• 보험의학회지
• /
• 제30권1호
• /
• pp.11-20
• /
• 2011

Both the enterically transmitted forms of viral hepatitis, hepatitis A and E are self-limited and do not cause chroni chepatitis. Chronic hepatitis occurs in patients with hepatitis B and C as well as in patients with chronic hepatitis D superimposed on chronic hepatitis B. Chronic hepatitis such as hepatitis B or C is important in terms of insurance underwriting and claims. General review of hepatitis B and C was performed in this article.

• 생명과학회지
• /
• 제11권1호
• /
• pp.43-47
• /
• 2001

A mutant tryptophan synthase $\alpha$-subunit, where Pro28 was replaced with Leu, tends to be expressed in recombinant E. coli. CD and fluorescence spectra of this protein indicate some changes in secondary and tertiary structure. Wild type protein was more or less affected by {TEX}$Ca^{2+}${/TEX} ion in regards of the fluorescent properties of its native, unfolded and intermediate forms, but the mutant protein was not at all. The dramatic structural changes may be related to the aggregation of this mutant protein.

• 대한가정학회지
• /
• 제19권4호
• /
• pp.1-8
• /
• 1981

French Revolution, while re-establishing the political and social structure, had also changed the cultural conditions of French life and manners. clothing, as with other features of daily life, had some characteristic changes, which this article tried to specify and related with the social conditions. Those specific changes pointed out as typical and discussed herewith are: 1. Clothing manipulated as a political identity kit. 2. Simplification of colors and forms of men's costume. 3. Tendency toward uniformity. 4. Clothing as the symbol of political utopia. 5. The attraction of military uniform. 6. Moral decadence.

• 한국식품저장유통학회지
• /
• 제7권2호
• /
• pp.211-217
• /
• 2000

The effects of Citrus flavonoids, hesperetin, hesderidin, naringenin, and naringin, on nonenzymatic lipid peroxidation were studied in three different in vitro experimental models. Hesperetin showed the most antioxidant effect in this experimental condition by measuring the malondialdehyde production using the thiobarbiturate and thiocyanate methods, the lipid peroxidation of microsomal membranes, and DPPH (${\alpha},{\alpha}'-diphenyl-{\beta}-picrylhydrazyl$) method. The antioxidative activity of the flavonoid aglycone forms, hesperetin, Citrus aglycone flavonoid, suggest the most antioxidant effect in this experimental condition, and this effect indicate more potent in the aglycones than their corresponding glycosides.

• 약학회지
• /
• 제55권6호
• /
• pp.473-477
• /
• 2011

Alzheimer's disease (AD), one of the most common forms of dementia, is a progressive neurodegenerative disorder symptomatically characterized by the decline in memory and cognitive abilities. To date, the successful therapeutic strategy to treat AD is to maintain the levels of acetylcholine (ACh) by inhibiting acetylcholinesterase (AChE) to lead five drugs in clinical use. In this study, several coumarin derivatives were designed based on the lead structure of scopoletin and evaluated for their AChE inhibitory activities.

• BMB Reports
• /
• 제40권1호
• /
• pp.15-21
• /
• 2007

Breast cancer is the most common malignancy among women, and mutations in the BRCA1 gene produce increased susceptibility to these malignancies in certain families. In this study, the forward 1-13 exons of breast cancer associated gene BRCA1 were cloned from breast cancer cell line ZR-75-30 by RT-PCR method. Sequence analysis showed that nine BRCA1 splice forms were isolated and characterized, compared with wild-type BRCA1 gene, five splice forms of which were novel. These splice isoforms were produced from the molecular mechanism of 5' and 3' alternative splicing. All these splice forms deleting exon 11b and the locations of alternative splicing were focused on two parts:one was exons 2 and 3, and the other was exons 9 and 10. These splice forms accorded with GT-AG rule. Most these BRCA1 splice variants still kept the original reading frame. Western blot analysis indicated that some BRCA1 splice variants were expressed in ZR-75-30 cell line at the protein level. In addition, we confirmed the presence of these new transcripts of BRCA1 gene in MDA-MB-435S, K562, Hela, HLA, HIC, H9, Jurkat and human fetus samples by RT-PCR analysis. These results suggested that breast cancer associated gene BRCA1 may have unexpectedly a large number of splice variants. We hypothesized that alternative splicing of BRCA1 possibly plays a major role in the tumorigenesis of breast and/or ovarian cancer. Thus, the identification of cancer-specific splice forms will provide a novel source for the discovery of diagnostic or prognostic biomarkers and tumor antigens suitable as targets for therapeutic intervention.

