• Nutritional Sciences
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• 제5권4호
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• pp.197-202
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• 2002

We compared the radical scavenging activity of flavonoids and their antioxidant effects on erythrocyte Na leak, platelet aggregation and TBARS (thiobarbituric acid reactive substance) production, using Sprague Dawley rats. The concentrations of flavonoids needed for scavenging radicals by 50% ($SC_{50}$) in 0.1mM DPPH (2,2 Diphenyl 1-picryl hydrazyl) were: Quercetin, 7.4/$\mu$M; Catechin, 10.6$\mu$M; Morin, 22$\mu$M; Hesperidin, 400uM; and Naringin, 3.95mM. Morin completed its antioxidant activity in 2 minutes, while catechin, hesperidin and naringin had slow but long lasting antioxidant activity. Whole blood platelet aggregation, when incubated with quercetin or catechin, was significantly decreased (P<0.05) compared with the control. Sodium leak in intact erythrocytes was significantly lower when incubated with quercetin, compared with other flavonoids (P<0.05). Morin, hesperidin and naringin somewhat increased Na leak in intact erythrocytes. Sodium leak in erythrocytes treated with phenazine methosulfate (PMS) was increased overall, but was not affected by flavonoids. Intracelluar Na and K were not affected by treatment with PMS. TBARS production in platelet rich plasma (PRP) was significantly lower (P<0.05) than the control when incubated with quercetin or hesperidin. PMS treatment caused an increase in TBARS production regardless of flavonoids. In the present study antioxidant effects of flavonoids were not well correlated with their radical scavenging activities, although quercetin, which showed the strongest radical scavenging activity, had the greatest antioxidant effect.

• Journal of Korean Neurosurgical Society
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• 제59권1호
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• pp.52-57
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• 2016

Objective : Many surgeons advocate for watertight dural reconstruction after posterior fossa surgery given the significant risk of cerebrospinal fluid (CSF) leak. Little evidence exists for posterior fossa dural reconstruction utilizing monolayer collagen matrix onlay graft in a non-watertight fashion. Our objective was to report the results of using collagen matrix in a non-watertight fashion for posterior fossa dural reconstruction. Methods : We conducted a retrospective review of operations performed by the senior author from 2004-2011 identified collagen matrix (DuraGen) use in 84 posterior fossa operations. Wound complications such as CSF leak, infection, pseudomeningocele, and aseptic meningitis were noted. Fisher's exact test was performed to assess risk factor association with specific complications. Results : Incisional CSF leak rate was 8.3% and non-incisional CSF leak rate was 3.6%. Incidence of aseptic meningitis was 7.1% and all cases resolved with steroids alone. Incidence of palpable and symptomatic pseudomeningocele in follow-up was 10.7% and 3.6% respectively. Postoperative infection rate was 4.8%. Previous surgery was associated with pseudomeningocele development (p<0.05). Conclusion : When primary dural closure after posterior fossa surgery is undesirable or not feasible, non-watertight dural reconstruction with collagen matrix resulted in incisional CSF leak in 8.3%. Incidence of pseudomeningocele, aseptic meningitis, and wound infection were within acceptable range. Data from this study may be used to compare alternative methods of dural reconstruction in posterior fossa surgery.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2019년도 춘계학술대회
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• pp.406-408
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• 2019

자동차에 사용되는 전동식 워터펌프에 적용되는 모터는 CANNED TYPE의 모터 구조이다. 모터의 구동 부품인 로터는 플라스틱 사출물의 격벽 구조 내에 위치하며, 부동액에 침수되어 있는 상태로 회전을 하게 된다. 플라스틱 사출물 격벽 구조 외부에 Stator가 위치되어 Rotor가 회전이 가능하도록 한다. Rotor의 구성은 Magnet와 Core, Shaft로 구성되며, Magnet와 Core의 경우 부품 특성상 수분 침투에 부식되는 재질이기 때문에 부품의 기밀 유지는 매우 중요하다. 차량에 장착된 상태에서는 120도의 환경조건에서 구동이 가능하여야 하며, 내부압력이 1 Bar 이상의 압력에도 누수가 없어야 한다. 본 논문에서는 이 조건을 만족하여 개발된 전동식 워터펌프의 불량을 검사하기 위하여 헬륨을 이용한 Leak 검사 자동화 시스템을 설계 및 구현하였다.

