• Journal of Pharmaceutical Investigation
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• 제36권4호
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• pp.223-229
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• 2006

[ $PGE_1$ ]-ethyl ester intraurethral solutions were prepared in ethanol/propylene glycol mixture with penetration enhancer and viscosity-enhancing agent. The stability of $PGE_1$-ethyl ester in intraurethral solution was investigated at various temperature. Simultaneous determination of $PGE_1$-ethyl ester and $PGE_1$ was performed using a validated HPLC technique. In pentobarbital anesthetized cats, increase in intracavernous pressure(ICP), increase in penile length and duration of erectile response were determined after intraurethral application of $PGE_1$-ethyl ester solutions. $PGE_1$-ethyl ester solutions, when instilled into the eyes of rabbits, produces no noticeable irritation, or slight transient conjunctival irritation. From these results, ocular irritation of this solutions was judged as practically non-irritating. The stability study indicates that the therapeutically effective content in solution is well maintained for 46 weeks or longer when they are stored at $4^{\circ}C$. After intraurethral application of $PGE_1$-ethyl ester, ICP was increased and penile erection was induced. $PGE_1$-ethyl ester intraurethral solutions for erectile dysfunction could be developed and evaluated by employing feline erection model.

• 한국동물학회지
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• 제31권1호
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• pp.21-28
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• 1988

dbcAMP에 의해 성숙이 억제된 생쥐난자의 수정능을 조사하기 위해 본 실험을 행하였다. dbcAMP로 일시 성숙이 억제되었던 난자를 배양액내에서 정자와 섞고 24시간 배양한 후 발생한 2세포기의 배아형성, 정자의 관입, 전액형성을 조사하여 2세포기로 배아발생이 진척된 것을 수정율의 기준으로 정하였다. dbcAMP를 처리하지 않은 난자는 약 53.3%의 수정율을 보였으며,dbcAMP가 함유되 배양액에서 배양한 후 기본 배양액에서 성숙시킨 난자들의 수정율은 dbcAMP의 처리시간에 비례하여 낮으나, 정자의 관입은 정상적으로 일어났다. 전자현미경적 관찰에 의하면 dbcAMP 처리는 난자의 미세구조에 어떠한 변화도 야기하지 않았다. 따라서 dbcAMP를 사전처리하여 성숙을 억제한 난자라할지라도 어느 정도의 수정능력을 보유하고 있다고 사료된다.

• 한국분무공학회지
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• 제23권4호
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• pp.192-204
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• 2018

In this study, a 3D CFD analysis method for the combustion process was established for a low calorific value syngas-diesel dual-fuel engine operating under very lean fuel-air mixture condition. Also, the accuracy of computational analysis was evaluated by comparing the experimental results with the computed ones. To simulate the combustion for the dual-fuel engine, a new dual-fuel chemical kinetics set was used that was constituted by merging two verified chemical kinetic sets: n-heptane (173 species) for diesel and Gri-mech 3.0 (53 species) for syngas. For dual-fuel mode operations, the early stage of combustion was dominated by the fuel burning inside or near the spray plume. After which, the flame propagated into the syngas in the piston bowl and then proceeded toward the syngas in the squish zone. With the baseline injection system and piston shape, a significant amount of unburned syngas was discharged. To solve this problem, effects of the injection parameters and piston shape on combustion characteristics were analyzed by calculation. The change in injection variables toward increasing the spray plume volume or the penetration length were effective to cause fast burning in the vicinity of TDC by widening the spatial distribution of diesel acting as a seed of auto-ignition. As a result, the unburned syngas fraction was reduced. Changing the piston shape with the shallow depth of the piston bowl and 20% squish area ratio had a significant effect on the combustion pattern and lessened the unburned syngas fraction by half.

