• The Journal of Asian Finance, Economics and Business
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• 제7권9호
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• pp.329-340
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• 2020

This study investigates the effect of capital structure on the financial performance of pharmaceutical enterprises which are listing on Vietnam's stock market. The study builds the regression using ROE as dependent variable and four independent variables, including self-financing, financial leverage, long-term asset and debt to assets ratios. In addition, we use other variables as controlling ones, such as firm size, fixed asset rate and growth. We collect data for the period from 2015 to 2019 of all 30 pharmaceutical enterprises which are currently listing on Vietnam's stock market. The least square regression (OLS) is used to test the effect of capital structure to the firms' financial performance. The analysis results show that the financial leverage ratio (LR), long-term asset ratio (LAR) and debt-to-assets ratio (DR) have positive relationship with firm performance, meanwhile the self-financing (E/C) affects negatively to the return on equity (ROE). Upon the findings we suggest that the Vietnamese government should focus on stabilizing macro environment to create favorable environment for enterprises. And the pharmaceutical enterprises should build more reasonable capital structure with higher debt proportion than equity, diversifying loan mobilization channels such as issuing long-term bonds. Additionally, the firms should expand the scale appropriately to maintain development and ability to pay debts.

• 디지털산업정보학회논문지
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• 제6권4호
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• pp.57-65
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• 2010

Application of WBAN technology in medical field facilitates the prevention of diseases by collecting the vital signs remotely. It also enables to prevent the accidental emergency situation in advance plus long-tem monitoring of patients with chronic diseases such as heart diseases, hypertension, or the elderly and infirm. For emergency patients, major vital signal information collected by the 'Sensing' should have the top priority and such information should be transferred as promptly as possible without competition. In addition, when an emergency occurs to a patient, a priority mechanism is necessitated for a urgent message to get through to the final destination. However, LR-WPAN IEEE 802.15.4 technology does not consider such emergency message handling features. To deal with aforementioned issues, the IEEE 802.15.4 super frame protocol structure has been designed for stable transfer of emergency information in WBAN environment in this study, and alternation to super frame structures have been made, allowing GTS(Guaranteed Time Slot) can be used first at CFP (Contention Free Period) by reserving the resources in advance and prioritize the emergency signals. NS-2 has been utilized for the performance test and analysis.

• 한방안이비인후피부과학회지
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• 제16권2호
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• pp.138-151
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• 2003

Although the use of acupuncture for pain has increased in recent years, the mechanisms of acupuncture analgesia (AA) remains obscure. The lack of suitable experimental animal models for persistent pain, which show clear AA, has been the major stumbling block in the investigation of the physiological mechanisms of AA. In the present study, we test AA in two knee arthritis model induced by injection of CFA or carrageenan as a chronic pain model. After induction of arthritis, the rat subsequently showed a reduced stepping force of the affected limb for the next several days. Electroacupuncture (EA) was applied to an acupuncture point each on the contralateral forelimb for 30 minutes under enflurane anesthesia. After the termination of EA, behavioral tests measuring stepping force were periodically conducted during the next several hours. EA produced a significant improvement of stepping force of the foot lasting for at least 2 hours when applied to LR2 In CFA model, and applied to ST36 in carrageenan model, but both points did not produce any significant effects in each other model. These data suggest that EA produce analgesic effect in knee arthritic pain and the analgesic effect is specific to the acupuncture point.

• Journal of Welding and Joining
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• 제17권6호
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• pp.53-61
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• 1999

