• Title/Summary/Keyword: Life-long effects

Search Result 747, Processing Time 0.025 seconds

The Korean Traditional Medicine Gyeongshingangjeehwan Reduces Lipid Accumulation in Skeletal Muscle and C2C12 Cells

  • Yoon, Mi-Chung
    • Biomedical Science Letters
    • /
    • v.17 no.4
    • /
    • pp.283-289
    • /
    • 2011
  • Our previous study demonstrated that the Korean traditional medicine Gyeongshingangjeehwan (GGEx) activates AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor ${\alpha}$ ($PPAR{\alpha}$) critical for fatty acid oxidation in skeletal muscle and C2C12 skeletal muscle cells. Thus, we examined whether GGEx can reduce lipid accumulation in these cells and tissues. After obese and type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats were treated with GGEx, we studied the effects of GGEx on skeletal muscle lipid accumulation. The effects of GGEx and/or the AMPK inhibitor compound C on lipid accumulation and expression of AMPK and $PPAR{\alpha}$ were measured in C2C12 skeletal muscle cells. Compared with lean Long-Evans Tokushima Otsuka rats, obese OLETF rats had increased triglyceride droplets. However, administration of GGEx to OLETF rats for 8 weeks significantly decreased triglyceride droplets in skeletal muscle. Consistent with the $in$ $vivo$ data, GGEx inhibited lipid accumulation, the degree of which was comparable to Wy14,643, the potent activator of $PPAR{\alpha}$. GGEx also increased skeletal muscle mRNA levels of AMPK${\alpha}1$, AMPK${\alpha}2$, and $PPAR{\alpha}$. However, compound C inhibited these effects in C2C12 cells. These results suggest that GGEx suppresses skeletal muscle lipid accumulation and this process may be mediated by AMPK and $PPAR{\alpha}$ activation.

Effects of Music Therapy and Rhythmic Exercise on Quality of Life, Blood Pressure and Upper Extremity Muscle Strength in Institution-Dwelling Elderly Women (음악요법과 율동운동이 시설 여성노인의 삶의 질, 혈압 및 상지근력에 미치는 효과)

  • Jeon, Eun-Young;Kim, Sook-Young;Yoo, Hyun-Suk
    • Journal of Korean Academy of Nursing
    • /
    • v.39 no.6
    • /
    • pp.829-839
    • /
    • 2009
  • Purpose: The purpose of this study was to determine the effects of music therapy and rhythmic exercise on health related quality of life, blood pressure and upper extremity muscle strength in the institution-dwelling elderly women. Methods: The study was designed using a nonequivalent control group pretest-posttest design. The participants consisted of 35 elders (18 in the experimental group and 17 in the control group). The music therapy and rhythmic exercise were developed by the investigators. The experimental group took part in this program twice a week for 8 weeks. The Short Form 36 health survey questionnaire, blood pressure and grasp power scale were used as instruments. The data were analyzed using SPSS 14.0. Results: Repeated measures ANOVA revealed that music therapy and rhythmic exercise had positive effects on quality of life, especially on vitality, general health and mental health. Also, there were statistically significant differences in diastolic blood pressure and upper extremity muscle strength between the pretest and posttest in the experimental group. Conclusion: The study suggests that this program can be applied for older women in long-term facilities to improve quality of life, blood pressure and upper extremity muscle strength.

A Meta-Analysis on the Effects of Mind-Body Therapy on Patients with Irritable Bowel Syndrome (심신요법이 과민성 장증후군 환자에 미치는 효과에 대한 메타분석)

