• Journal of Sensor Science and Technology
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• v.23 no.6
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• pp.416-419
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• 2014

We grew a $Li_6Lu(BO_3)_3:Ce^{3+}$ single crystal as a new scintillator. And, the scintillation and thermoluminescence properties of the scintillator were determined. The emission spectrum of $Li_6Lu(BO_3)_3:Ce^{3+}$ is located in the range of 370~530 nm, peaking at 416 nm and 439 nm, due to the $5d{\rightarrow}4f$ transition of $Ce^{3+}$ ions. The fluorescence decay time of the crystal is composed two components. The fast component is 34 ns (84%) and the slow component is 125 ns (16%) of the crystal. The afterglow is caused by the electron and hole traps in the crystal lattice. We determined physical parameters of the traps in the crystal. The thermoluminescence trap are composed a trap. The determined activation energy (E) and frequency factor (s) of the TL trap are 1.05 eV and $4.4{\times}10^{10}s^{-1}$, respectively.

• Journal of the Korean Society of Radiology
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• v.18 no.1
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• pp.21-26
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• 2024

The one of the famous deep learning models for object detection task is you only look once version 5 (YOLOv5) framework based on the one stage architecture. In addition, YOLOv5 model indicated high performance for accurate lesion detection using the bottleneck CSP layer and skip connection function. The purpose of this study was to evaluate the performance of YOLOv5 framework according to various hyperparameters in position emission tomogrpahy (PET) phantom images. The dataset was obtained from QIN PET segmentation challenge in 500 slices. We set the bounding box to generate ground truth dataset using labelImg software. The hyperparameters for network train were applied by changing optimization function (SDG, Adam, and AdamW), activation function (SiLU, LeakyRelu, Mish, and Hardwish), and YOLOv5 model size (nano, small, large, and xlarge). The intersection over union (IOU) method was used for performance evaluation. As a results, the condition of outstanding performance is to apply AdamW, Hardwish, and nano size for optimization function, activation function and model version, respectively. In conclusion, we confirmed the usefulness of YOLOv5 network for object detection performance in nuclear medicine images.

• Proceedings of the Korean Vacuum Society Conference
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• 1993.02a
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• pp.17-18
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• 1993

• Genomics & Informatics
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• v.17 no.2
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• pp.12.1-12.2
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• 2019

• Herbal Formula Science
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• v.26 no.1
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• pp.65-80
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• 2018