The use of thick plate in increasing in recent years due to the rapid expansion of chemical plants, nuclear plants, ships and other industrial plants. Welding is the most popular joining techniques employed in manufacturing industrial machineries and structures. Normally, Groove shapes are prepared according to appropriate rules and regulations such as KS, JIS, AWS, LR, DNV and etc. for various thicknesses of plate. However those groove angles tend to be too large. As a result of large groove angle, residual stress, deformation of material and strength reduction is obtained. Therefore, the reliability and safety of structures and machinery tend to be decreasing. Therefore, in this paper, theoretical as well as experimental study are carried out to find optimum groove shapes for T-welded joint of mild steel. The test specimen are made in same condition with simulation model. Welding residual stresses measurement by sectional cutting method. ⅰ) The mechanical difference for change the thickness of plate and groove angle are not appeared. ⅱ) In a mechanical point of view minimum preparation angle(40°) is more suitable than maximum groove angle(60℃). ⅲ) The measurement value and distribution of welding residual stresses are not effected largely by groove angle. It is mechanical restraint that mainly affect welding residual stresses distribution. In mechanical point of view minimum groove angle is more suitable than maximum groove angle. Therefore, it is appropriate to minimize the size of groove shape in strength and safety.

• Structural Engineering and Mechanics
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• 제56권5호
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• pp.787-796
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• 2015

When the temperature of a structure varies, there is a tendency to produce changes in the shape of the structure. The resulting actions may be of considerable importance in the analysis of the structures having non-prismatic members. The computation of design forces for the non-prismatic beams having symmetrical parabolic haunches (NBSPH) is fairly difficult because of the parabolic change of the cross section. Due to their non-prismatic geometrical configuration, their assessment, particularly the computation of fixed-end horizontal forces and fixed-end moments becomes a complex problem. In this study, the efficiency of the Artificial Neural Networks (ANN) and Adaptive Neuro Fuzzy Inference Systems (ANFIS) in predicting the design forces and the design moments of the NBSPH due to temperature changes was investigated. Previously obtained finite element analyses results in the literature were used to train and test the ANN and ANFIS models. The performances of the different models were evaluated by comparing the corresponding values of mean squared errors (MSE) and decisive coefficients ($R^2$). In addition to this, the comparison of ANN and ANFIS with traditional methods was made by setting up Linear-regression (LR) model.

• 미생물학회지
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• 제51권1호
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• pp.7-13
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• 2015

Hydrotrope-combined copper (HCC)는 구리의 용존성을 유지하기 위해 황산구리와 친수성 작용기를 결합시켜 제조한 구리 이온($Cu^{2+}$) 기반의 조류생장 억제제이다. 본 연구는 부영양성 담수에 분포하는 대표적인 남조세균 Microcystis aeruginosa에 대한 HCC의 생장 저해효과를 평가하였다. 이를 위하여 M. aeruginosa의 접종 농도 또는 생장배지인 BG-11의 희석 정도를 달리하면서 구리 이온 농도 기준 $5.5-550{\mu}g/L$의 범위에서 HCC를 첨가하고 생장저해효과를 chlorophyll-a 농도의 변화로 측정하였다. HCC는 M. aeruginosa의 생장을 현저히 저해하였으며 특히 1/4로 희석한 BG-11 액체배지에서는 구리 이온의 농도로 환산했을 때 $5.5{\mu}g/L$가 되는 HCC 첨가만으로도 생장을 완전히 억제하는 것으로 나타났다. HCC의 첨가로 인해 세포로부터 microcystin-LR 독소가 용출되는지 확인한 실험에서 HCC는 M. aeruginosa의 생장을 억제하는 유효 농도뿐만 아니라 그 이상의 농도($550{\mu}g/L$)에서도 독소를 용출시키지 않는 것으로 확인되었다. 한편 물벼룩(Daphnia magna)에 대한 HCC의 급성독성시험에서 50% 유영저해를 일으킨 시료에 함유된 구리의 농도는 약 0.30 mg/L로서 생장억제 유효농도를 훨씬 상회하였다. 추가로 HCC의 돌연변이원성과 유전독성을 평가하기 위해서 수행한 Ames test 및 SOS ChromoTest에서도 HCC는 M. aeruginosa의 생장억제 유효농도를 상회하는 농도 수준에서도 독성물질로 작용하지 않는 것으로 나타났다. 이상의 결과로부터 기존 구리 기반 조류생장 억제제의 한계를 개선한 HCC가 상습적으로 조류 대번식이 발생하는 수계에서 사전 또는 사후처리제로서 비교적 안전하고 유용하게 쓰일 수 있을 것으로 기대된다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6673-6680
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• 2013

