• 대한전자공학회논문지SP
• /
• 제45권2호
• /
• pp.95-102
• /
• 2008

본 논문에서는 다양한 배경잡음에 의해 열화된 음성을 강조하기 위하여 청각시스템을 기초로 한 적응적인 음성강조시스템을 제안한다. 제안한 시스템은 먼저 유성음과 무성음의 구간을 검출한 후, 각 입력 프레임에서 검출된 결과에 따라서 상호억제 계수와 진폭성분조정계수를 적응적으로 조정한다. 마지막으로 시간지연신경회로망을 사용하여 잡음신호를 제거한다. 실험결과 본 시스템은 신호대잡음비의 평가방법을 통하여 다양한 잡음에 의해서 열화된 음성신호를 백색잡음 및 유색잡음에 대해서 효과적인 것을 보여준다.

• 대한전자공학회논문지SP
• /
• 제42권5호
• /
• pp.165-172
• /
• 2005

잡음이 존재하는 환경 하에서 음성인식을 실시하는 경우, 잡음을 제거하고 음성을 강조하는 시스템이 필요하다. 따라서 우수한 스펙트럴 분석기강인 인간의 청각계를 모의하는 것은 음성강조에 있어서 효과적이다. 이러한 것을 구현하는 하나의 방법으로서 상호억제라고 하는 청각기강을 적응적으로 사용하는 방법을 제안한다. 이것은 신경회로망에 의해서 잡음의 크기를 추정하여 각 프레임에 대해서 그 크기에 따라서 적응적으로 상호억제 계수와 진폭성분조정 계수를 조정함으로써 음성을 강조하는 방법이다. 스펙트럴왜곡율 척도의 평가로부터 백색잡음뿐만 아니라 유색잡음 및 자동차의 주행잡음에 대해서도 본 방식이 효과적이라는 것을 확인한다.

• BMB Reports
• /
• 제55권12호
• /
• pp.621-626
• /
• 2022

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by the degeneration of motor neurons in the spinal cord. Main symptoms are manifested as weakness, muscle loss, and muscle atrophy. Some studies have reported that alterations in sphingolipid metabolism may be intimately related to neurodegenerative diseases, including ALS. Acid sphingomyelinase (ASM), a sphingolipid-metabolizing enzyme, is considered an important mediator of neurodegenerative diseases. Herein, we show that ASM activity increases in samples from patients with ALS and in a mouse model. Moreover, genetic inhibition of ASM improves motor function impairment and spinal neuronal loss in an ALS mouse model. Therefore, these results suggest the role of ASM as a potentially effective target and ASM inhibition may be a possible therapeutic approach for ALS.

• 대한통합의학회지
• /
• 제12권1호
• /
• pp.125-138
• /
• 2024

Purpose: The aim of this study was to apply suboccipital muscle inhibition combined with neck muscle stabilization exercise to 20~30s IT industry employees who suffer from chronic non-specific neck pain. Methods: This study was designed as single-blind and randomized controlled trial. The study participants were 20~30s IT industry employees with chonic non-specific neck pain (VAS 3/10) who were divided into an experimental group (n= 20) subjected to suboccipital muscle inhibition with neck muscle stabilization exercise, and control group (n= 20); suboccipital muscle inhibition only. The intervention was applied three times per week for eight weeks. The neck pain·pressure pain threshold·range of motion, and disability index were measured at the 1st, 8th, and 10th week at follow up, then analyzed with an analysis of variance(ANOVA) using the SPSS program. Results: The total number of study participants was 37 (experimental group 19, mean age 34.6±5.3, control group 18, mean age 35.7±4.9). The comparison and analysis of change in VAS, the pressure pain threshold, and the range of motion except the extension (p>.05) revealed a statistically significant decrease between groups over eight weeks and follow up measurement (p<.01). Regarding the within the group differences, the right side of the neck pressure pain threshold showed a statistically significant decrease over eight weeks in the control group (p<.01). The right and left lateral flexion, and the right and left rotation were statistically significant for the experimental group over eight weeks and follow up measurement, but only the left lateral flexion (p<.05) for the control group over eight weeks. The neck disability index showed a slight decrease but this was not satistically significant for the between-grop or the within-group differences (p>.05). Conclusion: The intervention of suboccipital muscle inhibition and a neck muscle stabilization exercise are more beneficial for neck pain and the range of motion than the application of suboccipital muscle inhibition alone.

