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http://dx.doi.org/10.15230/SCSK.2017.43.2.125

Study on Anti-oxidant and Anti-inflammatory Activity of Eggplant-cheongyeolsodokum  

Yoon, Jong-Moon (Department of Cosmeceutical Science, Daegu Haany University)
Kim, Dong-In (Department of Cosmeceutical Science, Daegu Haany University)
Lee, Ji-Hae (Department of Cosmeceutical Science, Daegu Haany University)
Han, So-Jung (Department of Cosmeceutical Science, Daegu Haany University)
Kim, Ha-Eun (Department of Cosmeceutical Science, Daegu Haany University)
Kim, Hyeon-Jeong (Institute of Technology, Herbnoori Co., Ltd.)
Nam, Kyu-Woo (THANK YOU FARMER Co., Ltd.)
Park, Ji-Yeon (THANK YOU FARMER Co., Ltd.)
Chi, Gyeong-Yup (Department of Cosmeceutical Science, Daegu Haany University)
An, Bong-Jeun (Department of Cosmeceutical Science, Daegu Haany University)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.43, no.2, 2017 , pp. 125-135 More about this Journal
Abstract
The purpose of this study is verification of the anti-oxidant effect and anti-inflammatory effect of Eggplant-cheongyeolsodokum composed of 8 herbs (Solanum melongena L., Lonicera japonica Thunb., Glycyrrhiza uralensis Fisch., Ligusticum chuanxiong Hort., Angelica gigas Nakai., Coptis deltoidea C. Y. Cheng et Hsiao., Gardenia jasminoides J. Ellis., Forsythia suspensa Vahl) to confirm the possibilities as useful cosmetic material. We used the modified prescription of 'cheongyeolsodokum' contained in Korean traditional medical book 'Donguibogam' as composition of Eggplant-cheongyeolsodokum and their proportions. Eggplant-cheongyeolsodokum were extracted with hot water, 70% ethanol and then powdered. To confirm anti-oxidant effect, we investigated radical scavenging ability (DPPH, $ABTS^+$, superoxide), superoxide dismutase (SOD)-like activity, total polyphenolic contents. Also to confirm anti-inflammatory effect, we investigated inhibition effect of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, and Inhibition effect of the expression of inflammatory-related proteins (iNOS, COX-2) by western blot analysis. As a result, Eggplant-cheongyeolsodokum showed good anti-oxidant and anti-inflammation effects, we suggest that it can be used as an active ingredient for cosmetics.
Keywords
anti-oxidant; anti-inflammatory; RAW264.7 cell; polyphenol; cosmetics;
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