• Title/Summary/Keyword: L.I.L.

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Effect of Ipomoea aquatica extract on anti-melanogenesis and skin barrier function (공심채 추출물의 멜라닌 생성 저해 및 피부장벽 개선 효과)

  • Kim, Hyun-Soo
    • Korean Journal of Food Science and Technology
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    • v.49 no.5
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    • pp.519-523
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    • 2017
  • We investigated the applications of functional materials through the examination of a variety of physiological activities of Ipomoea aquatica extract. I. aquatica extract showed low cytotoxicity against murine melanoma B16F10 cells. At concentrations that exerted little or no cytotoxicity to the cells, I. aquatica extract showed high DPPH radical scavenging activity ($ID_{50}$, $7.84{\mu}g/mL$), inhibited tyrosinase activity ($ID_{50}$, $106.56{\mu}g/mL$), and decreased melanin content ($ID_{50}$, $41.75{\mu}g/mL$). The treatment of B16F10 cells with I. aquatica extract suppressed the protein expression of tyrosinase in a dose-dependent manner. These findings suggested that I. aquatica extract inhibited melanin synthesis in murine melanoma B16F10 cells through the suppression of intracellular tyrosinase expression, as well as the simultaneous direct inhibition of tyrosinase activity. Additionally, I. aquatica extract promoted the expression of involucrin, which is related to skin barrier protection. These results indicate that I. aquatica extract may be an appropriate material for the improvement of skin barrier function.

Laser Damage Threshold Increase of A/R Coating Films for 200MHz AOM (A/R 코팅 변화에 따른 200MHz AOM의 laser damage threshold 증가)

  • Kim, Yong-Hun;Lee, Hang-Hun;Lee, Jin-Ho;Park, Yeong-Jun;Park, Jeong-Ho
    • Korean Journal of Materials Research
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    • v.7 no.3
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    • pp.213-217
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    • 1997
  • AOhf(Hcousto-r)l)tic niodulator) with :!OOlIiz freclucncl- and Sfi(;(Seconrl harmonic generation) green lasel-Lvith 53% nm wavelength were used for Il\'IIII~Dii.it,ii v~ilco disk recorder) FOI rhe appli~aptin of high densit]. optical recording, a high po\ver I ~ c r is r c ~ ~ l i ~ i l - u l ic I !tic. s\-sti,m a n d optic.,~I io;iting l,t)c>rs of each optical device must have a high laser damage threshoid hie rn;itie ant] retlwtive coatings on a $TeO_{2}$ singlc crystal. which is used as an acoustooptic material, by E-beam evaporation method. Laser damage threshold \vas nicdsureci hy Ar laser with the input power oi 0.55LV 1,aser damage threiholti 01 $ZrO_{2}$ and $SiO_{2}$. filn-is were higher than $AI_{2}O_{3}$ f i l m U'e also investigated a long--tern1 stability of the output po\ver of St{(; green laser

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Growth and Flowering of Cut Spray Chrysanthemum 'Ilweol' by Daminozide (스프레이 절화국화 '일월'의 daminozide에 의한 생육 및 개화)

  • Lee, Chang Hee
    • FLOWER RESEARCH JOURNAL
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    • v.18 no.4
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    • pp.231-237
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    • 2010
  • This study was conducted to improve commercial quality of a cut spray chrysanthemum 'Ilweol' bred in Korea by foliar application of daminozide, suppressing excessive elongation of peduncle caused by high temperature in summer season production. Applications were made at three floral bud developmental stage (I, II, and III), and concentrations used were 0, 500, 1000, and $2000mg{\cdot}L^{-1}$. Cut flower length and peduncle length showed the greatest repression of elongation through daminozide treatments at stage III and stage II, respectively. Daminozide also gradually reduced values of those in a concentration-dependant manner. Flower diameter increased compared to control as daminozide was sprayed at later stage but decreased in daminozide concentration-dependant manner. Angle of flower cluster on apical part of whole plant showed the best results when sprayed with $2,000mg{\cdot}L^{-1}$ at stage III. Among all combinations, $2,000mg{\cdot}L^{-1}$ daminozide at stage II recorded the highest angle of flower cluster and showed 31.3% increment as compared to control. The number of fully expanded flowers showed the highest values using $2,000mg{\cdot}L^{-1}$ daminozide at stage III than the other treatments and total floral buds also showed the highest values using $2,000mg{\cdot}L^{-1}$ daminozide at stage I than the other treatments. In cut spray chrysanthemum cultivar 'Ilweol' bred in Korea, foliar-applying with $2,000mg{\cdot}L^{-1}$ at stage III most effectively suppressed excessive peduncle elongation, angle of flower cluster, and increased the number of flowers in summer. However, this combination affected negatively the other commercial qualities, reducing cut flower length and flower diameter. Therefore, we recommended that foliar application stage and daminozide concentration was stage III and $500mg{\cdot}L^{-1}$, respectively, in a practical culture and cut flower quality for 'Ilweol'.