• 농업과학연구
• /
• 제29권1호
• /
• pp.8-14
• /
• 2002

MH 39는 품종과 처리농도에 관계없이 포도 부초신장을 유의하게 억제시켜 부초의 과번무를 막을 수 있는 약제로 인정되었다. 처리시기는 거봉은 만개 30일 후, 캠벨 얼리는 만개 35일 후 처리구가 이상적이었으나 이는 공시수의 수세에 따라 달라질 수 있다는 것이 확인되었다. 처리농도는 $3,900mg{\cdot}L^{-1}$의 경우 부초의 정단부가 고사 또는 탈락되는 등 과도한 반응이 나타났으므로 $1,950mg{\cdot}L^{-1}$이 적정농도임이 확인되었다. 부초생장의 억제효과는 마디수의 감소와 마디길이가 단축됨으로서 나타났다. 그러나 과실 품질에는 영향을 미치지 않았고 오히려 캠벨 얼리의 경우는 anthocyanin므로 포도의 부초제거의 노력을 생력화 할 수 있는 유용한 약제가 될 것으로 판단되었다.

• 생물환경조절학회지
• /
• 제16권1호
• /
• pp.47-53
• /
• 2007

본 실험은 고품질의 콩나물 생산을 위한 기초연구로서 식물생장조절제를 이용한 세근발생 억제 및 하배축비대촉진을 위한 처리 방법을 구명하고자 실험을 수행하여 다음과 같은 결과를 얻었다. 식물생장조절제 중 $GA_3$나 NAA 처리는 세근발생 억제효과가 미약하였다. 반면 BAP처이믐 세근발생이 전혀 일어나지 않았고 하배축의 비대를 촉진하였는데, 저농도인 $10mg{\cdot}L^{-1}$ 및 $15mg{\cdot}L^{-1}$ 처리에서도 그 효과가 인정되었다. BAP의 처리시간은 짧을수록 하배축 비대가 촉진되었고 하배축 비대를 촉진하는 처리시간은 6시간 처리였다. BAP 처리 후 24시간 간격으로 관수는 세근 발생율이 낮았고 하배축 비대는 촉진되었다. 인돌비는 적정농도로 알려져 있는 4.2%보다 낮은 농도인 1.1%용액을 처리하더라도 세근 발생이 크게 문제되지 않았다.

• 한국환경과학회지
• /
• 제1권2호
• /
• pp.145-155
• /
• 1992

The effect of various supplies of lead singly and in combination with aluminium on growth and chlorophyll biosynthesis was investigated in 7-day-old Vigna anguluris seedlings. Expose to 50 $\mu$N Pb or more drastically reduced root elongation rate. Significant depressions in root growth was observed within 1 day and no recovery of growth was seen over the duration of treatment period. Root elongation decreased depending on the Pb concentrations. Root growth inhibition was stronger than shoot growth inhibition. The initiation of lateral roots appeared to be more sensitive to Pb than the growth of main roots. Inhibition of root and shoot elongation by Pb was lessened by combined exposure of Pb and Al, suggesting that the presence of AA reverse the inhibitory effect of Pb alone. With the histochemical sodium rhodizonate method the rate of Pb uptake was dependent on the Pb concentration and exposure time of the roots to Pb salts. Pb was first deposited on the root surface and then translocated radially in the root cap cells. During a longer Pb administration (up to 72 h) Pb penetration was nonuniform, with accumulation within the cortex or endodermis. There was drastic reduction in chlorophyll content by Pb. The Pb inhibition of chlorophyll synthesis was concentration dependent. 5-Aminolevulinic acid dehydratase (ALAD) activity exhibited distinct inhibition from control. Reduction in chlorophyll content was accompanied by proportional changes in ALAD activity. Chlorophyll content and ALAD activity were less affected by combined exposure of Pb and Al, suggesting that Al has a protective effect against the inhibiting action of Pb on photosynthetic activity.

