• Reproductive and Developmental Biology
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• v.42 no.1
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• pp.1-6
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• 2018

In this study, we analyzed signal transduction by equine follicle-stimulating hormone receptor (eFSHR) on sti- mulation with recombinant $eelFSH{\beta}/{\alpha}$ ($rec-eelFSH{\beta}/{\alpha}$), natural porcine FSH (pFSH), and natural human FSH (hFSH). cAMP stimulation in CHO-K1 cells expressing eFSHR was determined upon exposure to different doses (0-1450 ng/mL) of these hormones. The $EC_{50}$ value of $rec-eelFSH{\beta}/{\alpha}$ was 53.35 ng/mL. The Rmax values of $rec-eelFSH{\beta}/{\alpha}$ and pFSH were 28.12 and 2.88 ng/mL, respectively. The activity of $rec-eelFSH{\beta}/{\alpha}$ was much higher than that of natural pFSH. However, signal transduction in CHO PathHunter Parental cells expressing eFSHR was not enhanced by stimulation with natural hFSH. Thus, $rec-eelFSH{\beta}/{\alpha}$ was completely active in cells expressing eFSHR. However, natural hFSH did not invoke a signal response in cells expressing eFSHR. Particularly, natural pFSH was weakly active in the same cells. These results showed that $eelFSH{\beta}/{\alpha}$ has potent activity in cells expressing eFSHR. Thus, $rec-eelFSH{\beta}/{\alpha}$ may efficiently bind to eFSHR, where as natural hFSH does not bind to eFSHR.

• KSBB Journal
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• v.22 no.4
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• pp.249-254
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• 2007

Anti-angiogenesis and anti-cell adhesion effects were investigated with different dose of Camellia japonica leaf (CJL) extract for applying anti-cancer, anti-metastasis and anti-obesity. Cytotoxicity on HUVECs was very low at 200 ug/mL of CJL-extract. Anti-angiogenic ratio at increasing dose of 1.5 ug/mL, 3.0 ug/mL, 15 ug/mL and 30 ug/mL was showed 30.7%, 38.5%, 53.8%, and 70.0%, respectively. Also, anti-cell adhesion effect at concentration of $50{\mu}g{/well},\;100{\mu}g{/well}\;and\;200{\mu}g{/well}$ was expressed on E-selectin by 46.7%, 66.7%, and 86.76%, on VCAM-1, 23.0%, 61.5%, and 84.6%, and on ICAM-1, 11%, 55.5%, and 88.8%, respectively. For inquiring anti-angiogenesis mechanism, when western blot was performed with different dose of CJL extract, signal molecules of VEGFR-2, $\beta$-catenin and PI3-K were suppressed. As the signal transduction from VEGFR-2, $\beta$-catenin and PI3-K to NF-${\kappa}$B was interupted, angiogenesis could not be occurred causing not activated NF-kB. C. japonica leaf (CJL) is a useful herb for developing therapeutics of angiogenesis related diseases such as cancer, metastasis, rheumathioid arthritis and obesity.

• Journal of the Institute of Convergence Signal Processing
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• v.3 no.2
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• pp.45-52
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• 2002

EMI(Electromagnetic Interface) is a measure of electomagnetic radiation from equipment in the range of 10KHz to 3GHz, and can cause unexpected reactions of electronics/electrical equipment. In this study, for safe and stable communication operation, a STGU(System Timing Genetation Unit), which is a 2.5Gbps SDH System and a major EMI source, was employed to simulate electromagnetic interface. In On-Site test, the power of fundamental frequency of EMI of interest and its harmonics were measured. Also, a low pass filter at cut-off frequency of 2GHz was specifically designed to minimize the effect of EMI between electronic components. When the low pass filter was implemented within the STGU, the power of EMI decreased more than 20dBm. Finally, when TIE and MTIE, two important quality measure in synchronous reference clcok, was assessed, ITU-T G8l3 requirements are satisfied.

• Journal of the Korea Institute of Military Science and Technology
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• v.14 no.1
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• pp.1-8
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• 2011

In this paper, dual-feed circularly polarized microstrip patch antenna for GPS L1, GPS L2, GLONASS L1 signal was fabricated by using stacked patch. It was fed by dual coaxial probe on the patch at 50ohm impedance, and was simulated to resonate at GPS L1, GPS L2, GLONASS L1. To realize characteristics of right hand circular polarization using dual-feed stacked patch antenna and hybrid coupler for $90^{\circ}$ phase difference. Output of hybrid coupler was contacted input of Low Noise Amplifier(LNA). The LNA using dual band pass filter was designed and fabricated. The measured results of the implemented antenna is VSWR < 1.5 : 1 and the gain of 32dB(Zenith) over at GPS L1, L2, GLONASS L1.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.48 no.3
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• pp.342-349
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• 1999

The metric defined on the domain deformation space better measures the similarity between bounded and continuous signals for the purpose of classification via the metric distances between signals. In this paper, a modified domain deformation theory is introduced for one-dimensional signal classification. A new metric defined on a modified domain deformation for measuring the distance between signals is employed. By introducing a newly defined metric space via the newly defined Integra-Normalizer, the assumption that domain deformation is applicable only to continuous signals is removed such that any kind of integrable signal can be classified. The metric on the modified domain deformation has an advantage over the $L^2$ metric as well as the previously introduced domain deformation does.

