Browse > Article
http://dx.doi.org/10.4062/biomolther.2015.152

Wogonin Attenuates Hippocampal Neuronal Loss and Cognitive Dysfunction in Trimethyltin-Intoxicated Rats  

Lee, Bombi (Acupuncture and Meridian Science Research Center)
Sur, Bongjun (Acupuncture and Meridian Science Research Center)
Cho, Seong-Guk (The Graduate School of Basic Science of Korean Medicine, College of Korean Medicine, Kyung Hee University)
Yeom, Mijung (Acupuncture and Meridian Science Research Center)
Shim, Insop (Acupuncture and Meridian Science Research Center)
Lee, Hyejung (Acupuncture and Meridian Science Research Center)
Hahm, Dae-Hyun (Acupuncture and Meridian Science Research Center)
Publication Information
Biomolecules & Therapeutics / v.24, no.3, 2016 , pp. 328-337 More about this Journal
Abstract
We examined whether wogonin (WO) improved hippocampal neuronal activity, behavioral alterations and cognitive impairment, in rats induced by administration of trimethyltin (TMT), an organotin compound that is neurotoxic to these animals. The ability of WO to improve cognitive efficacy in the TMT-induced neurodegenerative rats was investigated using a passive avoidance test, and the Morris water maze test, and using immunohistochemistry to detect components of the acetylcholinergic system, brain-derived neurotrophic factor (BDNF), and cAMP-response element-binding protein (CREB) expression. Rats injected with TMT showed impairments in learning and memory and daily administration of WO improved memory function, and reduced aggressive behavior. Administration of WO significantly alleviated the TMT-induced loss of cholinergic immunoreactivity and restored the hippocampal expression levels of BDNF and CREB proteins and their encoding mRNAs to normal levels. These findings suggest that WO might be useful as a new therapy for treatment of various neurodegenerative diseases.
Keywords
Wogonin; Trimethyltin; Memory; Cholinergic neurons; cAMP-response element-binding protein;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Kaur, S., Chhabra, R. and Nehru, B. (2013a) Ginkgo biloba extract attenuates hippocampal neuronal loss and cognitive dysfunction resulting from trimethyltin in mice. Phytomedicine 20, 178-186.   DOI
2 Kaur, S. and Nehru, B. (2013b) Alteration in glutathione homeostasis and oxidative stress during the sequelae of trimethyltin syndrome in rat brain. Biol. Trace Elem. Res. 153, 299-308.   DOI
3 Kim, J. K., Bae, H., Kim, M. J., Choi, S. J., Cho, H. Y., Hwang, H. J., Kim, Y. J., Lim, S. T., Kim, E. K., Kim, H. K., Kim, B. Y. and Shin, D. H. (2009) Inhibitory effect of Poncirus trifoliate on acetylcholinesterase and attenuating activity against trimethyltin-induced learning and memory impairment. Biosci. Biotechnol. Biochem. 73, 1105-1112.   DOI
4 Kim, B. K., Tran, H. Y., Shin, E. J., Lee, C., Chung, Y. H., Jeong, J. H., Bach, J. H., Kim, W. K., Park, D. H., Saito, K., Nabeshima, T. and Kim, H. C. (2013) IL-6 attenuates trimethyltin-induced cognitive dysfunction via activation of JAK2/STAT3, M1 mAChR and ERK signaling network. Cell. Signal. 25, 1348-1360.   DOI
5 Koda, T., Kuroda, Y. and Imai, H. (2008) Protective effect of rutin against spatial memory impairment induced by trimethyltin in rats. Nutr. Res. 28, 629-634.   DOI
6 Kotani, S., Yamauchi, T., Teramoto, T. and Oqura, H. (2006) Pharmacological evidence of cholinergic involvement in adult hippocampal neurogenesis in rats. Neuroscience 142, 505-514.   DOI
7 Lee, Y. M., Cheng, P. Y., Chen, S. Y., Chung, M. T. and Sheu, J. R. (2011) Wogonin suppresses arrhythmias, inflammatory responses, and apoptosis induced by myocardial ischemia/reperfusion in rats. J. Cardiovasc. Pharmacol. 58, 133-142.   DOI
8 Yang, M., Kim, J., Kim, T., Kim, S. H., Kim, J. C., Kim, J., Takayama, C., Hayashi, A., Joo, H. G., Shin, T. and Moon, C. (2012) Possible involvement of galectin-3 in microglial activation in the hippocampus with trimethyltin treatment. Neurochem. Int. 61, 955-962.   DOI
9 Zhao, B. (2009) Natural antioxidants protect neurons in Alzheimer's disease and Parkinson's disease. Neurochem. Res. 34, 630-638.   DOI
10 Nishimura, T., Schwarzer, C., Furtinger, S., Imai, H., Kato, N. and Sperk, G. (2001) Changes in the GABA-ergic system induced by trimethyltin application in the rat. Brain Res. Mol. Brain Res. 97, 1-6.   DOI
11 Park, H. J., Shim, H. S., Ahn, Y. H., Kim, K. S., Park, K. J., Choi, W. K., Ha, H. C., Kang, J. I., Kim, T. S., Yeo, I. H., Kim, J. S. and Shim, I. (2012) Tremella fuciformis enhances the neurite outgrowth of PC12 cells and restores trimethyltin-induced impairment of memory in rats via activation of CREB transcription and cholinergic systems. Behav. Brain Res. 229, 82-90.   DOI
12 Park, H. J., Shim, H. S., Choi, W. K., Kim, K. S., Bae, H. and Shim, I. (2011) Neuroprotective Effect of Lucium chinense Fruit on Trimethyltin-Induced Learning and Memory Deficits in the Rats. Exp. Neurobiol. 20, 137-143.   DOI
