• Progress in Medical Physics
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• v.23 no.4
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• pp.219-228
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• 2012

The tangential breast intensity modulated radiotherapy (T-B IMRT) technique, which uses the same tangential fields as conventional 3-dimensional conformal radiotherapy (3D-CRT) plans with physical wedges, was analyzed in terms of the calculated dose distribution feature and dosimetric accuracy of beam delivery during treatment. T-B IMRT plans were prepared for 15 patients with breast cancer who were already treated with conventional 3D-CRT. The homogeneity of the dose distribution to the target volume was improved, and the dose delivered to the normal tissues and critical organs was reduced compared with that in 3D-CRT plans. Quality assurance (QA) plans with the appropriate phantoms were used to analyze the dosimetric accuracy of T-B IMRT. An ionization chamber placed at the hole of an acrylic cylindrical phantom was used for the point dose measurement, and the mean error from the calculated dose was $0.7{\pm}1.4%$. The accuracy of the dose distribution was verified with a 2D diode detector array, and the mean pass rate calculated from the gamma evaluation was $97.3{\pm}2.9%$. We confirmed the advantages of a T-B IMRT in the dose distribution and verified the dosimetric accuracy from the QA performance which should still be regarded as an important process even in the simple technique as T-B IMRT in order to maintain a good quality.

• Investigative Magnetic Resonance Imaging
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• v.14 no.2
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• pp.95-102
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• 2010

Purpose : To evaluate the magnetic resonance imaging (MRI) and clinicopathological features of triple negative breast cancer, and compare them with those of non-triple negative breast cancer. Materials and Methods : This study included 231 pathologically confirmed breast cancers from January 2007 to May 2008. We retrospectively reviewed the MRI findings according to the Breast Imaging Reporting and Data System (BI-RADS) lexicon: mass or non-mass type, mass shape, mass margin, non-mass distribution, and enhancement pattern. Histologic type, histologic grade, and the results for epidermal growth factor receptor, p53, and Ki 67 were reviewed. Results : Of 231 patients, 43(18.6%) were triple negative breast cancer. Forty triple negative breast cancers (93.0%) were mass-type lesion on MRI. A round or oval or lobular shape (p=0.006) and rim enhancement (p=0.004) were significantly more in triple negative breast cancer than non- triple negative breast cancer. In contrast, irregular shape (p=0.006) and spiculated margins (p=0.032) were significantly more in non-triple negative breast cancer. Old age (p=0.019), high histologic grade (p<0.0001), EGFR positivity (p<0.0001), p53 overexpression (p=0.038), and Ki 67 expression (<0.0001) were significantly associated with the triple negative breast cancer. Conclusion : MRI finding may be helpful for differentiation between triple negative and non-triple negative breast cancer.

• Investigative Magnetic Resonance Imaging
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• v.13 no.1
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• pp.31-39
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• 2009

Purpose : This study proposes the keyhole method in order to improve the time resolution of the proton resonance frequency(PRF) MR temperature monitoring technique. The values of Root Mean Square (RMS) error of measured temperature value and Signal-to-Noise Ratio(SNR) obtained from the keyhole and full phase encoded temperature images were compared. Materials and Methods : The PRF method combined with GRE sequence was used to get MR temperature images using a clinical 1.5T MR scanner. It was conducted on the tissue-mimic 2% agarose gel phantom and swine's hock tissue. A MR compatible coaxial slot antenna driven by microwave power generator at 2.45GHz was used to heat the object in the magnetic bore for 5 minutes followed by a sequential acquisition of MR raw data during 10 minutes of cooling period. The acquired raw data were transferred to PC after then the keyhole images were reconstructed by taking the central part of K-space data with 128, 64, 32 and 16 phase encoding lines while the remaining peripheral parts were taken from the 1st reference raw data. The RMS errors were compared with the 256 full encoded self-reference temperature image while the SNR values were compared with the zero filling images. Results : As phase encoding number at the center part on the keyhole temperature images decreased to 128, 64, 32 and 16, the RMS errors of the measured temperature increased to 0.538, 0.712, 0.768 and 0.845$^{\circ}C$, meanwhile SNR values were maintained as the phase encoding number of keyhole part is reduced. Conclusion : This study shows that the keyhole technique is successfully applied to temperature monitoring procedure to increases the temporal resolution by standardizing the matrix size, thus maintained the SNR values. In future, it is expected to implement the MR real time thermal imaging using keyhole method which is able to reduce the scan time with minimal thermal variations.

