• 제목/요약/키워드: Lead optimization

검색결과 399건 처리시간 0.028초

Flip-chip 본딩 장비 제작 및 공정조건 최적화 (Bonding process parameter optimization of flip-chip bonder)

  • 심형섭;강희석;정훈;조영준;김완수;강신일
    • 한국정밀공학회:학술대회논문집
    • /
    • 한국정밀공학회 2005년도 추계학술대회 논문집
    • /
    • pp.763-768
    • /
    • 2005
  • Bare-chip packaging becomes more popular along with the miniaturization of IT components. In this paper, we have studied flip-chip process, and developed automated bonding system. Among the several bonding method, NCP bonding is chosen and batch-type equipment is manufactured. The dual optics and vision system aligns the chip with the substrate. The bonding head equipped with temperature and force controllers bonds the chip. The system can be easily modified for other bonding methods such as ACF In bonding process, the bonding forte and temperature are known as the most dominant bonding parameters. A parametric study is performed for these two parameters. For the test sample, we used standard flip-chip test kit which consists of FR4 boards and dummy flip-chips. The bonding test was performed fur two types of flip-chips with different chip size and lead pitch. The bonding temperatures are chosen between $25^{\circ}C\;to\;300^{\circ}C$. The bonding forces are chosen between 5N and 300N. The bonding strength is checked using bonding force tester. After the bonding force test, the samples are examined by microscope to determine the failure mode. The relations between the bonding strength and the bonding parameters are analyzed and compared with bonding models. Finally, the most suitable bonding condition is suggested in terms of temperature and force.

  • PDF

Liquid chromatography-tandem mass spectrometric analysis of oleracone D and its application to pharmacokinetic study in mice

  • Lim, Dong Yu;Lee, Tae Yeon;Lee, Jaehyeok;Song, Im-Sook;Han, Young Taek;Choi, Min-Koo
    • 분석과학
    • /
    • 제34권5호
    • /
    • pp.193-201
    • /
    • 2021
  • We have demonstrated a sensitive analytical method of measuring oleracone D in mouse plasma using a liquid chromatography-tandem mass spectrometry (LC-MS/MS). Oleracone D and oleracone F (internal standard) in mouse plasma samples were processed using a liquid-liquid extraction method with methyl tertbutyl ether, resulting in high and reproducible extraction recovery (80.19-82.49 %). No interfering peaks around the peak elution time of oleracone D and oleracone F were observed. The standard calibration curves for oleracone D ranged from 0.5 to 100 ng/mL and were linear with r2 of 0.992. The inter- and intra-day accuracy and precision and the stability fell within the acceptance criteria. The pharmacokinetics of oleracone D following intravenous and oral administration of oleracone D at doses of 5 mg/kg and 30 mg/kg, respectively, were investigated. When oleracone D was intravenously injected, it had first-order elimination kinetics with high clearance and volume of distribution values. The absolute oral bioavailability of this compound was calculated as 0.95 %, with multi-exponential kinetics. The low aqueous solubility and a high oral dose of oleracone D may explain the different elimination kinetics of oleracone D between intravenous and oral administration. Collectively, this newly developed sensitive LC-MS/MS method of oleracone D could be successfully utilized for investigating the pharmacokinetic properties of this compound and could be used in future studies for the lead optimization and biopharmaceutic investigation of oleracone D.

일반 공정시간을 갖는 버퍼 공유 라인 생산시스템의 스프레드시트 모형 분석 (Spreadsheet Model Approach for Buffer-Sharing Line Production Systems with General Processing Times)

