• Title/Summary/Keyword: Life Pattern

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Deficiency-excess and Cold-heat Pattern Identification and Analysis of the Characteristics of Asthma Patients (천식(喘息) 환자의 허실한열변증(虛實寒熱辨證)과 특성 비교 분석)

  • Bhang, Yeon-hee;Kim, Jae-hyo;Do, Ha-yoon;Kim, Mi-a;Kim, Kwan-il;Lee, Beom-joon;Jung, Hee-jae
    • The Journal of Internal Korean Medicine
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    • v.38 no.6
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    • pp.955-970
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    • 2017
  • Objectives: The aim of this observational study was to identify and analyze the patterns to compare the characteristics of asthma patients. Methods: The subjects were 40 asthma patients who had satisfied the inclusion and exclusion criteria. They were divided into deficiency syndrome and excess syndrome groups, and cold syndrome and heat syndrome groups. Their quality of life was measured by the quality of life questionnaire for adult Korean asthmatics (QLQAKA) and VAS. Heart rate variability (HRV) was measured, and the degree of obesity was evaluated by body mass index (BMI). Hematological, biochemical, and immunoglobulin (Ig) E laboratory tests were included. Results: Based on pattern identification, the 40 asthma patients could be divided into two categories of groups: 1) the deficiency syndrome (N=18) and the excess syndrome (N=22) groups: 2) the cold syndrome (N=35) and the heat syndrome (N=5) groups. The mean value of HF differed significantly between the deficiency and excess syndrome groups. The mean value of IgE in blood tests of asthmatics was greater than four times the reference value. For BMI, the subjects were classified into three groups: normal weight (N=12), overweight (N=12), and obese (N=16). Conclusions: Development of a more accurate asthma-specific pattern identification tool could play a crucial role in asthma control. In addition, good control of asthma can improve the quality of life. Obesity is one of the factors associated with asthma exacerbation.

Physicochemical Properties of Waxy Rice, Waxy Rice Flour and Waxy Rice Starch During Steeping (수침에 따른 찹쌀, 찹쌀 가루 및 찹쌀 전분의 물리화학적 특성 변화)

  • Kim, Sung-Woo;Kim, Dong-Seob;Kim, Byung-Yong;Baik, Moo-Yeol
    • Journal of Applied Biological Chemistry
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    • v.51 no.6
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    • pp.277-284
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    • 2008
  • The objective of this study was to investigate the effect of soaking time on physicochemical properties of waxy rice, waxy rice flour and waxy rice starch. Waxy rice (WR), waxy rice flour (WRF), waxy rice starch (WRS) were soaked at $18^{\circ}C$ for 14 days and dried at $40^{\circ}C$. Dried samples were grounded and sieved using 180 mesh. Physicochemical properties of the three samples, such as swelling power, solubility, moisture sorption isotherms and pasting properties using rapid visco analyzer (RVA) and crystal pattern using X-ray diffractometer were determined. In all samples, soaking time greatly influenced moisture sorption isotherms but no typical pattern was shown. Swelling power was not greatly changed by soaking time in the three samples. Solubility increased with increasing soaking time in all three samples, indicating that some soluble particles were exuded during soaking. In RVA pasting properties, WR and WRF showed a similar pattern, while WRS showed different pasting properties, suggesting that rice protein plays a significant role in pasting properties. X-ray diffraction patterns of all three samples showed typical A-type crystal pattern suggesting that soaking did not affect crystalline region of samples.

Location Inference of Twitter Users using Timeline Data (타임라인데이터를 이용한 트위터 사용자의 거주 지역 유추방법)

  • Kang, Ae Tti;Kang, Young Ok
    • Spatial Information Research
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    • v.23 no.2
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    • pp.69-81
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    • 2015
  • If one can infer the residential area of SNS users by analyzing the SNS big data, it can be an alternative by replacing the spatial big data researches which result from the location sparsity and ecological error. In this study, we developed the way of utilizing the daily life activity pattern, which can be found from timeline data of tweet users, to infer the residential areas of tweet users. We recognized the daily life activity pattern of tweet users from user's movement pattern and the regional cognition words that users text in tweet. The models based on user's movement and text are named as the daily movement pattern model and the daily activity field model, respectively. And then we selected the variables which are going to be utilized in each model. We defined the dependent variables as 0, if the residential areas that users tweet mainly are their home location(HL) and as 1, vice versa. According to our results, performed by the discriminant analysis, the hit ratio of the two models was 67.5%, 57.5% respectively. We tested both models by using the timeline data of the stress-related tweets. As a result, we inferred the residential areas of 5,301 users out of 48,235 users and could obtain 9,606 stress-related tweets with residential area. The results shows about 44 times increase by comparing to the geo-tagged tweets counts. We think that the methodology we have used in this study can be used not only to secure more location data in the study of SNS big data, but also to link the SNS big data with regional statistics in order to analyze the regional phenomenon.