• Clinical and Experimental Reproductive Medicine
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• v.26 no.3
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• pp.457-465
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• 1999

Objective: The presence of Y chromosome in patients with gonadal dysgenesis is related to the risk of gonadoblastoma. Since the patients with abnormal sexual differentiation may have cryptic Y mosaicism, it is important to detect the presence of Y material in these patients. But sometimes it is difficult to detect Y material only with karyotyping. This study was performed to evaluate the usefulness of the SRY gene screening in blood and gonad by using PCR in detecting the presence of Y material and possible tissue mosaicism in patients with gonadal dysgenesis as Turner syndrome and 46,XY pure gonadal dysgenesis (PGD, Swyer syndrome). Method: In 26 patients with gonadal dysgenesis, we screened for Y material by using PCR for SRY gene in peripheral leukocytes and in gonadal tissues of some patients. They were 22 cases of Turner syndrome (7 45,XO, 2 46,Xi(Xq), 3 45,XO/46,XX, 5 45,XO/46,Xi(Xq), 1 45, XO/46,XY, 1 45,XO/46,Xi(Yq), 1 45,XO/47,XYY, 1 46,XX,del(X)(q24) and 1 46,X,+mar) and 4 cases of 46,XY pure gonadal dysgenesis. PCR for SRY gene in the gonadal tissue was performed in 5 Turner syndrome and 2 PGD to determine the cryptic Y mosaicism between blood and gonad. Results: By using PCR analysis for SRY, Y chromosome material was detected in the blood of 4 of 22 Turner syndrome patients (45,XO/46,Xi(Xq), 45,XO/46,Xi(Yq), 45,XO/46,XY, and 45, XO/47,XYY), 3 of 4 46,XY pure gonadal dysgenesis. Discrepancy between karyotyping and blood PCR for SRY was noted in 1 Turner syndrome (45,XO/46,Xi(Xq)) and 1 PGD. Laparoscopic gonadectomy was performed in Y containing or SRY positive cases. In addition, PCR analysis for SRY in the gonads of 5 Turner syndrome and 2 PGD showed discrepancy between blood and gonad or between both gonads in 3 Turner syndrome (45,XO/46,Xi(Xq), 45,XO/46,Xi(Y q), 45,XO/46,XY) and 2 PGD patients. Conclusion: In gonadal dysgenesis, PCR analysis for SRY gene is useful to detect the cryptic Y mosaicism that is sometimes undetected by karyotyping. And since there may be tissue mosaicism, it is necessary to evaluate Y mosaicism in various tissues even in the case without Y chromosome on karyotyping.

• Journal of Sasang Constitutional Medicine
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• v.12 no.2
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• pp.143-152
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• 2000

1. Background and Purpose The faces of human being change as they grow older. We could know the characters of the each ages, through the facial comparison between the 30's, 40's and the 50's, 60's. As a conclusion, I carried out this Study because I thought that the errors of diagnosis would be reduced a lot through the standardization researches about the morphology of faces. 2. Objectives The object of this study is selected from the patients who were already diagnosed Sasang Constitutions at the department of Sasang Constitutional Medicine in Kyunghee Oriental Medical Center. The number of the patients were 69 men in 30's and 40's, and 74 men in 50's and 60's. 3. Method I took the photographs of front view and lateral view of the objectives by digital camera and obtained the 200 measure through the facial measurement program. I compared the measure of 50's and 60's with 30's and 40's by independant t-test. 4. Results 28 measures are different 30's and 40's with 50's and 60's in Soyangin, 31 measures in Soeumin, 40 measures in Taeumin. 5. Conclusion (1) Soyangin showed wider interpupillary distance in 30's and 40's than 50's and 60's. They also showed the large brow and cheek and their lips were thick and prominent and their ophyrion were prominent and their noses were wide and large and they showed wide bigonial breadth in 30's and 40's than 50's and 60's. (2) Soeumin showed the position of ears were higher and the brows were longer and larger in 30's and 40's than 50's and 60's. The width of both eyebrow were wider in 50's and 60's than 30's and 40's. The lower 2/3 portion of the face was longer and the shape of head was longer in vertical in 50's and 60's than 30's and 40's. (3) Taeumin showed the wider brow in 30's and 40's than 50's and 60's. The width of each eyes was wider and the width of cheek and face was larger, too. The ophyrion was prominent and the mouth was bigger and the face showed longer in 50's and 60's than 30's and 40's. (4) The upper 1/3 portion of the face was large in 30's and 40's and the lower 2/3 portion of the face showed large and long in 50's and 60's regardless Constitution.

