• 제목/요약/키워드: Life degradation

검색결과 1,408건 처리시간 0.035초

Jab1 as a Mediator of Nuclear Export and Cytoplasmic Degradation of p53

  • Lee, Eun-Woo;Oh, Wonkyung;Song, Jaewhan
    • Molecules and Cells
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    • 제22권2호
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    • pp.133-140
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    • 2006
  • Jun activation domain-binding protein 1 (Jab1) is involved in various cellular mechanisms including development in Drosophila and mouse, cell cycle control and signal transduction pathways. Recent studies also determined that Jab1 functions as a nuclear exporter and inducer of cytoplasmic degradation for several proteins including p53, p27, capsid of West Nile virus, and Smad4/7 proteins. In particular, p53 is shown to bind to and to be exported into the cytoplasm by Jab1, which helps to maintain low levels of p53 under normal conditions. This review was undertaken in an effort to understand the biological significance of the homeostasis of p53 as maintained in the presence of Jab1. Based on our observations, we have provided potential mechanistic hypotheses for the nuclear export of p53 in coordination with Jab1 and the role of other factors in these processes.

유류오염 토양 내 석유계 탄화수소 화합물의 분해에 대한 퇴비의 시용 효과 (The Effect of Compost Application on Degradation of Total Petroleum Hydrocarbon in Petroleum-Contaminated Soil)

  • 김성은;김용균;이상몽;박현철;김근기;손홍주;노용동;홍창오
    • 한국환경농학회지
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    • 제34권4호
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    • pp.268-273
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    • 2015
  • 본 연구는 유류로 오염된 토양의 정화를 위한 생물자극법에서 퇴비의 시용효과를 알아보기 위해 실시되었다. TPH로 오염된 토양에 퇴비를 수준별로 처리 한 후 TPH 함량 변화를 관찰 한 결과, 퇴비 처리량이 증가 할수록 토양 내 TPH 함량이 감소하는 경향이 나타났다. TPH 분해율을 알아보고자 퇴비 처리수준에 따른 TPH 함량 변화를 1차와 2차 kinetics 모델에 적용하여 결정계수(R2)를 비교 한 결과 second order kinetic 모델의 결정계수 값이 잘 적용되었다. 퇴비를 처리하였을 때 seond-order kinetic 모델의 reaction rate constant 값은 퇴비를 30 Mg/ha 이상 처리하였을 때 무처리 보다 4배 정도 높게 나타났으며, 퇴비 처리 수준이 높아질수록 그 값은 증가하는 경향을 보였다. 퇴비의 처리량을 증가시킴에 따라 토양 내 미생물의 수는 증가하는 경향을 나타냈다. 또한 퇴비의 처리량은 토양 내 미생물 수와 TPH 함량의 변화와 밀접한 관계가 있음을 보여주었다. 따라서 TPH로 오염된 토양 내 적합한 양의 퇴비 처리는 토양 내 미생물 수를 증가시켜 TPH 함량의 감소를 가속화시킬 수 있을 것으로 판단된다.

토양 수분, 온도, 특성이 imazamethabenz 분해에 미치는 영향 (Effects of Moisture, Temperature, and Characteristics of two Soils on Imazamethabenz Degradation)

  • 주진호
    • 한국토양비료학회지
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    • 제34권4호
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    • pp.245-254
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    • 2001
  • Imazamethabenz 분해에 미치는 토양수분, 온도와 토양특성에 관한 연구를 위하여 두 토양 (1.5% 유기물 함량과 pH 8.0인 Declo sandy loam 토양과 2.1% 유기물 함량과 pH 7.7인 Pancheri silt loam인 토양)이 사용되었다. 토양은 12 주간 조절된 조건 하에서 incubation되었다. 처리는 3개의 토양 수분 (45, 75, 100% field capacity)과 2개의 토양온도로서 factorial arrangement되었다. Imazamethabenz의 분해는 모든 토양수분-토양온도에서 대수직선관계를 나타냈으며, 토양온도와 토양 수분이 증가함에 비례하여 증가되는 경향을 보였다. 토양수분 효과는 토양 수분이 45에서 75%의 field capacity로 증가하였을 때가 75에서 100% 증가한 경우에 비해 더욱 크게 나타났으며, imazamethabenz의 분해는 Pancheri silt loam에서 더욱 빨리 일어났다. X-ray diffraction의 분석에 의하면 Pancheri silt loam 토양은 점토에 hydroxy interlayer를 함유하고 있어, 즉, 보다 적은 양의 imazamethabenz를 흡착할 수 있기 때문에 분해가 빨리 일어난 것이라 생각된다. Imazamethabenz로부터의 첫 번째 생성물인 imazamethabenz acid의 생성은 대부분의 토양수분-토양 온도에서 2차 방정식의 경향을 따랐는데, 초기에는 증가한 후 점치 감소하였다.

