Preparation of Biodegradable Polymer Microparticles Containing 5-FU Using Supercritical Carbon Dioxide
![]() |
Jung, Ju-Hee
(Department of Chemical and Biochemical Engineering, The University of Suwon)
Jung, In-Il (Department of Chemical and Biochemical Engineering, The University of Suwon) Joo, Hyun-Jae (Department of Chemical and Biochemical Engineering, The University of Suwon) Shin, Jae-Ran (Department of Chemical and Biochemical Engineering, The University of Suwon) Lim, Gio-Bin (Department of Chemical and Biochemical Engineering, The University of Suwon) Ryu, Jong-Hoon (Department of Chemical and Biochemical Engineering, The University of Suwon) |
1 | Langer, R. (2006), Biomaterials for drug delivery and tissue engineering, MRS Bull. 31(6), 477-485 DOI |
2 | Bahrami, M. and S. Ranjbarian (2007), Production of micro- and nano-composite particles by supercritical carbon dioxide, J. Supercrit. Fluids 40, 263-283 DOI ScienceOn |
3 | Kim, J. H., S. Y. Lee, B. Y. Kim, J. H. Ryu, and G. B. Lim (2003), Preparation of L-PLA microparticles using pure and cosolvent-modified supercritical carbon dioxide, Korean J. Biotechnol. Bioeng. 18, 385-392 |
4 | Longley, D. B. and P. G. Johnston (2007), 5-fluorouracil: Molecular mechanisms of cell death, In Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Vol. 1, R. Srivastava, Ed., p263, Humana Press, New Jersey |
5 | Rich, T. A., R. C. Shepard, and S. T. Mosley (2004), Four decades of continuing innovation with fluorouracil: Current and future approaches to fluorouracil chemoradiation therapy, J. Clin. Oncol. 22, 2214-2232 DOI ScienceOn |
6 | Guney, O. and A. Akgerman (2002), Synthesis of controlled-release products in supercritical medium, AIChE J. 48, 856-866 DOI ScienceOn |
7 | Hussain, M., G. Beale, M. Hughes, and S. Akhtar (2002), Co-delivery of an antisense oligonucleotide and 5-fluorouracil using sustained release poly (lactide-co-glycolide) microsphere formulations for potential combination therapy in cancer, Int. J. Pharm. 234, 129-138 DOI ScienceOn |
8 | Faisant N., J. Akiki, F. Siepmann, J. P. Benoit, and J. Siepmann (2006), Effects of the type of release medium on drug release from PLGA-based microparticles: Experiment and theory, Int. J. Pharm. 314, 189-197 DOI ScienceOn |
9 | Ritger, P. L. and N. A. Peppas (1987), A simple equation for description of solute release II. Fickian and anomalous release from swellable devices, J. Contro. Rel. 5, 37-42 DOI ScienceOn |
10 | Kompella, U. B. and K. Koushik (2001), Preparation of drug delivery systems using supercritical fluid technology, Crit. Rev. Ther. Drug Carr. Syst. 18, 173-199 |
11 | Dorgan, J. R., J. Janzen, M. P. Clayton, S. B. Hait, and D. M. Knauss (2005), Melt rheology of variable L-content poly (lactic acid), J. Rheol. 49, 607-619 DOI ScienceOn |
12 | Feng, S. S. and S. Chien (2003), Chemotherapeutic engineering: Application and further development of chemical engineering principles for chemotherapy of cancer and other diseases, Chem. Eng. Sci. 58, 4087-4114 DOI ScienceOn |
13 | Jain, R. A. (2000), The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices, Biomaterials 21, 2475-2490 DOI ScienceOn |
14 | Blanco-Prieto, M. J., K. Besseghir, O. Zerbe, D. Andris, P. Orsolini, F. Heimgartner, H. P. Merkle, and B. Gander (2000), In vitro and in vivo evaluation of a somatostatin analogue release from PLGA microspheres, J. Control. Rel. 67, 19-28 DOI ScienceOn |
15 | Yeo, S. D. and E. Kiran (2005), Formation of polymer particles with supercritical fluids: A review, J. Supercrit. Fluids 34, 287-308 DOI ScienceOn |
16 | Fu, Y. J., S. S. Shyu, F. H. Su, and P. C. Yu (2002), Development of biodegradable co-poly (d,l-lactide/glycolic acid) microspheres for the controlled release of 5-FU by the spray drying method, Colloids Surf. B 25, 269-279 DOI ScienceOn |
17 | Martin, A. and M. J. Cocero (2008), Micronization processes with supercritical fluids: fundamentals and mechanisms, Adv. Drug Del. Rev. 60, 339-350 DOI ScienceOn |
18 | Kim, K. K. and D. W. Pack (2006), Microspheres for drug delivery, In Biological and Biomedical Nanotechnology, A. P. Lee and L. J. Lee, Eds., p19, Springer, New York |
19 | Mittal, G., D. K. Sahana, V. Bhardwaj, and M. N. V. R. Kumar (2007), Estradiol loaded PLGA nanoparticles for oral administration: Effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo, J. Control. Rel. 119, 77-85 DOI ScienceOn |
20 | Park, J. H., M. Ye, and K. Park (2005), Biodegradable polymers for microencapsulation of drugs, Molecules 10, 146-161 DOI ScienceOn |
21 | Ghaderi, R. (2000), A supercritical fluids extraction process for the production of drug loaded biodegradable microparticles, Ph. D. Dissertation, Division of Pharmaceutics, Uppsala University, Uppsala, Sweden |
22 | Anderson, J. M. and M. S. Shive (1997), Biodegradation and biocompatibility of PLA and PLGA microspheres, Adv. Drug Del. Rev. 28, 5-24 DOI ScienceOn |
23 | Hsu, L. S. F. and T. C. Marss (1980), Determination of 5-fluorouracil in human plasma by high pressure ion-exchange chromatography, Ann. Clin. Biochem. 17, 272-276 DOI |
24 | Kim, C. (1999), Release kinetics of coated, donut-shaped tablets for water soluble drugs, Eur. J. Pharm. Sci. 7, 237-242 DOI ScienceOn |
![]() |