• Bulletin of the Korean Chemical Society
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• 제33권10호
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• pp.3213-3217
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• 2012

Reactive adsorption desulfurization (RADS) experiments were conducted over a series of commercial metal oxide supports ($Al_2O_{3-}$, $SiO_{2-}$, $TiO_{2-}$ and $ZrO_{2-}$) supported Ni/ZnO adsorbents. The adsorbents were characterized by X-ray diffraction (XRD), temperature programmed reduction (TPR), and Fourier transform infrared spectroscopy (FTIR) in order to find out the influence of specific types of surface chemistry and structural characteristics on the sulfur adsorptive capacity. The desulfurization performance of all the studied adsorbents decreased in the following order: Ni/ZnO-$TiO_2$ > Ni/ZnO-$ZrO_2$ > Ni/ZnO-$SiO_2$ > Ni/ZnO-$Al_2O_3$. Ni/ZnO-$TiO_2$ shows the best performance and the three hour sulfur capacity can achieve 12.34 mg S/g adsorbent with a WHSV of $4h^{-1}$. Various characterization techniques suggest that weak interaction between active component and support component, high dispersion of NiO and ZnO, high reducibility and large total Lewis acidity of the adsorbents are important factors in achieving better RADS performance.

• 대한전자공학회논문지SD
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• 제47권6호
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• pp.35-42
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• 2010

본 논문에서는 무선 통신 응용 시스템에 적합 하도록 10비트 80MHz 전류구동 방식의 D/A 변환기를 제안하였다. 제안한 회로는 $0.18{\mu}m$ CMOS n-well 1-poly 6-metal 공정을 이용하여 구현하였다. 10비트 중에서 LSB 4비트는 이진 디코더를 사용 하였으며, ULSB 3비트와 MSB 3비트는 온도계 디코더를 사용한 혼합구조를 채택하였다. 구현된 D/A 변환기의 측정결과, 샘플링 주파수가 80MHz, 입력 주파수 1MHz에서 SFDR은 60.42 dBc, 유효비트수는 8.75 비트를 보여주었다. INL/DNL은 ${\pm}$0.38LSB/${\pm}$0.32LSB로 측정되었으며, 글리치 에너지는 4.6 $pV{\cdot}s$로 나타났다. 전력 소모는 1.8V 전원전압에서 최대 속도인 80MHz일 때 48mW로 측정되었다.

• 대한기계학회논문집A
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• 제39권12호
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• pp.1237-1244
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• 2015

제로터(Gerotor) 오일펌프는 구조가 간단하고 1 회전당 토출량이 많기 때문에 소형화에 유리하며, 자동차의 엔진 윤활유 공급원 및 자동 변속기의 유압원으로 널리 사용되고 있다. 최근 자동차 산업에서는 연비향상 및 소음저감이 가장 중요한 문제로 대두되는데, 내접형 기어펌프 측면에서는 제로터의 치형설계 및 포트형상 설계를 통하여 이를 대처하고 있다. 이에 본 논문에서는 유량맥동이 매우 작은 값을 가지도록 조합된(타원 1-타원형 인벌루트-타원 2) 외부로브 형상에 대하여 치형의 기구학적 조건을 만족하는 식을 유도하여 내부로브 형상을 창출하였으며, 이에 대한 첨점 및 루프가 발생하지 않는 설계인자 범위를 결정하였다. 또한 설계인자의 변화가 치형의 형상 및 성능인자(유량, 유량맥동)에 미치는 영향을 파악하여 최적의 치형을 구하고자 하였다.

• 한국도서관정보학회지
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• 제38권1호
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• pp.195-210
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• 2007

이 연구는 재중 조선인의 조선문 잡지 출간상황과 발전방안을 살핀 것이다. 재중 조선문 잡지는 중국 해방 후부터 현재까지 20여종이 출간되었다. 이들 잡지는 대체로 정치적인 영향이나 독자층을 고려해서 정간, 복간, 개명 등의 변화를 가져왔다. 또한, 주제로 구분해 보면 정치, 문학, 예술분야의 잡지가 주종을 이룬다. 한편 잡지발간의 어려움의 요인은 조선족 인구감소 인구이동. 중국 정부의 지원축소와 폐지, 재료비 인상 등을 들 수 있다. 이를 극복하기 위해서는 한국어 독자층을 확대하고 2개 연어(중국어-한국어)로 구성된 잡지를 발간하며, 중국 내외의 활발한 문화교류를 개척하며, 한국으로부터의 다양한 지원이 강구되어야 한다.

• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2003년도 제3회 국제심포지움 및 학술대회
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• pp.105-105
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• 2003

In previous reports, pVPSV.IGR2.1 transgenic mouse were described that brain tumor and lymphoma by reason of Vasopressin-SV40 T antigen. In this study, we produced pVPSV.IGR3.6 transgenic mouse that used pVPSV.IGR3.6 vector. Expression of transgene was vary different in transgenic mouse. We obtained 6 transgenic mouse line, moreover they had died at the age of 2-6 weeks without transmitting the transgene to their offspring, and had tumorigenesis on same location with pVPSV.IGR2.1 transgenic mouse. Only a founder mouse was investigated for expression of fusion gene. Here we extended this transgenic approach to the study of tumor progression. From the mouse, we confirmed brain tumor cell, after then cultured for investigate characterization. In this report, we demonstrate that reduction of survival rate in transgenic mouse fused vasopressin gene length, acquisition of brain tumor cell, composition with astrocyte cells and neuronal cells. Finally, cells had no change with increase of passage.

• BMB Reports
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• 제40권4호
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• pp.525-531
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• 2007

As a $\beta_2$-adrenergic agonist, clenbuterol decreases body fat, but the molecular mechanism underlying this process is unclear. In the present study, we treated 293T and L-02 cells with clenbuterol and found that clenbuterol downregulates SREBP-1c expression and upregulates CREB1 expression. Considering SREBP-1c has the function of regulating the transcription of several lipogenic enzymes, we considered that the downregulation of SREBP-1c is responsible for body fat reduction by clenbuterol. Many previous studies have found that clenbuterol markedly increases intracellular cAMP levels, therefore, we also investigated whether CREB1 is involved in this process. The data from our experiments indicate that CREB1 overexpression inhibits SREBP-1c transcription, and that this action is antagonized by CREB2, a competitive inhibitor of CREB1. Furthermore, since PPARs are able to repress SREBP-1c transcription, we investigated whether clenbuterol and CREB1 function via a pathway involving PPAR activation. However, our results showed that clenbuterol or CREB1 overexpression suppressed PPARs transcription in 293T and L-02 cells, which suggested that they impair SREBP-1c expression in other ways.

• The Korean Journal of Physiology
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• 제28권2호
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• pp.159-167
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• 1994

The contraction of rabbit basilar artery was examined as a function of changes in the $Na^+$ electrochemical gradient in order to determine the contribution of $Na^+/Ca^{2+}$ exchange to the modulation of contractility. Ouabain $(10^{-5}\;M)$ or $K^+-free$ Tyrode solution caused an increase in tonic tension even in the presence of a $Ca^{2+}$ channel blocker $(10^{-6}\;M\;verapamil)$ and an ${\alpha}-receptor$ blocker $(10^{-5}\;M\;phentolamine)$. After treatment with ouabain $(10^{-5}\;M)$, contractions were augmented by reduction of external $Na^+$ concentration. The longer the treatment with ouabain $(10^{-5}\;M)$ was, the larger the amplitude of $Na^+-free$ contracture was. $Na^+-free$ contracture wag induced by either substitution of equimolar Tris for $Na^+$ or substitution of equimolar $Li^+\;for\;Na^+$. The competition between $Na^+\;and\;Ca^{2+}$ for the $Na^+/Ca^{2+}$ exchange carrier would exist, because it was observed that contractility was dependent on the $Na^+$ electrochemical gradient or the extracellular $Ca^{2+}$ concentration (2 mM, 4 mM). Ryanodine $(10^{-7}\;M)$, the blocker of intracellular $Ca^{2+}$ release from the sarcoplasmic reticulum, did not suppress the development of $Na^+-free$ contracture. The contractile response to norepinephrine $(10^{-6}\;M)$ was augmented by reducing the extracellular $Na^+$ concentration. The relaxation rate from caffeine-induced contraction was dependent on the extracellular $Na^+$ concentration (0 mM, 140 mM). From the above results, it could be suggested that $Na^+/Ca^{2+}$ exchange can move $Ca^{2+}$ either into or out of rabbit basilar arterial smooth muscle. $Ca^{2+}$ entry or extrusion is dependent upon the $Na^+$ electrochemical gradient. $Na^+/Ca^{2+}$ exchange plays a significant role in the regulation of contractility in rabbit basilar arterial smooth muscle.

