• Title/Summary/Keyword: Lianyungang

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A Study on the Development Strategies for China Lianyungang Port under One Belt One Road Policy (중국 일대일로(一帶一路)정책에 따른 연운항항(連雲港港)의 발전 전략에 관한 연구)

  • Zhang, Le;SHIN, Han-Won;SONG, Xiao-Ming
    • Journal of Fisheries and Marine Sciences Education
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    • v.28 no.6
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    • pp.1695-1705
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    • 2016
  • With the rapid development of global economic and trade, the ports in the North-east Asia region have developed greatly. In such a fierce competition, how to ascertain right evaluation methods to assess the competitiveness of the ports, and make scientific and rational development strategy for upgrading the overall level of competitiveness of ports in North-east Asia, has become the first task for all the ports for coping with the challenges. As China's sustained economic growth of more than 30 years, the economic power and comprehensive national strength has been changed, China's international status has been greatly improved. Also China has achieved remarkable new results in the construction of peripheral diplomacy, and further has consolidated the relationship of countries along the Silk Road Economic Belt. The strong position of RMB in foreign exchange market and the implementation of the strategy of "area" opening to the outside world accelerated economic belt along the silk road in China to the west open pace. On the basis of the SWOT analysis of the Lianyungang Port, combined with the comprehensive and practical port competitiveness evaluation indicators system and competitiveness evaluation method, calculate the competitiveness level of Lianyungang port in East China, and find out the problems must be solved. The development strategies for Lianyungang port under One Belt One Road were suggested.

KIF26B-AS1 Regulates TLR4 and Activates the TLR4 Signaling Pathway to Promote Malignant Progression of Laryngeal Cancer

  • Li, Li;Han, Jiahui;Zhang, Shujia;Dong, Chunguang;Xiao, Xiang
    • Journal of Microbiology and Biotechnology
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    • v.32 no.10
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    • pp.1344-1354
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    • 2022
  • Laryngeal cancer is one of the highest incidence, most prevalently diagnosed head and neck cancers, making it critically necessary to probe effective targets for laryngeal cancer treatment. Here, real-time quantitative reverse transcription PCR (qRT-PCR) and western blot analysis were used to detect gene expression levels in laryngeal cancer cell lines. Fluorescence in situ hybridization (FISH) and subcellular fractionation assays were used to detect the subcellular location. Functional assays encompassing Cell Counting Kit-8 (CCK-8), 5-ethynyl-2'-deoxyuridine (EdU), transwell and wound healing assays were performed to examine the effects of target genes on cell proliferation and migration in laryngeal cancer. The in vivo effects were proved by animal experiments. RNA-binding protein immunoprecipitation (RIP), RNA pulldown and luciferase reporter assays were used to investigate the underlying regulatory mechanisms. The results showed that KIF26B antisense RNA 1 (KIF26B-AS1) propels cell proliferation and migration in laryngeal cancer and regulates the toll-like receptor 4 (TLR4) signaling pathway. KIF26B-AS1 also recruits FUS to stabilize TLR4 mRNA, consequently activating the TLR4 signaling pathway. Furthermore, KIF26B-AS1 plays an oncogenic role in laryngeal cancer via upregulating TLR4 expression as well as the FUS/TLR4 pathway axis, findings which offer novel insight for targeted therapies in the treatment of laryngeal cancer patients.

