• Korean Journal of Acupuncture
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• v.30 no.2
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• pp.114-121
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• 2013

Objectives : The purpose of this study is to evaluate the efficacy of acupuncture treatment on the inflammatory lesions and body image disturbances in patients with vulgaris acnes. Methods : Fifteen inflammatory acne patients were enrolled and treated with facial acupuncture during 4 treatment sessions. We evaluated the number of papules and nodules using the Korean Acne Grading System (KAGS). We also evaluated patients' general subjective satisfaction and objective changes of inflammatory acnes symptoms using DermaVision-pro. Moreover, we observed the skin quality-of-life scale with skindex-29 and body image disturbance questionnaire (BIDQ) as secondary outcome. Adverse events were recorded as well at every visit. Results : After 4 treatment sessions, there were significant reductions in the number of papules and nodules of the patients. We found that subjective satisfactions of patients were enhanced as well as the objective inflammatory symptoms. We also found significant improvements in the quality of life and BIDQ. No serious treatment-related adverse events were reported. Conclusions : This study demonstrated that standardized facial acupuncture were effective and safe in the treatment of facial inflammatory acnes.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.25 no.2
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• pp.20-37
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• 2012

Objectives : The primary purpose of present study is to evaluate the effect of a supplement of Bee Larva on tinnitus. the second is to comparatively evaluate safety of this supplement. Methods : Among those patients who visited Semyung Oriental Medical Center from January 11st, 2010 to February 20th, 2010, we screened 45 patients considered suitable for this study after some examinations and consent of the patients. they were devided into 2 groups. Group A took 5 tablets of this supplement everyday for 4 weeks, group B, placebo, in the same way. for 4 weeks, we checked changes in intensity, duration, extent of tinnitus on daily life and sleep and THI(Tinnitus Handicap Inventory) score. to evaluate safety of this supplement, adverse events, assessment of vital sign, hematologic examination were recorded. Result : Through 4 weeks of the clinical trial, we found that this supplement is effective on tinnitus and it improves intensity, duration and extent (its influence on daily life) of tinnitus, influence of tinnitus on sleep and THI score more effectively than the placebo drug. Also, in the assessment of the safety of the study the supplement of bee Larva and placebo drug, there were no adverse events and side effects over the average which need treatment for it. Moreover, there were not any abnormal findings in change of blood pressure and hematologic examination. Conclusion : According to this experiment, we confirmed that the supplement of bee Larva can be used effectively and safely on tinnitus.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.34 no.8
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• pp.69-76
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• 2018

This study is basically about the changing appearance of the big pavilion, Yeongnamnu in Miryang city belonging to the government guesthouse of Joseon dynasty. And the purpose of this study confirms that even if the appearance of the building has not changed, the function of the building changes because the reason why people think about the building is also different. First, looked at the appearance of architecture and the function of architecture that changes with the times. In the course of the research, the changes of pavilion were traced by dividing it into five from Kory? dynasty which was first established to the present. Then, tried to find out the change patterns by analyzing important events related to buildings or places in each period. As a result, the following facts were confirmed. 1. Because of the Buddhist repression policy in Joseon Dynasty, the Yeongnamnu changed from the temple pavilion to the government pavilion. 2. Throughout the Joseon Dynasty, Yeongnamnu was the representative scenic of Miryang City. 3. In the late Joseon Dynasty, Yeongnamnu was famous as a place where a woman named Arang devoted her life in order to preserve his fidelity. 4. Since 1910, Yeongnamnu has become an important cultural asset, and space has been widely used as a venue for various public events. 5. From 1945 to 1999, Yeongnamnu was used mainly for the events of Arang Remembrance and Miryang Culture Festival. And the inner space of Yeongnamnu was rarely used because people thought preservation is important.

• Reproductive and Developmental Biology
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• v.34 no.3
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• pp.217-221
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• 2010

When fully grown oocytes are removed from their follicles, they can resume meiosis and mature spontaneously under in vitro conditions. However, nuclear maturation under in vitro condition is not accompanied by complete cytoplasmic maturation, which is essential for successful fertilization and the initiation of zygotic development. This study analyzed change of proteins in follicular fluids during the porcine follicular development. Follicular fluids were collected from follicles of diameter 1~2 mm, 2~6 mm and 6~10 mm in ovary of slaughtered pigs. Total proteins were extracted from follicular fluids by M-PER Mammalian Protein Extraction Reagent. We confirmed totally 27 same spots, 1 spot from follicle fluid of 2~6 mm follicle and 5 spots from follicle fluid of 6~10 mm in diameter were analyzed by MALDI mass spectrometry and searched on NCBInr. In results, spot No. 28 from 2~6 mm follicle was Ig lambda chain C region, and spot No.32 and 33 from 6~10 mm was Apolipoprotein A-(APOA4). Spot No.29 and 31 were failed to analyze. These results indicate that the porcine oocyte during in vitro maturation depend on specific different expressed proteins may play an important roles in the sequence of molecular events in porcine oocyte maturation and follicular development.

