• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2005년도 International Meeting on Information Displayvol.I
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• pp.616-619
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• 2005

OLED display are extremely sensitive to water and oxygen. Developing a thin film encapsulation for this technology has for a long time been elusive. Vitex has developed a multilayer barrier consisting of alternating inorganic and organic layers which can meet the requirements for a successful protection for such displays. In this paper we will discuss the basic process, the model, the results on top and bottom emission OLED displays as well as the application of Barix layers on plastic to create flexible OLED displays. We will show that for displays all the requirement for the telecommunication industry can be met and that the we can scale up to a mass manufacturing process.

• 약학회지
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• 제8권3호
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• pp.85-88
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• 1964

Pantothenic acid and biotin contents in Panax Ginseng roots were determined microbiologically with L. arabinosus 17-5. Detection of the vitamins was achieved by the thin-layer chromatography and PPC. Pantothenic acid and biotin were found at the Rf values of 0.42 and 0.55 respectively on the thin-layer chromatograms. In order to find out whether or not the L. arabinosus growth promoting factors contained in the respective ginseng extracts, as shown by the microbiological assay, were really the vitamins respectively, PPC was carried out. Microbiological assay of the vitamins met with results that the average pantothenic acid content in the roots was 6.6r/g, calculated as Ca-pantothenate, and the average biotin content 9.24 mr/g.

• 말소리와 음성과학
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• 제1권4호
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• pp.73-84
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• 2009

Despite the growing interest among researchers in the field of second language (L2) phonological acquisition and its apparent contribution to linguistic and acquisition theories, there have been concerns about the lack of pedagogical application of the research findings in L2 classrooms (Levis, 1999, Derwing & Munro, 2005). Based on the belief that meeting an existing pedagogic need is something that should receive primary attention in SLA, this study attempts to bridge the gap between L2 pronunciation research and pronunciation pedagogy. In so doing, this study provides a narrative literature review of papers on L2 pronunciation published from 1994 to 2008 in Korea. The articles for review were retrieved from five database search engines. In addition, six journals where relevant articles most frequently appeared were selected and electronic searches of these six journals were conducted. A total of 117 articles which met the selection criteria were collected, and were reviewed to answer the following three research questions: a) What are the current research trends in L2 pronunciation in Korea? b) Do the research trends reflect a shift of focus on L2 pronunciation teaching? and c) What is the range of research practices in L2 pronunciation? The review of the papers indicates that the number of studies on L2 pronunciation increased sharply from 1999 to 2003. Some changes in research topics were also noticed. Research on segmental features of English was dominant from 1994 to 1998, but became more balanced with research on suprasegmentals from 2004 to 2008. This review also discusses the range of research practices in L2 pronunciation and makes suggestions for future directions in L2 pronunciation research.

• 한국안광학회지
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• 제6권1호
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• pp.125-131
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• 2001

시중에서 시판되고 있는 완성품 선글라스를 고가형 23개, 저가형 55개를 대상으로 비파괴식 검사를 통하여 선글라스의 품질에 대한 분석을 행하였다. 선글라스렌즈의 일반적 광학성질은 규격을 대체적으로 만족할 정도였으며, 재질면에서 HIGH-type은 glass의 비율이 그리고 LOW-type은 Acrylate의 비율이 높았다. HIGH-type의 투과색은 무채색에 근접하였으나 LOW-type은 570 nm와 485 nm를 잊는 선상에 넓게 분포되었다. 렌즈 투과색의 자극순도의 규정을 벗어난 경우는 HIGH-type에서 7%, LOW-type에서 18%였다. UV/VIS cut-off는 HIGH-type의 경우에 350 nm, 380 nm, 400 nm를 초과하는 그룹으로 대별되었으며 LOW-type에서는 350 nm 이하 영역에 있는 경우가 6%에 달하였다. erythemal UV의 투과특성에 있어서 HIGH-type의 경우에는 모두 규격을 만족시켰으나 LOW-type의 경우에는 DIN 규격에서 최대 5개의 fail을 보였다. 또한 Near UV의 투과특성은 HIGH-type의 선글라스에서 더 많은 fail을 보였다. IR 투과특성에서는 LOW-type이 HIGH-type보다 열등한 특성을 보였다. 신호등 인지도의 경우에 HIGH-type은 모두 규격을 만족시켰지만 LOW-type은 21.8%가 만족시키지 못하였다. 대비감도 시력은 L의 증가와 함께 증가하였으며, 측정 거리의 감소와 함께 높아졌다. a와 b의 변화에 따른 대비감도 시력은 a-b 교점에 근접하는 경우 높은 값을 보였다. 선글라스 렌즈의 특성은 투과색, UV, IR, 신호등 가시도, 재질, 대비감도 시력 등의 종합적인 평가에 의해서 이뤄져야 하며 한가지 규격의 획일적 적용을 지양해야 한다. 비파괴식 선글라스 렌즈의 분석에 있어서 HIGH-type의 경우가 LOW-type에 비하여 종합적인 특성이 우수하였다.