Anti-diabetic activities of catalpol in db/db mice

  • Bao, Qinwen;Shen, Xiaozhu;Qian, Li;Gong, Chen;Nie, Maoxiao;Dong, Yan
    • The Korean Journal of Physiology and Pharmacology
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    • v.20 no.2
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    • pp.153-160
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    • 2016
  • The objective was to investigate the hypoglycemic action of catalpol in spontaneous diabetes db/db mice. 40 db/db mice were randomly divided into five groups: model control gourp; db/db plus catalpol 40, 80, 120 mg/kg body wt. groups and db/db plus metformin 250 mg/kg group. Age-matched db/m mice were selected as normal control group. The mice were administered with corresponding drugs or solvent by gavage for 4 weeks. The oral glucose tolerance test was carried out at the end of $3^{rd}$ week. After 4 weeks of treatment, the concentrations of fasting blood glucose (FBG), glycated serum protein (GSP), insulin (INS), triglyceride (TG), total cholesterol (TC) and adiponection (APN) in serum were detected. The protein expressions of phosphorylation-$AMPK{\alpha}$1/2 in liver, phosphorylation-$AMPK{\alpha}$1/2 and glucose transporter-4 (GLUT-4) in skeletal muscle and adipose tissues were detected by western blot. Real time RT-PCR was used to detect the mRNA expressions of acetyl-CoA carboxylase (ACC) and Hydroxymethyl glutaric acid acyl CoA reductase (HMGCR) in liver. Our results showed that catalpol could significantly improve the insulin resistance, decrease the serum concentrations of INS, GSP, TG, and TC. The concentrations of APN in serum, the protein expression of phosphorylation-$AMPK{\alpha}$1/2 in liver, phosphorylation-$AMPK{\alpha}$1/2 and GLUT-4 in peripheral tissue were increased. Catalpol could also down regulate the mRNA expressions of ACC and HMGCR in liver. In conclusion, catalpol ameliorates diabetes in db/db mice. It has benefit effects against lipid/glucose metabolism disorder and insulin resistance. The mechanism may be related to up-regulating the expression of phosphorylation-$AMPK{\alpha}$1/2.

Study on the trainferry shipping between Mokpo and Lianyungang (목포-연운항간 철도페리선에 관한 연구)

  • 김병만;김영훈;박종환
    • Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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    • 2001.10a
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    • pp.55-61
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    • 2001
  • Recently, the trade volume between Korea, China, and Europe is increasing gradually with various transport routes such as sea, railway. and linking of them. In this study, economic efficiency of existing transport routes are estimated and trainferry type shipping between Mokpo and Lianyungang is proposed as a efficient transport route considering the trade volume between Korea and China.

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A Study on Measuring the Efficiency of Korea-China Car Ferry Routes by using Data Envelopment Analysis (DEA를 활용한 한중 카페리 항로의 효율성 분석)

  • Lee, Nam-Yeon;Pak, Ji-Yeong;Yeo, Gi-Tae
    • Journal of Navigation and Port Research
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    • v.37 no.2
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    • pp.187-193
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    • 2013
  • In this prolonged economic recession, the countries in Northeast Asia play a crucial role in the global market and the relationship between Korea and China gets more attention due to its significant achievement during the past 20 years after the establishment of diplomatic ties in 1992. In this regards, this study presents general overview of Korea-China Car Ferry Route and evaluates the efficiency level of each operating route using DEA model. Incheon-Yingkou, Incheon-Lianyungang, Pyeong Taek-Lianyungang are analyzed as efficent routes, while from the view point of passenger efficiency, 4 routes i.e, Incheon-Dalian, Incheon-Dandong, Pyeong Taek- Weihai, Gunsan-Shidao are also noted as efficient routes. Consequently, other inefficient routes can benchmark these efficient routes by increasing cargo volume and passengers.

A research on the development of Lianyungang port (중국 연운항항 발전방향)

  • Ma, Chang-Ming;Jo, So-Hee;Nam, Ki-Chan
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • 2009.10a
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    • pp.206-207
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    • 2009
  • It is estimated that the potential of Chinese market is infinite. The success of Chinese economic reformation is generating the high economic growth in China. China is a rising logistics market as its growing throughput and port expansion but China's railway transportation system is not well-linked with ports. China built TCR(Trans-China Railway) which is across the Chinese territory and connected to as far as Europe. With this mode, it is possible to place more overseas freight and meet more customers' needs. Lian yun gang is a city on the East coast of China where the commencing station of TCR is located. This paper reviews the present conditions of Lianyungang and presents the development direction of the city to become a logistics point.