• Journal of Magnetics
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• v.10 no.4
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• pp.163-170
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• 2005

The RF integrated noise filters are fabricated by photolithography. The stack for the electromagnetic noise filters consists of the nano-granular ($Co_{41}Fe_{38}AI_{13}O_8$) soft magnetic film / $SiO_2$ / Cu transmission line / seed layer (Cu/Ti) / $SiO_2$-substrate. A good signal-attenuation feature along with a low signal-reflection feature is observed in the present filters. Especially in the noise filter incorporated with a $Co_{41}Fe_{38}AI_{13}O_8$ magnetic film with lateral dimensions of $2000{\mu}m$ wide, 15 mm long and $1{\mu}m$ thick, the maximum magnitude of signal attenuation reaches -55 dB, and the magnitude of signal reflection is below -10 dB in the overall frequency range. And this level of signal attenuation is much larger than that of a noise filter incorporated with a Fe magnetic film.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.36S no.9
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• pp.1-8
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• 1999

In this paper, we propose and analyze a concatenated coding scheme for DS/CDMA systems in asynchronous channels. In the concatenated coding, bandwidth efficient $2^{2L-2}$-state ${\frac{L}{L+1}}$-rate 2-MTCM with biorthogonal signal constellation is used for the inner code, and $(2^{L-1},\;{\lceil}\frac{2^{L-1}}{L/2}{\rceil})$ RS code is use for the outer code. It is shown that we can get considerable performance gain over the uncoded system without sacrificing the data transmission rate. The proposed system can be used as a coding scheme for reliable and high speed integrated information services of mobile communication systems.

• Proceedings of the IEEK Conference
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• 2000.11d
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• pp.49-52
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• 2000

This paper is to propose an algorithm to reduce the calculation time to perform the 2-dimensional Discrete Wavelet Transform(2DWT). We call this algorithm as Reduced 2-dimensional Discrete Wavelet Transformation(R2DWT). This algorithm uses a modified Mallat-tree such that in each level, the column transform is performed only with the low-pass filtered row transform result. The resulting number of sub-band regions is 2L＋1, meanwhile the original(2DWT) has 3L＋1 sub-regions, where L is the transform level. To show the proposed algorithm is useful without much loss in SNR(Signal-to-Noise Ratio), we performed experiments with various images. The results showed that above 5:1 in compression ratio, the proposed algorithm has less than 0.SdB difference in SNR from 2DWT with about 25% reduction in calculation time.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.10 no.2
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• pp.187-195
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• 1999

A series feedback DRO operating at 3.2 GHz applicable to the spectrum analyzer as the second local oscillator, is designed and fabricated. We can obtain a low noise by utilizing the small signal S-parameter of the transistor and adjusting the reflection coefficient from the coupling coefficient between dielectric resonator and microstrip line. The results show that output power is 10.50 dBm, a stable low phase noise is -116 dBc/Hz at a 10 kHz offset frequency and a harmonic characteristic is 19.33 dBc.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.33 no.4
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• pp.280-287
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• 2000

Three antimicrobial compounds (SL-l, SL-2 and SL-3) were isolated and identified from the marine red alga, Symphyocladia latiuscula. In addition, their biological functionalities such as cytotoxicity and desmutagenic activity were investigated. From the cryophyllized S. JatiuscuJa, SL-l, SL-2 and SL-3 were purified by solvent extractions and HPLC.SL-2 was crystallized in benzene-diethyl ether solvent. On the EI-MS spectra, it was found that they had three bromines in their structure which showed typical signal strength ratios at $M^+, [M+2]^+, [M+4]^+, [M+6]^+ (13: 38: 37: 12)$. $SL-l$ was identified as 2,3,6-tribromo-4,5-dihydroxybenzyl alcohol ($C_8H_7Br_3O_3, MW=374$) by NMR and MS spectra. SL-2 was assigned as 2,3,6-tribromo-4,5-dihydroxybenzyl methyl ether ($C_8H_7Br_3O_3, MW=388$) and confirmed by X-ray crystallographic analysis. SL-3 was presumed as an isomer of SL-2. Methanol extract of the S. latiuscula showed antimicrobial activities against all strains tested (bacteria, 15 strains; yeasts, 17 strains; fungi, 4 strains), much or less. The strongest inhibition activity of the methanol extract was to the Vibrio mimicus ($50 {\mu}g/ml$) and V. vulnificus ($50 {\mu}g/ml$). The mice injected intraperitoneally with 3 mg of SL-l and 5 mg of 5L-2 showed no acute toxicity response. SL-2 showed higher desmutagenic activity than SL-l against PhIP and MeIQx.