• Journal of Nutrition and Health
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• 제50권5호
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• pp.447-459
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• 2017

본 연구는 2015년 KNHANES 자료를 이용하여 30~64세 전당뇨병 대상자들의 유제품 및 어패류의 식품섭취와 대사증후군 위험인자와의 관련성을 분석하였다. 전당뇨병군과 혈당 정상군의 일반적인 특성에서 대사증후군 위험인자 관련 생화학적 지표가 유의적 차이를 보였다. 전당뇨병군의 유제품 섭취량에 따라 분석한 결과, 유제품 섭취 중앙값 (187.0 g) 이상 대상자의 대사증후군 위험인자 중 혈중 TC 수준과 양의 연관성을 보였다. 총 에너지 섭취량, 탄수화물, 단백질, 지방, MUFAs 및 무기질 섭취량은 중앙값 이상 대상자에서 유의적으로 높았으나, 대사증후군 위험인자에 대한 보호효과는 유의적이지 않았다. 어패류 섭취량에 따른 대사증후군 위험인자와의 연관성을 분석한 결과 BP와 혈중 LDL-C 수준은 중앙값 이상 섭취하였을 때 상승할 확률이 유의적으로 감소하였다. 따라서 섭취 유제품의 유형과 함유성분을 고려한 연구 수행이 필요할 것으로 보이며, 어패류는 식사의 반찬으로 제공되는 경우가 많기 때문에 적절한 섭취량 뿐 아니라 조리방법과 함께 섭취하는 식품에 대한 추가 분석을 수행하여 건강에 미치는 효과를 명확하게 규명할 연구수행이 수반되어야 할 것이다.

• 대한한방내과학회지
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• 제36권1호
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• pp.69-75
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• 2015

본 증례보고는 퇴행성 관절염으로 양방병원에서 치료를 받던 중에 발생한 약인성 간손상으로 한방병원에서 진단 및 치료 받은 73세의 여성 환자의 증례를 소개하고자 한다. 환자는 약 3개월 동안 양방병원에서 비스테로이드성 소염제와 근육이완제 등을 처방 받아 오던 중 점차적으로 피로감과 오심 구역감 등의 위장장애를 호소하였다. 양방 의원에서 수 차례 약물치료를 하였으나 호전되지 않고 점차 극심한 피로감과 무기력감 및 위장증상으로 한방병원을 찾게 되었다. 한방병원에서 혈액검사상에 급성감염(AST 90 IU/L, ALT 100 IU/L, ALP 191 IU/L, GGT 614 IU/L) 소견을 보였다. 초음파 검사상 정상적 소견과 다른 기저질환의 배제 및 RUCAM score가 9로서 약인성 간손상으로 진단이 되었다. 15일간의 뜸치료와 침치료 및 한약물 (청간플러스시럽)의 복용으로 주관적 증상은 완전히 소실되었으며 GGT를 제외한 간기능 검사도 정상으로 회복되었다. 그동안 한약물과 관련된 약인성 간손상에 대한 연구가 주로 양의학계에서 이루어지다보니 한약물의 안전성에 대한 부정적 평가가 많았었다. 그러한 의미에서 본 증례보고는 양약에 의한 약인성 간손상에 대한 전형적인 증상의 특성을 보여주고 약인성 간손상에 대한 한의학적 관리 및 치료의 향후 연구에 대한 의미있는 증례를 제시한다고 하겠다.

• 대한수의학회지
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• 제43권3호
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• pp.405-414
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• 2003

The purpose of this study was to assess the role of tachykinins (TK) in mediating nonadrenergic noncholinergic (NANC) contractions produced by electrical field stimulation (EFS) in the longitudinal muscle of the rat ileum. In the presence of atropine ($1{\mu}M$), guanethidine ($5{\mu}M$), and L-nitroarginine (L-NNA, $200{\mu}M$), EFS (0.5ms pulse duration, 120 V, 1-20 Hz for 2 min) produced a frequency-dependent slowly-developing tonic contraction with superimposed phasic contractions ('on'-contraction) followed by off slowly-decreasing tonic and superimposed phasic contractions ('off'-contraction) of mucosa-free longitudinal oriented muscle strip. These EFS induced responses were blocked by tetrotoxin. $NK_1$ receptor selective antagonist L-732,138 strongly inhibited the EFS-induced excitatory responses. However $NK_2$ receptor selective antagonist, GR 159897 and $NK_3$ receptor selective antagonist SB 222200 did not significantly inhibited the responses. $NK_1$ receptor selective agonist [$Sar^9$,$Met(O_2)^{11}$] Substance P and $NK_2$ receptor selective agonist [${\beta}-Ala^8$]-neurokinin A (4-10) induced tonic contraction with superimposed phasic contractions of longitudinal oriented muscle strip and almost blocked by selective antagonist L-732,138 and GR 159897, respectively. But $NK_3$ receptor selective agonist senktide did not showed any effect. Nifedipine ($1{\mu}M$) abolished the contraction produced either by EFS or by the TK receptor agonists [$Sar^9$,$Met(O_2)^{11}$] Substance P or [${\beta}-Ala^8$]-neurokinin A (4-10). It is concluded that, in the longitudinal muscle of rat ileum, both $NK_1$ and $NK_2$ receptors modulated the responses to exogenous tachykinins, whereas $NK_1$ is mainly involved in NANC neuromuscular contraction.

