• Title/Summary/Keyword: Lab-on-a-chip

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Design of Super-regenerative Oscillator for Ultra Low Power Receiver Implementation (극소전력 수신기 구현을 위한 Super-regenerative Oscillator 설계)

  • Kim, Jeong-Hoon;Kim, Jung-Jin;Kim, Eung-Ju;Park, Ta-Jun
    • Proceedings of the IEEK Conference
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    • 2006.06a
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    • pp.625-626
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    • 2006
  • An Ultra low power super-regenerative oscillator was implemented with on-chip inductor and quench signal generator. The super-regenerative oscillator detects the signal level as low as -70dBm while consuming only 0.48mA at 1.5V supply voltage. These results indicate that the super-regenerative oscillator can be outstanding candidate the simple, ultra low power receiver design.

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Array-based Nano-amplification Technique Was Applied in Detection of Hepatitis E Virus

  • Liu, Hui-Hui;Cao, Xuan;Yang, Yong;Liu, Ming-Gui;Wang, Ye-Fu
    • BMB Reports
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    • v.39 no.3
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    • pp.247-252
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    • 2006
  • A rapid method for the detection of Hepatitis E Virus (HEV) was developed by utilizing nano-gold labeled oligonucleotide probes, silver stain enhancement and the microarray technique. The 5'-end -$NH_2$ modified oligonucleotide probes were immobilized on the surface of the chip base as the capture probe. The detection probe was made of the 3'-end -SH modified oligonucleotide probe and nano-gold colloid. The optimal concentrations of these two probes were determined. To test the detection sensitivity and specificity of this technique, a conservative fragment of the virus RNA was amplified by the RT-PCR/PCR one step amplification. The cDNA was hybridized with the capture probes and the detection probes on microarray. The detection signal was amplified by silver stain enhancement and could be identified by naked eyes. 100 fM of amplicon could be detected out on the microarray. As the results, preparation of nano-gold was improved and faster. Development time also was shortened to 2 min. Thus, considering high efficiency, low cost, good specificity and high sensitivity, this technique is alternative for the detection of HEV.

A multi-radio sink node designed for wireless SHM applications

  • Yuan, Shenfang;Wang, Zilong;Qiu, Lei;Wang, Yang;Liu, Menglong
    • Smart Structures and Systems
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    • v.11 no.3
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    • pp.261-282
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    • 2013
  • Structural health monitoring (SHM) is an application area of Wireless Sensor Networks (WSNs) which usually needs high data communication rate to transfer a large amount of monitoring data. Traditional sink node can only process data from one communication channel at the same time because of the single radio chip structure. The sink node constitutes a bottleneck for constructing a high data rate SHM application giving rise to a long data transfer time. Multi-channel communication has been proved to be an efficient method to improve the data throughput by enabling parallel transmissions among different frequency channels. This paper proposes an 8-radio integrated sink node design method based on Field Programmable Gate Array (FPGA) and the time synchronization mechanism for the multi-channel network based on the proposed sink node. Three experiments have been performed to evaluate the data transfer ability of the developed multi-radio sink node and the performance of the time synchronization mechanism. A high data throughput of 1020Kbps of the developed sink node has been proved by experiments using IEEE.805.15.4.

Extremely large-area travelling-wave dielectrophoresis microbead separator using a multilayered bus bar (다층 버스 바를 이용한 극한 면적의 진행파 유전영동 미세입자 분류기)

  • Choi, Eun-Pyo;Kim, Byung-Kyu;Park, Jung-Yul
    • Journal of Sensor Science and Technology
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    • v.18 no.2
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    • pp.139-146
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    • 2009
  • A Multilayered microelectrode design is presented for large area travelling wave dielectrophoresis (TwDEP) separators. Most of typical TwDEP chip has been arrayed with 1000 electrodes in $20{\times}20\;mm^2$. However, there is a limitation of the device area that is critical in throughput, because when the area of TwDEP becomes larger, the resistance of microelectrodes for bus bar is also increased. In this paper, we successfully developed a novel TwDEP chip with extremely large area ($31{\times}25\;mm^2$) by a unique multilayered bus bar design. According to the resistance simulation of our microelectrodes, it is possible to realize a TwDEP chip with an infinite longitudinal length. We demonstrated the feasibility of our suggestion with latex microbeads and showed the potential of extremely high throughput separation with TwDEP technique.

Characteristics of Bio-filter Support Media for the Odor Control (악취가스 제어를 위한 Bio-filter 담체의 특성 비교)

  • Lee, Hye-Sung;Chu, Duk-Sung;Jung, Joon-Oh
    • Journal of Environmental Health Sciences
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    • v.34 no.1
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    • pp.101-107
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    • 2008
  • Bio-filtration utilizes microorganisms fixed to a porous medium to metabolize pollutants present in an air stream. The microorganisms grow in a bio-film on the surface of a medium or are suspended in the water phase surrounding the medium particles. Therefore, bio-filter support media play one of the most important key roles in bio-filtration of gas phase pollutants. To characterize and select the appropriate support media, gas adsorption capacity and microorganism immobilization were investigated in lab-scale experiments for the selected target support media which were compost I (compost from lab-scale process), compost II (compost from municipal facility), bark, wood chip, orchid stone and vermiculite. As odor materials, ammonia and trimethylamine were utilized. From the result of experiments, bark was superior to any other support media tested in adsorption capacity as much as 12.5 mg ammonia per 1 g bark. In trimethylamine adsorption, bark and wood chip showed a remarkable results of 21.1 and 14.1 mg/g respectively. On the other hand, microorganism fixation test determined by the count of nitrogen oxidizing microbes population, the compost II and wood chips showed the best results. Considering the characteristics of materials and the operating condition of the bio-filter, bark, wood chip, and compost II are applicable to the support media of bio-filter when they are appropriately blended on the basis of studying the media pH, packing porosity and moisture contents.