• 한국재료학회지
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• 제20권11호
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• pp.611-616
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• 2010

A cobalt oxide - tin oxide nanocomposite based gas sensor on an $SiO_2$ substrate was fabricated. Granular thin film of tin oxide was formed by a rheotaxial growth and thermal oxidation method using dc magnetron sputtering of Sn. Nano particles of cobalt oxide were spin-coated on the tin oxide. The cobalt oxide nanoparticles were synthesized by polymer-assisted deposition method, which is a simple cost-effective versatile synthesis method for various metal oxides. The thickness of the film can be controlled over a wide range of thicknesses. The composite structures thus formed were characterized in terms of morphology and gas sensing properties for reduction gas of $H_2$. The composites showed a highest response of 240% at $250^{\circ}C$ upon exposure to 4% $H_2$. This response is higher than those observed in pure $SnO_2$ (90%) and $Co_3O_4$ (70%) thin films. The improved response with the composite structure may be related to the additional formation of electrically active defects at the interfaces. The composite sensor shows a very fast response and good reproducibility.

• Biomolecules & Therapeutics
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• 제22권2호
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• pp.143-148
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• 2014

Marfan syndrome (MFS) is a dominantly inherited connective tissue disorder caused by mutations in the gene encoding fibrillin-1 (FBN1) and is characterized by aortic dilatation and dissection, which is the primary cause of death in untreated MFS patients. However, disease progression-associated changes in gene expression in the aortic lesions of MFS patients remained unknown. Using a mouse model of MFS, FBN1 hypomorphic mouse (mgR/mgR), we characterized the aortic gene expression profiles during the progression of the MFS. Homozygous mgR mice exhibited MFS-like phenotypic features, such as fragmentation of elastic fibers throughout the vessel wall and were graded into mgR1-4 based on the pathological severity in aortic walls. Comparative gene expression profiling of WT and four mgR mice using microarrays revealed that the changes in the transcriptome were a direct reflection of the severity of aortic pathological features. Gene ontology analysis showed that genes related to oxidation/reduction, myofibril assembly, cytoskeleton organization, and cell adhesion were differentially expressed in the mgR mice. Further analysis of differentially expressed genes identified several candidate genes whose known roles were suggestive of their involvement in the progressive destruction of aorta during MFS. This study is the first genome-wide analysis of the aortic gene expression profiles associated with the progression of MFS. Our findings provide valuable information regarding the molecular pathogenesis during MFS progression and contribute to the development of new biomarkers as well as improved therapeutic strategies.

• Wind and Structures
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• 제26권4호
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• pp.215-229
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• 2018

The appearance of a rivulet at the upper surface of a stay cable is responsible for rain-wind-induced vibration (RWIV) of cables of cable-stayed bridges. However, the formation mechanism of the upper rivulet and its aerodynamic effects on the stay cable has not been fully understood. Large eddy simulation (LES) method is used to investigate flow around and aerodynamics of a circular cylinder with an upper rivulet at a Reynolds number of 140,000. Results show that the mean lift coefficients of the circular cylinder experience three distinct stages, zero-lift stage, positive-lift stage and negative-lift stage as the rivulet located at various positions. Both pressure-induced and friction-induced aerodynamic forces on the upper rivulet are helpful for its appearance on the upside of the stay cable. The friction-induced aerodynamic forces, which have not been considered in the previous theoretical models, may not be neglected in modeling the RWIV. In positive-lift stage, the shear layer separated from the upper rivulet can reattach on the surface of the cylinder and form separation bubbles, which result in a high non-zero mean lift of the cylinder and potentially induces the occurrence of RWIV. The separation bubbles are intrinsically unsteady flow phenomena. A serial of small eddies first appears in the laminar shear layer separated from the upper rivulet, which then coalesces and reattaches on the side surface of the cylinder and eventually sheds into the wake.