• Biomolecules & Therapeutics
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• v.30 no.2
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• pp.203-211
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• 2022

Melanogenesis is the production of melanin from tyrosine by a series of enzyme-catalyzed reactions, in which tyrosinase and DOPA oxidase play key roles. The melanin content in the skin determines skin pigmentation. Abnormalities in skin pigmentation lead to various skin pigmentation disorders. Recent research has shown that the expression of EMP2 is much lower in melanoma than in normal melanocytes, but its role in melanogenesis has not yet been elucidated. Therefore, we investigated the role of EMP2 in the melanogenesis of MNT1 human melanoma cells. We examined TRP-1, TRP-2, and TYR expression levels during melanogenesis in MNT1 melanoma cells by gene silencing of EMP2. Western blot and RT-PCR results confirmed that the expression levels of TYR and TRP-2 were decreased when EMP2 expression was knocked down by EMP2 siRNA in MNT1 cells, and these changes were reversed when EMP2 was overexpressed. We verified the EMP2 gene was knocked out of the cell line (EMP2 CRISPR/Cas9) by using a CRISPR/Cas9 system and found that the expression levels of TRP-2 and TYR were significantly lower in the EMP2 CRISPR/Cas9 cell lines. Loss of EMP2 also reduced migration and invasion of MNT1 melanoma cells. In addition, the melanosome transfer from the melanocytes to keratinocytes in the EMP2 KO cells cocultured with keratinocytes was reduced compared to the cells in the control coculture group. In conclusion, these results suggest that EMP2 is involved in melanogenesis via the regulation of TRP-2 expression.

• Journal of Korean Philosophical Society
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• v.115
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• pp.249-279
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• 2010

The Law of the Heart, which appears in the chapter "B. The Actualization of Rational Self-consciousness Through its own Activity" in Hegel's Phenomenology of Spirit represents that the self-certainty of the reason may be the another face of the Madness. The Reason's indubitable certainty is the testimony of the truth for Descartes, and it also plays a role as the moral maxim of the conscience for Kant. But this subjective certainty unavoidably leads to the Madness of self-conceit, which unifies the consciousness and the reality ignoring the difference between them. The typical attitude appearing in the reformer like Don Quixote and also romantic idealists reveals the fact that modern reason and the psychosis can be both faces of one and the same coin. The Mirror Stage, the Imaginary, and the Formula of the Desire in Lacan's Theory shows that the Image of completeness is the result of Mis-understanding. Even if the Mirror stage is necessary for the Formation of the subject, at the same time it should also lead to the next stage, i.e., the Symbolic Order. It is considered as the realm of the Otherness, which refers to the realm of language or that of law. If the Ego can't go through the symbolic castration acted on by the Name of the Father, he will be remained in the prison of the Imaginary. The Madness also shows the similar process. For Hegel the Discipline of the Labor or the Death as absolute Otherness that inevitably delays the Desire plays the same role as the name of Father. It may be the experience of Separation or that of Sublation of the individual towards the universal, which is equivalent to the experience of Symbolic castration in Lacan. Furthermore there may be the difference between Hegel and Lacan as the following; while in Hegel the experience of Separation is founded on the spontaneity of the Spirit, for Lacan it is to be compelled and structured by the absolute Other.

• Journal of Popular Narrative
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• v.25 no.4
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• pp.361-395
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• 2019

This paper take a media archaeological approach to cinema transformed into a narrative medium during its transitional period, 1903-1915. To accomplish this, I will explore the question of as which narrative medium cinema was imagined and also how it was institutionalized as a narrative medium with authorship. I will explain that the imaginary and real ideas and changes on cinema resonated with each other on the foundation of its technological aspects such as indexicality, 23 frames/sec. and montage. It was during the transitional period that cinema was transformed from a medium representing spectacle to a medium of narration. The establishment of the American film copyright law in 1912 was an institutional, real outcome from the contemporary understanding of cinema as a narrative medium. At the same time, various ideas emerged that led to imagining of cinema as a complete narrative medium, incomparable to any other. From a media archaeological perspective, the imaginary ideas of media resonate with their actual course of development. These imaginary ideas are not just imaginary, but rather reflect the contemporary desire for the medium. This paper looks into the transitional period based on this media archaeological point of view. To this end, this paper will briefly introduce the notion of media archaeology as a media theory and then discuss Eric Kluitenberg's concept of 'an archaeology of imaginary media' and its methodologies. Second, it will explore literary and cinematic imagining of cinema as a powerful medium of storytelling, while discussing the ways in which cinema's technological characteristics played a decisive role in these imaginings. Also to show the techno-deterministic role of cinema in the real world, this paper will explore how its technological characteristics were considered as an important element in the processes through which America's first motion picture copyright was institutionalized in 1912 after two historical copyright cases: one is Edison v. Lubin in 1903 and Kalem v. Harper Brothers in 1909. Ultimately, this paper will lead us to an understanding of the history of cinema as a medium and its developments in more multi-layed way, as communication between the real and imaginary, and give us perspectives toward what cinema is.