• 한국실내디자인학회논문집
• /
• 제13호
• /
• pp.187-196
• /
• 1997

A Study on the Characteristics of the Modern Chair Design The features of the modern chair design results from the diverse life style unfolded as per the 20th century social structure and the change of the residential space, and new design has been being developed by the scientists and the artists in various fields through their cooperated work in a way. The field of the scientific or technical study and creation of arts can be developed where they can evoke the sympathy in the circumstances under which the various styles of both arts and science meet across, complement crash together, and grow up. The operation which can control in the network of such pluralistic sphere has been needed for a long period and it has been facing the needs from a time and society. The engineering furniture as the counterplan of the above has brought the value of materials into relief to the forms of human life by making the properties of matter the maximum value or changing it. It can be summarized as following characteristics in its materials and forms along as well as the 3 types (handycrafty, mechanical, and ecological expression) in process through the 20th century. 1. Characteristics in Materials elasticity of the chair as per the changes of the flexibility in the steel pipe development of systematic chair using the plasticity of the plywood, plastic, and wire lightweight due to the materials such as aluminum. 2. Formative characteristics formative simplicity for the increase of the function and the quality improvement such as sociality, productivity, environmental and aesthetic nature emphasis on the structure as per the architectural environment and tecniques pursuit of the forms as a container of the human body seeking for the formative values as the cultural symbols coping with the needs from thepluralistic social structure Furniture is not the makeup for convenience sake but most importantexpression as necessaries of our environments. It should identify itself always as per these kind of needs and also it should be able to used to keep the relation of such mutual division, otherwise the purchase of new furniture should be necessary according to every change of the existing situatiov. Our residence doesn't need the specific style but expresses only the properties of the dwellers.

• 한국콘텐츠학회논문지
• /
• 제12권4호
• /
• pp.304-314
• /
• 2012

본 연구는 서울에 거주하면서 여가-신체활동에 참여하는 60세 이상의 노인 여성 211명을 대상으로 삶의 의미, 낙관성 및 행복의 관계를 살펴보았다. 분석은 SPSS WIN 15.0과 AMOS 6.0 프로그램을 이용하여 탐색적-확인적 요인분석, 신뢰도분석, 상관관계 분석, 구조모형분석을 통해 결과를 도출하였다. 그 결과를 제시하면 다음과 같다. 첫째, 삶의 의미를 구성하는 의미발견은 낙관성에 통계적으로 유의미한 정적 영향을 미치는 것으로 나타나 삶의 의미발견을 추구할수록 낙관성도 높아지는 것으로 조사되었다. 의미추구도 낙관성에 통계적으로 유의미한 정적 영향을 미치는 것으로 나타나 삶의 의미발견을 추구할수록 낙관성도 높아지는 것으로 나타났다. 둘째, 낙관성은 행복을 구성하는 긍정적 정서에 통계적으로 유의미한 정적 영향을 미치는 것으로 나타나 여가-신체활동에 참여하는 노인이 낙관적일수록 긍정적 정서도 높아지는 것으로 조사되었다. 또한 여가-신체활동에 참여하는 노인의 낙관성은 부정적 정서에 부적 영향을 미치는 것으로 낙관적일수록 부정적 정서가 감소하는 것으로 조사되었다.

• 한국주거학회논문집
• /
• 제21권6호
• /
• pp.19-29
• /
• 2010

Vernacular houses in Southeast Asia are basically post and beam structures raised on pillars, with gabled roofs. They were designed and built by the people themselves to meet specific needs, accommodating the values, economies and ways of life of cultures that produce them. Their forms and housing cultures are very various according to the country and the region. But based on the common history and culture, the vernacular houses in Southeast definitely have commonality. The purpose of this study is to analyse the commonality and diversity of the vernacular houses in Southeast Asia in the aspect of two different perspectives. One is the climate perspective, for which the analysis was made on the primary characteristics such as the climate, material, structure of the vernacular houses. The other one is the social-cultural perspective which try to find the religion, belief, life style and social and family relationship which controlled the forms of the housing under the surface. As a result, this study summarise and find the outstanding and unique meaning and definition of the vernacular houses in Southeast Asia.

• Journal of Ecology and Environment
• /
• 제34권2호
• /
• pp.237-249
• /
• 2011

Land-use changes due to the socio-economic environment influence landscape patterns and processes, which affect habitats and biodiversity. This study considers the effects of such land-use changes, particularly on the traditional rural "Maeul" forested landscape, by analyzing landscape structure and vegetation changes. Three study areas were examined that have seen their populations decrease and age over the last few decades. Five types of plant life-forms (Raunkier life-forms) were distinguished to investigate ecosystem function. Principle component analysis was used to understand vegetation dynamics and community characteristics based on a vegetation similarity index. Ordination analysis transformed species-coverage data was introduced to clarify vegetation dynamics. Landscape indices, such as area metrics, edge metrics, and shape metrics, showed that spatial heterogeneity has increased over time in all areas. Pinus densiflora was the main land-use plant type in all study areas but decreased over time, whereas Quercus spp. increased. Over a decade, P. densiflora communities shifted to deciduous oak and plantation. These findings indicate that the impact of human activities on the Maeul landscape is twofold. While forestry activities caused heavy disturbances, the abandonment of traditional human activities has led to natural succession. Furthermore, it can be concluded that the type and intensity of these human impacts on landscape heterogeneity relate differently to vegetation succession. This reflects the cause and consequence of patch dynamics. We discuss an approach for sustainable landscape planning and management of the Maeul landscape based on traditional management.