Objectives : This study aims to sort out prescription candidates for four major symptoms of Parkinson's disease from Korean traditional medical publication, "Dongeuibogam". Methods : Medical terms related to four major symptoms of Parkinson's disease were primarily selected from "Dongeuibogam". Prescriptions that include at least one or more medical terms which are selected above were classified by the four major symptoms of Parkinson's disease, and finally analyzed to sort the most effective candidates. Results & Conclusions : 1. There are 18 medical terms in efficacy ($ch{\grave{i}}$ $z{\grave{o}}ng$, $j{\bar{u}}$ $lu{\acute{a}}n$, $j{\bar{i}}ng$${\check{u}}$ $ju{\check{a}}n$($ju{\check{a}}n$, $qu{\acute{a}}n$) $lu{\acute{a}}n$, $j{\bar{i}}ng$${\check{u}}$ $lu{\acute{a}}n$($lu{\acute{a}}n$) $t{\grave{o}}ng$, $j{\bar{i}}n$ $lu{\acute{a}}n$, $j{\bar{i}}n$ $t{\grave{i}}$, $sh{\check{o}}u$ $zh{\grave{e}}n$, $y{\acute{a}}ng$ $sh{\check{o}}u$, $lu{\acute{a}}n$ $j{\acute{i}}$, $lu{\acute{a}}n$ $b{\grave{i}}$, $r{\grave{o}}u$ $r{\acute{u}}n$, $zh{\grave{a}}n$ $di{\grave{a}}o$, $zh{\grave{a}}n$ $y{\acute{a}}o$, $zh{\grave{i}}$ $z{\acute{u}}$, $ch{\grave{e}}$ $t{\grave{o}}ng$, $ch{\bar{o}u}$ $ch{\grave{e}}$, $f{\bar{e}}ng$ $ch{\grave{u}}$, $ch{\grave{u}}$ $nu{\grave{o}}$) related to tremor, one of four major symptoms of Parkinson's disease. 2. There are 9 medical terms in efficacy ($qi{\acute{a}}ng$ $j{\acute{i}}$, $qi{\acute{a}}ng$ $zh{\acute{i}}$, $qi{\acute{a}}ng$ $t{\grave{o}}ng$, $j{\bar{u}}$ $j{\acute{i}}$, $j{\bar{i}}n$ $j{\acute{i}}$, $sh{\bar{e}}n$ $qi{\acute{a}}ng$, $lu{\acute{a}}n$ $j{\acute{i}}$, $y{\bar{a}}o$ $j{\acute{i}}$ $qi{\acute{a}}ng$, $xi{\grave{a}}ng$ $qi{\acute{a}}ng$) related to rigidity, one of four major symptoms of Parkinson's disease. 3. 38 prescription candidates (jiaweishouxingyuan, jiaweilonghusan, gehuajiexingtang, qiangfutang, qianghuoxuduantang, dawugongsan, duhuojishengtang, mahuangzuojingtang, fangfengbaizhumulitang, fangfengtongshengsan, baizhutang, buxinwan, fulingtang, binsusan, xieqingwan, sanbitang, shengdiqinliantang, shujinbaoansan, xingxiangsan, xiaotanfulingwan, shengjunwan, shenmizuojingtang, wuyaoshunqisan, yuzhenwan, wenjingyiyuantang, yiziqingjinsan, ziyinningshentang, shaoyaogancaotang, dingtongsan, zhushazhijiasan, cangzusan, chuanxiongfulingtang, tiedanyuan, choubaowan, duomingsan, xuanhusuosan, xuefengtang, huoluodan) were selected for tremor, one of the four major symptoms of Parkinson's disease. 4. 21 prescription candidates (qianghuoshengshitang, guizhiqianghuotang, guizhifuzitang, jiuweiqianghuotang(qianghuochonghetang), xiongzhixiangsusan, daqianghuotang, mahuangguizhitang, muguajian, fuzilizhongtang, shenzhusan, lianqiaobaidusan, yuzhensan, niuhuangjinhudan, renshenbaidusan, shaoyaogancaotang, jiuzhumuguazhou, cangzusan, shenxiangtianmatang, xiangjiaosan, xuefengtang, huishousan) were selected for rigidity, one of the four major symptoms of Parkinson's disease. 5. The results in this study ought to be verified by subsequent studies and clinical trials.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.17
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• pp.7037-7041
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• 2014

Background: 5-Fluorouracil (5-FU) is the most commonly used drug in colon cancer therapy. However, despite impressive clinical responses initially, development of drug resistance to 5-Fu in human tumor cells is the primary cause of failure of chemotherapy. In this study, we established a 5-Fu-resistant human colon cancer cell line for comparative chemosensitivity studies. Materials and Methods: Real time PCR and Western blotting were used to determine gene expression levels. Cell viability was measured by MTT assay. Glucose uptake was assess using an Amplex Red Glucose/Glucose Oxidase assay kit. Results: We found that 5-Fu resistance was associated with the overexpression of Glut1 in colon cancer cells. 5-Fu treatment at low toxic concentration induced Glut1 expression. At the same time, upregulation of Glut1 was detected in 5-Fu resistant cells when compared with their parental cells. Importantly, inhibition of Glut1 by a specific inhibitor, WZB117, significantly increased the sensitivity of 5-Fu resistant cells to the drug. Conclusions: This study provides novel information for the future development of targeted therapies for the treatment of chemo-resistant colon cancer patients. In particular it demonstrated that Glut1 inhibitors such as WZB117 may be considered an additional treatment options for patients with 5-Fu resistant colon cancers.