• Journal of Popular Narrative
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• v.25 no.3
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• pp.67-99
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• 2019

This paper analyzed romance novels imported into Korea in the 1980s and examined the traits of Korean girls' culture at that time. To this end, This paper chose as subjects the series of 'high-teen romance' published by Samjungdang, 'princess bestseller' by Seoul Publishing and the 'silhouette romance' by Joongang Ilbo in the 1980s. Through the aspects of the paperback romances, the traits of the artist, the content of the work, and the response of the reader, this paper analyzed the position and affection of romance as a genre in Korean culture in the 1980s. In the 1980s, most of the paperback romances available in Korea were translations of the modern and progressive present lines of Harlequin Enterprise's category romance. There were also many writers who were mostly introduced with progressive characters like Charlotte Lamb. The Harlequin romance depicts a story of sensual love. These translated 1980s paperback romance novels allowed girls in Korea to freely imagine the problems of sex and love. In particular, it showed a new perspective on women's sexuality. In Korean love novels, the sexuality of women was treated as an object for the gaze of men. The novels of female writers as college student who criticized this dealt with women's sexuality, but focused on criticism and resistance to the ideology of chastity. The paperback romance made it possible for women to freely enjoy their sexuality by escaping the ethical standards of reality. In addition, the paperback romance was an escape from the frustration of love. Romantic love in Korean love novels did not lead to the unification of mind and body, and always ended in tragedy. On the contrary, the paperback romance started with the fear of the girl who felt love for the first time, showed the process of winning over anxiety, confirming love and reaching a happy marriage. Through this, girls understood general love that was not subordinated to the ideology of chastity, and accepted love positively. The process of establishing romance as a genre in Korean culture and the traits of its readers have not yet been sufficiently clarified yet. This paper compared the romance genre with the other love novels of the day, explaining the position and meaning of the romance genre in Korean culture in the 1980s. Through this, we were able to chart the historical development of the Korean romance genre.

• Korean Journal of Mineralogy and Petrology
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• v.36 no.2
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• pp.135-145
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• 2023

Aggregate is used to produce stable materials like concrete and asphalt and is fundamental to meet the social needs of housing, industry, road, energy and health. A total of 42.35 billion tons of aggregate were produced in 2021 worldwide, an increase of 0.91% compared to the previous year. Among them, 2 billion tons were produced in China, India, European Union and United States, making up to 71.75% of the share. South Korea has witnessed a constant increase in aggregate production, overtaking Mexico and Japan for seventh place with 390 million tons and 0.85% of the share. The industrial sand and gravel produced globally amounted to 352.66 million tons. The top seven countries with the highest production were China, United States, Netherlands, Italy, India, Turkey and France, and their production exceeded 10 million tons and held a share of 74.69%. Exports of natural rock recorded $21.68 billion in 2021, increased by $2.3 billion compared to the previous year, while exports of artificial rock increased by $2.66 billion to $13.59 billion. Exports of sand reached $1.71 billion with United States, Netherlands, Germany and Belgium being the four countries with the highest exports of sand. The four countries exported more than $100 million in sand and took up 57.70% of the total amount. Exports of gravel totaled $2.75 billion, with China, Norway, Germany, Belgium, France and Austria in the lead, making up to 48.30% of the total share. The aggregate quarry started to surge in the 1950s due to the change in people's lifestyle such as population growth, urbanization and infrastructure delvelopment. Demand for aggregate is also skyrocketing to prevent land reclamation and flood caused by sea-level rise. Demand for aggregate, which was around 24 gigatons in 2011, is expected to double to 55 gigatons in 2060. However, it is likely that aggregate extraction will heavily damage the ecosystem and the world will eventually face a shortage of aggregate followed by tense social conflict.