• BMB Reports
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• v.42 no.9
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• pp.574-579
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• 2009

The regulatory effects of honokiol on the cellular responses of macrophages and monocytes were evaluated. Specifically, we investigated the effects of honokiol with respect to lipopolysaccharide (LPS)-induced cytotoxicity, LPS- or phorbol-12-myristate-13-acetate (PMA)-mediated morphological changes, and relevant events (FITC-dextran-induced phagocytic uptake). Honokiol blocked the LPS-induced cytotoxicity of RAW264.7 cells in a dose-dependent manner. In addition, honokiol appeared to block the production of cytotoxic cytokines such as interleukin (IL)-$1{\beta}$ and tumor necrosis factor (TNF)-$\alpha$, nitric oxide (NO), and reactive oxygen species (ROS). Moreover, honokiol strongly prevented the morphological changes in RAW 264.7 and U937 cells that were induced by LPS and PMA. The surface levels of marker proteins, which are up-regulated under the morphological changes of RAW264.7 and U937 cells, were also diminished. The data presented here strongly suggest that the honokiol modulates various cellular responses managed by macrophages and monocytes.

• Smart Structures and Systems
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• v.11 no.2
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• pp.199-215
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• 2013

During the service life of a structure, design complications and unexpected events may induce unforeseen vibrations. These vibrations can be generated by malfunctioning machinery or machines that are modified or placed without considering the original structural design because of a change in the intended use of the structure. Significant vibrations occurred at a natural gas plant cooling structure during its operation due to cavitation effect within the hydraulic system. This study presents findings obtained from the in-situ vibration measurements and following finite-element analyses of the cooling structure. Comments are made on the updated performance level and damage state of the structure using the results of these measurements and corresponding numerical analyses. An attempt was also made to assess the applicability of traditional displacement-based vulnerability estimation methods in the health monitoring of structures under vibrations with a character different from those due to seismic excitations.

• Journal of architectural history
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• v.27 no.1
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• pp.29-42
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• 2018

Mugiyeondang(舞沂蓮塘) is the garden that the provincial noble family in Yeongnam(嶺南) has constructed since the late Joseon period. Mugiyeondang is well known as a typical case of traditional garden in Joseon period. But it is also an exceptional case because of its informal layout that infers gradual space transition. This study aims to establish the historical story of the garden beyond the superficial description about existing spatial status and literature materials. Mugiyeondang had been constructed by seven generations of the family during two hundred years, and there were significant events at every transition points. The figure and name of elements reflects each historical change of the family. Mugiyeondang is an important case to notice that a garden was not just a subsidiary space for mere leisure life of the gentry of Joseon period, But it was an important for some families as their representative and symbolic space.

• Proceedings of the KSR Conference
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• 2009.05a
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• pp.296-305
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• 2009

Since the beginning of civilization, people live in the times that changes rapidly everyday. Above all things, In April, 2004 the first opening of KTX(high-speed railway) that has been considered as the greatest revolutionary project shrinks the whole nation into a quarter of a day life zone and has repeated the constant change and development. But now, In comparison with ordinary train system KTX fails to notice revenue for travel-product and other many factors of increased revenue. This study introduces and analyzes the present condition of high-speed railway and indicate 'the plan to increase revenue' and 'the effect of creating revenue' through a travel-product on the basis of the travel-products connected with KTX. This study focuses on 'KTX memory train travel' and propose revenue and advertisement-effect created from targeting the middle-aged market. In addition, For improving KORAIL's image and approaching the customer more and more friendly, it grasp diverse events and advertisement plans.

• KSBB Journal
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• v.29 no.4
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• pp.278-284
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• 2014

We present microfluidic method to rapidly analyze the effect of temperature on the change of morphologies of Antarctic bacteria (Pseudoalteromonas sp., Shewanella vesiculosa, Shewanella sp., and Cellulophaga sp.). The microfluidic device is able to generate stable temperature gradient from 7 to$40^{\circ}C$ and dramatically reduce the number of experiments, experimental cost and labor, and amount of sample. Based on this approach, we found that specific bacteria transforming morphology into filament or elongated body strongly depends on cultivation temperature. Interestingly, we found that the morphologies of Pseudoalteromonas sp., Shewanella vesiculosa, Shewanella sp., and Cellulophaga sp. are elongated at below $25^{\circ}C$, above $20^{\circ}C$, above $15^{\circ}C$ and above $35^{\circ}C$, respectively. We envision the microfluidic device is a useful approach to analyze biological events with a high throughput manner.

• Korean Journal of Agricultural and Forest Meteorology
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• v.18 no.3
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• pp.162-169
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• 2016

The agrometeorological reference index means 'the agrometeorological damage possibility' or the possibility of the normal year climate condition to damage the crop cultivation in a certain region. It is a reference used to compare the cultivation risk of a crop by region. The global climate warming is expected to increase the winter temperature. At the same time, the frequency of extreme weather events will also increase. Therefore, people pay attention to the potential of low temperature-induced damages (e.g., frost damage and injury) to fruit trees under the future climate condition. However, simple damage projection based on climate conditions does not help the climate change adaptation in the practical aspect because the climate change affects the phenology of fruit trees as well. This study predicted the phenology of the pear, peach, and apple trees by using the climate change scenarios of major regions. Furthermore, low temperature induced agrometeorological reference indices were calculated based on the effects of temperature on each plant growth stage to predict the damage possibility. It was predicted that the breaking rest would delay more in the future while the bud-burst date and flowering date will be earlier. In Daegu, Jeonju, and Mokpo, the breaking rest delayed more as time passed. The bud-burst date and flowering date of Seoul and Incheon regions were later than other regions. Seoul and Incheon showed a similar pattern, while Daegu and Jeonju revealed a similar pattern. Busan and Mokpo also showed a similar pattern. All regions were safe from the frost damage during the dormancy period. However, plants were vulnerable to frost damage between the breaking rest and the bud-burst period. Regions showed different frost damage patterns between the bud-burst period and the flowering period. During the bud-burst and flowering period, the risk level decreased in general, although the risk of some areas tended to increase.