• 정보과학회 논문지
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• 제42권3호
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• pp.361-366
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• 2015

틈(Gap) 파싱은 완전하지 않고 틈이 있는 입력 스트링에 대한 구문 분석을 수행한다. 이런 틈 파싱에 관한 기존 연구로서 임의의 문법에 대한 단일 틈 파싱 알고리즘과 LL(1) 문법에 대한 단일 틈 파싱 알고리즘이 제안되었으며, 이들의 시간복잡도는 각각 $O(n^3)$와 $O(n^2)$이다. 본 논문에서는 확장된 PLR(1) 문법에 대한 단일 틈 파싱 알고리즘을 제안한다. 확장된 PLR(1) 문법은 LR(1) 문법의 부분 클래스이지만 LL(1) 문법보다는 휠씬 넒은 범위의 문법 클래스이다. 이 문법 클래스에 대한 단일 틈 파싱 알고리즘이 LL(1) 문법에 대한 기존에 알려진 단일 틈 파싱 알고리즘의 복잡도와 동일한 $O(n^2)$임을 보인다.

• Journal of Pharmaceutical Investigation
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• 제35권2호
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• pp.75-80
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• 2005

A promising application of Lactococcus lactis is its use as live vehicles for production and delivery of heterologous proteins of vaccines and therapeutic substances. Because L. lactis has GRAS ('generally regarded as safe') status, we tested whether L. lactis could function as the carrier of the Ll protein of human papillomavirus (HPV) type 16. The RNA level expression of Ll gene was detected in L. Lactis. The Ll protein was expressed in L. lactis with Ll gene. The growth of strains L. lactis with an empty plasmid (pAMJ328) and L. lactis with Ll-encoding plasmid (pAMJ328-Ll) was slightly decreased in comparison with the growth of strains L. lactis (wild type). However, all the three strains of L. lactis maintained the ability to ferment sugars primarily into lactic acid, indicating that Ll protein did not affect the biochemical property of L. lactis. These results suggest that L. lactis, capable of carrying Ll protein, might be further developed as a biocompatible oral protein delivery system.

• 대한수학교육학회지:수학교육학연구
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• 제20권4호
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• pp.529-546
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• 2010

이 연구의 목적은 닮음 개념의 변천 과정에 대한 수학사 고찰을 바탕으로, 현재 수학 교과서에 나타난 닮음 정의를 분석하고 비판하는 것이다. 우선, 피타고라스학파의 닮음 정의, Euclid ${\ll}$원론${\gg}$의 닮음 정의, Clairaut의 ${\ll}$기하학원론${\gg}$의 닮음 정의, Birkhoff와 Beatly의 ${\ll}$기초기하학${\gg}$, SMSG의 ${\ll}$기하학${\gg}$의 닮음 정의를 분석하고, 현재 수학 교과서에 제시된 닮음 정의를 분석하였다. 수학사 고찰 결과를 바탕으로 교과서의 닮음 정의를 세 가지 측면에서 비판적으로 논의하고, 확인된 문제점에 대한 교육적 제언을 하였다.

• 한국축산식품학회:학술대회논문집
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• 한국축산식품학회 2005년도 정기총회 및 제35차 춘계 학술 발표대회
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• pp.331-337
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• 2005

한우와 홀스타인의 분변으로부터 MRS배지와 LAPT배지를 이용하여 무작위 선발법으로 54균주의 유산균을 1차로 분리 하였다. 1차로 분리된 54균주에 대해 내담즙성이 우수한 10균주를 분리 한 다음 내산성을 조사한 결과 인공위액 pH2.5에서 LS1, LS15 및 LL6 균주가 각각 66.5%, 82.6% 및 80.7%의 생존율을 나타내었다. Sal. typhimurium, Sta. aureus 및 Cl. perfringens 의 병원균에 대해 가장 큰 항균력을 보인 균주는 LL6와 LL7이었다. API CHL kit로 동정한 결과 LS1, LS2 및 LM1 균주는 모두 L. fermentum, LL6와 LL7 균주L. acidophilus, LS3 균주는 L. plantarum으로 각각동정 되고, 나머지 4균주는 Lactobacillus sp. 로 동정되어 분리된 10균주 모두 안전성 있는 유산 간균임을 확인하였다. 10종류의 항생제에 대한 내성을 조사한 결과 ampicillin, amoxicillin and erythromycin 에 대해서는 억제되었으나 colistin과 ciprofloxacin에 대해 모두 내성을 나타내었다. LB1, LL6 및 LL7 균주는 gentamicin과 neomycin에 대해 내성을 보여 주었다. 분리 동정된 균주 중에 내산성, 내담즙성 및 병원성균에 대한 항균력이 우수한 것으로 probiotic 유산균으로 사용가능성이 높은 것은 LL6인 L. acidophilus 로 나타났다.