• Clinical and Experimental Vaccine Research
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• 제13권3호
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• pp.242-252
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• 2024

Purpose: In this study, an in-house enzyme-linked immunosorbent assay (ELISA) was developed and validated. The titer of ELISA was calculated using the reference line (RFL) method based on the standard curve drawn using the international reference anti-mouse serum NIBSC (National Institute for Biological Standards and Control) 97/642. Materials and Methods: In the development step, signal to noise was depicted to select the buffers that showed the most appropriate ratio. In the validation step, standard range, precision, dilution linearity, and specificity were confirmed, and RFL and parallel line (PLL) methods were compared in precision and dilution linearity. Results: Coating concentration for plate was achieved at 0.1 ㎍/mL for pertussis toxin (PT), 0.15 ㎍/mL for filamentous hemagglutinin antigen (FHA), and 0.25 ㎍/mL for pertactin (PRN). The signal to noise ratio was 22.02 for PT, 14.93 for FHA, and 8.02 for PRN with 0.25% goat serum in phosphate-buffered saline (PBS) as a dilution buffer, and 2% skim milk in PBS as a blocking buffer. Based on the precision results, we assessed the lower limit of quantification by 1, 0.2, and 1.5 EU/mL concentration for PT, FHA, and PRN which met the ICH (International Council for Harmonization) M10 criteria of a 25% accuracy and total error of 40%. In specificity, homologous serum was spiked into heterologous serum and the accuracy met the criteria. There was no difference in the results between RFL and PLL calculations (p-value=0.3207 for PT, 0.7394 for FHA, 0.2109 for PRN). Conclusion: ELISA validated with RFL calculation method in this study is a relatively accurate assay for mouse humoral immunogenicity test.

• 한국물환경학회지
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• 제30권5호
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• pp.469-476
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• 2014

The focus of this study was to observe the growth of Chlorella sp., Nannochloris sp., and Botryococcus braunii under mixotrophic conditions (i.e., added glycerol) with the aim of increasing the growth of biomass and algae oil content. A significant growth of biomass was obtained when grown in glycerol rich environment comparing to autotrophic conditions. 5 g/L glycerol yielded the highest biomass concentration for these strains. Mixotrophic conditions improved both the growth of the microalgae and the accumulation of triacylglycerols (TAGs). The maximum amount of TAG in Botryococcus braunii was reached in the growth medium with 10 g/L glycerol and Chlorella sp., Nannochloris sp. with 2 g/L glycerol. The content of saturated fatty acids of Chlorella sp., Nannochloris sp., and Botryococcus braunii was found to be 34.94, 14.23 and 13.39%, and the amount of unsaturated fatty acids was 65.06, 85.78 and 86.61% of total fatty acids, respectively. The fatty acid profiles of the oil for the culture possibility met the necessary requirements and are, therefore, promising resource for biofuel production.

• KSBB Journal
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• 제29권1호
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• pp.1-8
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• 2014

Tyrosinases catalyze the hydroxylation of monophenolic compounds and the conversion of o-diphenols to oquinones. The enzymes are mainly involved in the modification of tyrosine into L-3,4-dihydroxyphenyl-alanine (L-DOPA) and DOPA/DOPAquinone-drived intermolecular cross-linking, which play the key roles of pigmentation to the cells. It is ubiquitously distributed in microorganisms, plants, and animals all around the nature world. They are classified as copper- containing dioxygen activating enzymes; two copper ions are coordinated with six histidine residues in their active sites and they are distinguished as met-, deoxy-, and oxy-form depending on their oxidative states. Natural extraction and recombinant protein approaches have been tried to obtain practical amounts of the enzymes for industrial application. Tyrosinases have been widely applied to industrial and biomedical usages such as detoxification of waste water containing phenolic compounds, L-DOPA as a drug of Parkinson's disease, biomaterials preparation based on the cross-linking ability and biosensors for the detection of phenolic compounds. Therefore, this review reports the mechanism of tyrosinase, biochemical and structural features and potential applications in industrial field.