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A Trend Analysis on Export Container Volume Between Korea and East Asian Ports (우리나라와 동아시아 항만간의 수출 컨테이너 물동량 추이 분석)

  • Lee, Choong-Bae;Noh, Jin-Ho
    • Journal of Korea Port Economic Association
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    • v.34 no.2
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    • pp.97-114
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    • 2018
  • The East Asian region, an important part of Korea's imports and exports, is expected to grow further driven by the geographical, political, economic, social, and cultural complementarity. With the recent increase in imports and exports, the port trade volume between Korea and East Asian countries is also growing. However, due to various factors, such as economic size, growth rate, port infrastructure level, and geographical location of these countries, the volume of traffic with these ports is fluctuating. Despite much research on the volatility of port trade volume and changes in port network, this study tries to supplement the gap in a more detailed study of ports in Korea and East Asia since these kinds of studies are limited. The purpose of this study is to analyze the trend of distribution routes of export container cargo among ports in Korea and to present policy and practical implications of Korean trading companies, shipping companies, logistics companies, and port authorities. This study analyzes the variability of the trade volume between Korea's major ports and Daedong. Results show that Shanghai, Ningbo, Ho Chi Minh, and Haiphong were the most important factors in terms of size and volume increase. In terms of ports, the Busan port is the port responsible for trades with Yantai, Weihai, Hakata, Kobe, Ho Chi Minh, and Haiphong; Incheon port deals with Lianyungang, Tianjin, Osaka, Kobe, Ho Chi Minh, Haiphong; Gwangyang port trades with Tianjinxingang, Weihai, Yokohama, Mihn and Tanjong, and Ulsan port is strategically important for the Yantai, Lianyungang, Nagoya, Kobe, Ho Chi Minh and Portkelang ports. Therefore, the Korean government, port authorities, and shipping and logistics companies need to strengthen logistic network cooperation with these ports and actively promote investments in them.

A Study on the Transmission-tribology Design Based on Existing Problem of the Gear Drive and Tribology

  • Lyu, Sung-Ki;Lu, Long;Wei, Yun-Long
    • International Journal of Precision Engineering and Manufacturing
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    • v.7 no.2
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    • pp.3-7
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    • 2006
  • We propose a new concept of transmission-tribology design based on the investigation of development and existing problems of the gear drive and tribology. The content of transmission-tribology and transmission-tribology design is probed. Some effective methods of transmission-tribology design is probed. Some effective methods of transmission-tribology design are put forward. Partial achievements in this research are introduced tersely. Mechanical transmission, which is represented by the gear drive, and tribology are two main branches of mechanical engineering. They have their own definite research field. In recent years, we have been doing our utmost to suggest combining mechanical transmission-tribology and transmission-tribology design. Partial achievements in this research area are obtained.

MicroRNA-155 Expression has Prognostic Value in Patients with Non-small Cell Lung Cancer and Digestive System Carcinomas

  • Xu, Tong-Peng;Zhu, Can-Hong;Zhang, Jian;Xia, Rui;Wu, Feng-Lei;Han, Liang;Shen, Hua;Liu, Ling-Xiang;Shu, Yong-Qian
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.12
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    • pp.7085-7090
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    • 2013
  • Objective: Published data have shown that microRNAs (miRNAs) could play a potential role as diagnostic and prognostic indicators in cancers. Data for the predictive value of microRNA-155 are inconclusive. The aim of the present analysis was therefore to evaluate the role of miR-155 in prognosis for patients with a variety of carcinomas. Methods: Relevant studies were identified by searching PubMed and EMBASE. Data were extracted from studies comparing overall survival (OS), recurrence-free survival (RFS) or cancer-specific survival (CSS) in patients with carcinoma with higher miR-155 expression and those with lower levels. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) of miR-155 for clinical outcome were calculated. Results: A total of 15 studies were included. The pooled hazard ratio (HR) for OS of higher miR-155 expression in cancerous tissue was 1.89 (95% CI: 1.20-2.99, P=0.006), which could markedly predict poorer survival in general cancer. For RFS/CSS, elevated miR-155 was also associated with poor prognosis of cancer (HR=1.50, 95% CI: 1.10-2.05, P=0.01). On subgroup analysis, the pooled HR for OS in non-small cell lung cancer (NSCLC) was 2.09 (95% CI: 0.68-6.41, P > 0.05), but for RFS/CSS was 1.28 (95% CI: 1.05-1.55, P=0.015), with statistical significance; the pooled HRs for OS and RFS/CSS in digestive system neoplasms were 3.04 (95% CI: 1.48-6.24, P=0.003) and 2.61 (95% CI: 1.98-3.42, P<0.05), respectively. Conclusions: The results indicated that the miR-155 expression level plays a prognostic role in patients with cancer, especially NSCLCs and digestive system carcinomas.