13 Paxinos, G. and Watson, C. (1986) The rat brain in stereotaxic coordinates. Academic Press., New York. U.S.A. 54-85.
14 Piao, H. Z., Choi, I. Y., Park, J. S., Kim, H. S., Cheong, J. H., Son, K. H., Jeon, S. J., Ko, K. H. and Kim, W. K. (2008) Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity. Int. Immunopharmacol. 8, 1658-1662.   DOI
15 Vaynman, S., Ying, Z. and Gomez-Pinilla, F. (2003) Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity. Neuroscience 122, 647-657.   DOI
16 Viviani, B., Bartesaghi, S., Corsini, E., Villa, P., Ghezzi, P., Garau, A., Galli, C. L. and Marinovich, M. (2005) Erythropoietin protects primary hippocampal neurons increasing the expression of brainderived neurotrophic factor. J. Neurochem. 93, 412-421.   DOI
17 Frautschy, S. A., Hu, W., Kim, P., Miller, S. A., Chu, T., Harris-White, M. E. and Cole, G. M. (2001) Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol. Aging 22, 993-1005.   DOI
18 Brabeck, C., Michetti, F., Geloso, M. C., Corvino, V., Goezalan, F., Meyermann, R. and Schluesener, H. J. (2002) Expression of EMAP-II by activated monocytes/microglial cells in different regions of the rat hippocampus after trimethyltin-induced brain damage. Exp. Neurol. 177, 341-346.   DOI
19 Chen, S., Xiong, J., Zhan, Y., Liu, W. and Wang, X. (2015) Wogonin inhibits LPS-induced inflammatory responses in rat dorsal root ganglion neurons via inhibiting TLR4-MyD88-TAK1-mediated NF-${\kappa}B$ and MAPK signaling pathway. Cell. Mol. Neurobiol. 35, 523-531.   DOI
20 Cho, J. and Lee, H. K. (2004) Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells. Eur. J. Pharmacol. 485, 105-110.   DOI
21 Gasparova, Z., Janega, P., Stara, V. and Ujhazy, E. (2012) Early and late stage of neurodegeneration induced by trimethyltin in hippocampus and cortex of male Wistar rats. Neuroendocrinol. Lett. 33, 689-696.
22 Geloso, M. C., Corvino, V., Cavallo, V., Toesca, A., Guadagni, E., Passalacqua, R. and Michetti, F. (2004) Expression of astrocytic nestin in the rat hippocampus during trimethyltin-induced neurodegeneration. Neurosci. Lett. 357, 103-106.   DOI
23 Geloso, M. C., Corvino, V. and Michetti, F. (2011) Trimethyltin-induced hippocampal degeneration as a tool to investigate neurodegenerative processes. Neurochem. Int. 58, 729-738.   DOI
24 Geloso, M. C., Vercelli, A., Corvino, V., Repici, M., Boca, M., Haglid, K., Zelano, G. and Michetti, F. (2002) Cyclooxygenase-2 and caspase 3 expression in trimethyltin-induced apoptosis in the mouse hippocampus. Exp. Neurol. 175, 152-160.   DOI
25 Giacobini, E. (2002) Long term stabilizing effect of cholinesterase inhibitors in the therapy of Alzheimer's disease. J. Neural Transm. Suppl. (62), 181-187.
26 Ishikura, N., Tsunashima, K., Watanabe, K., Nishimura, T., Minabe, Y. and Kato, N. (2002) Neuropeptide Y and somatostatin participate differently in the seizure-generating mechanisms following trimethyltin- induced hippocampal damage. Neurosci. Res. 44, 237-248.   DOI