• 대한한방소아과학회지
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• 제23권3호
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• pp.241-262
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• 2009

Objectives This study is designed to investigate the effects of Jujadokseo-hwan on the brain ability and inducing oxidative stresses. Methods We measured the changes of regional cerebral blood flow and mean arterial blood pressure. Then we analyzed histological examination, immunohistochemistric response and anti-oxidant activity of Jujadokseo-hwan. Results 1. Treatment of Jujadokseo-hwan significantly increased regional cerebral blood flow but decreased mean arterial blood pressure. 2. Treatment of Jujadokseo-hwan-induced increase of regional cerebral blood flow was significantly inhibited by pretreatment with indomethacin (1 mg/kg, i.p.), an inhibitor of cyclooxygenase. 3. In histological examination through TTC stain, group I was no change, but group II showed that discolored in the most cortical part. Group III showed that decreased discolor in the cortical part. 4. In immunohistochemistric response of BDNF, group II showed that lower response effect. Group III showed that increase response effect. 5. Treatment of Jujadokseo-hwan increased proliferation rates of Glial cell effectively 6. Treatment of Jujadokseo-hwan accelerated proliferation rates of C6 cells in vitro. In addition, protective effects on cell death induced by paraquat, rotenone and hydrogen peroxide. In addition, activity of SOD were increased by treatment with Jujadokseo-hwan. Conclusions In conclusion, Jujadokseo-hwan can improve of the brain ability, learning ability, memory ability and induce ischemic brain injuries.

• 대한물리의학회지
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• 제7권1호
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• pp.11-20
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• 2012

Purpose : This study is intended to examine the repetitive transcranial magnetic stimulation on cognitive function in the focal ischemic stroke rat model. Methods : This study selected 30 Sprague-Dawley rats of 8 weeks. The groups were divided into two groups and assigned 15 rats to each group. Control group: Non-treatment after injured by focal ischemic stroke; Experimental group: application of repetitive transcranial magnetic stimulation(0.1 Tesla, 25 Hz, 20 min/time, 2 times/day, 5 days/2 week) after injured by focal ischemic stroke. To assess the effect of rTMS, the passive avoidance test, spatial learning and memory ability test were analyzed at the pre, 1 day, $7^{th}$ day, $14^{th}$ day and immunohistochemistric response of BDNF were analyzed in the hippocampal dentate gyrus at $7^{th}$ day, $14^{th}$ day. Results : In passive avoidance test, the outcome of experimental group was different significantly than the control group at the $7^{th}$ day, $14^{th}$ day. In spatial learning and memory ability test, the outcome of experimental group was different significantly than the control group at the $7^{th}$ day, $14^{th}$ day. In immunohistochemistric response of BDNF in the hippocampal dentate gyrus, experimental groups was more increased than control group. Conclusion : These result suggest that improved cognitive function by repetitive transcranial magnetic stimulation after focal ischemic stroke is associated with dynamically altered expression of BDNF in hippocampal dentate gyrus and that is related with synaptic plasticity.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제16권12호
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• pp.3868-3888
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• 2022

A widely used social networking service like Twitter has the ability to disseminate information to large groups of people even during a pandemic. At the same time, it is a convenient medium to share irrelevant and unverified information online and poses a potential threat to society. In this research, conventional machine learning algorithms are analyzed to classify the data as either non-rumor data or rumor data. Machine learning techniques have limited tuning capability and make decisions based on their learning. To tackle this problem the authors propose a deep learning-based Rumor Detection Neural Network model to predict the rumor tweet in real-world events. This model comprises three layers, AttCNN layer is used to extract local and position invariant features from the data, AttBi-LSTM layer to extract important semantic or contextual information and HPOOL to combine the down sampling patches of the input feature maps from the average and maximum pooling layers. A dataset from Kaggle and ground dataset #gaja are used to train the proposed Rumor Detection Neural Network to determine the veracity of the rumor. The experimental results of the RDNN Classifier demonstrate an accuracy of 93.24% and 95.41% in identifying rumor tweets in real-time events.

• 직업교육연구
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• 제29권3호
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• pp.133-156
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• 2010

이 논문은 기업에서 학습지원이 개인의 학습참여와 조직학습에 어떠한 영향을 미치는 지를 분석하였다. 구체적으로, 기업에서 학습지원이 개인의 학습참여에 미치는 영향을 살펴보았고, 기업에서의 학습지원과 개인의 학습참여가 조직학습에는 어떠한 영향을 미치는지를 검토하였다. 이를 위해 한국고용정보원과 연세대학교가 공동으로 실시한 '대졸 청년층 직장생활 적응능력 향상 연구'의 설문조사 자료를 분석하였다. 통계 분석을 위해서 위계적 선형모형을 적용하였다. 분석 결과, 기업에서 형식학습과 무형식학습의 지원여부는 개인의 형식학습 참여와 공식적 관계학습참여에 유의미한 영향을 미쳤다. 또한, 기업의 학습지원과 개인의 학습참여는 조직학습의 각 요소(수용력, 조직기억, 학습능력, 환경적응)에 긍정적인 영향을 미치는 것으로 나타났다.