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Evaluation of Different Culture Conditions of Clostridium bifermentans DPH-1 for Cost Effective PCE Degradation

  • Humayra Afroze Syeda;Hasegawa Yuki;Nomura Izumi;Chang Young C.;Sato Takeshi;Takamizawa Kazuhiro
    • Biotechnology and Bioprocess Engineering:BBE
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    • 제10권1호
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    • pp.40-46
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    • 2005
  • Clostridium bifermentans strain DPH-1 has already been found to dechlorinate perchloroethylene (PCE) to cis-dichloroethylene (cis-DCE) via trichloroethylene (TCE). In this study, our investigation on different culture conditions of this DPH-1 strain was extended to find a more efficient and cost effective growth medium composition for this DPH-1 strain in bioremediation practices. Temperature dependency of strain DPH-1 showed that the growth starting time and PCE degradation at $15^{\circ}C$ was very slow compared to that of $30^{\circ}C$, but complete PCE degradation occurred in both cases. For the proper utilization of strain DPH-1 in more cost effective bioremediation practices, a simpler composition of an effective media was studied. One component of the culture medium, yeast extract, had been substituted by molasses, which served as a good source of electron donor. The DPH-1 strain in the medium containing molasses, in the presence of $K_{2}HPO_4\;and\;KH_{2}PO_4$, showed identical bacterial multiplication (0.135 mg protein $mL^{-1}h^{-1}$) and PCE degradation rates ($0.38\;{\mu}M/h$) to those of the yeast extract containing medium.

전기이중층커패시터의 가속열화시험 (An Accelerated Degradation Test of Electric Double-Layer Capacitors)

  • 정재한;김명수
    • 한국신뢰성학회지:신뢰성응용연구
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    • 제12권2호
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    • pp.67-78
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    • 2012
  • An electric double-layer capacitor(EDLC) is an electrochemical capacitor with relatively high energy density, typically hundreds of times greater than conventional electrolytic capacitors. EDLCs are widely used for energy storage rather than as general-purpose circuit components. They have a variety of commercial applications, notably in energy smoothing and momentary-load devices, and energy-storage and kinetic energy recovery system devices used in vehicles, etc. This paper presents an accelerated degradation test of an EDLC with rated voltage 2.7V, capacitance 100F, and usage temperature $-40^{\circ}C{\sim}65^{\circ}C$. The EDLCs are tested at $50^{\circ}C$, $60^{\circ}C$, and $70^{\circ}C$, respectively for 1,750hours, and their capacitances are measured at predetermined times by constant current discharge method. The failure times are predicted from their capacitance deterioration patterns, where the failure is defined as 30% capacitance decrease from the initial one. It is assumed that the lifetime distribution of EDLC follows Weibull and Arrhenius life-stress relationship holds. The life-stress relationship, acceleration factor, and $B_{10}$ life at design condition are estimated by analyzing the accelerated life test data.

난분해성 케라틴 폐기물 처리를 위한 우모 분해 미생물의 분리 및 특성 (Isolation and Characterization of Duck Feather-Degrading Microorganism for Treatment of Recalcitrant Keratinous Waste)

  • 고태훈;정진하;이나리;정성윤;박근태;손홍주
    • 한국환경과학회지
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    • 제21권2호
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    • pp.253-261
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    • 2012
  • We isolated and characterized novel duck feather-degrading bacteria producing keratinase. Twelve strains were isolated from soil and faces at poultry farm, and decayed feathers. They were identified as Bacillus methylotrophicus, Pseudomonas geniculata, Pseudomonas hibiscicola, Exiquobacterium profundum, Bacillus pumilus, Bacillus amyloliquefaciens, Chryseobacterium indologenes, Bacillus thuringiensis, Thermomonas koreensis, respectively, by phenotypic characters and 16S rRNA gene analysis. Generally, the level of keratinase production was not proportional to feather degradation rate. The highest keratinolytic activity was observed in the culture inoculated with Chryseobacterium indologenes D27. Although all strains did not degrade human hair, strains tested effectively degraded chicken feather(53.8-91.4%), wool(40.4-93.0%) and human nail (51.0-82.9%). These results suggest that strains isolated could be not only used to improve the nutritional value of recalcitrant feather waste but also is a potential candidate for biotechnological processes of keratin hydrolysis.

