• Korean Journal of Acupuncture
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• 제27권2호
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• pp.203-216
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• 2010

Objectives : The purpose of this study is to identify the effect of tonifying or sedative manipulation on LI4 and KI7 for sweet deficiency under cold environment. Methods : The participants were divided into 4 groups; intact group without acupuncture(Intact), acupuncture group inserting straightly with LI4 & KI7 method((LI4-straight KI7-straight), acupuncture group inserting twisting with LI4 tonificaton & KI7 tonificaton method(LI4-tonify KI7-tonify) and acupuncture group inserting twisting with LI4 sedation & KI7 sedation method(LI4-purge KI7-purge). We obtained the baseline data under cold condition with the temperature $14{\pm}1^{\circ}C$. After making the participant staying under cold condition for 10 minute, we measured sweating rate on skin surface and biological responses such as body temperature, oxygen saturation, pulse rate, systolic blood pressure, diastolic blood pressure, deoxy-Hb and oxy-Hb in subcutaneous. Results : The sweating rate on skin surface was not different in all treatment groups compared to the intact group. The body temperature was significantly increased in LI4-straight KI7-straight group compared to the intact group. The oxygen saturation significantly increased in LI4-purge KI7-purge group compared to the intact group. The systolic blood pressure was significantly increased in LI4-purge KI7-purge group compared to the intact group. The deoxy-Hb was significantly decreased in LI4-purge KI7-purge group compared to the intact group. Conclusions : The above results, the effect of LI4, KI7 acupuncture due to the tonifying or sedative manipulation on sweating control could be observed. However, other biological responses with the acupuncture of tonifying or sedative manipulation were giving different expressions. We suggest that continued research of tonifying or sedative manipulation is of importance order to find these expressions.

• 대한한의학원전학회지
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• 제28권1호
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• pp.35-53
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• 2015

Objectives : In order to find how reference books of Yi Xue Ru Men reflect the classification and criterion for low back pain(LBP). Methods : From reference books of Yi Xue Ru Men, select the texts on classification and criterion for LBP. Results : According to the causes of LBP, Chao Yuan Fang(巢元方) in Sui Dynasty assorted to 5 types of LBP at the very first. Chen Wu Ze(陳無擇) in Song Dynasty made 7 divisions by external, internal, and non-external, non-internal causes. According to the pulse of LBP, Yan Yong He(嚴用和) first categorized 4 groups, Zhu Zhen Heng(朱震亨) added another 4 groups. Aside from this standard, Zhu(朱震亨) adopted the cause standard. Depending on Yunqi(運氣), Lou Ying(樓英) classified 5 types. But his classification had been not adopted by any TCM books. According to symptom of 6 varieties(六變), Zhang Jie Bin(張介賓) assorted external(表), internal(裏), deficiency(虛), sufficiency(實), cold(寒) and heat(熱), add 2 groups besides them. But his categorization did not reflect Yi Xue Ru Men. Li Chan(李梴), the author of this book chose causes and pulse classification standards that Zhu Zhen Heng had adopt. Conclusions : In the side of classification and criterion for LBP, Li Chan first divided 2 group, external and internal injury. After it he subdivided both groups to 10 subgroup. His classification is similar to Chen(陳無擇)'s, but actually followed the classification for external and internal injury that was invented by Li Dong Yuan(李東垣).

• Korean Chemical Engineering Research
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• 제40권6호
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• pp.752-756
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• 2002

PDP(Plasma Display Panel)용 녹색 형광체인 $Zn_2SiO_4:Mn$ 형광체의 제조에 있어 콜로이드 분무 열분해법을 도입하고, $Zn_2SiO_4$ wellimite 결정의 $Si^{4+}$ 자리를 치환하는 $Gd^{3+}/Li^+$ 부활성제를 첨가하여 형광체의 발광특성을 향상시키고자 하였다. 14 nm 크기의 fumed silica 입자를 규소 전구체로 도입한 콜로이드 분무열분해법에 의해서 제조되어진 $Zn_2SiO_4:Mn$ 입자는 응집이 없는 구형의 형상, 작은 입자 크기 및 좁은 입도 분포를 가졌다. $Gd^{3+}/Li^+$ 함량은 $Zn_2SiO_4:Mn$ 형광체 입자의 발광특성에 영향을 끼쳤으며, 적정한 함량의 $Gd^{3+}/Li^+$ 부활성제를 첨가함으로써 진공 자외선하에서 형광체의 발광휘도를 향상시키고, 잔광시간을 크게 줄일 수 있었다. 분무 열분해법에 의한 $Gd^{3+}/Li^+$이 코도핑된 $Zn_2SiO_4:Mn$ 형광체 입자의 제조에 있어서 후열처리 온도는 형광체의 발광특성을 결정짓는 주요한 인자이다. 0.1 mol%의 $Gd^{3+}/Li^+$ 부활제를 포함하고 $1,145^{\circ}C$ 온도에서 소결된 $Zn_2SiO_4:Mn$ 형광체 입자는 상업용 형광체에 비해 5% 높은 발광 휘도과 5.7 ms의 잔광시간을 가졌다.