• Journal of Acupuncture Research
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• 제19권1호
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• pp.210-224
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• 2002

Objective : A study on $\ll$Maek-beop$\gg$ which is the first scription of pulse diagnosis method in history. Method : A translation of contents in $\ll$Maek-beop$\gg$ into modern concepts on the basis of researched books and the explanation of difficult characters and paragraphs to general concepts. Result : The pulse diagnosis method by comparison, moxibustion method, venesection method, a treatment of an abscess and the succession of treatment in $\ll$Maek-beop$\gg$ are delivered from $\ll$Sumen, 素問$\gg$, $\ll$Lingchui, 靈樞$\gg$. Conclusion : A $\ll$Maek-beop$\gg$ is the scription of the diagnosis of meridian and therapeutic method in $\ll$Zu bi shi yi mai jiu jing, 足臂十一脈灸經$\gg$, $\ll$yin yang shi yi mai jiu jing, 陰陽十一脈灸經$\gg$.

• 비교문화연구
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• 제27권
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• pp.255-289
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• 2012

In the course of completing a National Research Foundation project, I recently found that a handwritten Korean manuscript of The Tale of Mei Fei is kept in the Adan Collection, which is a significant scholarly discovery given that no relevant research is available. The editions of the Tale of Mei Fei available in Korea include ${\ll}$藝苑?華${\gg}$ edition, ${\ll}$說?${\gg}$ edition, and the handwritten manuscript in Korean collected in the Adan Collection. Being the only handwritten Korean translation of the work, the Tale of Mei Fei in the Adan Collection was appended by the translations of ${\ll}$한셩뎨됴비연합덕젼${\gg}$ and ${\ll}$당고종무후뎐${\gg}$. As for the practice of translation of the work, literal "word to word" translation was done for the most part of the text; some sentences were occasionally translated liberally. Also, as for the poems in the text, pronunciation of each Chinese character was provided along with the translated text.

• 한국정보과학회논문지:소프트웨어및응용
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• 제26권8호
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• pp.1028-1038
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• 1999

본 논문에선 LR 문법의 부분 클래스를 동치인 LL 문법으로 변환하는 방법을 제시한다. 이 변환이 적용 가능한 문법을 확장된k`-transformable 문법이라 정의한다. 변환된 문법은 left-to-right 커버의 성질을 만족한다. 기존 연구에서 제시한 변환 방법은 LR 문법의 부분 클래스인 {{{{k`-transformable 클래스와 PLR 클래스를 LL 문법으로 바꾼다. 이 논문에서 제시하는 새로운 변환 방법의 적용 가능한 문법의 범위는 k`-transformable 클래스와 PLR 클래스를 포함한다. 기존의 커버링 성질을 만족하는 LL로의 문법 변환은 보편적인 LR 파서의 행동을 시뮬레이션하여 얻어진다. 이 과정에서 쉬프트, 리듀스 행동 이외에 무한의 가능성을 가진 스택 스트링의 유한 표현을 위해 리덕션 심볼에 대한 예상 행동이 추가된다. 본 논문에서는 파싱 문맥을 나타내는 LR 아이템들을 기존의 스택 스트링 표현 형태에 추가하여 스택 스트링 표현법을 정제하고, 리덕션 심볼에 대한 예상 방법을 확장하는 정형식을 제시한다. 이에 근거하여 LL 커버링 문법이 존재하는 클래스를 확장된 {{{{k`-transformable 문법으로 확장시킨다.Abstract A new transformation of a subclass of LR(k`) grammars into equivalent LL(k`) grammars is studied. The subclass of LR(k`) grammars is called extended k`-transformable. The transformed LL(k`) grammars left-to-right cover the original LR(k`) grammars. Previous transformations transform k`-transformable and PLR(k`) into LL(k`). The new transformation is more powerful in that it handles the extended k`-transformable subclass of LR(k`), which strictly includes k`-transformable and PLR(k`) classes. The previous covering transformations into LL grammars are obtained by simulating the actions of the conventional LR parser. Specially, a predict action of reduction goals is added to the action set in order to finitely represent stack string. In this paper, the stack string representation is refined by adding LR items to represent a parsing context, and the prediction of reduction goal is extended by generalizing the prediction formalism. Based on them, the previous grammar classes with LL({{{{k`) covering grammars are extended to extended k`-transformable grammars.