고온가속노화시험을 이용한 추진제 KM10의 저장 수명 추정 (A study on the self-life estimation of the propellant KM10 by using high temperature acceleration aging tests)

  • 조기홍
    • 한국산학기술학회논문지
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    • 제11권5호
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    • pp.1735-1740
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    • 2010
  • 추진제 KM10은 NC(Nitrocellulose)를 주원료로 제조된 단기추진제로서 장기저장시 자연분해현상을 일으키는 것으로 알려져 있다. 저장수명추정은 잔류안정제 함량분석을 위해 일반적으로 이용되는 고온가속노화시험을 사용하였으며, 반응속도상수 산출을 위해 Arrhenius 식과 Berthelot 식을 사용하였다. 본 연구 결과에 따르면 Arrhenius 식과 Berthelot 식을 이용하여 추정한 추진제 KM10의 저장수명은 43.72년, 16.53년으로 큰 차이를 보였으며, E. R. Bixon의 연구결과[1]와 비교할 때 Arrhenius Equation을 이용하여 추정한 43.72년이 타당한 것으로 판단된다.

장기사용된 1Cr-0.5Mo 주증기관의 수명평가 (Life Evaluation of Long-time Used 1Cr-0.5Mo Main Steam Pipe)

  • 백수곤;홍성인
    • Journal of Welding and Joining
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    • 제16권1호
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    • pp.70-76
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    • 1998
  • Most fossil power plants and many critical components will be approaching the end of their nominal design life. At the same time, utilities are finding it economically attractive to extend the use of these plants for several more years, Especially Main steam pipe that operated under high temperature and pressure, often under the more severe operating conditions associated with cycling duty, is most important pipe system and critical component in fossil power plant. To extend the viability of older pipe system and to improve the operation and maintenance reliability, some technologies of precise diagnosis and life management have evolved out of the necessity. The purpose of this study is to descrive the related technologies and show the example of one power plants. The purpose of this study is to descrive the related technologies and show the example of one power plants. The stress analysis was done using ANSYS FEM Code. The branch area from main steam to turbine was the high stressed zone. To evaluate the degradation of the pipe material, replica, visual check, magnetic test, hardness test were done at the welding spot. The degradation level of welding point was E/F, so the remaining life of the welded area was about 0-25%.

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XLPE 절연체의 등가 및 가변온도 가속열화실험을 통한 기계적 특성 비교 분석 (A Comparison Study on Mechanical Properties of XLPE Insulation Thermally Degraded at Equivalent and Variable Temperature Conditions)

  • 김태준;황재상;정성훈;김태영
    • KEPCO Journal on Electric Power and Energy
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    • 제8권2호
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    • pp.73-77
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    • 2022
  • Recently, as the number of years of operation has increased for more than 30 years, interest in evaluating the remaining life of major power facilities such as transformers and ultra-high voltage cables is increasing. In particular, the risk of failure is increasing because the underground transmission XLPE cable has been built since 1980 and has been operating in excess of 30 years of design life or close proximity. Therefore, it is necessary to develop an algorithm to evaluate the residual life of the XLPE cable considering the load to determine the risk of failure. Since load data is large amount of data, it is necessary to make the variable load information equivalent to the time unit first in order to calculate the remaining life of the system quickly. In overseas literature, transformers are reported to be standardized for variable load equivalent conversion formulas, but they have not been reported for ultra-high voltage cables. Therefore, in this paper, whether the equivalent conversion formula of a transformer can be applied to XLPE cables was reviewed through accelerated degradation tests under equivalent and variable temperature conditions, and considerations were studied when evaluating the remaining operating life of XLPE cables based on the experimental results.