in spring and harvested after two year(RST), rhizome planted in autumn and harvested after one year(RAO), vegetative node planted in autumn and harvested after one year(VNAO), and vegetative node planted in spring and harvested after one year(VNSO). Leaf area index and dry leaf weight in VNSO were highest on August 16, but dry weights of stem and rhizome was increased until harvesting time. The appropriate harvesting time was October 17, in RST, November 9 in RAO and VNAO, and November 13 in VNSO. Yield in autumn planting was more increased than that in spring planting and also that in RST was 443kg per 10a and increased by 2.8 times compared to RAO. However the yield in the rhizome planting was more increased by 17 percent than the vegetative node planting, the latter planting was inexpensive and economic for purchasing seed materials.

• Korean Journal of Soil Science and Fertilizer
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• v.29 no.1
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• pp.20-25
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• 1996

This survey was conducted to investigate the chemical properties of soils cultivated medicinal plants. The soils were collected at 254 sites(Angelica gigas : 81, Astragalus membranceus : 38, Platycodn glandiflorum : 36, Paeonia albiflora : 34, Codonopsis lanoceolata : 32, Ligusticum chuanxiong : 17. Bupleurum falcatum : 16, respectively) throughout the country by 0-15cm depth. The chemical properties of soils were pH 5.6, O.M 3.0%. Av.$P_2O_5$ : 405 mg/kg, Ex.K : $0.67cmol^+/kg$, Ex.Ca : $6.3cmol^+/kg$, Ex.mg : $1.6cmol^+/kg$. The percentage distribution of pH on the basis of soil sample numbers were much more at the 5.1-6.0 range than any other ranges, especially those of below pH 6.0 were 83-91% for Angelica gigas, Platycodn glandiflorum and Codonopsis lanoceolata. The distribution of OM and Av.$P_2O_5$ in soils were much at the 2.1-4.0% and above 500mg/kg ranges, respectively. And the content of those in soils cultivated with Platycodn glandiflorum were lower than any other medicinal plants. The distribution of exchangeable cations in soils were much at the 0.2-0.8, 2.1-4.0 and $0.5-2.0cmol^+/kg$ of Ex.K. Ca and mg. respectively, and the contents were higher in soils cultivated Astragalus membranceus. and lower in soils cultivated Platycodn glandiflorum and Codonopsis lanoceolata than any other samples.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.43 no.2
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• pp.125-135
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• 2017

The purpose of this study is verification of the anti-oxidant effect and anti-inflammatory effect of Eggplant-cheongyeolsodokum composed of 8 herbs (Solanum melongena L., Lonicera japonica Thunb., Glycyrrhiza uralensis Fisch., Ligusticum chuanxiong Hort., Angelica gigas Nakai., Coptis deltoidea C. Y. Cheng et Hsiao., Gardenia jasminoides J. Ellis., Forsythia suspensa Vahl) to confirm the possibilities as useful cosmetic material. We used the modified prescription of 'cheongyeolsodokum' contained in Korean traditional medical book 'Donguibogam' as composition of Eggplant-cheongyeolsodokum and their proportions. Eggplant-cheongyeolsodokum were extracted with hot water, 70% ethanol and then powdered. To confirm anti-oxidant effect, we investigated radical scavenging ability (DPPH, $ABTS^+$, superoxide), superoxide dismutase (SOD)-like activity, total polyphenolic contents. Also to confirm anti-inflammatory effect, we investigated inhibition effect of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, and Inhibition effect of the expression of inflammatory-related proteins (iNOS, COX-2) by western blot analysis. As a result, Eggplant-cheongyeolsodokum showed good anti-oxidant and anti-inflammation effects, we suggest that it can be used as an active ingredient for cosmetics.

• Korean Journal of Soil Science and Fertilizer
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• v.29 no.2
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• pp.158-164
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• 1996

This survey was conducted to investigate the distribution of heavy metal contents in medicinal plants and soils. Plant and soil samples were collected at 254 sites(Angelica gigas : 81, Astragalus membranceus : 38, Platycodn glandiflorum : 36, Paeonia albilora : 34, Codonopsis lanoceolata : 32, Ligusticum chuanxiong : 17, Bupleurum falcatum : 16, respectively) over the country, Soil texture, pH values and heavy metal content of soils and medicinal plants were evaluated as major factors. Soil texture classification showed that sandy loam, loam, loamy sand and silt loam were 46.1%, 26.0%, 19.3% and 8.6% of the total, respectively. The contents of O.M, Ex.Ca. Ex.Mg and EC value were higher in loamy(sandy loam, loam and silt loam)soils than in sandy(loamy sand)soils, but available $P_2O_5$ contents of loamy sand soils were higher than those of sandy loam, loam, and silt loam. The contents of Cd, Cu, Pb, Zn and Ni in soil were high in loamy soils, while Cr content was high in loamy silt soils. The contents of Cu and Cr in Angelica gigas were high in loamy soils, and those of Pb in Astragalus membranceus, Paeonia albiflora and Codonopsis lanoceolata were high in sandy loam soils. Correlation coefficients between heavy metal contents in medicinal plants and their soils with soil texture were positively correlated in sandy loam and loam at Cu, loam at Zn, sandy loam, loam and loamy sand at Cr, respectively. Correlation coefficients between pH value of the soils and contents of Cd, Zn and Ni in medicinal plants were negatively correlated, but those of Cd, Pb, Zn and Ni in soils were positively correlated.