  • 서동원
    • 한국시뮬레이션학회논문지
    • /
    • 제28권2호
    • /
    • pp.119-129
    • /
    • 2019
  • 유한 버퍼를 갖는 라인 생산시스템은 오랜 기간 동안 연구되어왔지만, 몇몇 특별한 경우 외에는 대기시간(체류시간), 차단 확률과 같은 시스템 성능 값에 대한 분석 결과는 많지 않다. 최근에, max-plus 대수를 활용하여 상수 공정시간을 갖고 버퍼 완전 공유 정책을 따르는 시스템에서 대기시간의 고차평균과 꼬리확률에 대한 분석 결과가 소개되었다. 이와 같은 max-plus 대수를 활용한 분석이 이론적으론 일반 공정시간 모형에도 응용 가능하지만, 도출된 표현식에 대한 적절한 계산방법을 제공하지 못한다. 이러한 이유로, 본 연구에서는 max-plus 대수로 도출된 표현식과 @RISK 소프트웨어를 활용하여 스프레드시트 시뮬레이션 모형을 개발하고, 두 가지 차단정책(통신차단과 제조차단) 하에서 시스템 특성값인 대기시간(또는 체류시간)과 차단확률을 비교 분석하였다. 또한 차단확률에 대한 제약을 만족하는 공유 버퍼의 크기를 결정하는 최적화 문제도 분석하였다.

가학광산 중금속 오염토양의 세척 최적조건 연구 (A Study on Optimal Conditions for Washing the Heavy Metal Polluted Soil in Ka-hak Mine)

  • 김대엽;박제현;박주현
    • 한국자원공학회지
    • /
    • 제55권6호
    • /
    • pp.517-526
    • /
    • 2018
  • 본 연구는 가학광산 오염토양 정화를 위해 토양 세척 최적조건을 수립하는데 목적이 있다. 연구지역 내 토양은 다양한 중금속에 의해 오염되어 있는데 특히 구리, 납, 아연의 농도가 높게 나타난다. 염산을 활용한 세척실험 결과 1 M의 농도로 30분 세척 시 중금속의 제거 효과가 가장 좋게 나타났다. 전체 토양의 38%는 1.18 mm 이상의 굵은 입자로 오염도가 상대적으로 낮으나 0.075 mm 이하의 작은 입자들은 오염도가 높아 고농도의 염산용액과 긴 세척시간에도 불구하고 오염도를 기준치 이내로 낮추기 어려웠다. 따라서 오염도가 높고, 중금속 농도 저감이 어려운 작은 토양입자들을 토양세척 이전에 물리적인 방법으로 분리할 필요가 있는 것으로 판단된다. 습식 사이클론을 활용한 연속식 토양세척 실험 결과 20% 이상의 미립자를 제거한 경우 오염토양의 중금속 농도를 기준치 이내로 저감시킬 수 있었다.

다중이용시설의 화재 시 피난절차 최적화 방안 연구 - 멀티플렉스를 중심으로 - (A Study on the Optimization Method for Evacuation Procedure on Fire in Public Facilities - Focusing on Multiplex -)

  • 신영민;임유리;안용한
    • 한국화재소방학회논문지
    • /
    • 제33권1호
    • /
    • pp.113-120
    • /
    • 2019
  • 점차 삶의 수준이 향상됨에 따라 건강하고 여유로운 삶에 대한 니즈가 증가하고 있다. 문화에 대한 대중의 니즈를 반영하여 국내에는 여러 개의 상영관으로 구성된 멀티플렉스가 빠른 속도로 보급되고 있다. 그러나 화재발생 시 피난안전 측면에 있어 위험성을 내포하고 있다. 건물의 공간 형태에 익숙하지 않은 불특정 다수의 관객은 피난으로 인한 입장 및 퇴장 동선의 충돌로 혼잡을 겪게 되기 때문이다. 따라서 본 연구에서는 이러한 문제점을 해결하기 위하여 피난시간을 단축할 수 있는 방안을 마련하고자, 상영관별 단계적 피난을 적용하여 피난시뮬레이션을 실시하였다. 해석 결과, 전 상영관이 동시 피난하는 것보다 상영관별로 단계적인 피난하는 것이 피난시간 확보에 유리한 것으로 나타났다.