• Journal of Intelligence and Information Systems
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• v.29 no.2
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• pp.57-84
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• 2023

With the development of information and communications technology (ICT) and big data technology, anyone can easily obtain and utilize vast amounts of data through the Internet. Therefore, the capability of selecting high-quality data from a large amount of information is becoming more important than the capability of just collecting them. This trend continues in academia; literature reviews, such as systematic and non-systematic reviews, have been conducted in various research fields to construct a healthy knowledge structure by selecting high-quality research from accumulated research materials. Meanwhile, after the COVID-19 pandemic, remote healthcare services, which have not been agreed upon, are allowed to a limited extent, and new healthcare services such as health recommender systems (HRS) equipped with artificial intelligence (AI) and big data technologies are in the spotlight. Although, in practice, HRS are considered one of the most important technologies to lead the future healthcare industry, literature review on HRS is relatively rare compared to other fields. In addition, although HRS are fields of convergence with a strong interdisciplinary nature, prior literature review studies have mainly applied either systematic or non-systematic review methods; hence, there are limitations in analyzing interactions or dynamic relationships with other research fields. Therefore, in this study, the overall network structure of HRS and surrounding research fields were identified using citation network analysis (CNA). Additionally, in this process, in order to address the problem that the latest papers are underestimated in their citation relationships, the GraphSAGE algorithm was applied. As a result, this study identified 'recommender system', 'wireless & IoT', 'computer vision', and 'text mining' as increasingly important research fields related to HRS research, and confirmed that 'personalization' and 'privacy' are emerging issues in HRS research. The study findings would provide both academic and practical insights into identifying the structure of the HRS research community, examining related research trends, and designing future HRS research directions.

• The Korean Journal of Franchise Management
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• v.2 no.2
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• pp.95-110
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• 2011

As global economic conditions are getting uneasy and polarization of our economy is intensified, the economic sentiment of small businesses is still low and unstable. The collapse of worldwide banking systems due to sub prime crisis in 2007 became the catalyst that shakes financial industries in each country in the world; the most sentiment people, small businesspersons, also have hard time facing survival way out, facing a great crisis. All organizing powers including manufactures, wholesales and retails are being gradually greater in mutual relations and dependence, and unstable factors about risks are also increasing. For exterior environmental and physical risk factors which cannot make small businesses survive themselves by developing ways out are eventually increasing, those who cannot cope with these factors face a great crisis. Although the government tries hard to overcome this situation conducting many ways, the effect does not continue. It is the real state that independent business markets including overall employment and establishing business have vicious cycle that they cannot be improved, due to increase of employment centered on short-term labors which lack durability in creation of employment and decline of household income. Recently, growth shows indication of slowdown because of multinational risk factors including financial crisis in each country in Europe, the death of Kim Jung-il, relationship with North Korea, and unstability of war situation in the Middle East Asia. Experts expect that growth rate will be about 4%, and independent business that ordinary people feel is still gloomy. It's reality that there is no adequate alternative for lack of jobs, unstable employment and a means of living after retirement. Also, the fact that large companies enter the market which is narrow and in the excessive competition should be an environmental factor that makes the situation worse. The business concept, a franchise, is the part we should think about whether it is the institutional solution that can guarantee independent businessmen stable life. Major companies are frightfully entering the market today, breaking the barrier to entry and shouting of a win-win with independent businesses. It's the small businesspersons who go through painful domestic recession, cannot predict the future and manage confusing and unstable independent business. It's very important to restore the domestic economy through wisely boosting consumption as soon as possible. It's also important to lead the situation by gathering powers of the government and related organizations, agonizing, suggesting solutions, and establishing accurate directions. The purpose of this study, therefore, is to suggest ways to strengthen competitiveness of small businesspersons by examining small business support policies which are currently implemented.

