• Title/Summary/Keyword: Lee Sang Hyuk

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A Case of Lung Metastasis of Mesoblastic Nephroma in Adulthood (성인에서 발생한 중배엽성 신종의 폐전이 1예)

  • Moon, Jin Wook;Kim, Kil Dong;Shin, Dong Hwan;Hahn, Chang Hoon;Jung, Jae;Park, Mu Suk;Jung, Sang Youn;Lee, Jae Hyuk;Kim, Young Sam;Kim, Se Kyu;Kim, Sung Kyu;Chang, Joon
    • Tuberculosis and Respiratory Diseases
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    • v.55 no.4
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    • pp.402-407
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    • 2003
  • Mesoblastic nephroma is a neoplasm of the kidney which is characterized by interlacing bundles of spindle mesenchymal cells. It is usually diagnosed during the first six months of life and is mostly benign. Incidence in adults is exceedingly rare. In most cases, only total excision is required without postoperative adjuvant therapy, and the rare cases of local recurrence have usually been related to incomplete removal. However, mesoblastic nephroma may behave aggressively, in contrast to a congenital mesoblastic nephroma. Several cases of metastatic mesoblastic nephroma have been previously described. We report herein a case of a 42-year-old woman with mesoblastic nephroma which recurred as a large metastatic lung mass seven years after the nephrectomy. The patient presented with chest wall discomfort for four days. Seven years previously, total nephrectomy had been performed because of a right renal tumor which had been diagnosed as a mesoblastic nephroma. There had been no evidence of recurrence for five years, after which she discontinued follow-up. On readmission two years later, chest X-ray and CT scan revealed a large lung mass in the left upper lobe. It was completely excised and the pathologic examination was identical with that of the original renal tumor. Synovial sarcoma was excluded because the fusion transcripts of the SYT-SSX fusion gene associated with the t(X;18) translocation were negative. The final diagnosis was a lung metastasis of mesoblastic nephroma and the patient remained free of disease for 7 months postoperatively.

An Economic Analysis of Solvent Extraction Process under Mild Condition for Production of Ash-Free Coal (무회분 석탄 생산을 위한 온순조건 용매추출 공정의 경제성 분석)

  • Choi, Ho-Kyung;Kim, Sang-Do;Yoo, Ji-Ho;Chun, Dong-Hyuk;Lim, Jeong-Hwan;Rhim, Young-Joon;Lee, Si-Hyun
    • Korean Chemical Engineering Research
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    • v.50 no.3
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    • pp.449-454
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    • 2012
  • Economic feasibility of the process for a coal extraction under mild condition, which will produce ash-free coal at a temperature lower than that of coal softening, was analyzed. To this end, the plant of 6000 t/d in capacity was assumed to be constructed near a coal mine in Indonesia, and the IRR, NPV, B/C ratio, and DPP of the plant were calculated based on $96 million investment cost and 15 years service life. The IRR, NPV, B/C ratio, and DPP of the plant were calculated to be 31%, $87 million, 1.08, and 3.9 years, respectively, and which satisfied the evaluation criteria of investment. The economic feasibility of the plant was mainly dependent on the price of the coal initially fed and the residue coal remaining after the extraction, according to sensitivity analysis.

Extraction and Indexing Representative Melodies Considering Musical Composition Forms for Content-based Music Information Retrievals (내용 기반 음악 정보 검색을 위한 음악 구성 형식을 고려한 대표 선율의 추출 및 색인)