A Continuous Electrical Cell Lysis Chip using a DC Bias Voltage for Cell Disruption and Electroosmotic Flow (한 쌍의 전극으로 전기 삼투 유동과 세포 분쇄 기능을 동시에 구현한 연속적인 세포 분쇄기)

  • Lee, Dong-Woo;Cho, Young-Ho
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.32 no.10
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    • pp.831-835
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    • 2008
  • We present a continuous electrical cell lysis chip, using a DC bias voltage to generate the focused high electric field for cell lysis as well as the electroosmotic flow for cell transport. The previous cell lysis chips apply an AC voltage between micro-gap electrodes for cell lysis and use pumps or valves for cell transport. The present DC chip generates high electrical field by reducing the width of the channel between a DC electrode pair, while the previous AC chips reducing the gap between an AC electrode pair. The present chip performs continuous cell pumping without using additional flow source, while the previous chips need additional pumps or valves for the discontinuous cell loading and unloading in the lysis chambers. The experimental study features an orifice whose width and length is 20 times narrower and 175 times shorter than the width and length of a microchannel. With an operational voltage of 50 V, the present chip generates high electric field strength of 1.2 kV/cm at the orifice to disrupt cells with 100% lysis rate of Red Blood Cells and low electric field strength of 60 V/cm at the microchannel to generate an electroosmotic flow of $30{\mu}m/s{\pm}9{\mu}m/s$. In conclusion, the present chip is capable of continuous self-pumping cell lysis at a low voltage; thus, it is suitable for a sample pretreatment component of a micro total analysis system or lab-on-a-chip.

DESIGN CONCEPT FOR SINGLE CHIP MOSAIC CCD CONTROLLER

  • HAN WONYONG;JIN Ho;WALKER DAVID D.;CLAYTON MARTIN
    • Journal of The Korean Astronomical Society
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    • v.29 no.spc1
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    • pp.389-390
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    • 1996
  • The CCDs are widely used in astronomical observations either in direct imaging use or spectroscopic mode. However, the areas of available sensors are too small for large imaging format. One possibility to obtain large detection area is to assemble mosaics of CCD, and drive them simultaneously. Parallel driving of many CCDs together rules out the possibility of individual tuning; however, such optimisation is very important, when the ultimate low light level performance is required, particularly for new, or mixed devices. In this work, a new concept is explored for an entirely novel approach, where the drive waveforms are multiplexed and interleaved. This simultaneously reduces the number of leadout connections and permits individual optimisation efficiently. The digital controller can be designed within a single EPLD (Erasable Programmable Logic Device) chip produced by a CAD software package, where most of the digital controller circuits are integrated. This method can minimise the component. count., and improve the system efficiency greatly, based on earlier works by Han et a1. (1996, 1994). The system software has an open architecture to permit convenient modification by the user, to fit their specific purposes. Some variable system control parameters can be selected by a user with a wider range of choice. The digital controller design concept allows great flexibility of system parameters by the software, specifically for the compatibility to deal with any number of mixed CCDs, and in any format, within the practical limit.

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A Study on the Linearization of Notch Angles of SHE PWM Inverters (SHE PWM 인버터의 Notch Angle 선형화에 관한 연구)

  • Kim, Kwon-Ho;Yoon, Kwan-Cheol;Kim, Kwang-Bae;Ryou, Kyoung;Park, Gwi-Tae
    • Proceedings of the KIEE Conference
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    • 1989.11a
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    • pp.317-321
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    • 1989
  • The fully digitalized inverter has some difficulties in implementation because of the limitation of available memory capacity and computation time. In this paper schemes suitable for a one-chip microprocessor-based realization, which linearize notch angles of selected harmonic elimination (SHE) PWM, are presented. Also the detailed description of the scheme along with the realization is described. The simulation and experiment results show that proposed schemes have the predicted advantages such as good voltage waveforms and a memory-saving.

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Characterization of Dielectrophoretic Force for the Structural Shapes of Window in Microfluidic Dielectrophoretic Chip (미세유체칩내 electrode의 opening window형태에 따른 유전전기영동력 특성 규명)

  • Lee, Jaewoo;Kwak, Tae Joon;Yoon, Dae Sung;Lee, Sang Woo
    • Journal of Biomedical Engineering Research
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    • v.34 no.4
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    • pp.189-196
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    • 2013
  • Dielectrophoresis(DEP) is useful in manipulation and separation of micro-sized particles including biological samples such as bacteria, blood cells, and cancer cells in a micro-fluidic device. Especially, those separation and manipulation techniques using DEP in combination of micro fabrication technique have been researched more and more. Recently, it is revealed that a window structure of insulating layer in microfluidic DEP chip is key role in trap of micro-particles around the window structure. However, the trap phenomenon-driven by DEP force gradient did not fully understand and is still illusive. In this study, we characterize the trap mechanism and efficiency with different shapes of window in a microfluidic DEP chip. To do this characterization, we fabricated 4 different windows shapes such as rhombus, circle, squares, and hexagon inside a micro-fluidic chip, and performed micro-sized particles manipulation experiments as varying the frequency and voltage of AC signal. Moreover, the numerical simulation with the same parameters that were used in the experiment was also performed in order to compare the simulation results and the experimental results. Those comparison shows that both results are closely matched. This study may be helpful in design and development of microfluidic DEP chip for trapping micro-scaled biological particle.