• Korean Journal of Agricultural and Forest Meteorology
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• v.25 no.2
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• pp.80-98
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• 2023

This study explores the effectiveness of various data preprocessing algorithms for improving subseasonal to seasonal (S2S) climate predictions from six climate forecast models and their Multi-Model Ensemble (MME) using a deep learning-based postprocessing model. A pipeline of data transformation algorithms was constructed to convert raw S2S prediction data into the training data processed with several statistical distribution. A dimensionality reduction algorithm for selecting features through rankings of correlation coefficients between the observed and the input data. The training model in the study was designed with TimeDistributed wrapper applied to all convolutional layers of U-Net: The TimeDistributed wrapper allows a U-Net convolutional layer to be directly applied to 5-dimensional time series data while maintaining the time axis of data, but every input should be at least 3D in U-Net. We found that Robust and Standard transformation algorithms are most suitable for improving S2S predictions. The dimensionality reduction based on feature selections did not significantly improve predictions of daily precipitation for six climate models and even worsened predictions of daily maximum and minimum temperatures. While deep learning-based postprocessing was also improved MME S2S precipitation predictions, it did not have a significant effect on temperature predictions, particularly for the lead time of weeks 1 and 2. Further research is needed to develop an optimal deep learning model for improving S2S temperature predictions by testing various models and parameters.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.43 no.1
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• pp.43-54
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• 2023

Due to climate change, drought and flood occurrences have been increasing. Accurate projections of watershed discharges are imperative to effectively manage natural disasters caused by climate change. However, climate change and hydrological model uncertainty can lead to imprecise analysis. To address this issues, we used two lumped models, IHACRES and GR4J, to compare and analyze the changes in discharges under climate stress scenarios. The Hapcheon and Seomjingang dam basins were the study site, and the Nash-Sutcliffe efficiency (NSE) and the Kling-Gupta efficiency (KGE) were used for parameter optimizations. Twenty years of discharge, precipitation, and temperature (1995-2014) data were used and divided into training and testing data sets with a 70/30 split. The accuracies of the modeled results were relatively high during the training and testing periods (NSE>0.74, KGE>0.75), indicating that both models could reproduce the previously observed discharges. To explore the impacts of climate change on modeled discharges, we developed climate stress scenarios by changing precipitation from -50 % to +50 % by 1 % and temperature from 0 ℃ to 8 ℃ by 0.1 ℃ based on two decades of weather data, which resulted in 8,181 climate stress scenarios. We analyzed the yearly maximum, abundant, and ordinary discharges projected by the two lumped models. We found that the trends of the maximum and abundant discharges modeled by IHACRES and GR4J became pronounced as changes in precipitation and temperature increased. The opposite was true for the case of ordinary water levels. Our study demonstrated that the quantitative evaluations of the model uncertainty were important to reduce the impacts of climate change on water resources.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.17 no.2
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• pp.23-42
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• 2006

This is a study of the digital archives of Culturecontent.com where 'Cultural Archetype Contents' are currently in service. One of the major purposes of our study is to point out problems in the current system and eventually propose improvements to the digital archives. The government launched a four-year project for developing the cultural archetype content sources and establishing its related business with the hope of enhancing the nation's competitiveness. More specifically, the project focuses on the production of source materials of cultural archetype contents in the subjects of Korea's history. tradition, everyday life. arts and general geographical books. In addition, through this project, the government also intends to establish a proper distribution system of digitalized culture contents and to control copyright issues. This paper analyzes the digital archives system that stores the culture content data that have been produced from 2002 to 2005 and evaluates the current system's weaknesses and strengths. The summary of our findings is as follows. First. the digital archives system does not contain a semantic search engine and therefore its full function is 1agged. Second, similar data is not classified into the same categories but into the different ones, thereby confusing and inconveniencing users. Users who want to find source materials could be disappointed by the current distributive system. Our paper suggests a better system of digital archives with text mining technology which consists of five significant intelligent process-keyword searches, summarization, clustering, classification and topic tracking. Our paper endeavors to develop the best technical environment for preserving and using culture contents data. With the new digitalized upgraded settings, users of culture contents data will discover a world of new knowledge. The technology we introduce in this paper will lead to the highest achievable digital intelligence through a new framework.