  • Ku, Kyong-I;Lim, Sang-Hyuk;Lee, Jae-Heon;Kim, Yoo-Sung
    • The KIPS Transactions:PartD
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    • v.11D no.3
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    • pp.495-508
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    • 2004
  • Recently, in content-based music information retrieval systems, to enhance the response time of retrieving music data from large music database, some researches have adopted the indexing mechanism that extracts and indexes the representative melodies. The representative melody of music data must stand for the music itself and have strong possibility to use as users' input queries. However, since the previous researches have not considered the musical composition forms, they are not able to correctly catch the contrast, repetition and variation of motif in musical forms. In this paper, we use an index automatically constructed from representative melodies such like first melody, climax melodies and similarly repeated theme melodies. At first, we expand the clustering algorithm in order to extract similarly repeated theme melodies based on the musical composition forms. If the first melody and climax melodies are not included into the representative melodies of music by the clustering algorithm, we add them into representative melodies. We implemented a prototype system and did experiments on comparison the representative melody index with other melody indexes. Since, we are able to construct the representative melody index with the lower storage by 34% than whole melody index, the response time can be decreased. Also, since we include first melody and climax melody which have the strong possibility to use as users' input query into representative melodies, we are able to get the more correct results against the various users' input queries than theme melody index with the cost of storage overhead of 20%.

The Improvement of Curtain Wall Design Process using Value Stream Mapping Tools (VSM기법을 활용한 커튼월 공사의 설계 프로세스 개선)

  • Kim, Chang-Duk;Lee, Sang-Hyuk
    • Korean Journal of Construction Engineering and Management
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    • v.7 no.5
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    • pp.128-137
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    • 2006
  • This paper is to develop curtain wall process life-cycle system in high-rise buildings in order to establish effective cooperation communication channels among the diverse constituents. This paper is to provide a base toward a curtain wall life-cycle management system to support decision making and the effective flow in light of information and materials. The four objectives of the research are 1) the analysis of the current curtain wall life-cycle process, 2) the analysis and development of the curtain wall design process As-Is model, and 3) the Muda analysis of the design process As-Is model and the suggestion of the improvements, 4) the development of curtain wall design To-Be model and comparative analysis of the improvement in terms of value streams. This research indicates the wastes decrease (or the values increase) from 6.7% up to 100% in different decision criteria through the improvement by the comparative analysis between the As-ls and To-Be curtain wall design process. This research suggests the potential improvement by VSM and a curtain wall life-cycle management system in curtain wall construction for diverse constituents be significant.

Experimental study on the behavior of the adjacent ground due to the sidewall failure in a shallow tunnel (얕은터널에서 측벽파괴시 주변지반 거동에 대한 실험적 연구)

  • Park, Chan Hyuk;Lee, Sang Duk
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.19 no.6
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    • pp.871-885
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    • 2017
  • Nowadays, the construction of tunnels with a shallow depth drastically in urban areas increases. But the effect of sidewall displacement in shallow tunnel on its behavior is not well known yet. Most studies on the shallow tunnel have been limited to the stability and the failure of the tunnel and the adjacent ground in plane strain state. Therefore, the model tests were conducted in a model ground which was built with carbon rods, in order to investigate the impact of the tunnel sidewall displacement on the lateral load transfer to the adjacent ground. The lateral displacement of the tunnel sidewall and the load transfered to the adjacent ground were measured in model tests for various overburdens (0.50D, 0.75D, 1.00D, 1.25D). As results, if the cover depth of tunnel was over a constant depth (0.75D) in a shallow tunnel, the tunnel sidewall was failed with a constant shape not depending on the tunnel cover depth and also not affected by the opposite side of the wall. But, if the cover depth of tunnel was under a constant depth (0.75D), the failure of the tunnel sidewall could affect the opposite sidewall. In addition, if the displacement of tunnel sidewall with 50% of the critical displacement occurred, the tunnel failure was found to be at least 75%. However, additional studies are deemed necessary, since they may differ depending on the ground conditions.