도로교설계기준(한계상태설계법)의 콘크리트부재 설계를 위한 재료계수 결정법 및 신뢰도 분석 (New Approaches for Calibrating Material Factors of Reinforced Concrete Members in Korean Highway Bridge Design Code (Limit State Design) and Reliability Analysis)

  • 이해성;송상원;김지현
    • 대한토목학회논문집
    • /
    • 제39권1호
    • /
    • pp.13-24
    • /
    • 2019
  • 이 연구에서는 국내 도로교 한계상태설계법에서 콘크리트부재의 설계를 위하여 적용하고 있는 재료계수의 문제점을 제기하고, 잘 정립된 최적화 과정에 의한 재료계수를 제안하였다. 신뢰도분석을 통하여 현 설계기준의 하중계수와 제안 재료계수가 목표신뢰도지수 보다 높은 신뢰도수준을 확보하고 있음을 보이고, 역신뢰도해석을 통하여 목표신뢰도지수를 잘 근사할 수 있는 하중계수를 제시하였다. 유로코드에서 제시하고 있는 기본 개념에 근거하여 신뢰도기반 하중-재료계수 결정법을 정식화하였다. 제안된 접근법이 신뢰도개념에 의하여 유도되었지만, 이 접근법에 의하여 계산된 하중-재료 계수가 목표신뢰도지수를 정확히 만족시키지 못하는 요인으로서 재료와 부재간에 존재하는 불확실성의 차이를 지적하고, 이러한 차이를 고려하지 않는 유로코드의 개념적 문제점을 제기하였다.

Evaluation of contamination for the Andong-dam sediment and a magnetic separation for reducing the contamination level

  • Hong, H.P.;Kwon, H.W.;Kim, J.J.;Ha, D.W.;Kim, Young-Hun
    • 한국초전도ㆍ저온공학회논문지
    • /
    • 제21권2호
    • /
    • pp.31-35
    • /
    • 2019
  • Andong-dam was built up in 1967 and it is one of the biggest dams in Korea. Previous studies showed that the sediments are highly contaminated with heavy metals such as arsenic, cadmium, and lead. Many research projects are going on to find out the source of the contamination, to evaluate the toxicities to ecosystem, to estimate the volume of sediment to be treated and to find out a good remediation method. Reports show that the sediment is highly contaminated and the main contamination source is supposed to be abandoned mines and a zinc refinery located upper stream of the river. A magnetic separation has been tested as a treatment method for the dredged sediment. Lab scale test showed that the magnetically captured portion is about 10% in weight but the contamination of heavy metal is much higher than the contamination of the passed portion. This indicates that a magnetic separation could be applied for the purpose of reduction of sediment to be treated and for increasing the volume of low toxic sediments which can be dumped as general waste. A magnetic separation using a HGMS has been tested for the sediment with variable magnetic field and the results showed the higher magnetic field increase the captured portion but the concentrating effect of heavy metal was weakened. Further study is needed to establish a useful technology and optimization between decontamination and reduction of sediment volume.

다수기 원자력발전소 사고 시 소외 방사성물질 농도 계산 방법 (A Method to Calculate Off-site Radionuclide Concentration for Multi-unit Nuclear Power Plant Accident)

  • 이혜린;이기만;정우식
    • 한국안전학회지
    • /
    • 제33권6호
    • /
    • pp.144-156
    • /
    • 2018
  • Level 3 Probabilistic Safety Assessment (PSA) is performed for the risk assessment that calculates radioactive material dispersion to the environment. This risk assessment is performed with a tool of MELCOR Accident Consequence Code System (MACCS2 or WinMACCS). For the off-site consequence analysis of multi-unit nuclear power plant (NPP) accident, the single location (Center Of Mass, COM) method has been usually adopted with the assumption that all the NPPs in the nuclear site are located at the same COM point. It was well known that this COM calculation can lead to underestimated or overestimated radionuclide concentration. In order to overcome this underestimation or overestimation of radionuclide concentrations in the COM method, Multiple Location (ML) method was developed in this study. The radionuclide concentrations for the individual NPPs are separately calculated, and they are summed at every location in the nuclear site by the post-processing of radionuclide concentrations that is based on two-dimensional Gaussian Plume equations. In order to demonstrate the efficiency of the ML method, radionuclide concentrations were calculated for the six-unit NPP site, radionuclide concentrations of the ML method were compared with those by COM method. This comparison was performed for conditions of constant weather, yearly weather in Korea, and four seasons, and the results were discussed. This new ML method (1) improves accuracy of radionuclide concentrations when multi-unit NPP accident occurs, (2) calculates realistic atmospheric dispersion of radionuclides under various weather conditions, and finally (3) supports off-site emergency plan optimization. It is recommended that this new method be applied to the risk assessment of multi-unit NPP accident. This new method drastically improves the accuracy of radionuclide concentrations at the locations adjacent to or very close to NPPs. This ML method has a great strength over the COM method when people live near nuclear site, since it provides accurate radionuclide concentrations or radiation doses.