• Journal of Microbiology and Biotechnology
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• 제18권8호
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• pp.1431-1438
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• 2008

Immunomodulating activities of water-soluble exopolysaccharides (LL-EX) obtained from submerged mycelial culture of Lentinus lepideus were studied and their effectiveness was compared with lipopolysaccharide (LPS). The influence of the LL-EX on macrophage cellular lysosomal enzyme activity was to stimulate up to 267%, 392%, and 464% at the level of 10, 50, and $100{\mu}g/ml$, respectively. When the LL-EX was further fractionated into LL-Fr.I and Fr.II by Sepharose CL-6B gel chromatography, the cellular lysosomal enzyme activity of LL-Fr.II (2.1-fold) was higher than Fr.I (1.2-fold). Moreover, both LL-Fr.I and Fr.II stimulated the cytokines IL-1$\beta$, TNF-$\alpha$, and IL-6 in macrophages. In mixed lymphocyte reaction, LL-Fr.I and Fr.II enhanced the splenocyte proliferation up to 1.2-fold and 1.4-fold ($50{\mu}g/ml$), respectively, stimulating only T lymphocytes. The fractions of LL-EX not show any direct toxicity against human gastric adenocarcinoma cell (AGS). The molecular masses of LL-Fr.I and Fr.II were estimated to be about 1,986 kDa and 21 kDa, respectively. The total sugar and protein contents of the two fractions were 84.97% and 69.88%, and 15.03% and 30.12%, respectively. The sugar and amino acid compositions of the LL-Fr.I and Fr.II were also analyzed in detail.

• IMMUNE NETWORK
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• 제22권5호
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• pp.41.1-41.16
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• 2022

The human antimicrobial peptide LL-37 has chemotactic and modulatory activities in various immune cells, including dendritic cells. Because of its characteristics, LL-37 can be considered an adjuvant for vaccine development. In this study, we confirmed the possible adjuvant activity of LL-37 in mucosal vaccine development against Middle East respiratory syndrome-coronavirus (MERS-CoV) by means of intranasal immunization in C57BL/6 and human dipeptidyl peptidase 4 (hDPP4)-transgenic (hDPP4-Tg) mice. Intranasal immunization using the receptor-binding domain (RBD) of MERS-CoV spike protein (S-RBD) recombined with LL-37 (S-RBD-LL-37) induced an efficient mucosal IgA and systemic IgG response with virus-neutralizing activity, compared with S-RBD. Ag-specific CTL stimulation was also efficiently induced in the lungs of mice that had been intranasally immunized with S-RBD-LL-37, compared with S-RBD. Importantly, intranasal immunization of hDPP4-Tg mice with S-RBD-LL-37 led to reduced immune cell infiltration into the lungs after infection with MERS-CoV. Finally, intranasal immunization of hDPP4-Tg mice with S-RBD-LL-37 led to enhanced protective efficacy, with increased survival and reduced body weight loss after challenge infection with MERS-CoV. Collectively, these results suggest that S-RBD-LL-37 is an effective intranasal vaccine candidate molecule against MERS-CoV infection.

• Journal of Acupuncture Research
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• 제18권6호
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• pp.240-249
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• 2001

Obejective : Based on ${\ll}$sixty-ninth Nan${\gg}$ (${\ll}$難經${\cdot}$六十九難${\gg}$) the interpromoting of the five element's balance method to discuss following 'when deficiency than should strengthen mother and when excessive than eliminate son' theories. Method : This strengthening and eliminating method is based on Jang-bu organ's balance method when 'east is excessive (liver excessive (肝實 )) and west is deficiency (lung deficiency (肺虛))' then 'eliminate the south and strengthen the north's method. Results : The seventy-fifth Nan (${\ll}$難經${\cdot}$七十五難${\gg}$) explains' son effects mother's excessive and mother effects son's deficiency' theory where it balance method of the inter-overacting five elements controlling Jang-bu organ's differentiations. The eighty-first Nan (${\ll}$難經${\cdot}$八十一難${\gg}$) explains strengthening-eliminating method of 'lung excessive and liver deficiency.' Since there are two different perspective of seventy-fifth and eighty-first Nan, we must compare and discuss to make right point of view. Conclusion : the treatment method in ${\ll}$Nan kyoung sixty ninth nan${\gg}$ could be understood as a view of five element constitutional theory (五行體質理論), the treatment method in ${\ll}$Nan kyoung seventyty-fifth nan${\gg}$ of eleminating fire and strengthning water in case of liver excess and lung defficiency and the treatment method in ${\ll}$Nan kyoung eighty-first nan${\gg}$ of strengthning liver and eleminating lung in case of lung excess and liver defficiency could be understood as a view of the yin-yan constitutional theory (陰陽體質理論).