Curing behavior of Photo-Curable Materials by Photo-Shrinkage Test (광원 경화형 소재의 수축률평가를 통한 광경화 거동 평가)

  • Park, Ji-Won;Bae, Kyung-Yul;Kim, Pan-Seok;Lim, Dong-Hyuk;Kim, Hyun-Joong;Cho, Jin-Ku;Kim, Baek-Jin;Lee, Sang-Hyeup
    • Journal of Adhesion and Interface
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    • v.11 no.2
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    • pp.57-62
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    • 2010
  • Photo-curable material can be crosslinked among molecules by light source such as UV and visible light materials. Material properties are controlled by crosslink reaction. Shrinkage is occured during the curing reaction of material structure. Phenomenon of shrinkage stress occurs inside the product and reduce the stability of the product causes problems. Heat shrink the evaluation of the phenomenon has been formalized. But the evaluation of photo shrink is not enough. In this experiment, real-time contract with shrinkage tester phenomena and analysis degree of shrinkage of the material differences. According to the research, experimental results and theoretical analysis of the results were big differences. Shrinkage, especially for a number of different functional groups that were very different theory. These differences are occurred by the molecular structure different and not enough reaction.

Characterization of Two Novel mAbs Recognizing Different Epitopes on CD43

  • Kim, Soseul;Hong, Jeong Won;Cho, Woon-Dong;Moon, Yoo Ri;Yoon, Sang Soon;Kim, Min-Young;Hong, Kwon Pyo;Lee, Yong-Moon;Yi, Jae Hyuk;Ham, Young Jun;Rah, Hyung Chul;Kim, Seung Ryul;Song, Hyung Geun
    • IMMUNE NETWORK
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    • v.14 no.3
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    • pp.164-170
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    • 2014
  • JL1, a specific epitope on CD43, is a potential biomarker for the diagnosis of acute leukemia. Although qualitative assays for detecting leukemia-specific CD43 exist, there is a need to develop quantitative assays for the same. Here, we developed two novel monoclonal antibodies (mAbs), 2C8 and 8E10, recognizing different epitopes on CD43. These clones are capable of pairing with YG5, another mAb against JL1 epitope, because they were selectively obtained using sandwich ELISA. Antigens recognized by 2C8 and 8E10 were confirmed as CD43 by western blotting using the CD43-hFC recombinant protein. When expression on various leukemic cell lines was investigated, 2C8 and 8E10 displayed a disparity in the distribution of the epitope. Enzyme assays revealed that these mAbs recognized a sialic acid-dependent epitope on CD43. Using normal thymus and lymph node paraffin-embedded tissues, we confirmed a difference in the epitopes recognized by the two mAbs that was predicted based on the maturity of the cells in the tissue. In summary, we developed and characterized two mAbs, 2C8 and 8E10, which can be used with YG5 in a sandwich ELISA for detecting leukemia-specific CD43.

Neuroprotecticve Effect of Sophora Subprostrata on Transient Global Ischemia in Gerbil (광두근(廣豆根)의 Gerbil 전뇌(全腦)허혈에 대한 신경손상방어효능 연구)

  • Min, Hong-Kyu;Kang, Ho-Chang;Lee, Hyun-Sam;Kim, Sun-Yeou;Sohn, Young-Joo;Jung, Hyuk-Sang;Sohn, Nak-Won;Kim, Yoon-Bum
    • The Korea Journal of Herbology
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    • v.23 no.3
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    • pp.1-9
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    • 2008
  • Objectives : This research was performed to investigate protective effect of Sophora Subprostrata against transient global ischemic damage after 5-min two vessel occlusion. Methods : Gerbils were divided into three groups: Normal group, 5-min two vessel occlusion (2VO) group, Sophora Subprostrata administrated group after 2VO. The CCAs were occluded by microclip for 5min. Sophora Subprostrata was administrated orally(12mg/ml) for 7 days after 2VO. The histological and immunohistochemistrical analysis was performed at 72 hours and 7 days after the surgery each. For histological analysis, the brain tissue was stained with 1% cresyl violet solution and Immunohistochemistry for BAX and Bcl-2 was carried out to examine effect of Sophora Subprostrata on ischemic brain tissue. Results : The results showed that (1) Sophora Subprostrata has the protective effect against ischemia in CA1 area of the gerbil hippocampus 7 days after 5-minute occlusion, (2) the treatment of Sophora Subprostrata inhibits the expression of Bax relatively after 2VO-induced ischemia. That protective effect of the Sophora Subprostrata seems to be performed by regulating the proportion of Bax and Bcl-2 protein, (3) in hypoxia/reperfusion model using PC12 cell, the Sophora Subprostrata extract has the protective effect against ischemia in the dose of $2{\mu}/m{\ell}$ and $20{\mu}/m{\ell}$.This study suggests that Sophora Subprostrata has neuroprotective effect against neuronal damage following cerebral ischemia in vivo with a widely used experimental model of cerebral ischemia in Mongolian gerbils and that Sophora Subprostrata regulates the proportion of Bax and Bcl-2 protein following ischemia. And, Sophora Subprostrata extract has protective effects also on a hypoxia/reperfusion cell culture model using PC12 cell. Conclusions : Sophora Subprostrata has protective effects against ischemic brain damage at the early stage of ischemia.

