• Journal of Korean Tunnelling and Underground Space Association
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• v.13 no.3
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• pp.233-242
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• 2011

This study aims to evaluate the applicability of high-strength concrete mixed with blast furnace slag to shield segment lining in order to improve its performance and economic efficiency. Especially, it was also intended to derive the optimum replacing ratio of ground granulated blast furnace slag to ordinary cement as well as the optimum steam curing condition for shield segment concrete with the design strength of 60 MPa. From a series of experiments, the condition of 50% replacement of ordinary cement by ground granulated blast furnace slag and unit water content of 125 kg/$m^3$ was proposed as the optimum mixing condition. Comparing with standard curing conditions, it was also possible to expect approximately 110~442% strength improvement of concrete by steam curing in the same mixing condition.

• Biomedical Science Letters
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• v.20 no.2
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• pp.77-84
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• 2014

Periodic analysis of local epidemiologic data of prevalent pathogens of blood culture can provide clinicians with relevant information to guide empirical antibiotic therapy. In this study, we analyzed a pattern of change of causative microorganisms and antimicrobial resistance at a tertiary medical center in Chungcheong province from 2003 to 2012, retrospectively. Of 70,258 blood specimens cultured, 6,063 (8.6%) were positive. Among the positive isolates, 95.9% were aerobic or facultative anaerobic bacteria, 0.1% were anaerobes, and 3.9% were fungi. Coagulase-negative Staphylococci (CoNS) (32.9%), Escherichia coli (16.7%), Staphylococcus aureus (9.1%), Klebsiella pneumoniae (6.4%), and ${\alpha}$-hemolytic Streptococcus (5.9%) were commonly isolated bacteria, and Candida albicans (1.4%) was the most commonly isolated fungi. Enterococcus faecium progressively increased but Streptococcus pneumoniae, Acinetobacter baumannii and Proteus species gradually decreased over a period of 10 years. The multidrug-resistant microorganisms such as methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), cefotaxime-resistant E. coli, imipenem-resistant Pseudomonas aeruginosa (IRPA) and imipenem-resistant A. baumannii (IRAB), were significantly increased. Therefore, there is a need for a more strict control of antibiotics and a more updated guideline for the treatment of bloodstream infection.

• BMB Reports
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• v.34 no.6
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• pp.537-543
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• 2001

In the present study, an in vitro ELISA system to assess the interaction between Src homology (SH)2 domains and phosphotyrosine that contain peptides was established using purified GST-conjugated SH2 proteins and synthetic biotinylated phosphotyrosine that contain oligopeptides. The SH2 domains bound the relevant phosphopeptides that were immobilized in the streptavidin-coated microtiter plate in a highly specific and dose-dependent manner. The epidermal growth factor receptor (EGFR)-, T antigen (T Ag)-, and platelet-derived growth factor receptor (PDGFR)-derived phosphopeptides interacted with the growth factor receptor binding protein (Grb)2/SH2, Lck/SH2, and phosphatidyl inositol 3-kinase (PI3K) p85/SH2, respectively. No cross-reactions were observed. Competitive inhibition experiments showed that a short phosphopeptide of only four amino acids was long enough to determine the binding specificity. Optimal concentrations of the GST-SH2 fusion protein and phosphopeptide in this new ELISA system for screening the binding blockers were chosen at 2nM and 500nM, respectively. When two candidate compounds were tested in our ELISA system, they specifically inhibited the Lck/SH2 and/or p85/SH2 binding to the relevant phosphopeptides. Our results indicate that this ELISA system could be used as an easy screening method for the discovery of specific binding blockers of protein-protein interactions via SH2 domains.

• 한국벤처창업학회:학술대회논문집
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• 2007.04a
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• pp.279-311
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• 2007

The entrepreneurship education for promoting the entrepreneurship is(has been) rapidly proceeded in recent year. In spite of increasing importance of entrepreneurs for successful new venture creation, structured educational programs for entrepreneur development are very limited in Korea. This paper is to develop the new entrepreneurship education in universities and graduate schools. For this entrepreneurship education program development, the survey is designed to Babson College which is voted "The Entrepreneurship Education's Best College" by US News & World report thirteen years in a row. Program development model of entrepreneurship education indicates an entrepreneurship education model, a subject model and a curriculum model through the analysis of a syllabus, the interviews with students, a fieldwork. Based on these literature review was organized research papers, documentary records, small and medium business administration research data. And program designing and implementing stage was composed of analyzing each subject of plan and education training, interviewing with Babson College's students. And observing the field. In addition, the tool of analyzing was collected a course in entrepreneurship education, related matters, a learned society, a research institute at Babson College and some books on pedagogics.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.12 no.2
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• pp.101-108
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• 1992