Restoration of Cavernous Veno-Occlusive Function through Chronic Administration of a Jun-Amino Terminal Kinase Inhibitor and a LIM-Kinase 2 Inhibitor by Suppressing Cavernous Apoptosis and Fibrosis in a Rat Model of Cavernous Nerve Injury: A Comparison with a Phosphodiesterase Type 5 Inhibitor

  • Min Chul Cho;Junghoon Lee;Juhyun Park;Soo Woong Kim
    • The World Journal of Men's Health
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    • v.39 no.3
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    • pp.541-549
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    • 2021
  • Purpose: To determine if chronic administration of Jun-amino terminal kinase (JNK)-inhibitors and LIM-kinase 2 (LIMK2)-inhibitors from the immediate post-injury period in a rat model of cavernous-nerve-crush-injury could normalize cavernousveno-occlusive-function, and to compare it with phosphodiesterase type 5 (PDE5)-inhibitors. Materials and Methods: A total of 75 12-week-old male Sprague-Dawley-rats were randomized into five groups: sham-surgery (S), cavernous-nerve-crush-injury (I), cavernous-nerve-crush-injury treated with 10.0 mg/kg LIMK2-inhibitor (L) or 10.0 mg/kg JNK-inhibitor and 10.0 mg/kg LIMK2-inhibitor (J+L) or 20.0 mg/kg udenafil (P) for five-weeks. Five-weeks after surgery, dynamic-infusion-cavernosometry, histological-studies, caspase-3-activity-assay, and Western-blot were investigated. Results: Group-I had lower papaverine-response, higher maintenance-rate and higher drop-rate, compared to Group-S. Group-L, Group-J+L and Group-P showed improvement in the three dynamic-infusion-cavernosometry parameters. The papaverine-response and drop-rate in Group-J+L and Group-P recovered to sham-control level, but those in Group-L did not. Regarding apoptosis, Group-I had decreased content of α-smooth-muscle-actin, increased caspase-3 activity and increased cJun-phosphorylation. The cJun-phosphorylation improved only in Group-J+L. The α-smooth-muscle-actin content and caspase-3-activity in Group-J+L and Group-P improved, but those in Group-L were not. Regarding fibrosis, Group-I had decreased smooth muscle (SM)/collagen-ratio, increased protein-expression of fibronectin, and increased Cofilin-phosphorylation. Cofilin-phosphorylation was normalized in Group-L and Group-J+L, but not in Group-P. SM/collagen-ratio and proteinexpression of fibronectin in Group-L, Group-J+L and Group-P improved. Conclusions: Our data indicate that chronic inhibition of JNK and LIMK2 can restore cavernous-veno-occlusive-function by suppressing cavernous-apoptosis and cavernous-fibrosis, comparable to the results by PDE5-inhibitors. Chronic inhibition of JNK and LIMK2 might be a potential mechanism-specific targeted therapy for cavernous-veno-occlusive-dysfunction induced by cavernous nerve-injury.

『Chūn-qiū』Wáng-lì(『春秋』王曆)➂ - from Zhōu-lì(周曆) to Xià-lì(夏曆), and "Xíng-xià-zhī-shí(行夏之時)" Mentioned by Confucius (『춘추』 왕력(王曆)➂ - 주력(周曆)에서 하력(夏曆)으로, 그리고 공자의 "행하지시(行夏之時)")