• 한국자기학회지
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• 제22권1호
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• pp.15-18
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• 2012

Olivine 구조인 $LiFe_{0.9}Mn_{0.1}PO_4$ 분말 시료를 직접합성법(solid state method) 으로 제조하였으며, 결정학적 및 자기적 특성을 x-선 회절(x-ray diffractometer), 초전도 양자 간섭계(superconducting quantum interference devices) 및 뫼스바우어 분광(M$\ddot{o}$ssbauer spectroscopy) 실험을 이용하여 연구하였다. $LiFe_{0.9}Mn_{0.1}PO_4$ 시료의 결정구조는 공간그룹이 Pnma인 orthorhombic 구조임을 Rietveld 정련법으로 분석하였다. $LiFe_{0.9}Mn_{0.1}PO_4$ 시료의 닐온도 (N$\acute{e}$el temperature; $T_N$)는 50 K으로 나타내었고 닐온도에서 자기 상전이가 일어나는 것을 초전도 양자 간섭계 실험을 통하여 확인하였다. Fe(Mn)-O 이온간 거리를 분석하여 $FeO_6(MnO_6)$ 팔면체 구조가 비대칭임을 확인하였고 그 구조로 인하여 강한 결정장에 영향을 받으며, 닐온도 이상에서 자기 2중극자 상호작용은 사라지고, 강한 결정장에 의한 전기 4중극자 작용만이 존재하여 두 개의 흡수선이 나타나는 것을 뫼스바우어 분광 실험을 통하여 분석하였다.

• Korean Journal of Acupuncture
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• 제25권4호
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• pp.133-145
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• 2008

Objectives : The purpose of this study was to exam the effectiveness of acupuncture using the tonification & sedation manipulation for LI4(Hegu) and KI7(Fuliu) which was known to promote sweating for lack sweating and inhibit for excessive sweating. Methods : The subject of this study was 60 people who agreed with participating. The participants were divided into 6 groups as control group without acupuncture, acupuncture group with needle inserted perpendicularly at LI4, KI7 without manipulation(AT-A), acupuncture group with needle inserted and twisted at LI4 using sedation technique and KI7 using tonificaton technique(AT-B), acupuncture group with needle inserted and twisted at LI4 using tonificaton technique and KI7 using sedation technique(AT-C), acupuncture group with needle inserted and twisted at LI4 and KI7 using tonificaton technique(AT-D) and acupuncture group with needle inserted and twisted at LI4 and KI7 using sedation technique(AT-E). We obtained baseline data at a stable condition with the temperature of $25^{\circ}C$. After having the participant stay at $40^{\circ}C$ for 10 minute and treated with acupuncture for 10 minute, we measured the parameters such as sweating rate, water content in subcutaneous, water content in skin surface, systolic blood pressure, diastolic blood pressure, pulse rate, oxygen saturation and body temperature. Results : After the tonification & sedation manipulation at LI4 and KI7, the sweating rate was significantly decreased in AT-B, AT-D and AT-E groups. The water contents in skin surface was significantly decreased in AT-B and AT-E groups. The water contents in subcutaneous was significantly decreased in AT-B, AT-C, AT-D and AT-E groups. However, there were no significant changes in systolic blood pressure, diastolic blood pressure, pulse rate, oxygen saturation and body temperature. Conclusions : Acupuncture at LI4 and KI7 is effective in controling sweating, and the effect varies according to the tonification & sedation manipulation technique.

• 한국측량학회지
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• 제34권3호
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• pp.309-317
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• 2016

토석류는 태풍이나 집중호우 등에 의해 산사태가 일어나 토석이 물과 함께 하류로 밀려 떠내려가는 현상을 의미한다. 특히 우리나라는 지형학적 특성상 전체 국토의 약 70%가 산지로 구성되어 있고 매년 6~8월 집중적으로 태풍이나 집중호우가 발생하여 이 시기에 발생한 산사태 및 대규모 토석류로 인한 인명피해는 전체 재난 사망자의 약 20%에 이르고 있다. 따라서 이러한 토석류의 발생 규모를 예측하기 위한 핵심적인 부분은 복잡한 3차원 지형에서의 토석류 거동, 침식 및 퇴적 메커니즘을 이해하여야 한다. 본 연구에서는 강원도 평창군의 실제 규모 토석류 실험 전후에 나타난 지형적인 변화 및 변화가 발생한 지역에서의 지형학적 특성 등의 정량적 변화 분석 등을 수행하였으며, 이를 위해 발생 전후의 정량적 변화를 관측할 수 있는 GSD 10cm LiDAR DEM 데이터를 조사에 활용하였다.