• Environmental Sciences Bulletin of The Korean Environmental Sciences Society
• /
• 제1권2호
• /
• pp.145-155
• /
• 1997

The effect of various supplies of lead singly and in combination with aluminium on growth and chlorophyll biosynthesis was investigated in 7-day-old Vigna angularis seedlings. Expose to 50 uM Pb or more drastically reduced root elongation rate. Significant depressions in root growth was observed within 1 day and no recovery of growth was seen over the duration of treatment period. Root elongation decreased depending on the Pb concentrations. Root growth inhibition was stronger than shoot growth inhibition. The initiation of lateral roots appeared to be more sensitive to Pb than the growth of main roots. Inhibition of root and shoot elongation by Pb was lessened by combined exposure of Pb and Al, suggesting that the presence of Al reverse the inhibitory effect of Pb alone. With the histochemical sodium rhodizonate method the rate of Pb uptake was dependent on the Pb concentration and exposure time of the roots to Pb salts. Pb was first deposited on the root surface and then translocated radially in the root cap cells. During a longer Pb administration (up to 72 h) Pb penetration was nonuniform, with accumulation within the cortex or endodermis. There was drastic reduction in chlorophyll content by Pb. The Pb inhibition of chlorophyll synthesis was concentration dependent. $\delta-Aminolevulinic$ acid dehydratase (ALAD) activity exhibited distinct inhibition from control. Reduction in chlorophyll content was accompanied by proportional changes in ALAD activity. Chlorophyll content and ALAD activity were less affected by combined exposure of Pb and Al, suggesting that Al has a protective effect against the inhibiting action of Pb on photosynthetic activity.

• Journal of Ginseng Research
• /
• 제14권1호
• /
• pp.10-13
• /
• 1990

Effect of an acidic polysaccharide fraction In Korean white and red ginseng on lipolytic action of Toxohormone-L was studied. Crude acidic polysaccharide fraction was extracted from main and lateral root of Korean white and red ginseng separately and purified several times. Inhibitory effect of crude polysaccharide fraction was determined by unit (1 unit is loft inhibition rate per Is sample). Yields of purified crude polysaccharide fraction of main and lateral root of red ginseng were 2.9 and 2.2 times higher than those of white ginseng, respectively. Inhibitory effects of main root of white and red ginseng, 11.hen final reaction concentrations of sample were 50, 100, 200, 500 $\mu$g/ml, were 37.2가 and 23.7% higher than those of lateral root of white and red ginseng. Inhibitory effect of main root of red ginseng was 2.3 times higher than that of white ginseng.

• Molecules and Cells
• /
• 제40권4호
• /
• pp.280-290
• /
• 2017

Several lines of evidence suggest that endoplasmic reticulum (ER) stress plays a critical role in the pathogenesis of many neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Protein tyrosine phosphatase 1B (PTP1B) is known to regulate the ER stress signaling pathway, but its role in neuronal systems in terms of ER stress remains largely unknown. Here, we showed that rotenone-induced toxicity in human neuroblastoma cell lines and mouse primary cortical neurons was ameliorated by PTP1B inhibition. Moreover, the increase in the level of ER stress markers ($eIF2{\alpha}$ phosphorylation and PERK phosphorylation) induced by rotenone treatment was obviously suppressed by concomitant PTP1B inhibition. However, the rotenone-induced production of reactive oxygen species (ROS) was not affected by PTP1B inhibition, suggesting that the neuroprotective effect of the PTP1B inhibitor is not associated with ROS production. Moreover, we found that MG132-induced toxicity involving proteasome inhibition was also ameliorated by PTP1B inhibition in a human neuroblastoma cell line and mouse primary cortical neurons. Consistently, downregulation of the PTP1B homologue gene in Drosophila mitigated rotenone- and MG132-induced toxicity. Taken together, these findings indicate that PTP1B inhibition may represent a novel therapeutic approach for ER stress-mediated neurodegenerative diseases.