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Hygienic State and Awareness of Drink Vending Machines in a City (중소도시 지역의 음료 자동판매기에 대한 위생 실태 및 인식)

  • Park, Ji-Hyuk;Lim, Hyun-Sul;Kim, Sang-Kyu;Park, Byeong-Chan;Lee, Kwan;Kim, Hee-Soo
    • Journal of agricultural medicine and community health
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    • v.34 no.2
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    • pp.168-174
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    • 2009
  • Objective: This study was conducted to investigate the hygienic state and awareness of drink vending machines in a city. Methods: Twelve of the most frequently used vending machines in various areas were selected in October 2008. As soon as fresh samples of milk coffee and adlay tea were collected in sterile containers from each machine, the temperature was measured. The samples were carried on ice to the laboratory to test total plate counts and Escherichia coli contamination. College students were inquired about drink vending machine hygiene by implementing self-developed questionnaires. Results: The temperature of 6 milk coffee samples (50.0%) and 8 adlay tea samples (66.7%) turned out to be inadequate. The total plate counts of milk coffee samples were all adequate, although 9 adlay tea samples (75.0%) were inadequate. All the beverage samples were negative for E. coli. In questionnaires obtained from 74 users of coffee vending machines, only 2 (2.7%) expected the hygienic state of vending machines to be good. There were 27 people (33.3%) that knew the existence of hygiene-related laws for vending machines. Conclusions: This study reveals that the hygienic state of drink vending machines insufficiently reaches the standard for the hot beverage and that most people are not aware of importance of vending machine hygiene. It is necessary to make improvement in the hygiene of vending machines and public awareness in this city.

Development of an Unmanned Conveyor Belt Recovery Skimmer for Floating Marine Debris and High Viscosity Oil (무인 컨베이어 벨트식 부유쓰레기 및 고점도유 회수장비 개발 연구)

  • Han, Sang-goo;Lee, Won-ju;Jang, Se-hyun;Choi, Jae-hyuk
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.23 no.2
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    • pp.208-215
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    • 2017
  • When persistent oil, such as crude oil or Bunker C oil, is spilled at sea, viscosity increases through the weathering process. Equipment that can collect this oil when mixed with floating marine debris is very limited. In this study, devices that can be attached to the outside of existing oil skimmers have been applied to the inside of the main body, to develop an unmanned conveyor belt type floating marine debris and high viscosity oil recovery skimmer, which is composed of a conveyor belt, a sweeper with a forced inflow device, and a collection tank equipped with a buoyant body. The resulting skimmer was operated at a speed of 1.2 knots at a distance of 30 m in a sea area test. It was stable when moving laterally in any direction. An oil recovery performance test was conducted using a portable storage tank, and oil was recovered from a minimum of $7.8k{\ell}/h$ to a maximum of $23.3k{\ell}/h$. Moreover, recovery of $7.7k{\ell}/h$ was obtained in a wave water tank test with floating marine debris such as PET bottles and oil mixed. If the equipment developed in this study was used in the field for oil pollution accidents, it could be expected to contribute to improved response capability. We believe our equipment could be used in further studies to improvement the performance of existing portable oil skimmers.