• Proceedings of the Korean Fiber Society Conference
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• 2003.04a
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• pp.323-324
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• 2003

생분해성 고분자 중에서 폴리락타이드 (poly(1-lactide), PLA)는 대량생산이 가능하기 때문에 많은 관심을 끌고 있다.[l,2] 그러나 상온에서 딱딱하고, 쉽게 가수분해가 일어나기 때문에 일반적인 용도로 다양하게 사용되기 위해서는 이런 단점이 개선되어야 한다. 본 연구에서는 생분해성 포장재료로 사용할 목적으로 PLA에 저밀도폴리에틸렌 (LDPE)를 혼합하여 PLA/LDPE 블렌드를 제조하였다. PLA/LDPE 블렌드는 비상용성이므로 이를 제어하기 위한 반응형 상용화제 첨가효과를 연구하였다. (중략)

• Proceedings of the Korean Fiber Society Conference
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• 2007.11a
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• pp.97-100
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• 2007

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• Proceedings of the PSK Conference
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• 2003.04a
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• pp.301-302
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• 2003

With the aim of obtaining the early bone regeneration efficacy, poly (L-lactide) particulates were developed as a long-term drug carrier system.Biodegradable microparticulates have been used extensively as drug delivery devices. However, problems like poor encapsulation efficiencies of the drugs and complicated fabrication process are still remained to be solved. (omitted)

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2009.06a
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• pp.995-996
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• 2009

• Proceedings of the Korean Society of Applied Pharmacology
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• 2008.04a
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• pp.164-164
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• 2008

• Proceedings of the Korean Fiber Society Conference
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• 2001.10a
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• pp.452-455
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• 2001

고분자/실리케이트 나노복합체란 고분자 매트릭스에 층상 구조의 점토 광물을 나노 스케일의 시트상의 기본 단위로 박리(exfoliation)ㆍ분산시켜 얻어진 복합체를 말한다. 실리케이트를 구성하는 두께 1nm 정도의 판으로 박리ㆍ분산시키기 때문에 5wt% 정도의 첨가량만으로도 고분자의 획기적인 물성 개선이 가능하다는 장점을 가지고 있다[1]. (중략)

• Proceedings of the PSK Conference
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• 2000.10a
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• pp.268.2-269
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• 2000

• KSBB Journal
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• v.23 no.5
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• pp.452-459
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• 2008

To obtain maximal efficacy with minimal systemic side-effects, many studies have been carried out to achieve the controlled release of 5-fluorouracil (5-FU). In this study, biodegradable poly(L-lactide) (L-PLA) microparticles containing 5-FU were prepared by a process, called aerosol solvent extraction system (ASES), utilizing supercritical carbon dioxide. The effects of various organic solvents, drug/polymer feeding ratio, polymer molecular weight, and blending with the same polymers with different molecular weights on the formation of 5-FU loaded microparticles were investigated under a predetermined operating condition from our previous study. The drug recovery, entrapment efficiency, and in vitro drug release kinetics were determined by HPLC assays. The drug recovery obtained from the ASES process was found to be very high, whereas the drug entrapment efficiency was considerably low in all the experiments due to the poor affinity between L-PLA and 5-FU. These results indicated that the precipitation rate of L-PLA might be quite different from that of 5-FU so that there was little chance to form 5-FU loaded L-PLA microparticles.

• Polymer(Korea)
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• v.32 no.2
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• pp.143-149
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• 2008

We synthesized PEG-PLA (or PLGA) amphiphilic di-block copolymers, which consist of PEG as biocompatible and hydrophilic block and PLA (or PLGA) as biodegradable and hydrophobic block, by ring opening polymerization of LA in the presence of methoxy PEG as a macroinitiator. The compositions and the molecular weights of the copolymers were controlled by changing the feed ratio of LA (and GA) to PEG initiator. The di-block copolymers could self-assemble in aqueous media to form micellar structure. A hydrophobic model drug, pioglitazone, was loaded into the polymer micelle using solid dispersion and dialysis methods, and the drug-loaded micelles were characterized by AFM, DLS and HPLC measurements. The drug loading capacity and in vitro release studies were performed and evaluated under various conditions. These results indicated that the amphiphilic di-block copolymers of PEG-PLA (or PLGA) could solubilize pioglitazone by solid dispersion method and the drug release was modulated according to micellar chemical compositions.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.11
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• pp.5595-5600
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• 2012

This paper is to review and study about the crystallization nucleating agent to improve the heat-resistance properties of poly(lactic acid). Four sub-micron sized nucleating agents, metallic salts of 2,2'-methylene bis(4,6-di-tert-butylphenol), were prepared and used as a crystallization nucleating agent. Thermal and mechanical properties of polymer compounds were investigated by DSC, HDT and UTM. As the results, While the heat-resistance properties of the polymer compound samples were increased linearly with the contents of nucleating agent as well as their smaller size. Among them, the highest heat-resistance property of compound was observed with 2 wt% of MPZ2. HDT values of PL98Z2 compound was $116^{\circ}C$ at 0.455Mpa.