A careful re-examination has been conducted on the applicability of the concept of equilibrium riverbed slope to river engineering practice and on the validity of Aki's and Mononobe's formulas that are widely used in Korea for determination of equilibrium riverbed slope. A stream in equilibrium is one in which, over a period of years, slope is naturally adjusted to provide, with available water discharge and with prevailing channel characteristics, just the velocity required for transportation of the sediment load supplied from the upstream. The equilibrium riverbed slope is the bed slope of such river. The present river engineering practice to analyze the riverbed characteristics by applying so called 'the equilibrium riverbed slope formula' to such rivers, therefore, should be avoided. Also, the validities of Aki's and Mononobe's formulas, that are presently used for determination of stable channel slope, are very dubious and should not be used in river engineering practice.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.9 no.5
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• pp.1052-1058
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• 2005

This paper dealt with the design and fabrication of a low frequency electronic ballast for ruh attracting lamps. The proposed electronic ballast was composed of a full-wave rectifier, a step don converter operated as a constant power controled current source, an inverter operated by 130 Hz square wave, and an ignition circuit. An acoustic resonance phenomenon of discharge lamps could be eliminated by application of 130 Hz square wave. Also, a circuit of high voltage pulse generation for lamp ignition was added to the ballast. From the experimental results, voltage and current of the lamp operated by the electronic ballast were estimated 132.5 V and 7.6 A, respectively. and the power consumption was about 1,000 W. The weight of the ballast, which is one of important advantages, was reduced to one-fifth of conventional magnetic ballasts.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.10 no.4
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• pp.652-658
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• 2006

This paper deals with an electronic ballast for hish intensity short-arc discharge lamps, which consists of a boost converter, a step down converter operated as a current source with power regulation and a low frequency inverter with external ignition circuit The ignition circuit generates high voltage pulses of 130[Hz] up to 5 [kV]. A reignition circuit is equipped in the ballast, and it operates the lamp at a regular interval for protection when an ignition fails. Acoustic resonance phenomenon was eliminated by operating a low frequency square wave voltage and current. The measured lamp voltage, current and consumption power were 123.8 [V], 8.1 [A] and 1,002 [W], respectively. From the experiment, we confirmed that the prototype ballast operates the lamp with a constant power.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2002.11a
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• pp.155-159
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• 2002

Wire ropes are used in a myriad of various industrial applications such as elevator, mine hoist, construction machinery, lift, and suspension bridge. Especially, wire rope of crane is important component to container transfer. If it happens wire rope failures in operating, it may lead to safety accident, economic power loss by productivity decline, competitive power decline of container terminal and so on. To solve this problem, we developed wire rope fault detecting system as a portable instrument, and this system is consisted of 3 parts that fault detecting part using hall sensor, permanent magnets and analog unit, and digital signal processing part using data acquisition card, monitoring part using wavelet transform, denoising method. In this paper, a wire rope is scanned by this system after makes several broken parts on the surface of wire rope artificially. All detected signal has external noise or disturbance according to circumstances. So, we applied to discrete wavelet transform to extract a signal from noisy data that was used filter. In practical applications of denoising, it is shown that wavelet pursue it with little information loss and smooth signal display. It is verified that the detecting system by denoising has good efficiency for inspecting faults of wire ropes in service. As a result, by developing this system, container terminal could reduce expense because of extension of wire ropes exchange period and could competitive power. Also, this system is possible to apply in several fields like that elevator, lift and so on.

• Korean Journal of Medicinal Crop Science
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• v.18 no.2
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• pp.79-85
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• 2010

Enhancement effect of ultrasonification process on UV-protection and skin-whitening activities using Centella asiatica L. Urban extract was investigated. Cytotoxicity of the extracts measured on human skin fibroblast cells, CCD-986sk, and then, ultrasonification associated extracts showed 5~9% lower cytotoxicity then normal crude extracts on 1.0 mg/$m{\ell}$ of highest sample concentration. The associated extrats showed highest inhibition activity of hyaluronidase on 1.0 mg/$m{\ell}$ of concentration as 54.2%. Also, the associated extract reduced expression of MMP-1 on UV-irradiated CCD-986sk cells down to 100.2% from 136.1%, and revealed high inhibitory potency on tyrosinase as 74.6% by adding 1.0 mg/$m{\ell}$ of concentration. Ultrasonification associated extract showed strong inhibition effect of melanin production on Clone M-3 cells as 84.2% by adding 1.0 mg/$m{\ell}$ of concentration. From the preliminary observations, we considered that the extracts from C. asiatica could be potent natural materials for skin-whitening and anti-aging agent, and could enhance the activities by ultrasonification process.

• Journal of KIISE:Computing Practices and Letters
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• v.16 no.6
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• pp.707-711
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• 2010

Most relational database systems provide $B^+$-trees as their main index structures, and use bulk-loading techniques for creating new $B^+$-trees on existing data from scratch. Although bulk loadings are more effective than inserting keys one by one, they are still time-consuming because they have to sort all the keys from large data. To improve the performance of bulk loadings, this paper proposes an efficient parallel bulk loading method for $B^+$-trees based on CUDA, which is a parallel computing architecture developed by NVIDIA to utilize computing powers of graphic processor units for general purpose computing. Experimental results show that the proposed method enhance the performance more than 70 percents compared to existing bulk loading methods.