Genetic Variation and Population Structure of Alder (Alnus hirsuta : Betulaceae) in Korea

  • Park, Joo-Soo;Huh, Man-Kyu
    • Journal of Life Science
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    • v.10 no.1
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    • pp.14-19
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    • 2000
  • Variation at 25 allozyme loci in Korean wateralder (Alnus hirsuta Rupr.) from nine distinct populations was measured to estimate the amount and pattern of genetic diversity and population structure. The mean genetic diversity within population was 0.166. Korean alder populations have slightly high levels of genetic diversity compared to those present in associated temperature-zone species and two Canadian alder species. Among population s genetic differentiation accounted for an significant 9% of the total variation. High gene flow(Nm=2.63) was observed. Analysis of fixation indices, calculated for all polymorphic loci in each population, showed a substantial deficiency of heterozygotes relative to Hardy-Weinberg expectations. The mean GST value A. hirsuta in Korea (GST = 0.087) is similar to those of A. rogosa in Canada (GST = 0.052). These low values of GST in two countries. reflecting little spatial genetic differentiation, may indicate extensive gene flow (via pollen and/or seeds) and/or recent colonization. These factors reduce the effect of geographic isolation of breeding and the chance for genetic divergence. A pattern of increasing is observed with increasing rainfall per year. Regression analysis indicates that 54% (F = 4.67) of the variability observed can be explained by this relationship.

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Intragenic Control of Expression of a Rice MADS Box Gene OsMADS1

  • Jeon, Jong-Seong;Lee, Sichul;An, Gynheung
    • Molecules and Cells
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    • v.26 no.5
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    • pp.474-480
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    • 2008
  • OsMADS1 is a rice MADS box gene necessary for floral development. To identify the key cis-regulatory regions for its expression, we utilized transgenic rice plants expressing GUS fusion constructs. Histochemical analysis revealed that the 5.7-kb OsMADS1 intragenic sequences, encompassing exon 1, intron 1, and a part of exon 2, together with the 1.9-kb 5' upstream promoter region, are required for the GUS expression pattern that coincides with flower-preferential expression of OsMADS1. In contrast, the 5' upstream promoter sequence lacking this intragenic region caused ectopic expression of the reporter gene in both vegetative and reproductive tissues. Notably, incorporation of the intragenic region into the CaMV35S promoter directed the GUS expression pattern similar to that of the endogenous spatial expression of OsMADS1 in flowers. In addition, our transient gene expression assay revealed that the large first intron following the CaMV35S minimal promoter enhances flower-preferential expression of GUS. These results suggest that the OsMADS1 intragenic sequence, largely intron 1, contains a key regulatory region(s) essential for expression.

A Study on the Differences in the Dietary Pattern and Nutrient Intake of Lacto-ovo Vegetarian and Non-vegetarian in Korean Preschool Children (학령 전 아동에서 Lacto-ovo Vegetarian과 Non-vegetarian의 식생활 습관과 영양소 섭취 차이에 관한 연구)

  • Shin, Kyung-Ok;Choi, Gi-Young;Chung, Keun-Hee
    • Journal of the East Asian Society of Dietary Life
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    • v.17 no.4
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    • pp.474-482
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    • 2007
  • Korea used to be a country where individuals ate diets high in vegetables and rice, but in recent years, it has become a country where western-style diets are increasingly popular. Consequently, the age for chronicle disease, including obesity and diabetes, has become lower. The purpose of this study was to compare the dietary habits of kindergarten children between lacto-ovo vegetarian and non-vegetarian families. The data were collected from the children(n=300) at Sahmyook University Kindergarten. The results showed that non-vegetarians had higher intakes of cookies, cakes, processed foods, ice cream, and fast foods, while vegetarian children consumed high amounts of vegetables, fruits, and kimchi. The non-vegetarian children tended to have irregular meals, and ate high-fat meats such as kalbi and samgyupsal. However, the results show it is important that many children among both vegetarian and non-vegetarian families should be encouraged to have appropriate essential nutrients, because a high percentage of children in both groups appeared to have low intakes of energy, vitamin $B_2$, vitamin C, calcium, zinc, iron, etc.

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Activation of CREB by PKA Promotes the Chondrogeneic Differentiation of Chick Limb Bud Mesenchymal Cells

  • Kim, Kook-Hee;Lee, Young-Sup
    • Animal cells and systems
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    • v.13 no.3
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    • pp.289-295
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    • 2009
  • Cyclic AMP-mediated signaling pathways regulate a number of cellular functions. In this study, we examined the regulatory role of cAMP signaling pathways in chondrogenesis of chick limb bud mesenchymal cells in vitro. Forskolin, which increases cellular cAMP levels by the activation of adenylate cyclase, enhanced chondrogenic differentiation. Inhibition of PKA with specific inhibitors (H89 or KT5720) blocked pre-cartilage condensation stage, indicating that chondrogenesis is regulated by the increase in cellular cAMP level and subsequent activation of PKA. Downstream signaling pathway of PKA leading to gene expression was investigated by examination of several nuclear transcription factors. Forskolin treatment increased transcription level for a cartilage-specific marker gene Sox9. However, inhibition of PKA with H89 led to restore expression of Sox9, indicating PKA activity was required to regulate the expression of Sox9 in chondrogenesis. In addition, CREB was highly phosphorylated at early stage of mesenchyme culture, and followed by progressive dephosphorylation. CBP and ATF, another CRE related proteins were transiently expressed at the early stage of chondrogenesis with a pattern similar to CREB phosphorylation. Electrophoretic mobility shift assays confirmed that the binding activity of CREB to the CRE is closely correlated to the phosphorylation pattern of CREB. Therefore, cAMP-mediated signal transduction to nuclear events for the induction of genes appeared to be required at the early stage of chick limb bud chondrogenesis.