  • Choi, Eun Hui;Kim, Moon Ja;Lee, Eun Nam
    • Journal of Korean Academy of Nursing
    • /
    • v.50 no.3
    • /
    • pp.385-400
    • /
    • 2020
  • Purpose: Previous randomized controlled trials (RCT) found that mind-body therapy can improve the health outcomes of patients with irritable bowel syndrome (IBS). The purpose of this meta-analysis was to identify the combined effects of mind-body therapy on patients' IBS symptoms, quality of life, anxiety, and depression. Methods: A systematic literature search was conducted using various databases such as PubMed, EMBASE, CINAHL CENTRAL, DBpia, RISS, and KISS. The primary outcome variables were IBS symptoms and quality of life; the secondary outcome variables were anxiety and depression. Comprehensive Meta-Analysis version 3.0 was used to analyze the extracted data. The effect size was calculated using standardized mean difference (SMD) and 95% confidence interval (CI). Results: Eleven final RCTs were used for this meta-analysis. Mind-body therapy was found to have a significant effect on the IBS patients' symptoms (SMD, -0.63; 95% CI, -0.77 to -0.48), quality of life (SMD, 1.03; 95% CI, 0.40 to 1.66), anxiety (SMD, -0.28; 95% CI, -0.47 to -0.09), and depression (SMD, -0.31; 95% CI, -0.06 to -0.12). Conclusion: This meta-analysis reveals that mind-body therapy significantly improves IBS patients' symptoms, quality of life, anxiety, and depression. The results suggest that, in the future, appropriate mind-body therapy should be applied to Koreans suffering from IBS. Moreover, the therapy's long-term effects should be assessed.

Effects of Tai Chi Exercise on Cardiovascular Risk Factors and Quality of life in Post-menopausal Women (타이치 운동이 폐경기 여성의 심혈관 위험도와 삶의 질에 미치는 효과)

  • Song, Rha-Yun;Ahn, Suk-Hee;So, Hee-Young;Park, In-Sook;Kim, Hyun-Li;Joo, Kyung-Ok;Kim, Jong-Sung
    • Journal of Korean Academy of Nursing
    • /
    • v.39 no.1
    • /
    • pp.136-144
    • /
    • 2009
  • Purpose: Natural menopause resulting in the decline in endogenous estrogen concentrations is responsible for an increased risk of coronary heart disease in postmenopausal women. The purpose of the study was to examine the effects of a 6-month Tai Chi exercise program on cardiovascular risk factors and quality of life in post-menopausal women. Methods: A quasi-experimental design with pretest and posttest measures was used. The participants in the study, 29 women in the Tai Chi group and 31 in the control group, were enrolled for 6 months. Results: After 6 months of Tai Chi exercise, total cholesterol (M=213 to 185), LDL-cholesterol (M=135 to 128), and their 10 yr cardiovascular disease risk (M=2.62 to 2.27) had improved significantly for the Tai Chi participants compared to the control group. Total scores for quality of life along with the sub-dimensions of health perception and mental functioning were also significantly higher in the Tai Chi participants. Conclusion: Tai Chi exercise favorably affected cardiovascular health and quality of life in post-menopausal women after 6 months. Additional rigorous studies are needed to examine long term effects on the prevention of cardiovascular disease in this population.

Effects of Heating Temperature and Time on the Mechanical Properties of Heat-Treated Woods

  • Won, Kyung-Rok;Hong, Nam-Euy;Park, Han-Min;Moon, Sun-Ok;Byeon, Hee-Seop
    • Journal of the Korean Wood Science and Technology
    • /
    • v.43 no.2
    • /
    • pp.168-176
    • /
    • 2015
  • This study was performed to investigate the effects of heat treatment the on mechanical properties of two species of wood under different heating conditions including at $180^{\circ}C$ for 12 h and 24 h, and at $210^{\circ}C$ for 3 h and 6 h. Two species of wood, Pinus densiflora and Larix kaempferi, were exposed to different heat treatments to assess the effects on the volume change, bending properties in static and dynamic mode and compressive strength. The results showed heat treatment caused significant changes in mechanical properties such as the static and dynamic moduli of elasticity ($MOE_d$ and $MOE_s$), and the modulus of rupture (MOR). The volume of the wood after heat treatment decreased as the heating temperature and time were increased. The bending strength performance of the wood after heat treatment decreased as the heating temperature and time were increased. The effect of heat treatment at a high temperature on the bending MOR was greater in both species than that for a long time. However, the compressive strengths of all the heat-treated samples were higher than the control sample. Furthermore, highly significant correlations between $MOE_d$ and MOR, and $MOE_s$ and MOR were found for all heating conditions.