Objective: Insulin resistance (IR) is an established risk factor for colorectal cancer (CRC). Given that CRC and IR physiologically overlap and the calpain-10 gene (CAPN10) is a candidate for IR, we explored the association between CAPN10 and CRC risk. Methods: Blood samples of 400 case-control pairs were genotyped, and the lifestyle and dietary habits of these pairs were recorded and collected. Unconditional logistic regression (LR) was used to assess the effects of CAPN10 SNP43 and SNP19, and environmental factors. Both generalized multifactor dimensionality reduction (GMDR) and the classification and regression tree (CART) were used to test gene-environment interactions for CRC risk. Results: The GA+AA genotype of SNP43 and the Del/Ins+Ins/Ins genotype of SNP19 were marginally related to CRC risk (GA+AA: OR = 1.35, 95% CI = 0.92-1.99; Del/Ins+Ins/Ins: OR = 1.31, 95% CI = 0.84-2.04). Notably, a high-order interaction was consistently identified by GMDR and CART analyses. In GMDR, the four-factor interaction model of SNP43, SNP19, red meat consumption, and smoked meat consumption was the best model, with a maximum cross-validation consistency of 10/10 and testing balance accuracy of 0.61 (P < 0.01). In LR, subjects with high red and smoked meat consumption and two risk genotypes had a 6.17-fold CRC risk (95% CI = 2.44-15.6) relative to that of subjects with low red and smoked meat consumption and null risk genotypes. In CART, individuals with high smoked and red meat consumption, SNP19 Del/Ins+Ins/Ins, and SNP43 GA+AA had higher CRC risk (OR = 4.56, 95%CI = 1.94-10.75) than those with low smoked and red meat consumption. Conclusions: Though the single loci of CAPN10 SNP43 and SNP19 are not enough to significantly increase the CRC susceptibility, the combination of SNP43, SNP19, red meat consumption, and smoked meat consumption is associated with elevated risk.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.5889-5897
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• 2015

Background: The performance of combined testing visual inspection with acetic acid (VIA) and cervical cytology tests might differ from one setting to another. The average estimate of the testing accuracy across studies is informative, but no meta-analysis has been carried out to assess this combined method. Objective: The objective of this study was to estimate the average sensitivity and specificity of the combined VIA and cervical cytology tests for the detection of cervical precancerous lesions. Materials and Methods: We conducted a systematic review and a meta-analysis, according to the Cochrane Handbook for Systematic Review of Diagnostic Test Accuracy. We considered two cases. In the either-positive result case, a positive result implies positivity in at least one of the tests. A negative result implies negativity in both tests. In the both-positive case, a positive result implies having both tests positive. Eligible studies were identified using Pubmed, Embase, Website of Science, CINHAL and COCRANE databases. True positive, false positive, false negative and true negative values were extracted. Estimates of sensitivity and specificity, positive and negative likelihood (LR) and diagnostic odds ratios (DOR) were pooled using a hierarchical random effect model. Hierarchical summary receiver operating characteristics (HSROC) were generated and heterogeneity was verified through covariates potentially influencing the diagnostic odds ratio. Findings: Nine studies fulfilled inclusion criteria and were included in the analysis. Pooled estimates of the sensitivities of the combined tests in either-positive and both-positive cases were 0.87 (95% CI: 0.83-0.90) and 0.38 (95% CI: 0.29-0.48), respectively. Corresponding specificities were 0.79 (95% CI: 0.63-0.89) and 0.98 (95% CI: 0.96-0.99) respectively. The DORs of the combined tests in either-positive or both-positive result cases were 27.7 (95% CI: 12.5-61.5) and 52 (95% CI: 22.1-122.2), respectively. When including only articles without partial verification bias and also a high-grade cervical intraepithelial neoplasia as a threshold of the disease, DOR of combined test in both-positive result cases remained the highest. However, DORs decreased to 12.1 (95% CI: 6.05-24.1) and 13.8 (95% CI: 7.92-23.9) in studies without partial verification bias for the combined tests in the either-positive and both-positive result cases, respectively. The screener, the place of study and the size of the population significantly influenced the DOR of combined tests in the both-positive result case in restriction analyses that considered only articles with CIN2+ as disease threshold. Conclusions: The combined test in the either-positive result case has a high sensitivity, but a low specificity. These results suggest that the combined test should be considered in developing countries as a primary screening test if facilities exist to confirm, through colposcopy and biopsy, a positive result.