• Journal of Pharmaceutical Investigation
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• 제36권3호
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• pp.169-174
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• 2006

The aim of this work was to prepare tenoxicam-ethanolamine salt with improved physicochemical properties for transdermal application. Tenoxicam-ethanolamine salt was prepared in methylene chloride and its physicochemical properties were investigated by DSC and FT-lR. The broad peak of tenoxicam around 3600-3200 $cm^-1$ was shifted to lower wavenumber and more broadened. The characteristic endothermic melting peak of tenoxicam appeared at $223^{\circ}C$. The melting peak of tenoxicam-ethanolamine salt was shifted to $159^{\circ}C$. In contrast to relatively small difference in the partition coefficients of tenoxicam and the tenoxicam-ethanolamine salt, large difference in aqueous solubility was observed. $Crovol^{\circledR}$ PK4O (PEG-12 palm kernel glycerides) provided the highest skin flux for both compounds. The order of the enhancing effect of the various vehicles tested was similar for tenoxicam and tenoxicam-ethanolamine salt, which indicated that their enhancing mechanism for tenoxicam and tenoxicam-ethanolamine salt is similar. Tenoxicam-ethanolamine salt had a higher skin flux than tenoxicam by 1.2- to 31.7-fold, depending on the vehicles used. It is suggested that the vehicles with medium HLB value, 1 double bond, and lower ethylene oxide chain length have a better ability to modify the permeability of the stratum corneum and to promote the effective penetration of tenoxicam and tenoxicam-ethanolamine salt.

• 아시안잔디학회지
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• 제17권2_3호
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• pp.87-97
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• 2003

The growth characteristics of creeping bentgrass seeded in the seaside landfill golf course are as follows. 1. As a result of analysis on the chemical characteristics of soil mixture used for turfgrass ground in this experiment, soil pH was 7.9, which is somewhat higher than the creeping bentgrass reference value of pH 5.5∼6.5; T-N(%) was 0.02, which is proper for the reference value, and trace element too lacked. 2. The cultivar with the fastest water infiltration was Seaside II recorded as 226.2cm/sec, while that with the slowest water infiltration was Pennlinks recorded as 141.1 cm/hr which was too faster than the USGA water infiltration reference value of 15∼30cm/hr. For the surface hardness of turfgrass ground with different cultivars, no statistically significant variation was found between the Penncross grass and the Pennlinks recorded as 18.6mm and 19.1 mm, respectively. The soil penetration was the highest in Pennlinks recorded as 7.6kg/$\textrm{cm}^2$ and lowest in Penn A-1 as 6.1kg/$\textrm{cm}^2$. 3. As a result of evaluation on visual quality at the early stage of growth, Penncross showed the most excellent visual quality compared to the others. However, Penn A-1 showed the most excellent visual quality at a late stage of growth around Sep. 17, 2003, and it was also excellent in the evaluation of visual color. Seaside II showed higher density around the root and the longest root length and was highly resistant to salt compared to others, but the initial sprouting rate was not satisfied, and the visual quality in the summer season was inferior to others. 4. As a result of measurement of the traffic injury, Penncross showed the most tolerant to the traffic stress and Pennlinks showed the most susceptible.

• 한국도로학회논문집
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• 제19권5호
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• pp.69-75
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• 2017

PURPOSES : The purpose of this study is to evaluate different types of Ground Penetrating Radar (GPR) testing for characterizing the road cavity detection. The impulse and step-frequency-type GPR tests were conducted on a full-scale testbed with an artificial void installation. After analyzing the response signals of GPR tests for detecting the road cavity, the characteristics of each GPR response was evaluated for a suitable selection of GPR tests. METHODS : Two different types of GPR tests were performed to estimate the limitation and accuracy for detecting the cavities underneath the asphalt pavement. The GPR signal responses were obtained from the testbed with different cavity sizes and depths. The detection limitation was identified by a signal penetration depth at a given cavity for impulse and step-frequency-type GPR testing. The unique signal characteristics was also observed at cavity sections. RESULTS : The impulse-type GPR detected the 500-mm length of cavity at a depth of 1.0 m, and the step-frequency-type GPR detected the cavity up to 1.5 m. This indicates that the detection capacity of the step-frequency type is better than the impulse type. The step-frequency GPR testing also can reflect the howling phenomena that can more accurately determine the cavity. CONCLUSIONS :It is found from this study that the step-frequency GPR testing is more suitable for the road cavity detection of asphalt pavement. The use of step-frequency GPR testing shows a distinct image at the cavity occurrences.