• Biomolecules & Therapeutics
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• 제24권3호
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• pp.328-337
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• 2016

We examined whether wogonin (WO) improved hippocampal neuronal activity, behavioral alterations and cognitive impairment, in rats induced by administration of trimethyltin (TMT), an organotin compound that is neurotoxic to these animals. The ability of WO to improve cognitive efficacy in the TMT-induced neurodegenerative rats was investigated using a passive avoidance test, and the Morris water maze test, and using immunohistochemistry to detect components of the acetylcholinergic system, brain-derived neurotrophic factor (BDNF), and cAMP-response element-binding protein (CREB) expression. Rats injected with TMT showed impairments in learning and memory and daily administration of WO improved memory function, and reduced aggressive behavior. Administration of WO significantly alleviated the TMT-induced loss of cholinergic immunoreactivity and restored the hippocampal expression levels of BDNF and CREB proteins and their encoding mRNAs to normal levels. These findings suggest that WO might be useful as a new therapy for treatment of various neurodegenerative diseases.

• 영재교육연구
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• 제19권3호
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• pp.457-476
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• 2009

본 연구에서는 2009년도 대학교 부설 과학영재교육원 생물 영재반에 재학하고 있는 중학교 2학년 학생 20명을 대상으로 자기조절학습능력의 수준을 분석하고, 자기조절 학습능력의 수준에 따른 학생들의 개인적 성향과 이들의 학습선호도를 조사하였다. 생물 영재반에 소속된 중학교 2학년 학생들의 자기조절학습능력은 인지전략, 메타인지, 동기차원에서 선행연구의 영재들보다 높은 수준을 보인 반면, 환경차원에서는 상대적으로 낮은 수준으로 나타났다. 자기조절학습능력의 구성요소인 인지전략은 메타인지 및 동기차원과, 메타인지는 환경차원과 높은 상관관계를 가지는 것으로 나타났다. 연구대상 학생들 가운데 자기조절학습능력이 상위권에 속하는 학생들의 개인적 성향은 서로 다른 것으로 나타났다. 섬세하고 여리며 신중한 성격을 지닌 학생으로 의학계의 성향에 치우치며 장래 의사를 희망하는 반면, 과학자로서의 높은 포부를 표현한 학생은 자연계 성향으로서 추상적이고 창의적이며 확산적으로 사고하는 특성이 두드러졌다. 자기조절학습능력은 높으나 개인적 성향이 서로 다른 것으로 나타났지만 공통적으로 가장 싫어하는 과학수업은 암기위주 이론중심 강의수업이며, 생각하지 않고 필기만 하는 것이었다. 학생들은 실험과 토론, 실험, 또는 토론중심 과학 수업을 선호하는 것으로 나타났다. 토론을 선호하는 이유에는 다른 사람의 의견을 듣기 위한 것이 있는 반면, 자신의 의견을 발표하고자 하는 이유도 제시되었다. 가장 선호하는 과학교사는 질문하고 흥미를 일깨워주는 친근하고 활동적인 사람이었다. 결론적으로 과학영재교육은 우선적으로 개별학생들의 개인적 성향을 상세히 파악하고, 학생들이 선호하는 실험활동 중심 토론식 수업에서 개별학생이 흥미있어 하는 개별 맞춤식 주제 관련 질문을 강화하는 수업이 효율적임을 시사한다.

• Laboraroty Animal Research
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• 제34권4호
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• pp.317-328
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• 2018

Cognitive impairment responses are important research topics in the study of degenerative brain diseases as well as in understanding of human mental activities. To compare response to scopolamine (SPL)-induced cognitive impairment, we measured altered parameters for learning and memory ability, inflammatory response, oxidative stress, cholinergic dysfunction and neuronal cell damages, in Korl:ICR stock and two commercial breeder stocks (A:ICR and B:ICR) after relevant SPL exposure. In the water maze test, Korl:ICR showed no significant difference in SPL-induced learning and memory impairment compared to the two different ICRs, although escape latency was increased after SPL exposure. Although behavioral assessment using the manual avoidance test revealed reduced latency in all ICR mice after SPL treatment as compared to Vehicle, no differences were observed between the three ICR stocks. To determine cholinergic dysfunction induction by SPL exposure, activity of acetylcholinesterase (AChE) assessed in the three ICR stocks revealed no difference of acetylcholinesterase activity. Furthermore, low levels of superoxide dismutase (SOD) activity and high levels of inflammatory cytokines in SPL-treated group were maintained in all three ICR stocks, although some variations were observed between the SPL-treated groups. Neuronal cell damages induced by SPL showed similar response in all three ICR stocks, as assessed by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, Nissl staining analysis and expression analyses of apoptosis-related proteins. Thus, the results of this study provide strong evidence that Korl:ICR is similar to the other two ICR. Stocks in response to learning and memory capacity.

