• Molecules and Cells
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• v.46 no.4
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• pp.200-205
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• 2023

DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a member of the phosphatidylinositol 3-kinase-related kinase family is a well-known player in repairing DNA double-strand break through non-homologous end joining pathway. This mechanism has allowed us to understand its critical role in T and B cell development through V(D)J recombination and class switch recombination, respectively. We have also learned that the defects in these mechanisms lead to the severely combined immunodeficiency (SCID). Here we highlight some of the latest evidence where DNA-PKcs has been shown to localize not only in the nucleus but also in the cytoplasm, phosphorylating various proteins involved in cellular metabolism and cytokine production. While it is an exciting time to unveil novel functions of DNA-PKcs, one should carefully choose experimental models to study DNA-PKcs as the experimental evidence has been shown to differ between cells of defective DNA-PKcs and those of DNA-PKcs knockout. Moreover, while there are several DNA-PK inhibitors currently being evaluated in the clinical trials in an attempt to increase the efficacy of radiotherapy or chemotherapy, multiple functions and subcellular localization of DNA-PKcs in various types of cells may further complicate the effects at the cellular and organismal level.

• Wind and Structures
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• v.37 no.5
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• pp.331-346
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• 2023

This work investigates the effects of transverse inclination on an aeroelastic prism through forced-vibration wind tunnel experiments. The aerodynamic characteristics are tri-parametrically evaluated under different wind speeds, inclination angles, and oscillation amplitudes. Results show that transverse inclination fundamentally changes the wake phenomenology by impinging the fix-end horseshoe vortex and breaking the separation symmetry. The aftermath is a bi-polar, one-and-for-all change in the aerodynamics near the prism base. The suppression of the horseshoe vortex unleashes the Kármán vortex, which significantly increases the unsteady crosswind force. After the initial morphology switch, the aerodynamics become independent of inclination angle and oscillation amplitude and depend solely on wind speed. The structure's upper portion does not feel the effect, so this phenomenon is called Base Intensification. The phenomenon only projects notable impacts on the low-speed and VIV regime and is indifferent in the high-speed. In practice, Base Intensification will disrupt the pedestrian-level wind environment from the unleashed Bérnard-Kármán vortex shedding. Moreover, it increases the aerodynamic load at a structure base by as much as 4.3 times. Since fix-end stiffness prevents elastic dissipation, the load translates to massive stress, making detection trickier and failures, if they are to occur, extreme, and without any warnings.

• Journal of the Korean Home Economics Association
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• v.47 no.9
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• pp.101-110
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• 2009

The purpose of this study was to examine the effect for information load on perceived information quality and website quality, and the relationships among perceived information quality, website quality and behavioral intentions in online apparel shopping contexts. The information load theory provided the theoretical framework for this study. The research strategy employed an online experimentation using an apparel mock website. The total of 647 responses were used for data analyses. The model of the study was tested by MANOVA and SEM. The results of MANOVA revealed the effect of information load on perceived information quality and website quality. The medium level of information load was perceived as having more positive information quality and website quality as compared to the low or high level of information load. The findings of SEM revealed the positive effect of information quality on website quailty, the positive effect of website quality on WOM and willingness to pay more, and the negative effect of website quailty on willingness to switch. Online apparel retailers and website designers need to manage information quantity and quality by understanding the importance of information load.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.7
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• pp.1156-1168
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• 2007

The somatotropic (GH-IGF-I) axis consists of many hormonal and nutritional factors that control GH release from the somatotrophs in the anterior pituitary. The GH-releasing substances are GHRH and GHS (GHRP or ghrelin), while the GH release-inhibiting substances are somatostatin (SRIF), insulin-like growth factor-I (IGF-I), leptin and glucocorticoids. However, there is evidence showing that nutrition is involved in the control of the somatotropic axis. In addition, weaning is a drastic event for neonates because their alimentary and endocrine circumstances are changed due to the switch, even if gradual, from a liquid milk diet to one composed of such solids as hay and grains. The biological role of ghrelin is one of the hormonal factors that have been focused on ever since ghrelin was discovered at the end of the last century. A 27-amino acid peptide that is mainly synthesized and released from the abomasum epithelium, ghrelin has not been fully evaluated in relation to the somatotropic axis of the ruminant. It has also proven difficult even to investigate the cellular mechanisms of ghrelin action, because this hormone exerts animal-species-dependent actions via a complex set of intracellular signaling pathways. This is also the case for the action of leptin. Another substance, IGF-I, shows a partial inhibitory action on GH secretion in the ruminant. The effect of nutrition is also different among animal species. This is evident by the fact that undernutrition suppresses the circulating GH levels in rodents, but increases it in ruminants and humans. Recently, weaning has been shown to change the postprandial GH responses in ruminants; milk feeding increases, but hay and concentrate feeding suppress, the postprandial circulating GH levels. Even if the postprandial GH level is increased, the ghrelin level is decreased by milk feeding. Macronutrients also possess stimulatory and inhibitory actions on GH secretion in vivo and in vitro. These findings indicate the complexity of the control mechanisms of the somatotropic axis. In the present review, we summarize recent findings on the factors controlling the axis of the ruminant.