• 대한교통학회지
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• 제30권6호
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• pp.3-12
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• 2012

휴가철 여가통행시간 절감에 대한 합리적인 가치 산정을 위해 익산포항 및 동해고속도로 이용자들을 대상으로 여가통행시간 절감에 대한 추가적인 지불의사와 사회경제적 특성을 조사하였다. 여가통행시간 절감에 대해 평균 통행시간 2-3시간인 익산포항고속도로 이용자들은 여가통행시간 10분 절감에 723원, 평균 통행시간 3-4시간인 동해고속도로 이용자들은 854원의 지불의사가 있는 것으로 나타나 동해고속도로 이용Q 자들의 WTP가 높게 분석되었으며, 이는 통행시간이 길어짐에 따라 WTP도 증가하는 것으로 나타났다. 설문조사는 2010년 여름 성수기에 실시되었고, 각 노선당 유효 설문부수를 300부씩 확보하였으나, 콕스 검정 결과에 근거하여 각각의 개별모형으로 추정하였다.

• Tuberculosis and Respiratory Diseases
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• 제57권5호
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• pp.419-424
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• 2004

연구배경 : 기관지확장제 가역성 검사는 천식이나 COPD를 진단하거나 감별 진단할 때에 널리 사용하고 있지만 실제 천식과 COPD를 감별 진단하는데 도움이 되는지에 대해서 이견이 있고 기관지확장제 가역성을 평가하는 방법에 대해서도 일치된 의견이 없다. 기관지확장제 가역성 검사가 천식과 COPD를 감별 진단하는데 역할을 알아보고 기관지확장제 가역성 검사를 어느 방법으로 하는 것이 좋은지 알아 보았다. 방 법 : 천식 환자 26명과 COPD 환자 31명을 후향적으로 연구하였다. 기관지확장제를 흡입한 전후에 폐활량측정법을 시행하여 $FEV_1$, FVC를 얻었다. 기관지확장제 가역성 검사를 평가하는데 '기저치에 대한 백분율'과 '예측치에 대한 백분율' 그리고 '증가 절대값' 방법을 사용하였고 ROC curve의 곡선하 영역을 측정하여 비교하였다. 기관지확장제 가역성을 판단하는 기준 중 미국흉부학회 기준과 유럽호흡기학회 기준을 비교하였다. 결 과 : (1) '기저치에 대한 백분율' 방법으로 기관제확장제 가역성을 평가하였을 때 천식과 COPD를 감별 진단하는데 도움이 되지 않았지만 '예측치에 대한 백분율'이나 '증가 절대값' 방법으로 평가하였을 때는 도움이 되었다. 하지만, ROC curve의 곡선하 영역이 어느 방법을 쓰더라도 0.75 미만이므로 천식과 COPD를 감별 진단하는 능력은 약하였다. (2) 유럽호흡기학회 기준으로 기관지확장제 가역성을 평가하면 미국흉부학회 기준보다 양성 결과 우도비가 더 크고 음성 결과 우도비가 더 작으므로 천식과 COPD를 감별 진단하는데 유럽호흡기학회 기준이 더 좋았다. 결 론 : 기관지확장제 가역성은 천식과 COPD를 감별 진단하는데 도움을 줄 수 있기는 하지만 그 도움 정도가 약하므로 보조적인 검사로 사용하는 것이 좋을 것이다.