• 대한기계학회논문집A
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• 제28권4호
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• pp.352-361
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• 2004

One important element of the Leak-Before-Break analysis of nuclear piping is how to determine relevant fracture toughness (or the J-resistance curve) for nonlinear fracture mechanics analysis. The practice to use fracture toughness from a standard C(T) specimen is known to often give conservative estimates of toughness. To improve the accuracy, this paper proposes a new method to determine fracture toughness using a nonstandard testing specimen, curved wide-plate in tension. To show validity of the proposed curved wide-plate test, the J-resistance curve from the full-scale pipe test is compared with that from the curved wide-plate test and that from the C(T) specimen. It is shown that the J-resistance curve form the curved wide-plate tension test is similar to, but that from the C(T) specimen is lower than, the J-resistance curve from the full-scale pipe test. Further validation is performed by investigating crack-tip constraint conditions via detailed 3-D FE analyses, which shows that the crack-tip constraint condition in the curved wide-plate tension specimen is indeed similar to that in the full-scale pipe under bending.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1998년도 추계학술발표회요약집
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• pp.227-227
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• 1998

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2002년도 추계학술발표회요약집
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• pp.108-108
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• 2002

• 한국압력기기공학회 논문집
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• 제16권2호
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• pp.35-46
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• 2020

In this paper, a fracture mechanics evaluation system which can be used to assess the leak-before-break (LBB) of nuclear piping is developed. Existing solutions for calculating the fracture mechanics parameters (J-integral and crack opening displacement) required for LBB evaluation were firstly presented. Then a module for calculating J-integral and COD was developed, with an additional module for predicting the critical load based on the crack driving force diagram to finally develop a fracture mechanics evaluation system. To confirm the validity of the proposed evaluation system, finite element (FE) analysis was performed, and the FE J-integral and COD results were compared with prediction results using the J-integral and COD estimations program. Furthermore, the critical load assessment module was verified by comparing the actual pipe test results (Battelle test data) with prediction results using the proposed program.

• 대한기계학회논문집A
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• 제28권4호
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• pp.435-442
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• 2004

This paper presents a hermetic MEMS on-chip package bonded by a closed-loop AuSn solder-line. We design three different package specimens, including a substrate heated specimen without interconnection-line (SHX), a substrate heated specimen with interconnection-line (SHI) and a locally heated specimen with interconnection-line (LHI). Pressurized helium leak test has been carried out for hermetic seal evaluation in addition to the critical pressure test for bonding strength measurement. Substrate heating method (SHX, SHI) requires the bonding time of 40min. at 400min, while local heating method (LHI) requires 4 min. at the heating power of 6.76W. In the hermetic seal test. SHX, SHI and LHI show the leak rates of 5.4$\pm$6.7${\times}$$^{-10}$ mbar-l/s, 13.5$\pm$9.8${\times}$$^{-10}$ mbar-l/s and 18.5$\pm$9.9${\times}$$^{-10}$ mbar-l/s, respectively, for an identical package chamber volume of 6.89$\pm$0.2${\times}$$^{-10}$. In the critical pressure test, no fracture is found in the bonded specimens up to the applied pressure of 1$\pm$0.1MPa, resulting in the minimum bonding strength of 3.53$\pm$0.07MPa. We find that the present on-chip packaging using a closed AuSn solder-line shows strong potential for hermetic MEMS packaging with interconnection-line due to the hermetic seal performance and the shorter bonding time for mass production.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2011년도 춘계학술대회 논문집
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• pp.136-141
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• 2011

In a power plant, an oil and steam leakage is generated once in a while. This is because the operating temperature and pressure of oil are very high. It is very difficult to monitor oil leakage, because oil leakage is almost invisible. Therefore a method to oil leakage detecting quickly and accurately is needs. In this paper, we proposed the method for the detecting oil leakage by using image processing and CCTV. To test the performance of this technique, experiments have been performed for simple case. Results show that the proposed technique is quite powerful in the oil leak detection.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2000년도 춘계학술대회논문집
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• pp.1829-1835
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• 2000

The experimental results of sodium-water reaction noise measurement in frequency range $1{/sim}200kHz$ are presented. The experiments of noise generation under the condition of sodium test facility, water leak rate $0.01{\sim}1.2g/s$ and temperature of sodium $250{\sim}500^{\circ}C$, were carried out. From theoretical study it is noted that the noise resonant attenuation on hydrogen bubbles in liquid sodium plays the significant role for leak noise spectra formation. Interaction of leak noise and hydrogen bubbles in sodium being accompanied by thermal, emission and viscosity energy dissipation was studied. Acoustic noise spectra were investigated from point of view of water leak detection in sodium/water steam generator. The results of sodium-water reaction noise absorption on hydrogen bubbles in liquid sodium by temperature $250{\sim}500^{\circ}C$ are presented. The theoretical model of noise absorption using the coefficients of attenuation was developed. From calculation the coefficients of attenuation were estimated.