• Korean Journal of Plant Resources
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• v.30 no.4
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• pp.364-371
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• 2017

Limonium tetragonum is a halophyte grown naturally in the coastal region in South Korea. This study was conducted to investigate the effects of salt concentrations on seed germination, seedling growth, and antioxidant capacity of L. tetragonum. Seeds were collected from naturally grown plants of L. tetragonum and those at full maturity were used in this experiment. All experiments were performed at 0%, 0.5%, 1.0%, or 2.0% of salt concentrations. Seed germination rate was highest as 86% at $20^{\circ}C$ and followed as higher in order of $25^{\circ}C$, $30^{\circ}C$ and $15^{\circ}C$. The germination rate was about 80% at 0% or 0.5% of salt concentration, but it was very low at the salt concentrations higher than 1%. Growth of L. tetragonum seedlings showed no difference in Hoagland solution containing NaCl in the range of 0% to 1.0% and seedlings survived at 2.0% of NaCl concentration. As the salt concentration increased, the content of $Na^+$ in the shoot increased, but that of $K^+$, $Ca^{{+}{+}}$, or $Mg^{{+}{+}}$ decreased. The antioxidant activity and the content of total polyphenol and total flavonoid in the shoot were similar at 0% and 0.5% of NaCl and were highest at 2.0% of NaCl concentration. In conclusion, performance of seed germination and plant growth of L. tetragonum was highest at 0% and 0.5% of NaCl concentration, and showed no difference in antioxidant activity, total polyphenol contents, and total flavonoid contents at the same salt concentrations.

• Journal of dental hygiene science
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• v.12 no.5
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• pp.477-485
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• 2012

This study evaluate the influence of food staining food and bleaching on the color (CIELAB) and reflectivity of two-way (anterior & posterior) composite resin and flowable composite resin. There were 6 immersion media: kimchi, red pepper paste, blueberry, tea, curry and distilled water. A total of 36 specimens ($11{\times}11{\times}2$ mm) were prepared and immersed in each immersion media for 8 days at $37^{\circ}C$. Their color and reflectivity measured with the spectrophotometer at baseline and every 24 hours. Data from the color change and reflectivity were collected and subjected to statistical analysis by ANOVA, ANCOVA and RM-ANOVA. Curry showed the highest influence on color change and blueberry on brightness (p<0.001) on both resins. Bleaching after polishing made color change more than polishing or bleaching independently on two-way (anterior & posterior) composite resin, but not on flowable composite resin. It was suggested cleaning the mouth after taking curry and blueberry be needed to maintain the original color of composite resin.

• Journal of dental hygiene science
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• v.9 no.4
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• pp.435-441
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• 2009