• IMMUNE NETWORK
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• 제14권3호
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• pp.138-148
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• 2014

MicroRNAs (miRNAs) are endogenous small RNA molecules best known for their function in post-transcriptional gene regulation. Immunologically, miRNA regulates the differentiation and function of immune cells and its malfunction contributes to the development of various autoimmune diseases including systemic lupus erythematosus (SLE). Over the last decade, accumulating researches provide evidence for the connection between dysregulated miRNA network and autoimmunity. Interruption of miRNA biogenesis machinery contributes to the abnormal T and B cell development and particularly a reduced suppressive function of regulatory T cells, leading to systemic autoimmune diseases. Additionally, multiple factors under autoimmune conditions interfere with miRNA generation via key miRNA processing enzymes, thus further skewing the miRNA expression profile. Indeed, several independent miRNA profiling studies reported significant differences between SLE patients and healthy controls. Despite the lack of a consistent expression pattern on individual dysregulated miRNAs in SLE among these studies, the aberrant expression of distinct groups of miRNAs causes overlapping functional outcomes including perturbed type I interferon signalling cascade, DNA hypomethylation and hyperactivation of T and B cells. The impact of specific miRNA-mediated regulation on function of major immune cells in lupus is also discussed. Although research on the clinical application of miRNAs is still immature, through an integrated approach with advances in next generation sequencing, novel tools in bioinformatics database analysis and new in vitro and in vivo models for functional evaluation, the diagnostic and therapeutic potentials of miRNAs may bring to fruition in the future.

• 설비공학논문집
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• 제18권9호
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• pp.753-760
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• 2006

The purpose of the present work is to investigate the influence of the refrigerant adulteration by LiBr solution on the cooling capacity and COP for three different types of abso게tion chillers: a single-effect type, a series-flow double-effect type and a parallel-flow with double-effect type. A simulation program has been prepared for the cyclic analysis of absorption chillers. With some assumptions, the calculations have been performed by solving the mass balance equation, energy balance equation and the state equation simultaneously. The range of the LiBr concentration of refrigerant was 0% to 20% in the present study. For the single-effect absorption chiller, the maximum decrease in the cooling capacity was 10% at the 20% of LiBr concentration. For the double-effect chiller, the capacity was decreased by 11.1% for the parallel-flow type and the series-flow type. Also, the COP was reduced by 3.0% in single-effect, 2.8% in series-flow type (SR=0.4) and 2.3% in parallel-flow type.

• Wind and Structures
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• 제30권6호
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• pp.575-595
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• 2020

The characteristics of winds associated with tropical cyclones are of great significance in many engineering fields. This paper presents an investigation of wind characteristics over a coastal urban terrain based on field measurements collected from multiple cup anemometers and ultrasonic anemometers equipped at 13 height levels on a 356-m-high meteorological tower in Shenzhen during severe Typhoon Hato. Several wind quantities, including wind spectrum, gust factor, turbulence intensity and length scale as well as wind profile, are presented and discussed. Specifically, the probability distributions of fluctuating wind speeds are analyzed in connection with the normal distribution and the generalized extreme value distribution. The von Karman spectral model is found to be suitable to depict the energy distributions of three-dimensionally fluctuating winds. Gust factors, turbulence intensity and length scale are determined and discussed. Moreover, this paper presents the wind profiles measured during the typhoon, and a comparative study of the vertical distribution of wind speeds from the field measurements and existing empirical models is performed. The influences of the topography features and wind speeds on the wind profiles were investigated based on the field-measured wind records. In general, the empirical models can provide reasonable predictions for the measured wind speed profiles over a typical coastal urban area during a severe typhoon.

• Molecules and Cells
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• 제38권3호
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• pp.202-209
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• 2015

Hepatocellular carcinoma (HCC), a highly malignant disease and the third leading cause of all cancer mortalities worldwide, often responses poorly to current treatments and results in dismal outcomes due to frequent chemoresistance and tumor relapse. The heterogeneity of HCC is an important attribute of the disease. It is the outcome of many factors, including the cross-talk between tumor cells within the tumor microenvironment and the acquisition and accumulation of genetic and epigenetic alterations in tumor cells. In addition, there is accumulating evidence in recent years to show that the malignancy of HCC can be attributed partly to the presence of cancer stem cell (CSC). CSCs are capable to self-renew, differentiate and initiate tumor formation. The regulation of the stem cell-like properties by several important signaling pathways have been found to endow the tumor cells with an increased level of tumorigenicity, chemoresistance, and metastatic ability. In this review, we will discuss the recent findings on hepatic CSCs, with special emphasis on their putative origins, relationship with hepatitis viruses, regulatory signaling networks, tumor microenvironment, and how these factors control the stemness of hepatic CSCs. We will also discuss some novel therapeutic strategies targeted at hepatic CSCs for combating HCC and perspectives of future investigation.