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.1
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• pp.65-70
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• 2012

Synaptic long-term potentiation (LTP) and long-term depression (LTD) have been studied as mechanisms of ocular dominance plasticity in the rat visual cortex. Serotonin (5-hydroxytryptamine, 5-HT) inhibits the induction of LTP and LTD during the critical period of the rat visual cortex (postnatal 3~5 weeks). However, in adult rats, the increase in 5-HT level in the brain by the administration of the selective serotonin reuptake inhibitor (SSRI) fluoxetine reinstates ocular dominance plasticity and LTP in the visual cortex. Here, we investigated the effect of 5-HT on the induction of LTP in the visual cortex obtained from 3- to 10-week-old rats. Field potentials in layer 2/3, evoked by the stimulation of underlying layer 4, was potentiated by theta-burst stimulation (TBS) in 3- and 5-weekold rats, then declined to the baseline level with aging to 10 weeks. Whereas 5-HT inhibited the induction of LTP in 5-week-old rats, it reinstated the induction of N-methyl-D-aspartate receptor (NMDA)-dependent LTP in 8- and 10-week-old rats. Moreover, the selective SSRI citalopram reinstated LTP. The potentiating effect of 5-HT at 8 weeks of age was mediated by the activation of 5-$HT_2$ receptors, but not by the activation of either 5-$HT_{1A}$ or 5-$HT_3$ receptors. These results suggested that the effect of 5-HT on the induction of LTP switches from inhibitory in young rats to facilitatory in adult rats.

• Asian-Australasian Journal of Animal Sciences
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• v.13 no.11
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• pp.1523-1528
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• 2000

Four Suffolk ewes were used in Latin Square switch over design to study the effects of varying levels and sources of protein on heat production and thermoregulatory responses at daytime high ($33^{\circ}C$ temperature. They were fed Italian ryegrass hay supplemented with fishmeal and/or urea, providing three different levels of crude protein (CP) (low/unsupplemented: 7.9, medium: 11.6, and high: 15.8%) at $1.5{\times}maintenance$. Feeds were distributed at 0900 (30%) and 1700 (70%). Urea diet caused higher heat production and increased vaginal temperature compared to fishmeal and fishmeal-urea mix diets. Time spent standing, skin temperature and respiration rate of sheep fed urea were similar with those of sheep fed fishmeal. Sheep fed diet with low CP level had higher heat production, increased vaginal and skin temperature than sheep fed diet with medium CP content. Sheep on high CP diet produced significantly more heat than sheep fed medium CP diets. Their vaginal temperatures were similar with those of sheep fed medium CP diet but lower than those of sheep fed low CP diet. Respiration rates of sheep and time spent by them for standing on all diets did not differ significantly. These results suggest that urea is inferior protein supplement for thermoregulation of animal at hot environment, as it induced higher heat production than fishmeal and fishmeal-urea mix. Thermoregulatory response on fishmeal-urea mix diet was similar to fishmeal diet. Increasing CP of the diet from low to medium gives advantage for thermoregulation of animal. Increasing CP further to high level was not beneficial as it resulted in the responses of sheep similar to those on low protein diet.