• Journal of Korea Water Resources Association
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• v.54 no.spc1
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• pp.1143-1154
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• 2021

The selection of activation function has a great influence on the groundwater level prediction performance of artificial neural network (ANN) model. In this study, five activation functions were applied to ANN model for two groundwater level observation wells in the middle mountainous area of the Pyoseon watershed in Jeju Island. The results of the prediction of the groundwater level were compared and analyzed, and the optimal activation function was derived. In addition, the results of LSTM model, which is a widely used recurrent neural network model, were compared and analyzed with the results of the ANN models with each activation function. As a result, ELU and Leaky ReLU functions were derived as the optimal activation functions for the prediction of the groundwater level for observation well with relatively large fluctuations in groundwater level and for observation well with relatively small fluctuations, respectively. On the other hand, sigmoid function had the lowest predictive performance among the five activation functions for training period, and produced inappropriate results in peak and lowest groundwater level prediction. The ANN-ELU and ANN-Leaky ReLU models showed groundwater level prediction performance comparable to that of the LSTM model, and thus had sufficient potential for application. The methods and results of this study can be usefully used in other studies.

• Bulletin of the Korean Chemical Society
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• v.25 no.5
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• pp.673-675
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• 2004

The tetranuclear copper(II) cluster compound $[Cu_4OCl_6(C_{14}H_{12}N_2)_4]$ has been synthesized by hydrothermal reaction and studied by X-ray diffraction. The four copper(II) atoms locate four capsheaves of a tetrahedral skeletal structure and a oxygen atom as interstitial atom occupies the center position of the same tetrahedron, and each edge of the Cu-Cu tetrahedron is bridged by one ${\mu}_2$-Cl anion. The copper atom possesses slightly distorted trigonal bipyramidal geometry with three ${\mu}_2$-Cl atoms in equatorial position and the interstitial O atom and one N atom from 3-benzyl-benzimidazole ligand occupying axial position. The Cu-Cu distances are in the range of 3.0986-3.1162 ${\AA}$. The EPR spectrum suggested that the copper(II) ground state $d_{x2-y2}$ and the coordination geometry was trigonal bipyramidal.

• Microbiology and Biotechnology Letters
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• v.20 no.2
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• pp.219-224
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• 1992

The changes of yeast population were investigated in Mul-kimchi containing 3% salt, fermented at $15^{\circ}C$. The total viable count increased to the maximum at the optimum ripening period and then decreased rapidly. Among twenty-nine strains isolated at the optimum ripening period, the yeasts of genus Saccharomyces were predominant. The growth of five strains, Saccharomyces saitoanus Y17, Saccharomyces capensis Y29, Saccharomyces chevalieri Y13, Kluyveromyces fragilis Y2, Torulopsis candida Y9, was measured in mixed culture with each selected lactic strains, hctobaczllus plantarum Lp2, Pedzococcus pentosaceus PI, Leuconostoc mesenteroides Lu5. The results indicated that all the yeasts tested were inhibited significantly by lactic strains, however the sensitivity of yeast strains varied greatly.

• Journal of Veterinary Clinics
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• v.21 no.4
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• pp.395-397
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• 2004

A fifteen-year-old spayed female Pug was referred to Veterinary Medical Teaching Hospital of Seoul National University. The clinical sign was a restriction of the movement of the headneck and acutely presented for 5 days ago. On the basis of physical, laboratory and radiological examinations, the dog was diagnosed acute torticollis (wry neck). We treated two times the dog with acupuncture therapy for 2 weeks. The acupuncture points BL10, BL11, LU7 and SI3 were used. When the dog was rechecked at three weeks after the therapy, torticollis was disappeared and voluntarily head movement found. Thus, it is suggested that traditional acupuncture might be effective therapy for acute torticollis.