The Effect of Job Stress on the Quality of Life of Y oung Farmers - Moderating Effects of Work Hours - (청년농업인의 직무스트레스가 삶의 질에 미치는 영향 - 근로시간의 조절효과 -)

  • Jung Shin Choi;Yoon Ji Choi;Joo Lee Son;Yong Kyu Park
    • Journal of Agricultural Extension & Community Development
    • /
    • v.30 no.2
    • /
    • pp.69-82
    • /
    • 2023
  • This study aims to examine the moderating effects of work hours between job stress and quality of life of young farmers. A survey was conducted on 618 young farmers for one month from July 1, 2022. The main analysis results are as follows. First, quality of life and job stress, quality of life and work hours had a negative correlation, and job stress and work hours had a positive correlation. Second, work hours were found to have a moderating effect on the relationship between job stress and quality of life. Third, as a result of identifying the area of significance of work hours, it was found that work hours played a role in moderating the relationship between quality of life and job stress when work hours were longer than 1.327 hours. Fourth, as a result of visualizing the moderating effect by dividing work hours into three groups: high, medium, and low, it was found that even if the level of job stress was the same, the farmers with long work hours perceived their quality of life to be worse than those with shorter work hours. It can be said that in order for young farmers to settle down and live stably in agriculture and rural areas as professionals, it is very important to actively develop and support policies to improve the working environment in the agricultural sector that can secure time to enjoy culture and leisure and relieve job stress.

Relationship Between Status of Physical and Mental Function and Quality of Life Among the Elderly People Admitted from Long-Term Care Insurance (장기요양 인정자의 신체적 및 정신적 기능 상태와 삶의 질과의 관계)

  • Kim, Hyeong-Seon;Bae, Nam-Kyou;Kwon, In-Sun;Cho, Young-Chae
    • Journal of Preventive Medicine and Public Health
    • /
    • v.43 no.4
    • /
    • pp.319-329
    • /
    • 2010
  • Objectives: This study was performed to determine the levels of quality of life (QOL) according to the grade of long-term care service for the elderly people who were admitted from long-term care insurance, and to reveal its association with the physical and mental functioning such as the Activity of Daily Living (ADL), the Instrumental Activity of Daily Living (IADL), the Center for Epidemiologic Studies Depression Scale (CES-D), and the Mini-Mental State Examination-Korean version (MMSE-K). Methods: The interviews were performed during the period from March 1 to May 31, 2009, for 958 elderly people in urban and rural areas. The questionnaire items included various indices such as the ADL, IADL, CES-D, and MMSE-K, as independent variables and the index of QOL, as the dependent ones. For statistical analysis, t-tests were used for the mean scores of QOL according to gender and the grade of long-term care services, and Spearman's correlation was used for each variable. The effects of physical and mental functioning for QOL were assessed by covariance structure analysis. The statistical significance was set at p<0.05. Results: The mean scores of QOL among all the subjects was $55.4{\pm}15.62$ (Grade I: $49.7{\pm}14.17$, Grade II: $56.8{\pm}14.62$, Grade III: $59.4{\pm}16.36$), and it was lower according to the higher grade of long-term care insurance. In terms of the correlation matrix of the QOL and the physical and mental function factors, the QOL showed positive correlation with the ADL, IADL and MMSE-K, while it had negative correlation with depression. On the analysis of covariance, mental functioning (depression and the MMSE-K) had a greater influence on the level of QOL than the physical functioning (ADL and IADL). Conclusions: The level of the QOL in the elderly people who were admitted from long-term care insurance was lower according to higher the grade of long-term care insurance. Also, the mental functioning (depression and MMSE-K) was more influential on the level of the QOL than the physical functioning (ADL and IADL).