유전자 알고리즘을 이용한 프로젝트 포트폴리오 투입인력 최적화 모델에 관한 연구 (A Study on the Optimization Model for the Project Portfolio Manpower Assignment Using Genetic Algorithm)

  • 김동욱;이원영
    • 한국IT서비스학회지
    • /
    • 제17권4호
    • /
    • pp.101-117
    • /
    • 2018
  • Companies are responding appropriately to the rapidly changing business environment and striving to lead those changes. As part of that, we are meeting our strategic goals through IT projects, which increase the number of simultaneous projects and the importance of project portfolio management for successful project execution. It also strives for efficient deployment of human resources that have the greatest impact on project portfolio management. In the early stages of project portfolio management, it is very important to establish a reasonable manpower plan and allocate performance personnel. This problem is a problem that can not be solved by linear programming because it is calculated through the standard deviation of the input ratio of professional manpower considering the uniformity of load allocated to the input development manpower and the importance of each project. In this study, genetic algorithm, one of the heuristic methods, was applied to solve this problem. As the objective function, we used the proper input ratio of projects, the input rate of specialist manpower for important projects, and the equal load of workload by manpower. Constraints were not able to input duplicate manpower, Was used as a condition. We also developed a program for efficient application of genetic algorithms and confirmed the execution results. In addition, the parameters of the genetic algorithm were variously changed and repeated test results were selected through the independent sample t test to select optimal parameters, and the improvement effect of about 31.2% was confirmed.

A cylindrical shell model for nonlocal buckling behavior of CNTs embedded in an elastic foundation under the simultaneous effects of magnetic field, temperature change, and number of walls

  • Timesli, Abdelaziz
    • Advances in nano research
    • /
    • 제11권6호
    • /
    • pp.581-593
    • /
    • 2021
  • This model is proposed to describe the buckling behavior of Carbon Nanotubes (CNTs) embedded in an elastic medium taking into account the combined effects of the magnetic field, the temperature, the nonlocal parameter, the number of walls. Using Eringen's nonlocal elasticity theory, thin cylindrical shell theory and Van der Waal force (VdW) interactions, we develop a system of partial differential equations governing the buckling response of CNTs embedded on Winkler, Pasternak, and Kerr foundations in a thermal-magnetic environment. The pre-buckling stresses are obtained by applying airy's stress function and an adjacent equilibrium criterion. To estimate the nonlocal critical buckling load of CNTs under the simultaneous effects of the magnetic field, the temperature change, and the number of walls, an optimization technique is proposed. Furthermore, analytical formulas are developed to obtain the buckling behavior of SWCNTs embedded in an elastic medium without taking into account the effects of the nonlocal parameter. These formulas take into account VdW interactions between adjacent tubes and the effect of terms involving differences in tube radii generally neglected in the derived expressions of the critical buckling load published in the literature. Most scientific research on modeling the effects of magnetic fields is based on beam theories, this motivation pushes me to develop a cylindrical shell model for studying the effect of the magnetic field on the static behavior of CNTs. The results show that the magnetic field has significant effects on the static behavior of CNTs and can lead to slow buckling. On the other hand, thermal effects reduce the critical buckling load. The findings in this work can help us design of CNTs for various applications (e.g. structural, electrical, mechanical and biological applications) in a thermal and magnetic environment.