• The Journal of Advanced Prosthodontics
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• v.9 no.1
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• pp.45-51
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• 2017

PURPOSE. This study aims to investigate the effects of four different lateral occlusion schemes and different excursions on peri-implant strains of a maxillary canine implant. MATERIALS AND METHODS. Four metal crowns with different occlusion schemes were attached to an implant in the maxillary canine region of a resin model. The included schemes were canine-guided (CG) occlusion, group function (GF) occlusion, long centric (LC) occlusion, and implant-protected (IP) occlusion. Each crown was loaded in three sites that correspond to maximal intercuspation (MI), 1 mm excursion, and 2 mm excursion. A load of 140 N was applied on each site and was repeated 10 times. The peri-implant strain was recorded by a rosette strain gauge that was attached on the resin model buccal to the implant. For each loading condition, the maximum shear strain value was calculated. RESULTS. The different schemes and excursive positions had impact on the peri-implant strains. At MI and 1 mm positions, the GF had the least strains, followed by IP, CG, and LC. At 2 mm, the least strains were associated with GF, followed by CG, LC, and IP. However, regardless of the occlusion scheme, as the excursion increases, a linear increase of peri-implant strains was detected. CONCLUSION. The peri-implant strain is susceptible to occlusal factors. The eccentric location appears to be more influential on peri-implant strains than the occlusion scheme. Therefore, adopting an occlusion scheme that can reduce the occurrence of occlusal contacts laterally may be beneficial in reducing peri-implant strains.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.18
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• pp.8271-8279
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• 2016

Background: Hepato-carcinogenesis is multifaceted in its molecular aspects. Among the interplaying agents are altered gap junctions, the proteasome/autophagy system, and mitochondria. The present experimental study was designed to outline the roles of these players and to investigate the tumor suppressive effects of curcumin with or without mesenchymal stem cells (MSCs) in hepatocellular carcinoma (HCC). Materials and Methods: Adult female albino rats were divided into normal controls and animals with HCC induced by diethyl-nitrosamine (DENA) and $CCl_4$. Additional groups treated after HCC induction were: Cur/HCC which received curcumin; MSCs/HCC which received MSCs; and Cur+MSCs/HCC which received both curcumin and MSCs. For all groups there were histopathological examination and assessment of gene expression of connexin43 (Cx43), ubiquitin ligase-E3 (UCP-3), the autophagy marker LC3 and coenzyme-Q10 (Mito.Q10) mRNA by real time, reverse transcription-polymerase chain reaction, along with measurement of LC3II/LC3I ratio for estimation of autophagosome formation in the rat liver tissue. In addition, the serum levels of ALT, AST and alpha fetoprotein (AFP), together with the proinflammatory cytokines $TNF{\alpha}$ and IL-6, were determined in all groups. Results: Histopathological examination of liver tissue from animals which received DENA-$CCl_4$ only revealed the presence of anaplastic carcinoma cells and macro-regenerative nodules. Administration of curcumin, MSCs; each alone or combined into rats after induction of HCC improved the histopathological picture. This was accompanied by significant reduction in ${\alpha}$-fetoprotein together with proinflammatory cytokines and significant decrease of various liver enzymes, in addition to upregulation of Cx43, UCP-3, LC3 and Mito.Q10 mRNA. Conclusions: Improvement of Cx43 expression, nonapoptotic cell death and mitochondrial function can repress tumor growth in HCC. Administration of curcumin and/or MSCs have tumor suppressive effects as they can target these mechanisms. However, further research is still needed to verify their effectiveness.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.3
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• pp.419-424
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• 2014

Metabolite profiling of blueberry (cultivar "Spartan") was performed by extraction using different solvents, methanol and ethyl acetate, through metabolomic analysis using LC-MS/MS. Unsupervised classification method (PCA) and supervised prediction model (OPLS-DA) provided good categorization of metabolites according to the extraction solvents. Metabolites of the anthocyanin family, including delphinidin hexoside, delphinidin, 5-O-feruloylquinic acid, malvidin hexoside, malvidin-3-arabinoside, petunidin-3-arabinoside, and petunidin hexoside, were mainly detected in methanol fractions, whereas those of the flavonoid family, including chlorogenic acid, chlorogenic acid dimer, 6,8-di-C-arabinopyranosyl-luteolin, and luteolin were successfully prepared in the ethyl acetate fraction. Thus, metabolomic analysis of blueberry extracts allows for the simple profiling of whole and distinctive metabolites for future applications.

• Ocean Systems Engineering
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• v.11 no.1
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• pp.83-97
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• 2021

The submerged U-shape breakwater interaction with the solitary wave is simulated by the Boussinesq equations using the finite-difference scheme. The wave reflection, transmission, and dissipation (RTD) coefficients are used to investigate the U-shape breakwater's performance for different crest width, Lc1, and indent breakwater height, du. The results show that the submerged breakwater performance for a set of U-shape breakwater with the same cross-section area is related to the length of submerged breakwater crest, Lc1, and the distance between the crests, Lc2 (or the height of du). The breakwater has the maximum performance when the crest length is larger, and at the same time, the distance between them increases. Changing the Lc1 and du of the U-shape breakwaters result in a significant change in the RTD coefficients. Comparison of the U-shape breakwater, having the best performance, with the averaged RTD values shows that the transmission coefficients, Kt, has a better performance of up to 4% in comparison to other breakwaters. Also, the reflection coefficients KR and the diffusion coefficients, Kd shows a better performance of about 30% and 55% on average, respectively. However, the model governing equations are non-dissipative. The non-energy conserving of the transmission and reflection coefficients due to wave and breakwater interaction results in dissipation type contribution. The U-shape breakwater with the best performance is compared with the rectangular breakwater with the same cross-section area to investigate the economic advantages of the U-shape breakwater. The transmission coefficients, Kt, of the U-shape breakwater shows a better performance of 5% higher than the rectangular one. The reflection coefficient, KR, is 60% lower for U-shape in comparison to rectangular one; however, the diffusion coefficients, Kd, of U-shape breakwater is 35% higher than the rectangular breakwater. Therefore, we could say that the U-shape breakwater has a better performance than the rectangular one.