  • Seo, Jeong-Hwa
    • The Journal of Korean Philosophical History
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    • no.54
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    • pp.153-184
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    • 2017
  • During the Pre-Qin(秦) Dynasty era, there were the records that there had been many calendar systems, such as $g{\check{u}}-li{\grave{u}}-l{\grave{i}}$(古六曆 : six ancient calendar systems). Then, the fact that particularly $zh{\bar{o}}u-l{\grave{i}}$(周曆) and $xi{\grave{a}}-l{\grave{i}}$(夏曆) were mainly discussed among them resulted from a lot of discussions from the differences in the calendar system in "$Ch{\bar{u}}n-qi{\bar{u}}$(春秋)" known to have been written by Confucius from the calendar system in "$X{\acute{i}}ng-xi{\grave{a}}-zh{\bar{i}}-sh{\acute{i}}$(行夏之時 : implement the calendar of Ha dynasty.)" that Confucius mentioned himself to his disciple. $zh{\bar{o}}u-l{\grave{i}}$(周曆) with $d{\bar{o}}ngzh{\grave{i}}-yu{\grave{e}}$(冬至月 : the 11th month of the lunar calendar) as the first month of a year had the system of the lunar calendar, and $xi{\grave{a}}-l{\grave{i}}$(夏曆) called as the calendar of Ha(夏) dynasty had the system of $ji{\acute{e}}-q{\grave{i}}-l{\grave{i}}$(節氣曆 : a kind of the solar calendar that divides one year of 365 days into 24 solar terms) with $y{\acute{i}}n-yu{\grave{e}}$(寅月 :one month from the present Feb 5) as the first month of a year. These two calendars had definite differences in the first months of a year, names of seasons, and the lunar calendar and the solar calendar. The fundamental reason why Confucius recommended the performance of $xi{\grave{a}}-l{\grave{i}}$(夏曆) as a way to run the nation was not that it started from the philosophical view of the universe that among the 'three $zh{\bar{e}}ng$'(三正)' of $ti{\bar{a}}n-zh{\bar{e}}ng$(天正 : the first month of a year with the heaven as the standard), $d{\grave{i}}-zh{\bar{e}}ng$(地正 : the first month of a year with the earth as the standard) and $r{\acute{e}}n-zh{\bar{e}}ng$(人正 : the first month of a year with humans as the standard), but that he wanted to emphasize the importance of practical national economic policies to enhance agricultural productivity. It becomes the criterion that even though Confucius emphasized that politicians should not have moral flaws ideally, with regard to public policies, he wanted to stress politicians' duties based on the reality a lot.

L'etude du Costume Liturgique (그리스도교의 전례복에 관한 연구)

  • 오춘자
    • Journal of the Korean Home Economics Association
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    • v.12 no.34
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    • pp.743-769
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    • 1974
  • Au debut I'habit Iiturgique ne differait de I'habit de fete du simple citoyen que par sa richesse. C'est seulement quand, dans la vie courante, on adopta la robe courte que le vetememt liturgique commenca a se distinguer, meme par la forme, du costume civil. Les ornements liturgiques, en effet, ne sont qu'une forme stylisee de l'habit de fete de la fin de l'Empire Romain (du IIIeme au Veme siecle). Pour une ceremonie religieuse on se presente bien habille. Le meme sentiment de respect des choses sacrees a amene deja, vers la fin de l'antiquite chretienne, a donner au pretre un vetememt liturgique special. Pour celebrer la messe, le pretre revet par-dessus sa soutane un costume special, compose de l'amict, de l'aube, du cordon, du manipule, de l'etole et de la chasuble. Aux messes solennelles, les eveques ajoutent a ces ornements des bas et sandales, des gants, la tunique et la dalmatique avee la mitre ; en certain cas, les archeveques y joingnent le pallium. Aux messes solennelles, le diacre porte sur ; l'aube le manipule et la tunique. De ces pieces du costume liturgique, on dira brievement, apres leur emploi et leur forme actel, l'origine et l'histoire, mais seulement apres avoir marque les lignes generales parition et des transformations du costume liturgique dans son ensemble. L'evolution du costume liturgique a partir du XIIIeme siecle peut se resumer en quelques mots en raison souvent de la lourdeur des riches etoffes (velours et brocarts) et de l'importance donne a la decoration, toujours par rechereche d'une plus grande commodite on a abandonne lentement d'abord, puis rapidement adapte a partir du XVI eme siecle, les formes amples pour des formes courtes et etriquees. Il faut faire quelques exceptions qui marquent l'influence des gouts decoratifs de gouts epoque : La periode de 1700 a 1850 marque la complete decadence du costum liturgique. On a depuis essaye de lui rendre sa beaute et aussi sa signification symbolique, par un retour aux etoffes et a la decoration de la deuxieme partie du moyen age. Souhations que, sous la direction des liturgistes, en respectant l'essentiel de la liturgie aujourd'hui, avec le concours d'artistes epris du sens liturgique et des connaisseurs des tradtions et de toutes les ressources actuelles on trouve des costumes liturgiques adaptes a notre temps dans un style plus simple et correspondant au besoins actuels.