• KIEAE Journal
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• v.14 no.2
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• pp.77-86
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• 2014

Plenty of efforts have been made in the traditional architecture of Korea, Hanok, to develop various elements such as restoration, the introduction of new design, and energy-saving while systemic setups on standard and evaluation of eco-friendly energy design of Hanok are lacking. If we evaluate energy performance based on current standards without reflecting unique features of Hanok on the system, Hanok will be included in the very low grade among the residential buildings being included in the approval system of eco-friendly architecture or the unique features will be modified and the burden of increased construction cost. Therefore, this study is to prepare the basic reference for the introductory evaluation system by evaluating the energy performance level of NEO-Hanok based on the current building energy rating system. The result for NEO-Hanok based on the building energy rating system, we propose the rating standard with scorecard elements of NEO-Hanok by considering the necessity of identity and standard for NEO-Hanok. As a result of infiltration test to check the tightness, it was measured as 10.81 times/h (50 ACH). As we switch from the main insulation for the wall from the glass wool 64k(0.035W/mk) to rigid polyurethane foam first class first unit (0.024W/mk), the result was slightly increased from the first demand quantity rating yield $249.8kWh/m^2{\cdot}yr$ to $235.0kWh/m^2{\cdot}yr$. Current certificate system is focused more on the heating load than the cooling load, it is disadvantageous for Hanok, which has less cooling energy consumption in summer. The rating result from the target building study is level 4.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.6 no.2
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• pp.236-247
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• 2002

We propose a cell－multiplexing scheme for the real－time communication service in ATM network and a new service discipline guarantee end-to-end delay based on pseudo-isochronous cell switching. The proposed scheme consists of two level frame hierarchy, upper and lower frame, which is used to assign the bandwidth and to guarantee the requested delay bound, respectively. Since the Proposed algorithm employs two level frame hierarchy, it can overcome the coupling problem which is inherent to the framing strategy It can be comparatively reduce the complexity, and still guarantee the diverse delay bounds of end-to-end. Besides, it consists of two components, traffic controller and scheduller, as the imput traffic description model and regulates the input traffic specification. The function of the traffic controller is to shape real -time traffic to have the same input pattern at every switch along the path. The end-to-end delay is bounded by the scheduller which can limit the delay variation without using per-session jitter controllers, and therefore it can decrease the required buffer size. The proposed algorithm can support the QoS's of non-real time traffic as well as those of real time traffic.

• Journal of Power Electronics
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• v.17 no.1
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• pp.222-231
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• 2017

In this paper, a new architecture for a cost-effective power conditioning systems (PCS) using a single-sourced asymmetric cascaded H-bridge multilevel inverter (MLI) for photovoltaic (PV) applications is proposed. The asymmetric MLI topology has a reduced number of parts compared to the symmetrical type for the same number of voltage level. However, the modulation index threshold related to the drop in the number of levels of the inverter output is higher than that of the symmetrical MLI. This problem results in a modulation index limitation which is relatively higher than that of the symmetrical MLI. Hence, an extra voltage pre-regulator becomes a necessary component in the PCS under a wide operating bias variation. In addition to pre-stage voltage regulation for the constant MLI dc-links, another auxiliary pre-regulator should provide isolation and voltage balance among the multiple H-bridge cells in the asymmetrical MLI as well as the symmetrical ones. The proposed PCS uses a single-ended DC-DC converter topology with a coupled inductor and charge-pump circuit to satisfy all of the aforementioned requirements. Since the proposed integrated-type voltage pre-regulator circuit uses only a single MOSFET switch and a single magnetic component, the size and cost of the PCS is an optimal trade-off. In addition, the voltage balance between the separate H-bridge cells is automatically maintained by the number of turns in the coupled inductor transformer regardless of the duty cycle, which eliminates the need for an extra voltage regulator for the auxiliary H-bridge in MLIs. The voltage balance is also maintained under the discontinuous conduction mode (DCM). Thus, the PCS is also operational during light load conditions. The proposed architecture can apply the module-integrated converter (MIC) concept to perform distributed MPPT. The proposed architecture is analyzed and verified for a 7-level asymmetric MLI, using simulation results and a hardware implementation.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.27 no.5C
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• pp.445-453
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• 2002

We propose a cell-multiplexing scheme for the real-time communication service in ATM network and a new service discipline guarantee end-to-end delay based on pseudo-isochronous cell switching. The proposed scheme consists of two level frame hierarchy, upper and lower frame, which is used to assign the bandwidth and to guarantee the requested delay bound, respectively. Since the proposed algorithm employs two level frame hierarchy, it can overcome the coupling problem which is inherent to the framing strategy. The proposed scheme consists of two components, traffic controller and scheduller, as the imput traffic description model and regulates the input traffic specification. The function of the traffic controller is to shape real-time traffic to have the same input pattern at every switch along the path. The end-to-end delay is bounded by the scheduller which can limit the delay variation without using per-session jitter controllers, and therefore it can decrease the required buffer size. The proposed algorithm can support the QoS's of non-real time traffic as well as those of real time traffic