Die Life Estimation of Hot Forging for Surface Treatment and Lubricants

  • Dong-Hwan;Byung-Min;Chung-Kil
    • International Journal of Precision Engineering and Manufacturing
    • /
    • v.5 no.4
    • /
    • pp.5-13
    • /
    • 2004
  • This study explains the effects of lubricant and surface treatment on the life of hot forging dies. The thermal load and thermal softening, that occur when there is contact between the hotter billet and the cooler dies in hot forging, cause wear, thermal cracking and fatigue, and plastic deformation. Because the cooling effect and low friction are essential to the long life of dies, the proper selection of lubricant and surface treatment is very important in hot forging process. The two main factors that decide friction and heat transfer conditions are lubricant and surface treatment, which are directly related to friction factor and surface heat transfer coefficient. Experiments were performed for obtaining the friction factors and the surface heat transfer coefficients in different lubricants and surface treatments. For lubrication, oil-base and water-base graphite lubricants were used, and ion-nitride and carbon-nitride were used as surface treatment conditions. The methods for estimating die service life that are suggested in this study were applied to a finisher die during the hot forging of an automobile part. The new techniques developed in this study for estimating die service life can be used to develop more feasible ways to improve die service life in the hot forging process.

Effects of Conjugated Linoleic Acid on Body Fat Reduction and Physical Exercise Enhancement of Obese Male Middle School Students (Conjugated linoleic acid의 비만 남자중학생 체지방 감소와 운동력 증진효과)

  • Ha, Yeong-L.;Jeong, So-Bong
    • Journal of Life Science
    • /
    • v.20 no.12
    • /
    • pp.1844-1850
    • /
    • 2010
  • Body fat reducing and physical-activity enhancing effects, along with artherosclerosis improving effects, of conjugated linoleic acid (CLA) were elucidated on obese male middle school students with more than 30% body fat. Twenty-four volunteers were randomly divided into control (placebo, n=12) and CLA treatment (n=12) groups. Subjects were daily fed 6 g CLA (6 capsules, twice a day) or a placebo for 12 weeks. At the end of the experiment, body composition, blood lipid composition and exercise capacities of subjects were measured. CLA significantly reduced body fat content and body mass index (BMI) along with body weight, while the placebo did not have any such effects. Similarly, CLA significantly reduced low-density lipoprotein (LDL)-cholesterol, total cholesterol, and triglyceride, but elevated high-density lipoprotein (HDL)-cholesterol content in blood. Meanwhile, in terms of exercise capacity, there were significant enhancements of trunk flexion, closed-eyes foot balance, standing long jump, shuttle run, and sit-up activities in the CLA treatment group. These results indicate that CLA consumption reduced body fats, improved atherosclerosis factors in blood and improved physical activity of young male obese middle school students, and suggest that CLA could be a useful material for the heath care of obese young men.

MICROMETEOROLOGY IN PADDY FIELD AND ITS APPLICATION TO ESTIMATION OF SPRAY DRIFT

  • J. Y. Rhee;E. S. An;Kim, Y. J.
    • Proceedings of the Korean Society for Agricultural Machinery Conference
    • /
    • 2000.11c
    • /
    • pp.749-756
    • /
    • 2000
  • Chemical application, one of the most important crop management processes happened to cause spray drift, that would threaten farmers in field as well as dwellers in rural region. Spray drift was affected by micro-meteorological parameters. In Korea, a boom sprayer was introduced but good effects of a boom sprayer was not evaluated. A study to evaluate short distance drift characteristics of a boom sprayer in paddy fields has been undergoing and determining wind characteristics in paddy field was the main purpose of this paper. Micro-meteorological information has been pre-requisite information for evaluating drift in both long and short distances or in both theoretical and experimental ways. Wind velocity, Reynolds stresses, turbulence intensity, skewness, kurtosis etc. were evaluated with height from the ground using a 2-dimensional probe and a hot wire anemometer system.

  • PDF