• 대한기계학회논문집B
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• 제41권6호
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• pp.415-421
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• 2017

환경규제의 강화에 따라 수처리 비용이 증가하는 추세이므로 폭기공정의 에너지 이용효율을 제고할 수 있는 소요동력에 대한 보다 정량적인 연구가 필요하다. 본 논문은 폭기공정의 물질전달 특성을 규명하기 위해 물질전달 계수와 기체 포집율 및 소요동력에 대한 상관관계식을 제시하였다. 소요동력이 커지면 기체 포집율은 감소하고 레이놀드 수는 증가하며, 혼합유동 선단 도달거리와 확산도가 증대되므로 물질전달 계수는 증가하였다. 물질전달 계수와 기체 포집율 및 소요동력의 상관관계 규명을 위해 제시한 실험식은 최대 약 ${\pm}10%$의 오차 범위에서 실험결과와 일치하였다.

• 대한기계학회논문집B
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• 제21권9호
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• pp.1149-1164
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• 1997

In this study, the applicability of the RNG k-.epsilon. model to the analysis of the complex flows is studied. The governing equations based on a non-orthogonal coordinate formulation with Cartesian velocity components are used and discretized by the finite volume method with non-staggered variable arrangements. The predicted results using the RNG k-.epsilon. model of three complex flows, i.e., the flow over a backward-facing step and a blunt flat plate, the flow around a 2D model car are compared to these from the standard k-.epsilon. model and experimental data. That of the unsteady axisymmetric turbulent flow within a cylinder of reciprocating model engine including port/valve assembly and the spray characteristics within a chamber of direct injection model engine are compared to these from the standard k-.epsilon. model and experimental data. The results of reattachment length, separated eddy size, average surface pressure distribution using the RNG k-.epsilon. model show more reasonable trends comparing with the experimental data than those using the modified k-.epsilon. model. Although the predicted rms velocity using the modified k-.epsilon. model is lower considerably than the experimental data in incylinder flow with poppet valve, predicted axial and radial velocity distributions at the valve exit and in-cylinder region show good agreements with the experimental data. The spray tip penetration predicted using the RNG k-.epsilon. model is more close to the experimental data than that using the modified k-.epsilon. model. The application of the RNG k-.epsilon. model seems to have some potential for the simulations of the unsteady turbulent flow within a port/valve-cylinder assembly and the spray characteristics over the modified k-.epsilon. model.

• 유기물자원화
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• 제27권3호
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• pp.75-80
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• 2019

본 연구는 난류로 흐르는 물에서 미세먼지 전구체 중 하나인 암모니아가 흡수되는 거동을 해석하였다. 물의 흐름이 층류보다 난류인 조건에서 암모니아의 침투 깊이가 더 깊으므로 레이놀즈 수가 $10^4$보다 큰 난류 조건이 고려된다. 거동 해석을 위하여, 무차원 물질전달 지배방정식과 상온 기준의 일정한 물성치들이 사용되었다. 물에서의 암모니아 확산계수와 물의 동점도계수는 각각 $2.45{\times}10^{-9}m^2/s$와 $1{\times}10^{-6}m^2/s$이었다. 물에서의 암모니아 농도 분포는 암모니아에 노출되기 시작하는 지점으로부터의 위치에 대하여 산출되었다. 혼합 깊이에 따른 정량적인 분포 또한 도출되었다. 이와 같은 정량적인 해석은 난류로 흐르는 물이 층류로 흐르는 것과 비교하여 얼마나 더욱 효율적으로 암모니아를 제거할 수 있는지에 대한 통찰력을 제시할 수 있다.

• 한국분무공학회지
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• 제15권2호
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• pp.74-82
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• 2010

In order to understand the behavior of transient gaseous injection used in an LPG (Liquefied Petroleum Gas) engine, turbulent incompressible transient jets with butane and propane were measured and analyzed at pressures of 1.5 bar and 2.0 bar with injector diameters of 3 mm and 5 mm. Mie-scattering method with a tracer was used, and images were processed to investigate the behavior of butane and propane jets. Distances from the nozzle to transition region were measured as $L_e/d_{inj}$=4.35~19.4, where $L_e$ and $d_{inj}$ indicate respectively a distance from nozzle to transition point and nozzle diameter. Slits and tubes around jet at near-field were introduced to measure the effect of entrainment and the diameter of jet, which revealed that the entrainment of surrounding air is significant for developing jet diameter. When the entrainment is restricted, the behavior of jet became deviating from the baseline. It was found that the virtual origin located outside of a nozzle towards jet tip within the conditions of this work, and its location was estimated as $x_o/d_{inj}$=0.56~7.25, where $x_o$ is a distance from nozzle to virtual origin.