The purpose of this study was to examine the use of dentifrice among preschoolers in an attempt to provide consumers with the right information on the choice of dentifrice and toothbrush for different age groups of children. The subjects in this study were parents who raised preschoolers in Seoul and Gyeonggi Province. A self-administered survey was conducted over approximately three months from May to July 2007 to find out the state of their children's use of dentifrice. After the collected data were analyzed, the following findings were given: The greatest group (51.5%) needed parental help with toothbrushing. The biggest group of the patients (35.6%) considered it necessary for children at the age of 6 and 7 to brush their teeth with the help of their parents. As to dentifrice squeezing and parental outlook on that, the biggest group of the parents (49.4%) replied their children squeezed the dentifrice for themselves, and the greatest group (42.2%) thought that children needed parental help with dentifrice squeezing by the age of five. Regarding dentifrice swallowing and parental perception of it, the biggest group (61.9%) saw their children swallowing the dentifrice, and the greatest group (73.7%) believed that children must not swallow the dentifrice. The biggest group of those who found it okay for children to swallow the dentifrice (62.5%) thought that it would be no problem to swallow the dentifrice for child. Concerning the use of toothbrushes, the biggest group (96.7%) had their children use toothbrushes for child. The above-mentioned findings of the study showed that the children who are at the age of 3 or down should use non-fluoride containing dentifrice or just a small amount of fluoride that is as equal as the size of a pea. Children must brush their teeth under the guidance of their parents, and sustained education should be provided about that.

• Korean Journal of Ichthyology
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• v.18 no.3
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• pp.184-192
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• 2006

To investigate reproductive cycle of Tridentiger obscurus in Jeju, total 408 fish were collected in brackish area (May 2004 to August 2005) and total 271 fish were collected in tidal pool (July 2004 to August 2005), respectively. Water temperature ranged $11.0{\sim}21.6^{\circ}C$ in brackish area. Water temperature of tidal pool ($11.1{\sim}24.5^{\circ}C$) in 2005 was similar to that of brackish area although it were highest $30.1{\sim}29.2^{\circ}C$ from July to August in 2004. In brackish area, female gonadosomatic index (GSI) increased in April and maintained high values from May to August. The reproductive cycle can be grouped into the following successive stages in the ovary: immature (November to May), maturing (March to September), ripe and spawning (May to September), and degenerating (July to December). In the tidal pool, female GSI rapidly increased in April and maintained high values until July in 2005. However, it has been low in July 2004 when water temperature was highest. The reproductive cycle can be grouped into the following successive stages in the ovary: immature (August to April), maturing (March to August), ripe and spawning (March to July), and degenerating (July to August 2004 and August 2005). Fecundity of mature female ranged from 1,214 to 12,109 in brackish and ranged from 2,427 to 13,892 in tidal pool area. The fecundity of fish in the tidal pool was significantly higher than that of fish in brackish area. Fecundity was correlated positively with total length and body weigh. Although the large group (> 111 mm total length) in brackish area observed only in spawning season, one in the tidal pool observed from October 2004 until next spawning season. Frequency of the large group was 0 to 12% and 11.4 to 57.9% in brackish area and tidal pool, respectively. These results were indicated that gonadal development of T. obscurus was affected to water temperature and day length.

• Journal of agricultural medicine and community health
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• v.30 no.1
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• pp.63-74
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• 2005

Objectives: The present study aimed to provide the fundamental data for guiding establishment of measures among the rural elderly population with physical disabilities. The specific goals of this report are to reveal the prevalence of their disabilities, its tendency according to their increasing age, and to assess the background explanations. Methods: The self-administered questionnaires have been performed 432 persons of rural residents age 40 and greater in Kumsan-Gun and Chongyang-Gun, Chungchongnamdo Province. The questionnaire items included presence or not. of disabilities. specific causes for disabilities, anthropometric measures, and amount of physical activities. Results: The proportion of disabilities was higher in women than men, and the functional degree of their limbs decreased with the increasing age. The proportion of disabling extremities was higher in the lower extremities than in the upper ones. Joint diseases were the most prevalent causes for disabilities of extremities. Concerning the degree of depression, 41.2% of study subjects were normal, 47.5% had mild depression, 6.3% moderate, and 5.1% severe depression, with no statistical difference based on age and sex. The worse are the functional degree of both extremities, the greater the degree of depression the subjects had. The odds ratio for presence of disabilities of extremities was 2.6 times higher in women than in men for sex and for age, 50's were 3.5 times, 60's 4.3 times, 70's 4.9 times than 40's, respectively, with increasing tendency with increasing age. The odds ratio for depression was 1.2 times greater in subjects with disabilities than in normal population with no statistical difference. Conclusions: More efforts are needed to establish elderly specific measures for providing proper public health services centering on maintenance of physical functioning among elderly population.