• 대한한의학방제학회지
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• 제16권1호
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• pp.131-145
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• 2008

With tablets and powder, decoction has been a widely-used method of medicine formula. However, for these formulas have unique bitter tastes and flavors of herbal component materials as it is, the compliance of herbal medicine is severly decreased especially for female and younger patients. Consequently, expected treatment effects can't be acquired completely. If loathsome tastes and flavors of decoction were effectively reduced while pharmacological activity were kept intact, the compliance could be promoted Chong-Myung-Tang has been widely prescribed for student patients with memory This study shows that Chong-Myung-Tang+chocolate have no difference from Chong-Myung-Tang in terms of pharmacological activity. Sensory difference with net chocolate was also surved. In order to observe the difference of Chong-Myung-Tang+chocolate and Chong-Myung-Tang, memory impairment was induced by intraventricular injection of $A{\beta}_{25-35}$ peptides on mice and Chong-Myung-Tang and Chong-Myung-Tang+chocolate were administered orally for 14 days. In water maze task, improvement of learning ability during acquisition period and significant increase of memory score during retention period resulted from the treatment of Chong-Myung-Tang and Chong-Myung-Tang+chocolate with respect to the $A{\beta}-injected$ control animals. Furthermore, the $A{\beta}_{25-35}$ toxicity on the hippocampus was assessed with immunohistochemistry (Bax, TUNEL), and differences in antioxidant activity was observed through TBARS and DPPH test. We employed sensory tests using chocolate flavor, herb flavor, and bitter taste & hardness as standards to show sensory differences with net chocolate. In this study, it is demonstrated that Chong-Myung-Tang+chocolate do not disturb the pharmacological activity of Chong-Myung-Tang, and have no sensory difference with net chocolate. Chong-Myung-Tang+chocolate can be used to enhance the compliance remarkably and thought of as an effective, functional formula to maximize expected treatment.

• 한국기계가공학회지
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• 제19권11호
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• pp.94-101
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• 2020

In the age of industry 4.0, artificial intelligence is being widely used to realize machinery condition monitoring. Due to their excellent performance and the ability to handle large volumes of data, machine learning techniques have been applied to realize the fault diagnosis of different equipment. In this study, we performed the failure mode effect analysis (FMEA) of an aluminum electrolytic capacitor by using deep learning and big data. Several tests were performed to identify the main failure mode of the aluminum electrolytic capacitor, and it was noted that the capacitance reduced significantly over time due to overheating. To reflect the capacitance degradation behavior over time, we employed the Vanilla long short-term memory (LSTM) neural network architecture. The LSTM neural network has been demonstrated to achieve excellent long-term predictions. The prediction results and metrics of the LSTM and Vanilla LSTM models were examined and compared. The Vanilla LSTM outperformed the conventional LSTM in terms of the computational resources and time required to predict the capacitance degradation.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2008년도 학술대회 2부
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• pp.507-512
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• 2008

본 연구는 경도인지장애(MCI)환자의 가상환경(VE)내 길찾기 학습능력을 측정하였으며, 전통 신경심리검사를 이용하여 길찾기 능력을 구성하는 인지기능에 대해 조사하였다. 피험자는 정상노인집단(N=27)과 MCI 환자집단(N=22)으로 구성되었다. 피험자는 간이정신집단검사, 시각 기억력을 측정하는 Rey Complex Figure Test(RCFT), 시각적 보존력을 측정하는 Benton Visual Retention(BVRT), 주의력을 측정하는 Trail-Making Test(TMT; A형과 B형), 성인용 웩슬러 지능검사의 하위검사인 숫자외우기(바로/거꾸로), 및 집행기능 및 기억력을 측정하는 2차원공간에서의 미로학습검사 Groton Maze Learning Test(GMLT)(12회기)를 마친 후, 가상현실(VE) 내 길찾기과제(6회기)를 수행하였다. 그 결과, VE 길찾기 과제에 대하여 유의미한 집단효과가 나타났다. 즉, MCI집단의 길찾기 수행이 정상노인집단의 길찾기 수행보다 떨어지는 결과가 발견되었다. 집단과 회기간 상호작용 및 유의미한 회기효과는 나타나지 않았다. GMLT에서는 유의미한 상호작용, 집단효과, 및 회기효과가 나타나지 않았다. 신경심리검사에서는 RCFT와 BVRT에서 유의미한 집단간 차이가 발견되었다. 또한, VE과제는 RCFT, BVRT, 그리고 GMLT와 상관이 있었으며, 이를 기반으로한 회기분석 실시 결과 RCFT와 BVRT는 가상환경 내 길찾기 행동에 대한 45%의 설명력을 지니고 있었다. 결론적으로, 본 연구결과는 MCI환자의 길찾기 능력이 정상인에 비하여 떨어지며, MCI환자의 시공간기억기능 결함으로 이와 같은 길찾기 능력저하를 설명할 수 있음을 함의한다.