• Proceedings of the IEEK Conference
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• 2002.07b
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• pp.770-773
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• 2002

Two sinusoidal voltage-controlled oscillators using linear operational transconductance amplifiers are presented in this paper: One is based on the positive-feedback bandpass oscillator model and the other on the negative-feedback Colpitts model. The bandpass VCO consists of a noninverting amplifier and a current-controlled LC-tuned circuit which is realized by two linear OTA's and two grounded capacitors, while the Colpitts VCO consists of an inverting amplifier and a current-controlled LC-tuned circuit realized by three linear OTA's and three grounded capacitors. Prototype circuits have been built with discrete components. The experimental results have shown that the Colpitts VCO has a linearity error of less than 5 percent, a temperature coefficient of less than rm 100 ppm/$^{circ}C$, and a $pm1.5 Hz $frequency drift over an oscillation frequency range from 712Hz to 6.3kHz. A total harmonic distortion of 0.3 percent has been measured for a 3.3kHz oscillation and the corresponding peak-to-peak amplitude was 1V. The experimental results for bandpass VCO are also presented.

• Fire Science and Engineering
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• v.25 no.6
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• pp.27-31
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• 2011

In this study, combustion toxicity evaluation for building interior materials and study for toxicity as using FT-IR analysis. this experiment for the calculation of toxicity index, it using a cone calorimeter model in KS F ISO/TR 9122-4 as a fire model. It is following ISO 19702 procedure for assessing fire toxic gas using FT-IR. This experiment used calculation method for toxicity index (FED) among the international standards. $LC_{50}$ is a concentration that it can cause death to 50 % of experimental animal in 30 minutes - exposure gas test. comparison with the three kinds of toxicity fire gas of construction materials using toxicity index.

• Proceedings of the Korean Society of Applied Entomolohy Conference
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• 2005.05a
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• pp.167-167
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• 2005

• YAKHAK HOEJI
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• v.46 no.6
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• pp.472-476
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• 2002

Contact hypersensitivity (CHS) serves as a good model of cell-mediated reaction. Epidermal langerhans cell (LC) are thought to playa crucial role in the regulation of immune reaction of the skin, which elicit the CHS response by presenting Antigen to trafficking Ag-specific T cells within the skin. However, contact hypersensitivity is regarded as a negative side of immunities, caused by increased damaging immune response. Therefore, the study of effector molecule causing immune suppression is thought to be meaningful in the skin immune response. For this aim, this study investigated the influence of pedunculagin on cytokine, IL-$\beta$ expression from langerhans cell (LC). In vitro and in vivo, pedunculagin up-regulated the expression of IL-1$\beta$ mRNA. After PMA stimulation in vitro and DNFB sensitization in vivo, the expression of IL-1$\beta$ mRNA was down-regulated. This results suggested that pedunculagin could be immuno-modulator in skin immune system by modulating IL-1$\beta$ expression.

• Journal of the Korean Society for Precision Engineering
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• v.24 no.12
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• pp.57-64
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• 2007

There have been many researches for optimal controllers in multivariable systems, and they generally use accurate linear models of the plant dynamics. Real systems, however, contain nonlinearities and high-order dynamics that may be difficult to model using conventional techniques. Therefore, it is necessary a PID gain tuning method without explicit modeling for the multivariable plant dynamics. The PID tuning method utilizes the sign of Jacobian and gradient descent techniques to iteratively reduce the error-related objective function. This paper, especially, focuses on the role of I-controller when there is a steady state error. However, it is not easy to tune I-gain unlike P- and D-gain because I-controller is mainly operated in the steady state. Simulations for an overhead crane system with dynamic friction show that the proposed PID-LC algorithm improves controller performance, even in the steady state error.

• Journal of Information Display
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• v.5 no.1
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• pp.34-40
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• 2004

Time resolved infrared IR absorption spectroscopy is carried out to investigate the dynamics of electric field induced reorientation of the biphenyl molecular core and alkyl tail sub-fragments of the nematic liquid crystal 5CB (4-pentyl-4-cyano-biphenyl). The planar to homeotropic transition for high pre-tilt planar aligned cells, is studied for switching times ranging from 200 ${\mu}sec$ down to 80 ${\mu}sec$, the latter a factor of 1000 times faster than any previous nematic IR study. The reorientation rates of the core and tail are found to be the same to within experimental error and scale inversely with applied field squared, as expected for the balance of field and viscous torques. Thus any molecular conformation change during switching must relax on a shorter time scale. A simple model shows that no substantial differences exist between the reorientational dynamics of the tails and cores on the time scales longer than on the order of 10 ${\mu}s$.