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Inhibitory Effect of the Leaves of Rumex crispus L. on LPS-induced Nitric Oxide Production and the Expression of iNOS and COX-2 in Macrophages

  • Im, Nam-Kyung;Jung, Yeon-Seop;Choi, Jun-Hyeok;Yu, Mi-Hee;Jeong, Gil-Saeng
    • Natural Product Sciences
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    • v.20 no.1
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    • pp.51-57
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    • 2014
  • In this study, the anti-inflammatory effects of ethanol extract of Rumex crispus L. and its fractions were investigated in RAW 264.7 macrophages. To evaluate the anti-inflammatory effects of extract, we studied nitric oxide (NO), prostaglandin $E_2$ ($PGE_2$), and tumor necrosis factor-alpha ($TNF-{\alpha}$) levels in RAW 264.7 cells. The ethanol extract of R. crispus L. significantly decreased NO production and the levels of other inflammatory factors, such as PGE2 and $TNF-{\alpha}$, in lipopolysaccharide (LPS)-stimulated macrophages in a dose-dependent manner. We also assessed the inducible nitric oxide synthase (iNOS) and the cyclooxygenase 2 (COX-2) protein expression by western blot. Ethyl acetate fraction of R. crispus L. had the strongest anti-inflammatory effect. These results suggest that ethyl acetate extract of R. crispus L. might be beneficial in the treatment of chronic inflammatory diseases.

SELF-ADJOINT INTERPOLATION ON Ax = y IN ALG$\cal{L}$

  • Kwak, Sung-Kon;Kang, Joo-Ho
    • Journal of applied mathematics & informatics
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    • v.29 no.3_4
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    • pp.981-986
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    • 2011
  • Given vectors x and y in a Hilbert space $\cal{H}$, an interpolating operator is a bounded operator T such that Tx = y. An interpolating operator for n vectors satisfies the equations $Tx_i=y_i$, for i = 1, 2, ${\cdots}$, n. In this paper the following is proved : Let $\cal{L}$ be a subspace lattice on a Hilbert space $\cal{H}$. Let x and y be vectors in $\cal{H}$ and let $P_x$ be the projection onto sp(x). If $P_xE=EP_x$ for each $E{\in}\cal{L}$, then the following are equivalent. (1) There exists an operator A in Alg$\cal{L}$ such that Ax = y, Af = 0 for all f in $sp(x)^{\perp}$ and $A=A^*$. (2) sup $sup\;\{\frac{{\parallel}E^{\perp}y{\parallel}}{{\parallel}E^{\perp}x{\parallel}}\;:\;E\;{\in}\;{\cal{L}}\}$ < ${\infty}$, $y\;{\in}\;sp(x)$ and < x, y >=< y, x >.

Observation on the Low Back Pain with Myofascial Pain Syndrome (근막동통 증후군의 요통환자에 대한 고찰)

  • Her, Young-Gu
    • Journal of Korean Physical Therapy Science
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    • v.1 no.2
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    • pp.235-241
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    • 1994
  • Myofascial pain syndrome is a common cause of physical disability and reduces the activity of the patient. The purpose of this study was review and analysis efficiency of myofascial pain syndrome with low back pain on 50 case who were treated at the Tae Jon Nam, Myung Ho rehabilitation clinic, from January 1, 1994 to May 31, 1994. The results of this study are as follows : 1. of the 50 cases, 24(48.0%) were male and 26(52.0 %) were female. The most common age group was 40 to 30 years old. 2. The most common duration of the treatment and onset were more than 25 months with 22(44.0 %) and less : 3. As for a major causative disease of low back pain with myofascial pain sndrome, without known cause(30.0 %), lifting object(16.0 %), post exercise(14.0 %) and heavy work(12.0 %). 4. Involved muscle with low back pain reviewed I. C. L(31.0 %), Q. L, Gluteus and others muscle(23.0 %). 5. Disease history and treatment duration were proportioned. 6. Involved muscle distribution for causative disease was 26.0 % post exercise to I. C. L, 33.5 % lifting object to Q. L, 40.0 % without known to gluteus. 7. Low back pain with syndrome was buttock and thigh Pain with 44.0 %, only low back pain with 36.0 %. 8. The improvement by physical therapy on the low back pain was good 24.0 %, fair 56.0 % etc respectively. * I.C.L : Iliocostalis lumborum * Q.L : Quadratus lumborum.

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