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Preparation and Characterization of PEG-PLA(PLGA) Micelles for Solubilization of Pioglitazone  

Im, Jeong-Hyuk (School of Applied Chemistry and Biological Engineering, Chungnam National University)
Lee, Yong-Kyu (Department of Chemical and Biological Engineering, Chungju National University)
Huh, Kang-Moo (School of Applied Chemistry and Biological Engineering, Chungnam National University)
Publication Information
Polymer(Korea) / v.32, no.2, 2008 , pp. 143-149 More about this Journal
Abstract
We synthesized PEG-PLA (or PLGA) amphiphilic di-block copolymers, which consist of PEG as biocompatible and hydrophilic block and PLA (or PLGA) as biodegradable and hydrophobic block, by ring opening polymerization of LA in the presence of methoxy PEG as a macroinitiator. The compositions and the molecular weights of the copolymers were controlled by changing the feed ratio of LA (and GA) to PEG initiator. The di-block copolymers could self-assemble in aqueous media to form micellar structure. A hydrophobic model drug, pioglitazone, was loaded into the polymer micelle using solid dispersion and dialysis methods, and the drug-loaded micelles were characterized by AFM, DLS and HPLC measurements. The drug loading capacity and in vitro release studies were performed and evaluated under various conditions. These results indicated that the amphiphilic di-block copolymers of PEG-PLA (or PLGA) could solubilize pioglitazone by solid dispersion method and the drug release was modulated according to micellar chemical compositions.
Keywords
PEG-PLA(PLGA) diblock copolymer; polymer micelle; pioglitazone; solid dispersion method;
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